SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5idn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ILQ_C_ACAC7_1
(INTERLEUKIN-8
PRECURSOR
INTERLEUKIN-8
RECEPTOR A)		 5idn CYCLIN-DEPENDENT
KINASE 8
(Homo
sapiens) 		4 / 6 HIS A 276
ASP A 269
MET A 273
PRO A 274
 None
 1.41A 1ilqA-5idnA:
undetectable
1ilqC-5idnA:
undetectable		 1ilqA-5idnA:
13.48
1ilqC-5idnA:
3.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUO_A_ADNA1_1
(AURORA-RELATED
KINASE 1)		 5idn CYCLIN-DEPENDENT
KINASE 8
(Homo
sapiens) 		6 / 9 GLY A  28
VAL A  35
ALA A  50
TYR A  99
ALA A 100
LEU A 158
 6A7  A 401 (-3.6A)
6A7  A 401 ( 4.5A)
6A7  A 401 (-3.3A)
6A7  A 401 (-4.9A)
6A7  A 401 (-3.7A)
6A7  A 401 (-4.8A)
 0.72A 1muoA-5idnA:
9.6		 1muoA-5idnA:
26.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_1
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 5idn CYCLIN-DEPENDENT
KINASE 8
(Homo
sapiens) 		6 / 12 ALA A  50
LYS A  52
GLU A  66
LEU A  70
LEU A 142
HIS A 149
 6A7  A 401 (-3.3A)
6A7  A 401 ( 2.9A)
FMT  A 404 ( 4.2A)
None
None
FMT  A 403 (-4.6A)
 0.81A 1uwhB-5idnA:
12.1		 1uwhB-5idnA:
26.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		 5idn CYCLIN-DEPENDENT
KINASE 8
(Homo
sapiens) 		7 / 12 LYS A  52
PHE A  97
ASP A 103
ASN A 156
LEU A 158
ALA A 172
ASP A 173
 6A7  A 401 ( 2.9A)
6A7  A 401 (-3.8A)
6A7  A 401 ( 4.9A)
FMT  A 403 ( 4.7A)
6A7  A 401 (-4.8A)
6A7  A 401 ( 4.1A)
FMT  A 403 ( 3.3A)
 1.00A 2eufB-5idnA:
22.1		 2eufB-5idnA:
33.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)		 5idn CYCLIN-DEPENDENT
KINASE 8
(Homo
sapiens) 		7 / 12 VAL A  35
LYS A  52
PHE A  97
ASP A 103
LEU A 158
ALA A 172
ASP A 173
 6A7  A 401 ( 4.5A)
6A7  A 401 ( 2.9A)
6A7  A 401 (-3.8A)
6A7  A 401 ( 4.9A)
6A7  A 401 (-4.8A)
6A7  A 401 ( 4.1A)
FMT  A 403 ( 3.3A)
 0.85A 2eufB-5idnA:
22.1		 2eufB-5idnA:
33.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EVA_A_ADNA498_1
(TAK1 KINASE - TAB1
CHIMERA FUSION
PROTEIN)		 5idn CYCLIN-DEPENDENT
KINASE 8
(Homo
sapiens) 		7 / 11 VAL A  27
GLY A  28
VAL A  35
ALA A  50
TYR A  99
ALA A 100
LEU A 158
 6A7  A 401 (-4.7A)
6A7  A 401 (-3.6A)
6A7  A 401 ( 4.5A)
6A7  A 401 (-3.3A)
6A7  A 401 (-4.9A)
6A7  A 401 (-3.7A)
6A7  A 401 (-4.8A)
 0.63A 2evaA-5idnA:
14.1		 2evaA-5idnA:
28.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 5idn CYCLIN-DEPENDENT
KINASE 8
(Homo
sapiens) 		7 / 12 GLY A  28
VAL A  35
GLU A  66
LEU A  95
TYR A  99
ALA A 100
LEU A 158
 6A7  A 401 (-3.6A)
6A7  A 401 ( 4.5A)
FMT  A 404 ( 4.2A)
None
6A7  A 401 (-4.9A)
6A7  A 401 (-3.7A)
6A7  A 401 (-4.8A)
 0.70A 2ivuA-5idnA:
11.4		 2ivuA-5idnA:
26.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_0
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 5idn CYCLIN-DEPENDENT
KINASE 8
(Homo
sapiens) 		7 / 12 VAL A  35
GLU A  66
LEU A  70
LEU A  95
TYR A  99
ALA A 100
LEU A 158
 6A7  A 401 ( 4.5A)
FMT  A 404 ( 4.2A)
None
None
6A7  A 401 (-4.9A)
6A7  A 401 (-3.7A)
6A7  A 401 (-4.8A)
 0.74A 2ivuA-5idnA:
11.4		 2ivuA-5idnA:
