SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ifk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_A_SAMA401_1
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 5ifk PURINE NUCLEOSIDE
PHOSPHORYLASE
(Kluyveromyces
lactis) 		4 / 4 HIS A 201
ASP A 294
SER A 292
ASP A 141
 None
 0.92A 1n2xA-5ifkA:
undetectable		 1n2xA-5ifkA:
22.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5ifk PURINE NUCLEOSIDE
PHOSPHORYLASE
(Kluyveromyces
lactis) 		9 / 10 GLY A 131
PHE A 213
GLU A 214
VAL A 230
GLY A 231
MET A 232
THR A 255
ASN A 256
HIS A 281
 HPA  A 401 (-3.5A)
HPA  A 401 (-4.9A)
HPA  A 401 (-2.7A)
HPA  A 401 (-4.5A)
HPA  A 401 (-3.5A)
HPA  A 401 ( 4.3A)
HPA  A 401 (-4.0A)
HPA  A 401 (-2.9A)
None
 0.73A 1pwyE-5ifkA:
37.1		 1pwyE-5ifkA:
44.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V3Q_E_2DIE290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5ifk PURINE NUCLEOSIDE
PHOSPHORYLASE
(Kluyveromyces
lactis) 		9 / 10 GLY A 131
PHE A 213
GLU A 214
VAL A 230
GLY A 231
MET A 232
THR A 255
ASN A 256
HIS A 281
 HPA  A 401 (-3.5A)
HPA  A 401 (-4.9A)
HPA  A 401 (-2.7A)
HPA  A 401 (-4.5A)
HPA  A 401 (-3.5A)
HPA  A 401 ( 4.3A)
HPA  A 401 (-4.0A)
HPA  A 401 (-2.9A)
None
 0.54A 1v3qE-5ifkA:
38.3		 1v3qE-5ifkA:
44.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1V3Q_E_2DIE290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 5ifk PURINE NUCLEOSIDE
PHOSPHORYLASE
(Kluyveromyces
lactis) 		5 / 10 GLY A 231
PHE A 213
GLU A 214
GLY A 210
HIS A 281
 HPA  A 401 (-3.5A)
HPA  A 401 (-4.9A)
HPA  A 401 (-2.7A)
None
None
 1.27A 1v3qE-5ifkA:
38.3		 1v3qE-5ifkA:
44.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_A_CIOA603_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 5ifk PURINE NUCLEOSIDE
PHOSPHORYLASE
(Kluyveromyces
lactis) 		5 / 12 TYR A  19
LEU A  24
ILE A  65
PHE A  68
PHE A  82
 None
 1.48A 1xomA-5ifkA:
undetectable		 1xomA-5ifkA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOM_B_CIOB601_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D)		 5ifk PURINE NUCLEOSIDE
PHOSPHORYLASE
(Kluyveromyces
lactis) 		5 / 12 TYR A  19
LEU A  24
ILE A  65
PHE A  68
PHE A  82
 None
 1.48A 1xomB-5ifkA:
undetectable		 1xomB-5ifkA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_A_EV1A1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 5ifk PURINE NUCLEOSIDE
PHOSPHORYLASE
(Kluyveromyces
lactis) 		6 / 12 LEU A 118
LEU A  24
ILE A  65
TYR A  62
PHE A  68
PHE A  82
 None
 1.47A 2weyA-5ifkA:
undetectable		 2weyA-5ifkA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AY0_B_ADNB402_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 5ifk PURINE NUCLEOSIDE
PHOSPHORYLASE
(Kluyveromyces
lactis) 		5 / 10 GLY A 203
ASP A 228
ILE A 133
ASN A 134
PHE A 151
 None
 1.30A 3ay0B-5ifkA:
undetectable		 3ay0B-5ifkA:
21.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3E9R_A_ACTA700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5ifk PURINE NUCLEOSIDE
PHOSPHORYLASE
(Kluyveromyces
lactis) 		5 / 6 GLY A 131
GLU A 214
GLY A 231
MET A 232
ASN A 256
 HPA  A 401 (-3.5A)
HPA  A 401 (-2.7A)
HPA  A 401 (-3.5A)
HPA  A 401 ( 4.3A)
HPA  A 401 (-2.9A)
 0.49A 3e9rA-5ifkA:
39.6		 3e9rA-5ifkA:
42.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3E9R_C_ACTC700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5ifk PURINE NUCLEOSIDE
PHOSPHORYLASE
(Kluyveromyces
lactis) 		5 / 6 GLY A 131
GLU A 214
GLY A 231
MET A 232
ASN A 256
 HPA  A 401 (-3.5A)
HPA  A 401 (-2.7A)
HPA  A 401 (-3.5A)
HPA  A 401 ( 4.3A)
HPA  A 401 (-2.9A)
 0.53A 3e9rC-5ifkA:
39.3		 3e9rC-5ifkA:
42.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_A_ADNA300_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5ifk PURINE NUCLEOSIDE
