SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5idi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD6_0
(GRAMICIDIN A)		 5idi 1,4-BETA-D-GLUCAN
GLUCOHYDROLASE
(Thermotoga
neapolitana) 		3 / 3 TRP A 132
ALA A 179
VAL A 168
 None
 0.98A 1av2C-5idiA:
undetectable
1av2D-5idiA:
undetectable		 1av2C-5idiA:
3.05
1av2D-5idiA:
3.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQU_A_EQIA329_0
(PROTEIN (ESTRADIOL
17
BETA-DEHYDROGENASE
1))		 5idi 1,4-BETA-D-GLUCAN
GLUCOHYDROLASE
(Thermotoga
neapolitana) 		5 / 10 VAL A 288
LEU A 250
GLY A 289
HIS A 241
GLU A 339
 None
 1.38A 1equA-5idiA:
2.5		 1equA-5idiA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT7_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 5idi 1,4-BETA-D-GLUCAN
GLUCOHYDROLASE
(Thermotoga
neapolitana) 		5 / 11 LEU A  84
LEU A 148
VAL A 147
TYR A  99
LEU A  96
 None
 1.37A 1kt7A-5idiA:
undetectable		 1kt7A-5idiA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_1
(POL POLYPROTEIN)		 5idi 1,4-BETA-D-GLUCAN
GLUCOHYDROLASE
(Thermotoga
neapolitana) 		5 / 11 GLY A  70
VAL A 395
GLY A 430
ILE A 426
VAL A  12
 None
 0.89A 1t7jA-5idiA:
undetectable		 1t7jA-5idiA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_W_CHDW4060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 5idi 1,4-BETA-D-GLUCAN
GLUCOHYDROLASE
(Thermotoga
neapolitana) 		4 / 7 ILE A 253
LEU A 250
ARG A 197
LEU A 165
 None
 0.86A 1v54N-5idiA:
undetectable
1v54W-5idiA:
undetectable		 1v54N-5idiA:
21.38
1v54W-5idiA:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1W5U_B_DVAB8_0
(GRAMICIDIN D)		 5idi 1,4-BETA-D-GLUCAN
GLUCOHYDROLASE
(Thermotoga
neapolitana) 		3 / 3 VAL A 168
VAL A 192
TRP A 132
 None
 0.94A 1w5uA-5idiA:
undetectable
1w5uB-5idiA:
undetectable		 1w5uA-5idiA:
3.05
1w5uB-5idiA:
3.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5idi 1,4-BETA-D-GLUCAN
GLUCOHYDROLASE
(Thermotoga
neapolitana) 		4 / 5 PHE A 265
LEU A 174
PHE A 239
MET A 240
 None
 0.98A 1wrkB-5idiA:
undetectable		 1wrkB-5idiA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5idi 1,4-BETA-D-GLUCAN
GLUCOHYDROLASE
(Thermotoga
neapolitana) 		4 / 7 PHE A 265
LEU A 174
PHE A 239
MET A 240
 None
 1.01A 1wrlA-5idiA:
undetectable
1wrlB-5idiA:
undetectable		 1wrlA-5idiA:
11.49
1wrlB-5idiA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_E_TFPE212_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 5idi 1,4-BETA-D-GLUCAN
GLUCOHYDROLASE
(Thermotoga
neapolitana) 		4 / 7 PHE A 265
LEU A 174
PHE A 239
MET A 240
 None
 1.04A 1wrlE-5idiA:
undetectable		 1wrlE-5idiA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5idi 1,4-BETA-D-GLUCAN
GLUCOHYDROLASE
(Thermotoga
neapolitana) 		4 / 7 ILE A 253
LEU A 250
ARG A 197
LEU A 165
 None
 0.82A 2dyrN-5idiA:
undetectable
2dyrW-5idiA:
undetectable		 2dyrN-5idiA:
21.38
2dyrW-5idiA:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5idi 1,4-BETA-D-GLUCAN
GLUCOHYDROLASE
(Thermotoga
neapolitana) 		4 / 8 ILE A 253
LEU A 250
ARG A 197
LEU A 165
 None
 0.87A 2eijN-5idiA:
undetectable
2eijW-5idiA:
undetectable		 2eijN-5idiA:
21.38
2eijW-5idiA:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIK_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5idi 1,4-BETA-D-GLUCAN
GLUCOHYDROLASE
(Thermotoga
neapolitana) 		4 / 8 ILE A 253
LEU A 250
ARG A 197
LEU A 165
 None
 0.89A 2eikN-5idiA:
undetectable
2eikW-5idiA:
undetectable		 2eikN-5idiA:
21.38
2eikW-5idiA:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5idi 1,4-BETA-D-GLUCAN
GLUCOHYDROLASE
(Thermotoga
neapolitana) 		4 / 8 ILE A 253
LEU A 250
ARG A 197
LEU A 165
 None
 0.85A 2eilN-5idiA:
undetectable
2eilW-5idiA:
undetectable		 2eilN-5idiA:
21.38
2eilW-5idiA:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_C_DVAC8_0
(GRAMICIDIN D)		 5idi 1,4-BETA-D-GLUCAN
GLUCOHYDROLASE
(Thermotoga
neapolitana) 		3 / 3 VAL A 192
TRP A 132
VAL A 168
 None
 0.96A 2izqC-5idiA:
undetectable
2izqD-5idiA:
undetectable		 2izqC-5idiA:
3.05
2izqD-5idiA:
3.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYU_B_SAMB201_1
(PUTATIVE RIBOSOMAL
RNA
METHYLTRANSFERASE 2)		 5idi 1,4-BETA-D-GLUCAN
GLUCOHYDROLASE
(Thermotoga
neapolitana) 		4 / 5 ALA A 352
ASP A 400
ASP A 418
ASP A 366
 None
 1.20A 2nyuB-5idiA:
undetectable		 2nyuB-5idiA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA803_0
(FERROCHELATASE)		 5idi 1,4-BETA-D-GLUCAN
GLUCOHYDROLASE
(Thermotoga
neapolitana) 		4 / 5 LEU A 122
PRO A 123
LEU A 126
ILE A 137
 None
 0.76A 2qd4A-5idiA:
undetectable		 2qd4A-5idiA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_0
(CATECHOL
O-METHYLTRANSFERASE)		 5idi 1,4-BETA-D-GLUCAN
GLUCOHYDROLASE
(Thermotoga
neapolitana) 		5 / 12 VAL A 262
TYR A 269
TYR A 186
HIS A 193
ARG A 135
 None
 1.48A 2zthA-5idiA:
undetectable		 2zthA-5idiA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5idi 1,4-BETA-D-GLUCAN
GLUCOHYDROLASE
(Thermotoga
neapolitana) 		4 / 7 ILE A 253
LEU A 250
ARG A 197
LEU A 165
 None
 0.77A 3ablA-5idiA:
undetectable
3ablJ-5idiA:
undetectable		 3ablA-5idiA:
21.38
3ablJ-5idiA:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5idi 1,4-BETA-D-GLUCAN
GLUCOHYDROLASE
(Thermotoga
neapolitana) 		4 / 8 ILE A 253
LEU A 250
ARG A 197
LEU A 165
 None
 0.77A 3ablN-5idiA:
undetectable
3ablW-5idiA:
undetectable		 3ablN-5idiA:
21.38
3ablW-5idiA:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AF0_A_PAUA314_0
(PANTOTHENATE KINASE)		 5idi 1,4-BETA-D-GLUCAN
GLUCOHYDROLASE
(Thermotoga
neapolitana) 		4 / 8 VAL A 218
GLY A 349
TYR A 293
HIS A 119
 None
None
ACT  A 501 ( 4.8A)
None
 0.96A 3af0A-5idiA:
undetectable		 3af0A-5idiA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AF3_A_PAUA314_0
(PANTOTHENATE KINASE)		 5idi 1,4-BETA-D-GLUCAN
GLUCOHYDROLASE
(Thermotoga
neapolitana) 		4 / 6 PHE A 243
MET A 240
PHE A 239
PHE A 265
 None
 1.36A 3af3A-5idiA:
undetectable		 3af3A-5idiA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG3_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5idi 1,4-BETA-D-GLUCAN
GLUCOHYDROLASE
(Thermotoga
neapolitana) 		4 / 8 ILE A 253
LEU A 250
ARG A 197
LEU A 165
 None
 0.83A 3ag3N-5idiA:
undetectable
