SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ie2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTI_E_CCSE47_0
(GLUTATHIONE
S-TRANSFERASE)		 5ie2 OXALATE--COA LIGASE
(Arabidopsis
thaliana) 		4 / 7 TRP A 256
LEU A 219
GLY A 221
LEU A 200
 None
 0.98A 1gtiE-5ie2A:
undetectable		 1gtiE-5ie2A:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_B_PODB700_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 5ie2 OXALATE--COA LIGASE
(Arabidopsis
thaliana) 		5 / 12 VAL A 341
LEU A   6
ALA A 188
LYS A 192
ASN A 193
 None
 1.11A 1sa1A-5ie2A:
undetectable
1sa1B-5ie2A:
undetectable		 1sa1A-5ie2A:
22.42
1sa1B-5ie2A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 5ie2 OXALATE--COA LIGASE
(Arabidopsis
thaliana) 		5 / 12 SER A 287
LEU A 292
SER A 322
VAL A 337
ILE A 424
 None
None
None
ATP  A 601 (-4.9A)
None
 1.39A 1uobA-5ie2A:
undetectable		 1uobA-5ie2A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F78_A_BEZA1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 5ie2 OXALATE--COA LIGASE
(Arabidopsis
thaliana) 		4 / 7 VAL A 232
SER A 225
HIS A 216
THR A 258
 None
None
ACY  A 603 (-4.5A)
None
 1.10A 2f78A-5ie2A:
undetectable		 2f78A-5ie2A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_A_ACTA601_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 5ie2 OXALATE--COA LIGASE
(Arabidopsis
thaliana) 		4 / 7 ALA A 230
SER A 225
SER A 205
THR A 206
 None
 1.05A 2i91A-5ie2A:
undetectable		 2i91A-5ie2A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I91_B_ACTB602_0
(60 KDA SS-A/RO
RIBONUCLEOPROTEIN)		 5ie2 OXALATE--COA LIGASE
(Arabidopsis
thaliana) 		4 / 7 ALA A 230
SER A 225
SER A 205
THR A 206
 None
 1.05A 2i91B-5ie2A:
undetectable		 2i91B-5ie2A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_0
(STRUCTURAL PROTEIN
VP3)		 5ie2 OXALATE--COA LIGASE
(Arabidopsis
thaliana) 		5 / 12 GLY A 227
ALA A 188
ALA A  14
VAL A  13
ASN A  12
 None
 1.00A 3jb3A-5ie2A:
undetectable		 3jb3A-5ie2A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGP_B_017B200_1
(FIV PROTEASE)		 5ie2 OXALATE--COA LIGASE
(Arabidopsis
thaliana) 		5 / 10 LEU A  10
ALA A 188
ILE A 194
VAL A  13
LEU A   9
 None
 0.99A 3ogpA-5ie2A:
undetectable		 3ogpA-5ie2A:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGJ_A_1PQA304_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5ie2 OXALATE--COA LIGASE
(Arabidopsis
thaliana) 		4 / 8 PHE A  73
PHE A  69
GLY A 217
ASN A  65
 None
 0.98A 4fgjA-5ie2A:
4.0
4fgjB-5ie2A:
4.0		 4fgjA-5ie2A:
17.37
4fgjB-5ie2A:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1N_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 5ie2 OXALATE--COA LIGASE
(Arabidopsis
thaliana) 		5 / 11 ILE A  77
ALA A  81
LEU A  61
PHE A  73
LEU A 218
 None
 1.38A 4i1nA-5ie2A:
undetectable		 4i1nA-5ie2A:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_C_ESTC600_1
(ESTROGEN RECEPTOR
BETA)		 5ie2 OXALATE--COA LIGASE
(Arabidopsis
thaliana) 		5 / 12 LEU A 218
LEU A  61
ILE A  40
ILE A  71
LEU A  23
 None
 1.22A 4j24C-5ie2A:
undetectable		 4j24C-5ie2A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_B_9TPB601_1
(SERUM ALBUMIN)		 5ie2 OXALATE--COA LIGASE
(Arabidopsis
thaliana) 		5 / 12 LEU A  61
ILE A  77
LEU A 168
LEU A 182
GLY A 164
 None
 0.89A 4l9qB-5ie2A:
undetectable		 4l9qB-5ie2A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_A_ML1A303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5ie2 OXALATE--COA LIGASE
(Arabidopsis
thaliana) 		4 / 8 PHE A  73
PHE A  69
GLY A 217
ASN A  65
 None
 0.99A 4qoiA-5ie2A:
undetectable
4qoiB-5ie2A:
3.8		 4qoiA-5ie2A:
17.57
4qoiB-5ie2A:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RN6_A_15UA301_1
(THROMBIN HEAVY CHAIN)		 5ie2 OXALATE--COA LIGASE
(Arabidopsis
thaliana) 		5 / 10 HIS A 264
LEU A 292
LEU A 210
ALA A 220
ALA A 259
 None
 1.49A 4rn6A-5ie2A:
undetectable		 4rn6A-5ie2A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_B_RTZB602_1
