SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ig1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRB_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)
5ig1 CAMK/CAMK2 PROTEIN
KINASE

(Salpingoeca
rosetta)
6 / 12 ILE A 209
PHE A 103
ILE A 124
LEU A 146
ILE A 206
THR A 289
None
1.44A 1drbB-5ig1A:
undetectable
1drbB-5ig1A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FMO_E_ADNE351_1
(CAMP-DEPENDENT
PROTEIN KINASE)
5ig1 CAMK/CAMK2 PROTEIN
KINASE

(Salpingoeca
rosetta)
7 / 12 VAL A  78
VAL A  97
GLU A 101
ASN A 145
LEU A 147
THR A 160
ASP A 161
None
0.73A 1fmoE-5ig1A:
28.6
1fmoE-5ig1A:
28.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)
5ig1 CAMK/CAMK2 PROTEIN
KINASE

(Salpingoeca
rosetta)
6 / 12 ILE A 209
PHE A 103
ILE A 124
LEU A 146
ILE A 206
THR A 289
None
1.38A 1ra2A-5ig1A:
undetectable
1ra2A-5ig1A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)
5ig1 CAMK/CAMK2 PROTEIN
KINASE

(Salpingoeca
rosetta)
6 / 12 ILE A 209
PHE A 103
ILE A 124
LEU A 146
ILE A 206
THR A 289
None
1.39A 1ra8A-5ig1A:
undetectable
1ra8A-5ig1A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)
5ig1 CAMK/CAMK2 PROTEIN
KINASE

(Salpingoeca
rosetta)
6 / 12 ILE A 209
PHE A 103
ILE A 124
LEU A 146
ILE A 206
THR A 289
None
1.38A 1rb2A-5ig1A:
undetectable
1rb2A-5ig1A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)
5ig1 CAMK/CAMK2 PROTEIN
KINASE

(Salpingoeca
rosetta)
6 / 12 ILE A 209
PHE A 103
ILE A 124
LEU A 146
ILE A 206
THR A 289
None
1.37A 1rd7A-5ig1A:
undetectable
1rd7A-5ig1A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)
5ig1 CAMK/CAMK2 PROTEIN
KINASE

(Salpingoeca
rosetta)
6 / 12 ILE A 209
PHE A 103
ILE A 124
LEU A 146
ILE A 206
THR A 289
None
1.39A 1rx2A-5ig1A:
undetectable
1rx2A-5ig1A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S8F_A_BEZA1501_0
(RAS-RELATED PROTEIN
RAB-9A)
5ig1 CAMK/CAMK2 PROTEIN
KINASE

(Salpingoeca
rosetta)
4 / 5 ILE A 252
TRP A 241
LEU A 256
PRO A 216
None
1.22A 1s8fA-5ig1A:
undetectable
1s8fB-5ig1A:
undetectable
1s8fA-5ig1A:
21.21
1s8fB-5ig1A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_1
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)
5ig1 CAMK/CAMK2 PROTEIN
KINASE

(Salpingoeca
rosetta)
8 / 12 VAL A  32
ALA A  45
LYS A  47
GLU A  65
VAL A  78
GLY A 100
LEU A 147
ASP A 161
None
1.05A 1t46A-5ig1A:
23.0
1t46A-5ig1A:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XKK_A_FMMA91_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
5ig1 CAMK/CAMK2 PROTEIN
KINASE

(Salpingoeca
rosetta)
6 / 12 GLY A 100
ASP A 104
LEU A 147
THR A 160
ASP A 161
PHE A 162
None
1.05A 1xkkA-5ig1A:
17.7
1xkkA-5ig1A:
25.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_A_GBNA2414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)
5ig1 CAMK/CAMK2 PROTEIN
KINASE

(Salpingoeca
rosetta)
4 / 8 GLY A 282
THR A 246
ALA A 247
ALA A 248
None
0.30A 2ej3A-5ig1A:
undetectable
2ej3A-5ig1A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EUF_B_LQQB401_1
(CELL DIVISION
PROTEIN KINASE 6)
5ig1 CAMK/CAMK2 PROTEIN
KINASE

(Salpingoeca
rosetta)
7 / 12 ILE A  24
VAL A  32
LYS A  47
VAL A  78
PHE A  94
LEU A 147
ASP A 161
None
1.00A 2eufB-5ig1A:
27.7
2eufB-5ig1A:
26.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1500_1
(CYTOCHROME P450 3A4)
5ig1 CAMK/CAMK2 PROTEIN
KINASE

(Salpingoeca
rosetta)
5 / 11 PHE A 296
LEU A 125
ALA A 119
GLU A 101
LEU A 210
None
1.30A 2v0mA-5ig1A:
undetectable
2v0mA-5ig1A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN1_A_FK5A501_2
(70 KDA
PEPTIDYLPROLYL
ISOMERASE)
5ig1 CAMK/CAMK2 PROTEIN
KINASE

(Salpingoeca
rosetta)
4 / 6 LEU A  51
SER A   8
PHE A  10
ASP A  11
None
1.23A 2vn1B-5ig1A:
undetectable
2vn1B-5ig1A:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7J_D_B49D1294_1
(PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM)
5ig1 CAMK/CAMK2 PROTEIN
KINASE

