SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ies'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA302_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 5ies VRC01CHUGL2 FAB
HEAVY CHAIN
(Homo
sapiens) 		4 / 6 LEU H 189
GLY H 190
ALA H 125
PRO H 126
 None
 0.52A 3huoA-5iesH:
undetectable		 3huoA-5iesH:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 5ies VRC01CHUGL2 FAB
HEAVY CHAIN
(Homo
sapiens) 		6 / 12 VAL H 184
THR H 135
LEU H 159
VAL H 163
GLY H 162
VAL H 211
 None
 1.50A 6a94B-5iesH:
undetectable		 6a94B-5iesH:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPY_A_ACTA408_0
(THIOREDOXIN
REDUCTASE)		 5ies VRC01CHUGL2 FAB
HEAVY CHAIN
(Homo
sapiens) 		3 / 3 PRO H 185
SER H 187
SER H 188
 None
 0.68A 6bpyA-5iesH:
undetectable		 6bpyA-5iesH:
21.39