(CYTOCHROME P450 2D6)		 5ie2 OXALATE--COA LIGASE
(Arabidopsis
thaliana) 		5 / 12 LEU A  36
GLY A   8
LEU A   6
VAL A 191
VAL A  70
 None
 1.00A 4wnwB-5ie2A:
undetectable		 4wnwB-5ie2A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 5ie2 OXALATE--COA LIGASE
(Arabidopsis
thaliana) 		4 / 7 ALA A 383
ASP A 394
ARG A 409
GLU A 412
 None
ATP  A 601 (-2.9A)
ATP  A 601 (-3.1A)
None
 0.85A 5bs8A-5ie2A:
2.7
5bs8B-5ie2A:
undetectable
5bs8C-5ie2A:
2.7		 5bs8A-5ie2A:
22.16
5bs8B-5ie2A:
19.85
5bs8C-5ie2A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_E_GFNE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)		 5ie2 OXALATE--COA LIGASE
(Arabidopsis
thaliana) 		4 / 7 ALA A 383
ASP A 394
ARG A 409
GLU A 412
 None
ATP  A 601 (-2.9A)
ATP  A 601 (-3.1A)
None
 0.87A 5btdA-5ie2A:
2.7
5btdB-5ie2A:
undetectable
5btdC-5ie2A:
3.3		 5btdA-5ie2A:
22.16
5btdB-5ie2A:
19.85
5btdC-5ie2A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		 5ie2 OXALATE--COA LIGASE
(Arabidopsis
thaliana) 		4 / 8 ALA A 237
ASN A  65
ARG A 239
THR A 244
 None
 1.15A 5db5A-5ie2A:
undetectable
5db5B-5ie2A:
3.3		 5db5A-5ie2A:
24.34
5db5B-5ie2A:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5ie2 OXALATE--COA LIGASE
(Arabidopsis
thaliana) 		4 / 5 ALA A 228
HIS A  33
MET A   1
LEU A 226
 None
 1.37A 5dzkb-5ie2A:
undetectable
5dzkp-5ie2A:
undetectable		 5dzkb-5ie2A:
20.32
5dzkp-5ie2A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Q_BEZQ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5ie2 OXALATE--COA LIGASE
(Arabidopsis
thaliana) 		4 / 5 ALA A 228
HIS A  33
MET A   1
LEU A 226
 None
 1.37A 5dzkc-5ie2A:
undetectable
5dzkq-5ie2A:
undetectable		 5dzkc-5ie2A:
20.32
5dzkq-5ie2A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_A_ACTA1231_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT
PUTATIVE XANTHINE
DEHYDROGENASE YAGT
IRON-SULFUR-BINDING
SUBUNIT)		 5ie2 OXALATE--COA LIGASE
(Arabidopsis
thaliana) 		3 / 3 ARG A 283
THR A 201
ASP A 204
 None
 0.78A 5g5gA-5ie2A:
undetectable
5g5gB-5ie2A:
undetectable		 5g5gA-5ie2A:
20.19
5g5gB-5ie2A:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K4P_A_SORA611_0
(PROBABLE
PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-1)		 5ie2 OXALATE--COA LIGASE
(Arabidopsis
thaliana) 		4 / 6 GLY A 338
TYR A 403
GLY A 335
ASN A 324
 None
 0.86A 5k4pA-5ie2A:
undetectable		 5k4pA-5ie2A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_D_ADND502_2
(ADENOSYLHOMOCYSTEINA
SE)		 5ie2 OXALATE--COA LIGASE
(Arabidopsis
thaliana) 		3 / 3 THR A 173
THR A 392
LEU A 406
 ATP  A 601 (-3.3A)
None
ATP  A 601 (-4.5A)
 0.69A 5m66D-5ie2A:
4.6		 5m66D-5ie2A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_C_CHDC401_0
(BILE SALT HYDROLASE)		 5ie2 OXALATE--COA LIGASE
(Arabidopsis
thaliana) 		4 / 8 LEU A 431
ILE A 470
PHE A 488
LEU A 493
 None
 0.82A 5y7pC-5ie2A:
undetectable		 5y7pC-5ie2A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_B_SAMB601_1
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 5ie2 OXALATE--COA LIGASE
(Arabidopsis
thaliana) 		4 / 7 ALA A 231
GLY A 229
GLY A 227
ASN A 253
 None
 0.80A 5ybbB-5ie2A:
undetectable		 5ybbB-5ie2A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_2
(TUBULIN BETA CHAIN)		 5ie2 OXALATE--COA LIGASE
(Arabidopsis
thaliana) 		4 / 5 LEU A 300
THR A 258
PRO A 235
ARG A 239
 None
 1.05A 6ew0F-5ie2A:
undetectable		 6ew0F-5ie2A:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_D_ADND502_2
(-)		 5ie2 OXALATE--COA LIGASE
(Arabidopsis
thaliana) 		4 / 5 ILE A 395
GLN A 355
THR A 392
LEU A 404
 None
 1.14A 6f3mD-5ie2A:
4.2		 6f3mD-5ie2A:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JMJ_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 5ie2 OXALATE--COA LIGASE
(Arabidopsis
thaliana) 		4 / 5 GLY A 499
THR A 496
HIS A 214
SER A 171
 None
None
ATP  A 601 ( 4.2A)
ATP  A 601 (-2.9A)
 1.13A 6jmjA-5ie2A:
2.9		 6jmjA-5ie2A:
15.88