(Salpingoeca
rosetta)
6 / 10 ILE A  24
VAL A  32
ALA A  45
PHE A  94
GLY A 100
LEU A 147
None
1.00A 2y7jD-5ig1A:
26.9
2y7jD-5ig1A:
28.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BBT_D_FMMD91_1
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4)
5ig1 CAMK/CAMK2 PROTEIN
KINASE

(Salpingoeca
rosetta)
7 / 12 VAL A  32
ALA A  45
LYS A  47
LEU A  92
GLY A 100
LEU A 147
THR A 160
None
1.11A 3bbtD-5ig1A:
23.0
3bbtD-5ig1A:
26.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB2_A_SAMA1101_1
(STRUCTURAL PROTEIN
VP3)
5ig1 CAMK/CAMK2 PROTEIN
KINASE

(Salpingoeca
rosetta)
3 / 3 GLU A 240
ASP A 242
ASP A 235
None
0.53A 3jb2A-5ig1A:
undetectable
3jb2A-5ig1A:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LFA_A_1N1A361_1
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)
5ig1 CAMK/CAMK2 PROTEIN
KINASE

(Salpingoeca
rosetta)
4 / 8 ALA A  45
LYS A  47
GLU A  65
LEU A  92
None
0.41A 3lfaA-5ig1A:
22.5
3lfaA-5ig1A:
27.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TI1_A_B49A299_1
(CYCLIN-DEPENDENT
KINASE 2)
5ig1 CAMK/CAMK2 PROTEIN
KINASE

(Salpingoeca
rosetta)
5 / 9 ILE A  24
ALA A  45
VAL A  78
PHE A  94
LEU A 147
None
0.88A 3ti1A-5ig1A:
23.4
3ti1A-5ig1A:
27.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_A_0LIA1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)
5ig1 CAMK/CAMK2 PROTEIN
KINASE

(Salpingoeca
rosetta)
5 / 9 ILE A  68
LEU A  72
ILE A  77
TYR A  96
ILE A 159
None
None
None
PO4  A 401 (-4.8A)
None
0.75A 3zosA-5ig1A:
23.0
3zosA-5ig1A:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOS_B_0LIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)
5ig1 CAMK/CAMK2 PROTEIN
KINASE

(Salpingoeca
rosetta)
5 / 9 ILE A  68
LEU A  72
ILE A  77
TYR A  96
ILE A 159
None
None
None
PO4  A 401 (-4.8A)
None
0.74A 3zosB-5ig1A:
23.2
3zosB-5ig1A:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BKJ_B_STIB1000_2
(EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1)
5ig1 CAMK/CAMK2 PROTEIN
KINASE

(Salpingoeca
rosetta)
4 / 5 LYS A  47
LEU A  72
TYR A  96
ARG A 139
None
None
PO4  A 401 (-4.8A)
None
1.46A 4bkjB-5ig1A:
23.3
4bkjB-5ig1A:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C8B_A_0LIA1000_2
(RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2)
5ig1 CAMK/CAMK2 PROTEIN
KINASE

(Salpingoeca
rosetta)
4 / 5 VAL A  32
ILE A  77
TYR A  96
ILE A 159
None
None
PO4  A 401 (-4.8A)
None
0.57A 4c8bA-5ig1A:
24.1
4c8bA-5ig1A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EXS_B_X8ZB301_1
(BETA-LACTAMASE NDM-1)
5ig1 CAMK/CAMK2 PROTEIN
KINASE

(Salpingoeca
rosetta)
4 / 8 VAL A 266
HIS A 138
ASP A 199
HIS A 132
None
0.94A 4exsB-5ig1A:
undetectable
4exsB-5ig1A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAA_A_RTZA401_1
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)
5ig1 CAMK/CAMK2 PROTEIN
KINASE

(Salpingoeca
rosetta)
6 / 11 VAL A  32
ALA A  45
LYS A  47
GLU A 144
LEU A 147
ASP A 161
None
0.93A 4iaaA-5ig1A:
26.7
4iaaA-5ig1A:
28.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KJL_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)
5ig1 CAMK/CAMK2 PROTEIN
KINASE

(Salpingoeca
rosetta)
6 / 12 ILE A 209
PHE A 103
ILE A 124
LEU A 146
ILE A 206
THR A 289
None
1.36A 4kjlA-5ig1A:
undetectable
4kjlA-5ig1A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMS_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)
5ig1 CAMK/CAMK2 PROTEIN
KINASE

(Salpingoeca
rosetta)
7 / 11 ILE A  24
ALA A  45
LYS A  47
GLU A  65
TYR A  96
LEU A 147
ASP A 161
None
None
None
None
PO4  A 401 (-4.8A)
None
None
1.04A 4qmsA-5ig1A:
31.6
4qmsA-5ig1A:
28.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QMZ_A_B49A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 24)
5ig1 CAMK/CAMK2 PROTEIN
KINASE