26.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WGJ_A_VGHA2346_1
(HEPATOCYTE GROWTH
FACTOR RECEPTOR)		 5idn CYCLIN-DEPENDENT
KINASE 8
(Homo
sapiens) 		6 / 12 GLY A  28
VAL A  35
ALA A  50
TYR A  99
ALA A 172
ASP A 173
 6A7  A 401 (-3.6A)
6A7  A 401 ( 4.5A)
6A7  A 401 (-3.3A)
6A7  A 401 (-4.9A)
6A7  A 401 ( 4.1A)
FMT  A 403 ( 3.3A)
 0.64A 2wgjA-5idnA:
15.4		 2wgjA-5idnA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_1
(PHOSPHOLIPASE A2)		 5idn CYCLIN-DEPENDENT
KINASE 8
(Homo
sapiens) 		4 / 8 VAL A 128
GLY A 126
LYS A 123
PRO A 339
 None
 0.95A 3bjwA-5idnA:
undetectable		 3bjwA-5idnA:
15.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GP0_A_NILA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 5idn CYCLIN-DEPENDENT
KINASE 8
(Homo
sapiens) 		7 / 12 VAL A  35
ALA A  50
GLU A  66
LEU A  69
LEU A  70
ILE A  79
HIS A 149
 6A7  A 401 ( 4.5A)
6A7  A 401 (-3.3A)
FMT  A 404 ( 4.2A)
None
None
6A7  A 401 (-4.2A)
FMT  A 403 (-4.6A)
 0.95A 3gp0A-5idnA:
13.8		 3gp0A-5idnA:
31.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GP0_A_NILA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 5idn CYCLIN-DEPENDENT
KINASE 8
(Homo
sapiens) 		7 / 12 VAL A  35
ALA A  50
GLU A  66
LEU A  70
ILE A  79
HIS A 149
ASP A 173
 6A7  A 401 ( 4.5A)
6A7  A 401 (-3.3A)
FMT  A 404 ( 4.2A)
None
6A7  A 401 (-4.2A)
FMT  A 403 (-4.6A)
FMT  A 403 ( 3.3A)
 1.15A 3gp0A-5idnA:
13.8		 3gp0A-5idnA:
31.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HEG_A_BAXA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 5idn CYCLIN-DEPENDENT
KINASE 8
(Homo
sapiens) 		6 / 12 VAL A  27
VAL A  35
ALA A  50
LYS A  52
GLU A  66
ILE A  79
 6A7  A 401 (-4.7A)
6A7  A 401 ( 4.5A)
6A7  A 401 (-3.3A)
6A7  A 401 ( 2.9A)
FMT  A 404 ( 4.2A)
6A7  A 401 (-4.2A)
 0.74A 3hegA-5idnA:
20.9		 3hegA-5idnA:
32.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3HEG_A_BAXA1_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 5idn CYCLIN-DEPENDENT
KINASE 8
(Homo
sapiens) 		6 / 12 VAL A  35
ALA A  50
LYS A  52
GLU A  66
LEU A  70
ILE A  79
 6A7  A 401 ( 4.5A)
6A7  A 401 (-3.3A)
6A7  A 401 ( 2.9A)
FMT  A 404 ( 4.2A)
None
6A7  A 401 (-4.2A)
 1.00A 3hegA-5idnA:
20.9		 3hegA-5idnA:
32.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_A_C2FA314_0
(UNCHARACTERIZED
PROTEIN)		 5idn CYCLIN-DEPENDENT
KINASE 8
(Homo
sapiens) 		5 / 12 LEU A 311
LEU A 123
ILE A 157
LEU A 136
ILE A 139
 None
 1.09A 3ijdA-5idnA:
undetectable		 3ijdA-5idnA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_0
(UNCHARACTERIZED
PROTEIN)		 5idn CYCLIN-DEPENDENT
KINASE 8
(Homo
sapiens) 		5 / 12 LEU A 311
LEU A 123
ILE A 157
LEU A 136
ILE A 139
 None
 1.07A 3ijdB-5idnA:
undetectable		 3ijdB-5idnA:
22.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LFA_A_1N1A361_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 5idn CYCLIN-DEPENDENT
KINASE 8
(Homo
sapiens) 		5 / 8 VAL A  27
ALA A  50
LYS A  52
GLU A  66
LEU A  95
 6A7  A 401 (-4.7A)
6A7  A 401 (-3.3A)
6A7  A 401 ( 2.9A)
FMT  A 404 ( 4.2A)
None
 0.56A 3lfaA-5idnA:
