SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ier'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2A15_A_NCAA1001_0
(HYPOTHETICAL PROTEIN
RV0760C)		 5ier OHP9
(synthetic
construct) 		5 / 11 TRP A  24
ILE A  64
LEU A  69
LEU A  89
TYR A 109
 3QZ  A 201 ( 4.5A)
3QZ  A 201 ( 4.4A)
3QZ  A 201 (-4.0A)
3QZ  A 201 ( 4.5A)
None
 0.91A 2a15A-5ierA:
25.3		 2a15A-5ierA:
95.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FJ1_A_CTCA222_0
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 5ier OHP9
(synthetic
construct) 		5 / 12 THR A 118
VAL A 111
LEU A   6
ILE A  85
SER A  79
 SO4  A 203 ( 4.2A)
None
None
None
None
 1.42A 2fj1A-5ierA:
undetectable		 2fj1A-5ierA:
18.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2Z77_D_NCAD200_0
(PUTATIVE STEROID
ISOMERASE)		 5ier OHP9
(synthetic
construct) 		5 / 9 TRP A  13
TRP A  24
LEU A  69
LEU A  89
TYR A 109
 None
3QZ  A 201 ( 4.5A)
3QZ  A 201 (-4.0A)
3QZ  A 201 ( 4.5A)
None
 0.85A 2z77D-5ierA:
26.0		 2z77D-5ierA:
95.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4A_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 5ier OHP9
(synthetic
construct) 		4 / 8 PHE A  59
THR A  16
THR A  43
LEU A  69
 3QZ  A 201 ( 4.5A)
3QZ  A 201 (-2.9A)
3QZ  A 201 (-3.2A)
3QZ  A 201 (-4.0A)
 0.98A 4l4aA-5ierA:
undetectable		 4l4aA-5ierA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4E_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 5ier OHP9
(synthetic
construct) 		4 / 8 PHE A  59
THR A  16
THR A  43
LEU A  69
 3QZ  A 201 ( 4.5A)
3QZ  A 201 (-2.9A)
3QZ  A 201 (-3.2A)
3QZ  A 201 (-4.0A)
 0.89A 4l4eA-5ierA:
undetectable		 4l4eA-5ierA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4F_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 5ier OHP9
(synthetic
construct) 		4 / 8 PHE A  59
THR A  16
THR A  43
LEU A  69
 3QZ  A 201 ( 4.5A)
3QZ  A 201 (-2.9A)
3QZ  A 201 (-3.2A)
3QZ  A 201 (-4.0A)
 0.91A 4l4fA-5ierA:
undetectable		 4l4fA-5ierA:
18.52