SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5if3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_A_SALA2006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5if3 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Burkholderia
vietnamiensis) 		4 / 6 THR A  15
VAL A  39
LEU A  60
ALA A 120
 None
 1.08A 2e1qA-5if3A:
undetectable		 2e1qA-5if3A:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_C_SALC4006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5if3 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Burkholderia
vietnamiensis) 		4 / 6 THR A  15
VAL A  39
LEU A  60
ALA A 120
 None
 1.03A 2e1qC-5if3A:
undetectable		 2e1qC-5if3A:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QJ7_A_SPMA264_1
(THYMIDYLATE SYNTHASE)		 5if3 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Burkholderia
vietnamiensis) 		4 / 8 ARG A 178
ALA A 131
LEU A  77
ASP A  82
 None
 1.02A 3qj7A-5if3A:
undetectable
3qj7D-5if3A:
undetectable		 3qj7A-5if3A:
21.55
3qj7D-5if3A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U52_A_CUA515_0
(PHENOL HYDROXYLASE
COMPONENT PHL
PHENOL HYDROXYLASE
COMPONENT PHN)		 5if3 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Burkholderia
vietnamiensis) 		3 / 3 HIS A 168
HIS A 142
ILE A 182
 None
 0.77A 3u52A-5if3A:
undetectable
3u52C-5if3A:
undetectable		 3u52A-5if3A:
18.09
3u52C-5if3A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_A_SALA1344_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 5if3 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Burkholderia
vietnamiensis) 		4 / 7 THR A  15
VAL A  39
LEU A  60
ALA A 120
 None
 1.03A 3uniA-5if3A:
undetectable		 3uniA-5if3A:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 5if3 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Burkholderia
vietnamiensis) 		4 / 5 ASP A 175
ASN A 177
ILE A 182
VAL A 129
 None
 1.25A 4hytA-5if3A:
4.0		 4hytA-5if3A:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_2
(MEDI2452 LIGHT CHAIN)		 5if3 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Burkholderia
vietnamiensis) 		4 / 8 SER A  40
GLY A  16
ALA A 113
GLY A  94
 None
 0.84A 5albL-5if3A:
undetectable		 5albL-5if3A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_B_STRB502_1
(CYTOCHROME P450
CYP260A1)		 5if3 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Burkholderia
vietnamiensis) 		4 / 6 LEU A  72
ALA A 127
LEU A  62
THR A  15
 None
 0.68A 6f88B-5if3A:
undetectable		 6f88B-5if3A:
18.65