SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ido'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRG_A_ADNA300_1
(ALPHA-MOMORCHARIN)		 5ido 3' TERMINAL URIDYLYL
TRANSFERASE
(Trypanosoma
brucei) 		5 / 9 ILE A 311
GLY A 307
ILE A 470
ALA A 276
GLU A 466
 None
 1.37A 1mrgA-5idoA:
undetectable		 1mrgA-5idoA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_A_FUAA702_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5ido 3' TERMINAL URIDYLYL
TRANSFERASE
(Trypanosoma
brucei) 		5 / 12 PHE A 313
SER A 475
PHE A 479
VAL A 300
ALA A 309
 None
None
UTP  A 701 (-4.5A)
None
None
 1.33A 1q23A-5idoA:
undetectable
1q23B-5idoA:
undetectable		 1q23A-5idoA:
17.58
1q23B-5idoA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RU9_H_ACTH611_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 5ido 3' TERMINAL URIDYLYL
TRANSFERASE
(Trypanosoma
brucei) 		4 / 6 LEU A 678
TRP A 599
LEU A 650
PHE A 521
 None
 1.40A 1ru9H-5idoA:
undetectable
1ru9L-5idoA:
undetectable		 1ru9H-5idoA:
17.13
1ru9L-5idoA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 5ido 3' TERMINAL URIDYLYL
TRANSFERASE
(Trypanosoma
brucei) 		5 / 12 GLY A 600
HIS A 224
TYR A 679
LEU A 678
LEU A 210
 None
 1.26A 1zgyA-5idoA:
undetectable		 1zgyA-5idoA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7A_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5ido 3' TERMINAL URIDYLYL
TRANSFERASE
(Trypanosoma
brucei) 		5 / 9 LEU A 546
LEU A 486
ARG A 482
ILE A 548
TYR A 656
 None
 1.28A 2f7aA-5idoA:
undetectable		 2f7aA-5idoA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 5ido 3' TERMINAL URIDYLYL
TRANSFERASE
(Trypanosoma
brucei) 		4 / 5 LEU A 452
ALA A 448
LEU A 401
MET A 427
 None
 0.88A 2oaxA-5idoA:
undetectable		 2oaxA-5idoA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA602_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 5ido 3' TERMINAL URIDYLYL
TRANSFERASE
(Trypanosoma
brucei) 		4 / 7 ALA A 437
ALA A 436
ALA A 440
GLN A 416
 None
 0.69A 3a2qA-5idoA:
undetectable		 3a2qA-5idoA:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G9E_A_RO7A1_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5ido 3' TERMINAL URIDYLYL
TRANSFERASE
(Trypanosoma
brucei) 		5 / 12 HIS A 224
TYR A 679
LEU A 678
ILE A 604
LEU A 210
 None
 1.20A 3g9eA-5idoA:
undetectable		 3g9eA-5idoA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXZ_A_0LIA1_2
(TYROSINE-PROTEIN
KINASE ABL1)		 5ido 3' TERMINAL URIDYLYL
TRANSFERASE
(Trypanosoma
brucei) 		5 / 9 TYR A 524
LYS A 505
ILE A 502
LEU A 487
VAL A 300
 UTP  A 701 (-4.2A)
UTP  A 701 (-3.0A)
None
None
None
 1.47A 3oxzA-5idoA:
undetectable		 3oxzA-5idoA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_C_08JC3_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5ido 3' TERMINAL URIDYLYL
TRANSFERASE
(Trypanosoma
brucei) 		4 / 8 VAL A 283
LEU A 280
LEU A 467
ILE A 362
 None
 0.86A 3u5kC-5idoA:
undetectable		 3u5kC-5idoA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ7_B_SAMB302_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 5ido 3' TERMINAL URIDYLYL
TRANSFERASE
(Trypanosoma
brucei) 		4 / 5 TYR A 656
SER A 484
ASP A 654
ILE A 652
 None
UTP  A 701 (-3.1A)
None
None
 1.19A 3uj7B-5idoA:
undetectable		 3uj7B-5idoA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A9J_A_TYLA1188_1
(BROMODOMAIN
CONTAINING 2)		 5ido 3' TERMINAL URIDYLYL
TRANSFERASE
(Trypanosoma
brucei) 		4 / 5 VAL A 283
LEU A 280
LEU A 467
ILE A 362
 None
 0.96A 4a9jA-5idoA:
undetectable		 4a9jA-5idoA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5ido 3' TERMINAL URIDYLYL
TRANSFERASE
(Trypanosoma
brucei) 		4 / 8 ILE A 295
ASP A 312
ILE A 311
GLY A 307
 None
UTP  A 701 ( 4.7A)
None
None
 0.61A 4acaC-5idoA:
undetectable		 4acaC-5idoA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 5ido 3' TERMINAL URIDYLYL
TRANSFERASE
(Trypanosoma
brucei) 		4 / 8 ILE A 295
ASP A 312
ILE A 311
GLY A 307
 None
UTP  A 701 ( 4.7A)
None
None
 0.60A 4acbC-5idoA:
undetectable		 4acbC-5idoA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDC_A_DEXA1778_2
(GLUCOCORTICOID
RECEPTOR)		 5ido 3' TERMINAL URIDYLYL
TRANSFERASE
(Trypanosoma
brucei) 		3 / 3 MET A 585
GLN A 536
TYR A 532
 None
 0.95A 4udcA-5idoA:
undetectable		 4udcA-5idoA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YP2_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 5ido 3' TERMINAL URIDYLYL
TRANSFERASE
(Trypanosoma
brucei) 		5 / 9 ILE A 311
GLY A 307
ILE A 470
ALA A 276
GLU A 466
 None
 1.38A 4yp2B-5idoA:
undetectable		 4yp2B-5idoA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CF9_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 5ido 3' TERMINAL URIDYLYL
TRANSFERASE
(Trypanosoma
brucei) 		5 / 9 ILE A 311
GLY A 307
ILE A 470
ALA A 276
GLU A 466
 None
 1.40A 5cf9B-5idoA:
undetectable		 5cf9B-5idoA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_2
(CDL2.2)		 5ido 3' TERMINAL URIDYLYL
TRANSFERASE
(Trypanosoma
brucei) 		5 / 12 PRO A 445
VAL A 415
ILE A 386
LEU A 431
GLY A 414
 None
 1.18A 5ienA-5idoA:
undetectable		 5ienA-5idoA:
12.84