10.7		 3lfaA-5idnA:
32.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OHT_A_1N1A1000_1
(P38A)		 5idn CYCLIN-DEPENDENT
KINASE 8
(Homo
sapiens) 		7 / 12 VAL A  27
GLY A  28
VAL A  35
ALA A  50
LYS A  52
ILE A  79
LEU A 158
 6A7  A 401 (-4.7A)
6A7  A 401 (-3.6A)
6A7  A 401 ( 4.5A)
6A7  A 401 (-3.3A)
6A7  A 401 ( 2.9A)
6A7  A 401 (-4.2A)
6A7  A 401 (-4.8A)
 0.97A 3ohtA-5idnA:
3.1		 3ohtA-5idnA:
32.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3OHT_A_1N1A1000_1
(P38A)		 5idn CYCLIN-DEPENDENT
KINASE 8
(Homo
sapiens) 		7 / 12 VAL A  27
GLY A  28
VAL A  35
ALA A  50
LYS A  52
LEU A  70
ILE A  79
 6A7  A 401 (-4.7A)
6A7  A 401 (-3.6A)
6A7  A 401 ( 4.5A)
6A7  A 401 (-3.3A)
6A7  A 401 ( 2.9A)
None
6A7  A 401 (-4.2A)
 0.73A 3ohtA-5idnA:
3.1		 3ohtA-5idnA:
32.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_C_T44C128_1
(5-HYDROXYISOURATE
HYDROLASE)		 5idn CYCLIN-DEPENDENT
KINASE 8
(Homo
sapiens) 		4 / 6 LEU A 136
LEU A 132
LEU A 316
LEU A 312
 None
 1.04A 3q1eA-5idnA:
undetectable
3q1eC-5idnA:
undetectable		 3q1eA-5idnA:
17.19
3q1eC-5idnA:
17.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RGF_A_BAXA465_1
(CYCLIN-DEPENDENT
KINASE 8)		 5idn CYCLIN-DEPENDENT
KINASE 8
(Homo
sapiens) 		10 / 12 VAL A  35
ALA A  50
GLU A  66
LEU A  70
ILE A  79
PHE A  97
TYR A  99
ALA A 100
LEU A 142
HIS A 149
 6A7  A 401 ( 4.5A)
6A7  A 401 (-3.3A)
FMT  A 404 ( 4.2A)
None
6A7  A 401 (-4.2A)
6A7  A 401 (-3.8A)
6A7  A 401 (-4.9A)
6A7  A 401 (-3.7A)
None
FMT  A 403 (-4.6A)
 0.70A 3rgfA-5idnA:
45.0		 3rgfA-5idnA:
91.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RGF_A_BAXA465_1
(CYCLIN-DEPENDENT
KINASE 8)		 5idn CYCLIN-DEPENDENT
KINASE 8
(Homo
sapiens) 		10 / 12 VAL A  35
ALA A  50
LEU A  70
ILE A  79
PHE A  97
TYR A  99
ALA A 100
LEU A 142
HIS A 149
ALA A 172
 6A7  A 401 ( 4.5A)
6A7  A 401 (-3.3A)
None
6A7  A 401 (-4.2A)
6A7  A 401 (-3.8A)
6A7  A 401 (-4.9A)
6A7  A 401 (-3.7A)
None
FMT  A 403 (-4.6A)
6A7  A 401 ( 4.1A)
 0.53A 3rgfA-5idnA:
45.0		 3rgfA-5idnA:
91.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WAR_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA)		 5idn CYCLIN-DEPENDENT
KINASE 8
(Homo
sapiens) 		4 / 8 VAL A  35
LYS A  52
ILE A  79
PHE A  97
 6A7  A 401 ( 4.5A)
6A7  A 401 ( 2.9A)
6A7  A 401 (-4.2A)
6A7  A 401 (-3.8A)
 0.31A 3warA-5idnA:
19.5		 3warA-5idnA:
27.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZE_A_BAXA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 5idn CYCLIN-DEPENDENT
KINASE 8
(Homo
sapiens) 		4 / 8 VAL A  78
LEU A 158
ILE A 171
ASP A 173
 None
6A7  A 401 (-4.8A)
None
FMT  A 403 ( 3.3A)
 0.70A 3wzeA-5idnA:
13.1		 3wzeA-5idnA:
25.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5idn CYCLIN-DEPENDENT
KINASE 8
(Homo
sapiens) 		7 / 12 ALA A  50
LYS A  52
LEU A 142
HIS A 149
ARG A 150
LEU A 158
ALA A 172
 6A7  A 401 (-3.3A)
6A7  A 401 ( 2.9A)
None
FMT  A 403 (-4.6A)
None
6A7  A 401 (-4.8A)
6A7  A 401 ( 4.1A)
 0.67A 3zosA-5idnA:
20.5		 3zosA-5idnA:
26.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5idn CYCLIN-DEPENDENT
KINASE 8
(Homo
sapiens) 		7 / 12 ALA A  50
LYS A  52
GLU A  66
ILE A  79
LEU A 142
HIS A 149
ARG A 150
 6A7  A 401 (-3.3A)
6A7  A 401 ( 2.9A)
FMT  A 404 ( 4.2A)
6A7  A 401 (-4.2A)
None
FMT  A 403 (-4.6A)
None
 0.83A 3zosB-5idnA:
20.5		 3zosB-5idnA:
26.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5idn CYCLIN-DEPENDENT
KINASE 8
(Homo
sapiens) 		7 / 12 ALA A  50
LYS A  52
ILE A  79
HIS A 149
LEU A 158
ALA A 172
ASP A 173
 6A7  A 401 (-3.3A)
6A7  A 401 ( 2.9A)
6A7  A 401 (-4.2A)
FMT  A 403 (-4.6A)
6A7  A 401 (-4.8A)
6A7  A 401 ( 4.1A)
FMT  A 403 ( 3.3A)
 0.74A 3zosB-5idnA:
20.5		 3zosB-5idnA:
26.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5idn CYCLIN-DEPENDENT
KINASE 8
(Homo
sapiens) 		8 / 12 ALA A  50
LYS A  52
ILE A  79
LEU A 142
HIS A 149
ARG A 150
LEU A 158
ALA A 172
 6A7  A 401 (-3.3A)
6A7  A 401 ( 2.9A)
6A7  A 401 (-4.2A)
None
FMT  A 403 (-4.6A)
None
6A7  A 401 (-4.8A)
6A7  A 401 ( 4.1A)
 0.64A 3zosB-5idnA:
20.5		 3zosB-5idnA:
26.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_A_STIA1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5idn CYCLIN-DEPENDENT
KINASE 8
(Homo
sapiens) 		7 / 12 VAL A  35
ALA A  50
ILE A  79
TYR A  99
LEU A 158
ALA A 172
ASP A 173
 6A7  A 401 ( 4.5A)
6A7  A 401 (-3.3A)
6A7  A 401 (-4.2A)
6A7  A 401 (-4.9A)
6A7  A 401 (-4.8A)
6A7  A 401 ( 4.1A)
FMT  A 403 ( 3.3A)
 0.86A 4bkjA-5idnA:
20.6		 4bkjA-5idnA:
26.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_B_STIB1000_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5idn CYCLIN-DEPENDENT
KINASE 8
(Homo
sapiens) 		6 / 12 VAL A  35
ALA A  50
ILE A  79
LEU A 158
ALA A 172
ASP A 173
 6A7  A 401 ( 4.5A)
6A7  A 401 (-3.3A)
6A7  A 401 (-4.2A)
6A7  A 401 (-4.8A)
6A7  A 401 ( 4.1A)
FMT  A 403 ( 3.3A)
 0.87A 4bkjB-5idnA:
20.6		 4bkjB-5idnA:
26.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_1
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)		 5idn CYCLIN-DEPENDENT
KINASE 8
(Homo
sapiens) 		7 / 12 ALA A  50
LYS A  52
LEU A  70
HIS A 149
LEU A 158
ALA A 172
ASP A 173
 6A7  A 401 (-3.3A)
6A7  A 401 ( 2.9A)
None
FMT  A 403 (-4.6A)
6A7  A 401 (-4.8A)
6A7  A 401 ( 4.1A)
FMT  A 403 ( 3.3A)
 0.87A 4c8bA-5idnA:
22.5		 4c8bA-5idnA:
25.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 5idn CYCLIN-DEPENDENT
KINASE 8
(Homo
sapiens) 		8 / 12 VAL A  35
ALA A  50
ILE A  79
ASP A 103
ASP A 151
ASN A 156
LEU A 158
ASP A 173
 6A7  A 401 ( 4.5A)
6A7  A 401 (-3.3A)
6A7  A 401 (-4.2A)
6A7  A 401 ( 4.9A)
FMT  A 403 (-3.9A)
FMT  A 403 ( 4.7A)
6A7  A 401 (-4.8A)
FMT  A 403 ( 3.3A)
 1.00A 4i41A-5idnA:
24.7		 4i41A-5idnA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 5idn CYCLIN-DEPENDENT
KINASE 8
(Homo
sapiens) 		8 / 12 VAL A  35
ALA A  50
ILE A  79
ASP A 103
ASP A 151
LYS A 153
ASN A 156
LEU A 158
 6A7  A 401 ( 4.5A)
6A7  A 401 (-3.3A)
6A7  A 401 (-4.2A)
6A7  A 401 ( 4.9A)
FMT  A 403 (-3.9A)
FMT  A 403 ( 4.1A)
FMT  A 403 ( 4.7A)
6A7  A 401 (-4.8A)
 1.12A 4i41A-5idnA:
24.7		 4i41A-5idnA:
24.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 5idn CYCLIN-DEPENDENT
KINASE 8
(Homo
sapiens) 		6 / 11 VAL A  35
ALA A  50
LYS A  52
ASP A 103
LEU A 158
ASP A 173
 6A7  A 401 ( 4.5A)
6A7  A 401 (-3.3A)
6A7  A 401 ( 2.9A)
6A7  A 401 ( 4.9A)
6A7  A 401 (-4.8A)
FMT  A 403 ( 3.3A)
 0.99A 4iaaA-5idnA:
24.4		 4iaaA-5idnA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QRC_A_0LIA802_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 5idn CYCLIN-DEPENDENT
KINASE 8
(Homo
sapiens) 		5 / 12 ALA A  50
GLU A  66
LEU A 142
ARG A 150
ALA A 172
 6A7  A 401 (-3.3A)
FMT  A 404 ( 4.2A)
None
None
6A7  A 401 ( 4.1A)
 0.95A 4qrcA-5idnA:
15.9		 4qrcA-5idnA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TYJ_A_0LIA801_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 5idn CYCLIN-DEPENDENT
KINASE 8
(Homo
sapiens) 		7 / 12 ALA A  50
GLU A  66
ALA A 100
HIS A 149
LEU A 158
ALA A 172
ASP A 173
 6A7  A 401 (-3.3A)
FMT  A 404 ( 4.2A)
6A7  A 401 (-3.7A)
FMT  A 403 (-4.6A)
6A7  A 401 (-4.8A)
6A7  A 401 ( 4.1A)
FMT  A 403 ( 3.3A)
 1.11A 4tyjA-5idnA:
21.4		 4tyjA-5idnA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UXQ_A_0LIA1752_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 5idn CYCLIN-DEPENDENT
KINASE 8
(Homo
sapiens) 		5 / 12 ALA A  50
LEU A 142
HIS A 149
LEU A 158
ALA A 172
 6A7  A 401 (-3.3A)
None
FMT  A 403 (-4.6A)
6A7  A 401 (-4.8A)
6A7  A 401 ( 4.1A)
 0.41A 4uxqA-5idnA:
15.3		 4uxqA-5idnA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UXQ_A_0LIA1752_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 4)		 5idn CYCLIN-DEPENDENT
KINASE 8
(Homo
sapiens) 		5 / 7 VAL A  35
ILE A  79
ALA A 100
ARG A 150
ILE A 171
 6A7  A 401 ( 4.5A)
6A7  A 401 (-4.2A)
6A7  A 401 (-3.7A)
None
None
 0.55A 4uxqA-5idnA:
15.3		 4uxqA-5idnA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5idn CYCLIN-DEPENDENT
KINASE 8
(Homo
sapiens) 		5 / 12 ALA A  50
ALA A 100
LEU A 142
HIS A 149
ALA A 172
 6A7  A 401 (-3.3A)
6A7  A 401 (-3.7A)
None
FMT  A 403 (-4.6A)
6A7  A 401 ( 4.1A)
 0.54A 4v01A-5idnA:
13.7		 4v01A-5idnA:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5idn CYCLIN-DEPENDENT
KINASE 8
(Homo
sapiens) 		6 / 9 VAL A  35
ILE A  79
TYR A  99
ARG A 150
LEU A 158
ILE A 171
 6A7  A 401 ( 4.5A)
6A7  A 401 (-4.2A)
6A7  A 401 (-4.9A)
None
6A7  A 401 (-4.8A)
None
 0.76A 4v01A-5idnA:
13.7		 4v01A-5idnA:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5idn CYCLIN-DEPENDENT
KINASE 8
(Homo
sapiens) 		5 / 12 ALA A  50
ALA A 100
LEU A 142
HIS A 149
ALA A 172
 6A7  A 401 (-3.3A)
6A7  A 401 (-3.7A)
None
FMT  A 403 (-4.6A)
6A7  A 401 ( 4.1A)
 0.48A 4v01B-5idnA:
7.4		 4v01B-5idnA:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_B_0LIB1770_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5idn CYCLIN-DEPENDENT
KINASE 8
(Homo
sapiens) 		6 / 9 VAL A  35
LYS A  52
ILE A  79
TYR A  99
LEU A 158
ILE A 171
 6A7  A 401 ( 4.5A)
6A7  A 401 ( 2.9A)
6A7  A 401 (-4.2A)
6A7  A 401 (-4.9A)
6A7  A 401 (-4.8A)
None
 0.70A 4v01B-5idnA:
6.1		 4v01B-5idnA:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_A_0LIA1772_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5idn CYCLIN-DEPENDENT
KINASE 8
(Homo
sapiens) 		7 / 12 VAL A  35
ALA A  50
GLU A  66
ALA A 100
HIS A 149
ALA A 172
GLY A 175
 6A7  A 401 ( 4.5A)
6A7  A 401 (-3.3A)
FMT  A 404 ( 4.2A)
6A7  A 401 (-3.7A)
FMT  A 403 (-4.6A)
6A7  A 401 ( 4.1A)
FMT  A 404 ( 4.3A)
 1.41A 4v04A-5idnA:
15.5		 4v04A-5idnA:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_A_0LIA1772_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5idn CYCLIN-DEPENDENT
KINASE 8
(Homo
sapiens) 		7 / 12 VAL A  35
ALA A  50
GLU A  66
ALA A 100
LEU A 142
HIS A 149
ALA A 172
 6A7  A 401 ( 4.5A)
6A7  A 401 (-3.3A)
FMT  A 404 ( 4.2A)
6A7  A 401 (-3.7A)
None
FMT  A 403 (-4.6A)
6A7  A 401 ( 4.1A)
 0.81A 4v04A-5idnA:
15.5		 4v04A-5idnA:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_A_0LIA1772_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5idn CYCLIN-DEPENDENT
KINASE 8
(Homo
sapiens) 		4 / 8 ILE A  79
TYR A  99
LEU A 158
ILE A 171
 6A7  A 401 (-4.2A)
6A7  A 401 (-4.9A)
6A7  A 401 (-4.8A)
None
 0.81A 4v04A-5idnA:
15.5		 4v04A-5idnA:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_1
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5idn CYCLIN-DEPENDENT
KINASE 8
(Homo
sapiens) 		6 / 10 VAL A  35
ILE A  79
TYR A  99
ARG A 150
LEU A 158
ILE A 171
 6A7  A 401 ( 4.5A)
6A7  A 401 (-4.2A)
6A7  A 401 (-4.9A)
None
6A7  A 401 (-4.8A)
None
 0.93A 4v04B-5idnA:
15.6		 4v04B-5idnA:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V04_B_0LIB1771_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)		 5idn CYCLIN-DEPENDENT
KINASE 8
(Homo
sapiens) 		6 / 12 ALA A  50
GLU A  66
ALA A 100
LEU A 142
HIS A 149
ALA A 172
 6A7  A 401 (-3.3A)
FMT  A 404 ( 4.2A)
6A7  A 401 (-3.7A)
None
FMT  A 403 (-4.6A)
6A7  A 401 ( 4.1A)
 0.78A 4v04B-5idnA:
15.6		 4v04B-5idnA:
26.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_B_29SB601_2
(ESTROGEN RECEPTOR)		 5idn CYCLIN-DEPENDENT
KINASE 8
(Homo
sapiens) 		4 / 5 LEU A 158
GLU A 165
LEU A  70
HIS A 149
 6A7  A 401 (-4.8A)
None
None
FMT  A 403 (-4.6A)
 0.96A 4xi3B-5idnA:
undetectable		 4xi3B-5idnA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 5idn CYCLIN-DEPENDENT
KINASE 8
(Homo
sapiens) 		4 / 7 ASP A 344
ARG A 166
GLY A 163
GLU A 162
 None
 1.13A 5btfA-5idnA:
undetectable
5btfC-5idnA:
2.4
5btfD-5idnA:
undetectable		 5btfA-5idnA:
23.12
5btfC-5idnA:
23.12
5btfD-5idnA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BVW_A_1N1A1009_1
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)		 5idn CYCLIN-DEPENDENT
KINASE 8
(Homo
sapiens) 		8 / 12 VAL A  35
ALA A  50
LYS A  52
GLU A  66
ILE A  79
TYR A  99
LEU A 158
ALA A 172
 6A7  A 401 ( 4.5A)
6A7  A 401 (-3.3A)
6A7  A 401 ( 2.9A)
FMT  A 404 ( 4.2A)
6A7  A 401 (-4.2A)
6A7  A 401 (-4.9A)
6A7  A 401 (-4.8A)
6A7  A 401 ( 4.1A)
 0.81A 5bvwA-5idnA:
20.9		 5bvwA-5idnA:
26.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5idn CYCLIN-DEPENDENT