3ag3W-5idiA:
undetectable		 3ag3N-5idiA:
21.38
3ag3W-5idiA:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_W_CHDW1059_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 5idi 1,4-BETA-D-GLUCAN
GLUCOHYDROLASE
(Thermotoga
neapolitana) 		4 / 8 ILE A 253
LEU A 250
ARG A 197
LEU A 165
 None
 0.84A 3asnN-5idiA:
undetectable
3asnW-5idiA:
undetectable		 3asnN-5idiA:
21.38
3asnW-5idiA:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF509_2
(PHOSPHOLIPASE A2)		 5idi 1,4-BETA-D-GLUCAN
GLUCOHYDROLASE
(Thermotoga
neapolitana) 		4 / 8 TYR A 118
ASN A 163
PHE A 412
TRP A 396
 None
None
ACT  A 501 ( 4.0A)
ACT  A 501 (-3.4A)
 1.44A 3bjwD-5idiA:
undetectable		 3bjwD-5idiA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BUF_A_AEGA394_0
(BETA-SECRETASE 1)		 5idi 1,4-BETA-D-GLUCAN
GLUCOHYDROLASE
(Thermotoga
neapolitana) 		4 / 5 LEU A 390
ILE A 329
ILE A 384
GLY A 392
 None
 0.85A 3bufA-5idiA:
undetectable		 3bufA-5idiA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL5_B_1UNB201_2
(PROTEASE)		 5idi 1,4-BETA-D-GLUCAN
GLUCOHYDROLASE
(Thermotoga
neapolitana) 		6 / 12 GLY A  70
ALA A  71
VAL A 395
GLY A 430
ILE A 426
VAL A  12
 None
 1.16A 3el5B-5idiA:
undetectable		 3el5B-5idiA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_B_EAAB214_1
(GLUTATHIONE
S-TRANSFERASE P)		 5idi 1,4-BETA-D-GLUCAN
GLUCOHYDROLASE
(Thermotoga
neapolitana) 		4 / 8 PHE A 149
VAL A 210
GLY A 213
GLY A 153
 None
 0.68A 3n9jB-5idiA:
undetectable		 3n9jB-5idiA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W2T_B_LF7B801_1
(DIPEPTIDYL PEPTIDASE
4)		 5idi 1,4-BETA-D-GLUCAN
GLUCOHYDROLASE
(Thermotoga
neapolitana) 		5 / 12 ARG A  75
TYR A 293
VAL A 167
ASN A 163
HIS A 119
 None
ACT  A 501 ( 4.8A)
None
None
None
 1.49A 3w2tB-5idiA:
undetectable		 3w2tB-5idiA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_A_PXLA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 5idi 1,4-BETA-D-GLUCAN
GLUCOHYDROLASE
(Thermotoga
neapolitana) 		4 / 7 GLY A  21
ASP A  50
GLY A  49
HIS A  38
 None
 0.78A 4c5nA-5idiA:
3.4		 4c5nA-5idiA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_C_PXLC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 5idi 1,4-BETA-D-GLUCAN
GLUCOHYDROLASE
(Thermotoga
neapolitana) 		4 / 8 GLY A  21
ASP A  50
GLY A  49
HIS A  38
 None
 0.75A 4c5nC-5idiA:
2.3		 4c5nC-5idiA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5idi 1,4-BETA-D-GLUCAN
GLUCOHYDROLASE
(Thermotoga
neapolitana) 		4 / 4 LEU A 122
PRO A 123
LEU A 126
ILE A 137
 None
 0.85A 4f4dB-5idiA:
undetectable		 4f4dB-5idiA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4II8_A_010A210_0
(LYSOZYME C)		 5idi 1,4-BETA-D-GLUCAN
GLUCOHYDROLASE
(Thermotoga
neapolitana) 		4 / 7 ASP A  54
GLN A 422
ASN A  57
TRP A  59
 None
 0.91A 4ii8A-5idiA:
undetectable		 4ii8A-5idiA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_B_FOLB301_1
(FOLATE RECEPTOR
ALPHA)		 5idi 1,4-BETA-D-GLUCAN
GLUCOHYDROLASE
(Thermotoga
neapolitana) 		3 / 3 ASP A 121
TRP A 396
SER A  77
 None
ACT  A 501 (-3.4A)
None
 0.98A 4lrhB-5idiA:
undetectable		 4lrhB-5idiA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_F_FOLF301_1
(FOLATE RECEPTOR
ALPHA)		 5idi 1,4-BETA-D-GLUCAN
GLUCOHYDROLASE
(Thermotoga
neapolitana) 		3 / 3 ASP A 121
TRP A 396
SER A  77
 None
ACT  A 501 (-3.4A)
None
 1.08A 4lrhF-5idiA:
undetectable		 4lrhF-5idiA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_A_ADNA501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 5idi 1,4-BETA-D-GLUCAN
GLUCOHYDROLASE
(Thermotoga
neapolitana) 		5 / 12 VAL A  12
SER A 429
ASP A 400
GLY A 430
ASP A 366
 None
 1.38A 4pevA-5idiA:
undetectable		 4pevA-5idiA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 5idi 1,4-BETA-D-GLUCAN
GLUCOHYDROLASE
(Thermotoga
neapolitana) 		5 / 12 VAL A  12
SER A 429
ASP A 400
GLY A 430
ASP A 366
 None
 1.38A 4pevC-5idiA:
undetectable		 4pevC-5idiA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN)		 5idi 1,4-BETA-D-GLUCAN
GLUCOHYDROLASE
(Thermotoga
neapolitana) 		5 / 12 SER A 294
GLY A 222
ALA A 236
MET A 240
PHE A 224
 ACT  A 502 (-2.8A)
ACT  A 502 ( 4.8A)
None
None
None
 1.27A 4r29A-5idiA:
undetectable		 4r29A-5idiA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN)		 5idi 1,4-BETA-D-GLUCAN
GLUCOHYDROLASE
(Thermotoga
neapolitana) 		5 / 12 SER A 294
GLY A 222
ALA A 236
MET A 240
PHE A 224
 ACT  A 502 (-2.8A)
ACT  A 502 ( 4.8A)
None
None
None
 1.27A 4r29C-5idiA:
undetectable		 4r29C-5idiA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5idi 1,4-BETA-D-GLUCAN
GLUCOHYDROLASE
(Thermotoga
neapolitana) 		4 / 7 ILE A 253
LEU A 250
ARG A 197
LEU A 165
 None
 0.95A 5b1bA-5idiA:
undetectable
5b1bJ-5idiA:
undetectable		 5b1bA-5idiA:
21.38
5b1bJ-5idiA:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 5idi 1,4-BETA-D-GLUCAN
GLUCOHYDROLASE
(Thermotoga
neapolitana) 		5 / 12 ILE A 370
LEU A 373
GLY A 430
ILE A 414
GLY A 362
 None
 0.97A 5d4uC-5idiA:
undetectable		 5d4uC-5idiA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 5idi 1,4-BETA-D-GLUCAN
GLUCOHYDROLASE
(Thermotoga
neapolitana) 		5 / 12 ILE A 370
LEU A 373
GLY A 430
ILE A 414
GLY A 362
 None
 0.94A 5d4uD-5idiA:
undetectable		 5d4uD-5idiA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5idi 1,4-BETA-D-GLUCAN
GLUCOHYDROLASE
(Thermotoga
neapolitana) 		4 / 7 ILE A 253
LEU A 250
ARG A 197
LEU A 165
 None
 0.87A 5iy5A-5idiA:
undetectable
5iy5J-5idiA:
undetectable		 5iy5A-5idiA:
21.38
5iy5J-5idiA:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_B_RBFB201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 5idi 1,4-BETA-D-GLUCAN
GLUCOHYDROLASE
(Thermotoga
neapolitana) 		5 / 12 GLU A  20
ASN A 151
VAL A 147
TYR A 144
ASN A 100
 None
 1.43A 5kbwB-5idiA:
undetectable		 5kbwB-5idiA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_I_BEZI1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 5idi 1,4-BETA-D-GLUCAN
GLUCOHYDROLASE
(Thermotoga
neapolitana) 		3 / 3 SER A 294
TYR A 293
TYR A 292
 ACT  A 502 (-2.8A)
ACT  A 501 ( 4.8A)
None
 0.81A 5lakA-5idiA:
undetectable
5lakI-5idiA:
undetectable		 5lakA-5idiA:
22.07
5lakI-5idiA:
4.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_J_BEZJ1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 5idi 1,4-BETA-D-GLUCAN
GLUCOHYDROLASE
(Thermotoga
neapolitana) 		3 / 3 SER A 294
TYR A 293
TYR A 292
 ACT  A 502 (-2.8A)
ACT  A 501 ( 4.8A)
None
 0.68A 5lakC-5idiA:
undetectable
5lakJ-5idiA:
undetectable		 5lakC-5idiA:
22.07
5lakJ-5idiA:
4.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 5idi 1,4-BETA-D-GLUCAN
GLUCOHYDROLASE
(Thermotoga
neapolitana) 		4 / 8 ILE A 253
LEU A 250
ARG A 197
LEU A 165
 None
 0.83A 5xdxN-5idiA:
undetectable
5xdxW-5idiA:
undetectable		 5xdxN-5idiA:
21.38
5xdxW-5idiA:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_2
(PROTEIN CYP51)		 5idi 1,4-BETA-D-GLUCAN
GLUCOHYDROLASE
(Thermotoga
neapolitana) 		4 / 7 VAL A  43
PRO A 123
LEU A 126
PHE A 124
 None
 0.98A 6aycA-5idiA:
undetectable		 6aycA-5idiA:
8.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B1E_B_LF7B801_1
(DIPEPTIDYL PEPTIDASE
4)		 5idi 1,4-BETA-D-GLUCAN
GLUCOHYDROLASE
(Thermotoga
neapolitana) 		5 / 12 ARG A  75
TYR A 293
VAL A 167
ASN A 163
HIS A 119
 None
ACT  A 501 ( 4.8A)
None
None
None
 1.50A 6b1eB-5idiA:
undetectable		 6b1eB-5idiA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_A_CXQA507_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 5idi 1,4-BETA-D-GLUCAN
GLUCOHYDROLASE
(Thermotoga
neapolitana) 		4 / 5 ALA A 375
TYR A 372
GLN A 379
ILE A 329
 None
 1.35A 6f6sA-5idiA:
undetectable
6f6sB-5idiA:
undetectable		 6f6sA-5idiA:
10.93
6f6sB-5idiA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_A_Y00A406_1
(BETA-1 ADRENERGIC
RECEPTOR)		 5idi 1,4-BETA-D-GLUCAN
GLUCOHYDROLASE
(Thermotoga
neapolitana) 		4 / 6 GLY A 289
VAL A 380
PHE A   8
PHE A   4
 None
 0.96A 6h7lA-5idiA:
undetectable		 6h7lA-5idiA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7L_B_Y00B405_1
(BETA-1 ADRENERGIC
RECEPTOR)		 5idi 1,4-BETA-D-GLUCAN
GLUCOHYDROLASE
(Thermotoga
neapolitana) 		4 / 6 GLY A 289
VAL A 380
PHE A   8
PHE A   4
 None
 0.96A 6h7lB-5idiA:
undetectable		 6h7lB-5idiA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5idi 1,4-BETA-D-GLUCAN
GLUCOHYDROLASE
(Thermotoga
neapolitana) 		3 / 3 ARG A 238
LEU A 261
PHE A 265
 None
 0.63A 6nknP-5idiA:
undetectable		 6nknP-5idiA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5idi 1,4-BETA-D-GLUCAN
GLUCOHYDROLASE
(Thermotoga
neapolitana) 		4 / 7 ILE A 253
LEU A 250
ARG A 197
LEU A 165
 None
 0.74A 6nmfA-5idiA:
undetectable
6nmfJ-5idiA:
undetectable		 6nmfA-5idiA:
21.38
6nmfJ-5idiA:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5idi 1,4-BETA-D-GLUCAN
GLUCOHYDROLASE
(Thermotoga
neapolitana) 		4 / 7 ILE A 253
LEU A 250
ARG A 197
LEU A 165
 None
 0.74A 6nmpA-5idiA:
undetectable
6nmpJ-5idiA:
undetectable		 6nmpA-5idiA:
21.38
6nmpJ-5idiA:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5idi 1,4-BETA-D-GLUCAN
GLUCOHYDROLASE
(Thermotoga
neapolitana) 		4 / 5 ILE A 253
LEU A 250
ARG A 197
LEU A 165
 None
 0.83A 6nmpN-5idiA:
undetectable
6nmpW-5idiA:
undetectable		 6nmpN-5idiA:
21.38
6nmpW-5idiA:
8.68