PHOSPHORYLASE
(Kluyveromyces
lactis) 		9 / 12 SER A  42
ALA A 129
GLY A 131
GLU A 214
VAL A 230
GLY A 231
MET A 232
ASN A 256
VAL A 284
 None
HPA  A 401 (-4.0A)
HPA  A 401 (-3.5A)
HPA  A 401 (-2.7A)
HPA  A 401 (-4.5A)
HPA  A 401 (-3.5A)
HPA  A 401 ( 4.3A)
HPA  A 401 (-2.9A)
HPA  A 401 ( 4.7A)
 1.00A 3f8wA-5ifkA:
38.8		 3f8wA-5ifkA:
42.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_A_ADNA300_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5ifk PURINE NUCLEOSIDE
PHOSPHORYLASE
(Kluyveromyces
lactis) 		10 / 12 TYR A 100
ALA A 129
GLY A 131
GLU A 214
VAL A 230
GLY A 231
MET A 232
ASN A 256
HIS A 281
VAL A 284
 None
HPA  A 401 (-4.0A)
HPA  A 401 (-3.5A)
HPA  A 401 (-2.7A)
HPA  A 401 (-4.5A)
HPA  A 401 (-3.5A)
HPA  A 401 ( 4.3A)
HPA  A 401 (-2.9A)
None
HPA  A 401 ( 4.7A)
 0.41A 3f8wA-5ifkA:
38.8		 3f8wA-5ifkA:
42.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_B_ADNB301_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5ifk PURINE NUCLEOSIDE
PHOSPHORYLASE
(Kluyveromyces
lactis) 		10 / 12 HIS A  98
TYR A 100
GLY A 131
GLU A 214
VAL A 230
GLY A 231
MET A 232
ASN A 256
HIS A 281
VAL A 284
 None
None
HPA  A 401 (-3.5A)
HPA  A 401 (-2.7A)
HPA  A 401 (-4.5A)
HPA  A 401 (-3.5A)
HPA  A 401 ( 4.3A)
HPA  A 401 (-2.9A)
None
HPA  A 401 ( 4.7A)
 0.41A 3f8wB-5ifkA:
38.7		 3f8wB-5ifkA:
42.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_B_ADNB301_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5ifk PURINE NUCLEOSIDE
PHOSPHORYLASE
(Kluyveromyces
lactis) 		8 / 12 SER A  42
GLY A 131
GLU A 214
VAL A 230
GLY A 231
MET A 232
ASN A 256
VAL A 284
 None
HPA  A 401 (-3.5A)
HPA  A 401 (-2.7A)
HPA  A 401 (-4.5A)
HPA  A 401 (-3.5A)
HPA  A 401 ( 4.3A)
HPA  A 401 (-2.9A)
HPA  A 401 ( 4.7A)
 0.97A 3f8wB-5ifkA:
38.7		 3f8wB-5ifkA:
42.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_C_ADNC302_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5ifk PURINE NUCLEOSIDE
PHOSPHORYLASE
(Kluyveromyces
lactis) 		10 / 12 HIS A  98
TYR A 100
ALA A 129
GLY A 131
GLU A 214
VAL A 230
GLY A 231
MET A 232
ASN A 256
VAL A 284
 None
None
HPA  A 401 (-4.0A)
HPA  A 401 (-3.5A)
HPA  A 401 (-2.7A)
HPA  A 401 (-4.5A)
HPA  A 401 (-3.5A)
HPA  A 401 ( 4.3A)
HPA  A 401 (-2.9A)
HPA  A 401 ( 4.7A)
 0.35A 3f8wC-5ifkA:
38.9		 3f8wC-5ifkA:
42.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3F8W_C_ADNC302_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 5ifk PURINE NUCLEOSIDE
PHOSPHORYLASE
(Kluyveromyces
lactis) 		9 / 12 SER A  42
ALA A 129
GLY A 131
GLU A 214
VAL A 230
GLY A 231
MET A 232
ASN A 256
VAL A 284
 None
HPA  A 401 (-4.0A)
HPA  A 401 (-3.5A)
HPA  A 401 (-2.7A)
HPA  A 401 (-4.5A)
HPA  A 401 (-3.5A)
HPA  A 401 ( 4.3A)
HPA  A 401 (-2.9A)
HPA  A 401 ( 4.7A)
 1.00A 3f8wC-5ifkA:
38.9		 3f8wC-5ifkA:
42.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_A_VIBA223_1
(THIAMINE
PYROPHOSPHOKINASE)		 5ifk PURINE NUCLEOSIDE
PHOSPHORYLASE
(Kluyveromyces
lactis) 		4 / 7 LEU A 298
LEU A 142
SER A  42
THR A 255
 None
None
None
HPA  A 401 (-4.0A)
 0.92A 3lm8A-5ifkA:
undetectable
3lm8C-5ifkA:
undetectable		 3lm8A-5ifkA:
19.56
3lm8C-5ifkA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5ifk PURINE NUCLEOSIDE
PHOSPHORYLASE
(Kluyveromyces
lactis) 		4 / 7 ALA A  11
ILE A  13
HIS A 110
GLY A  67
 None
 0.83A 3v4tH-5ifkA:
undetectable		 3v4tH-5ifkA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B52_A_OAQA302_0
(SULFOTRANSFERASE)		 5ifk PURINE NUCLEOSIDE
PHOSPHORYLASE
(Kluyveromyces
lactis) 		5 / 12 PRO A 236
LEU A 105
SER A 104
MET A  93
LEU A  80
 None
 1.23A 6b52A-5ifkA:
undetectable		 6b52A-5ifkA:
22.39