KINASE 8
(Homo
sapiens) 		5 / 12 TYR A 199
ILE A 351
TYR A 353
GLY A 167
LEU A 131
 None
 1.33A 5esgA-5idnA:
undetectable		 5esgA-5idnA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 5idn CYCLIN-DEPENDENT
KINASE 8
(Homo
sapiens) 		6 / 12 VAL A  35
ALA A  50
ILE A  79
TYR A  99
ALA A 100
GLY A 175
 6A7  A 401 ( 4.5A)
6A7  A 401 (-3.3A)
6A7  A 401 (-4.2A)
6A7  A 401 (-4.9A)
6A7  A 401 (-3.7A)
FMT  A 404 ( 4.3A)
 0.97A 5hesA-5idnA:
7.2		 5hesA-5idnA:
27.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_B_032B401_1
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 5idn CYCLIN-DEPENDENT
KINASE 8
(Homo
sapiens) 		6 / 12 VAL A  35
ALA A  50
LYS A  52
TYR A  99
ALA A 100
GLY A 175
 6A7  A 401 ( 4.5A)
6A7  A 401 (-3.3A)
6A7  A 401 ( 2.9A)
6A7  A 401 (-4.9A)
6A7  A 401 (-3.7A)
FMT  A 404 ( 4.3A)
 0.99A 5hesB-5idnA:
21.2		 5hesB-5idnA:
27.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI2_A_BAXA801_1
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 5idn CYCLIN-DEPENDENT
KINASE 8
(Homo
sapiens) 		6 / 12 ALA A  50
LYS A  52
GLU A  66
LEU A  70
LEU A 142
HIS A 149
 6A7  A 401 (-3.3A)
6A7  A 401 ( 2.9A)
FMT  A 404 ( 4.2A)
None
None
FMT  A 403 (-4.6A)
 0.83A 5hi2A-5idnA:
12.4		 5hi2A-5idnA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)		 5idn CYCLIN-DEPENDENT
KINASE 8
(Homo
sapiens) 		4 / 7 GLY A  28
GLY A  30
VAL A  35
LYS A  52
 6A7  A 401 (-3.6A)
None
6A7  A 401 ( 4.5A)
6A7  A 401 ( 2.9A)
 0.48A 5izjA-5idnA:
14.9		 5izjA-5idnA:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)		 5idn CYCLIN-DEPENDENT
KINASE 8
(Homo
sapiens) 		4 / 7 GLY A  28
GLY A  30
VAL A  35
LYS A  52
 6A7  A 401 (-3.6A)
None
6A7  A 401 ( 4.5A)
6A7  A 401 ( 2.9A)
 0.40A 5j5xA-5idnA:
23.7		 5j5xA-5idnA:
25.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 5idn CYCLIN-DEPENDENT
KINASE 8
(Homo
sapiens) 		6 / 12 GLY A  28
VAL A  35
ALA A  50
ASP A 103
LEU A 158
ALA A 172
 6A7  A 401 (-3.6A)
6A7  A 401 ( 4.5A)
6A7  A 401 (-3.3A)
6A7  A 401 ( 4.9A)
6A7  A 401 (-4.8A)
6A7  A 401 ( 4.1A)
 0.63A 5l2iA-5idnA:
14.3		 5l2iA-5idnA:
32.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 5idn CYCLIN-DEPENDENT
KINASE 8
(Homo
sapiens) 		6 / 12 GLY A  28
VAL A  35
ALA A  50
PHE A  97
LEU A 158
ALA A 172
 6A7  A 401 (-3.6A)
6A7  A 401 ( 4.5A)
6A7  A 401 (-3.3A)
6A7  A 401 (-3.8A)
6A7  A 401 (-4.8A)
6A7  A 401 ( 4.1A)
 0.68A 5l2iA-5idnA:
14.3		 5l2iA-5idnA:
32.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 5idn CYCLIN-DEPENDENT
KINASE 8
(Homo
sapiens) 		6 / 12 GLY A  28
ALA A  50
PHE A  97
ASP A 103
LEU A 158
ALA A 172
 6A7  A 401 (-3.6A)
6A7  A 401 (-3.3A)
6A7  A 401 (-3.8A)
6A7  A 401 ( 4.9A)
6A7  A 401 (-4.8A)
6A7  A 401 ( 4.1A)
 0.83A 5l2tA-5idnA:
14.5		 5l2tA-5idnA:
32.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L2T_A_6ZZA900_1
(CYCLIN-DEPENDENT
KINASE 6)		 5idn CYCLIN-DEPENDENT
KINASE 8
(Homo
sapiens) 		6 / 12 GLY A  28
VAL A  35
ALA A  50
PHE A  97
LEU A 158
ALA A 172
 6A7  A 401 (-3.6A)
6A7  A 401 ( 4.5A)
6A7  A 401 (-3.3A)
6A7  A 401 (-3.8A)
6A7  A 401 (-4.8A)
6A7  A 401 ( 4.1A)
 0.78A 5l2tA-5idnA:
14.5		 5l2tA-5idnA:
32.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_1
(SCRFP-TAG,GP41)		 5idn CYCLIN-DEPENDENT
KINASE 8
(Homo
sapiens) 		5 / 12 LYS A 153
LEU A 205
LEU A 206
GLU A 203
LEU A 204
 FMT  A 403 ( 4.1A)
None
None
None
None
 1.16A 5nwwA-5idnA:
undetectable		 5nwwA-5idnA:
7.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_1
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 5idn CYCLIN-DEPENDENT
KINASE 8
(Homo
sapiens) 		5 / 12 GLY A  28
VAL A  35
ALA A  50
PHE A  97
ALA A 172
 6A7  A 401 (-3.6A)
6A7  A 401 ( 4.5A)
6A7  A 401 (-3.3A)
6A7  A 401 (-3.8A)
6A7  A 401 ( 4.1A)
 0.37A 5xv7A-5idnA:
26.5		 5xv7A-5idnA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_B_NIOB401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 5idn CYCLIN-DEPENDENT
KINASE 8
(Homo
sapiens) 		4 / 7 VAL A  35
LYS A  52
PHE A  97
ASP A 173
 6A7  A 401 ( 4.5A)
6A7  A 401 ( 2.9A)
6A7  A 401 (-3.8A)
FMT  A 403 ( 3.3A)
 0.80A 5yf9B-5idnA:
17.4		 5yf9B-5idnA:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_X_NIOX401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 5idn CYCLIN-DEPENDENT
KINASE 8
(Homo
sapiens) 		5 / 9 VAL A  35
LYS A  52
ILE A  79
PHE A  97
ASP A 173
 6A7  A 401 ( 4.5A)
6A7  A 401 ( 2.9A)
6A7  A 401 (-4.2A)
6A7  A 401 (-3.8A)
FMT  A 403 ( 3.3A)
 0.77A 5yf9X-5idnA:
13.5		 5yf9X-5idnA:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_A_1E8A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5idn CYCLIN-DEPENDENT
KINASE 8
(Homo
sapiens) 		6 / 12 GLY A  28
VAL A  35
ALA A  50
LYS A  52
LEU A  95
LEU A 158
 6A7  A 401 (-3.6A)
6A7  A 401 ( 4.5A)
6A7  A 401 (-3.3A)
6A7  A 401 ( 2.9A)
None
6A7  A 401 (-4.8A)
 0.66A 5yu9A-5idnA:
16.1		 5yu9A-5idnA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YWM_X_NIOX403_0
(CASEIN KINASE II
SUBUNIT ALPHA')		 5idn CYCLIN-DEPENDENT
KINASE 8
(Homo
sapiens) 		4 / 7 LYS A  52
ILE A  79
PHE A  97
ASP A 173
 6A7  A 401 ( 2.9A)
6A7  A 401 (-4.2A)
6A7  A 401 (-3.8A)
FMT  A 403 ( 3.3A)
 0.59A 5ywmX-5idnA:
16.1		 5ywmX-5idnA:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YWM_X_NIOX403_0
(CASEIN KINASE II
SUBUNIT ALPHA')		 5idn CYCLIN-DEPENDENT
KINASE 8
(Homo
sapiens) 		4 / 7 VAL A  35
LYS A  52
ILE A  79
PHE A  97
 6A7  A 401 ( 4.5A)
6A7  A 401 ( 2.9A)
6A7  A 401 (-4.2A)
6A7  A 401 (-3.8A)
 0.40A 5ywmX-5idnA:
16.1		 5ywmX-5idnA:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_B_LEVB801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 5idn CYCLIN-DEPENDENT
KINASE 8
(Homo
sapiens) 		3 / 3 TYR A  99
LEU A 158
ASP A 173
 6A7  A 401 (-4.9A)
6A7  A 401 (-4.8A)
FMT  A 403 ( 3.3A)
 0.80A 5zv2B-5idnA:
21.5		 5zv2B-5idnA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ESM_A_PZEA307_1
(MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9)		 5idn CYCLIN-DEPENDENT
KINASE 8
(Homo
sapiens) 		3 / 3 TYR A 353
HIS A 102
PHE A 346
 None
 1.05A 6esmA-5idnA:
undetectable		 6esmA-5idnA:
13.46