(Salpingoeca
rosetta)
6 / 12 ILE A  24
GLY A  25
VAL A  32
ALA A  45
TYR A  96
LEU A 147
None
None
None
None
PO4  A 401 (-4.8A)
None
0.86A 4qmzA-5ig1A:
31.2
4qmzA-5ig1A:
28.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)
5ig1 CAMK/CAMK2 PROTEIN
KINASE

(Salpingoeca
rosetta)
6 / 10 VAL A  32
GLU A  65
LEU A  72
ILE A  77
TYR A  96
ILE A 159
None
None
None
None
PO4  A 401 (-4.8A)
None
0.84A 4u0iA-5ig1A:
22.8
4u0iA-5ig1A:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U0I_A_0LIA1001_1
(MAST/STEM CELL
GROWTH FACTOR
RECEPTOR
KIT,MAST/STEM CELL
GROWTH FACTOR
RECEPTOR KIT)
5ig1 CAMK/CAMK2 PROTEIN
KINASE

(Salpingoeca
rosetta)
6 / 10 VAL A  32
LEU A  72
ILE A  77
VAL A  78
TYR A  96
ILE A 159
None
None
None
None
PO4  A 401 (-4.8A)
None
0.81A 4u0iA-5ig1A:
22.8
4u0iA-5ig1A:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V01_A_0LIA1776_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B)
5ig1 CAMK/CAMK2 PROTEIN
KINASE

(Salpingoeca
rosetta)
6 / 9 VAL A  32
LYS A  47
TYR A  96
ARG A 139
LEU A 147
ILE A 159
None
None
PO4  A 401 (-4.8A)
None
None
None
1.29A 4v01A-5ig1A:
23.2
4v01A-5ig1A:
26.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)
5ig1 CAMK/CAMK2 PROTEIN
KINASE

(Salpingoeca
rosetta)
6 / 12 ILE A 209
PHE A 103
ILE A 124
LEU A 146
ILE A 206
THR A 289
None
1.35A 4x5iA-5ig1A:
undetectable
4x5iA-5ig1A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_A_WJZA304_0
(BETA-LACTAMASE NDM-1)
5ig1 CAMK/CAMK2 PROTEIN
KINASE

(Salpingoeca
rosetta)
4 / 8 VAL A 266
HIS A 138
ASP A 199
HIS A 132
None
0.86A 5a5zA-5ig1A:
undetectable
5a5zA-5ig1A:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)
5ig1 CAMK/CAMK2 PROTEIN
KINASE

(Salpingoeca
rosetta)
6 / 12 ILE A 209
PHE A 103
ILE A 124
LEU A 146
ILE A 206
THR A 289
None
1.43A 5eajA-5ig1A:
undetectable
5eajA-5ig1A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXT_A_0LAA1376_1
(DNA POLYMERASE III
SUBUNIT BETA)
5ig1 CAMK/CAMK2 PROTEIN
KINASE

(Salpingoeca
rosetta)
4 / 7 LEU A 256
PRO A 216
ILE A 209
MET A 121
None
1.08A 5fxtA-5ig1A:
undetectable
5fxtA-5ig1A:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZJ_G_AZ1G2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAR-DAR)
5ig1 CAMK/CAMK2 PROTEIN
KINASE

(Salpingoeca
rosetta)
4 / 7 GLY A  25
GLY A  27
VAL A  32
LYS A  47
None
0.33A 5izjA-5ig1A:
22.1
5izjA-5ig1A:
28.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J5X_B_AZ1B2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
47P-AZ1-DAL-DAR-DAR-
DAR-DAR)
5ig1 CAMK/CAMK2 PROTEIN
KINASE

(Salpingoeca
rosetta)
4 / 7 GLY A  25
GLY A  27
VAL A  32
LYS A  47
None
0.41A 5j5xA-5ig1A:
28.6
5j5xA-5ig1A:
28.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2I_A_LQQA900_1
(CYCLIN-DEPENDENT
KINASE 6)
5ig1 CAMK/CAMK2 PROTEIN
KINASE

(Salpingoeca
rosetta)
7 / 12 ILE A  24
GLY A  25
VAL A  32
ALA A  45
VAL A  78
PHE A  94
LEU A 147
None
0.84A 5l2iA-5ig1A:
7.8
5l2iA-5ig1A:
28.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5LVN_A_ADNA402_1
(3-PHOSPHOINOSITIDE-D
EPENDENT PROTEIN
KINASE 1)
5ig1 CAMK/CAMK2 PROTEIN
KINASE

(Salpingoeca
rosetta)
6 / 11 GLY A  25
VAL A  32
ALA A  45
VAL A  78
TYR A  96
LEU A 147
None
None
None
None
PO4  A 401 (-4.8A)
None
0.47A 5lvnA-5ig1A:
24.5
5lvnA-5ig1A:
30.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MAF_A_XINA403_1
(MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE)
5ig1 CAMK/CAMK2 PROTEIN
KINASE

(Salpingoeca
rosetta)
8 / 12 ILE A  24
GLY A  25
VAL A  32
ALA A  45
LYS A  47
GLU A  65
TYR A  96
GLY A 100
None
None
None
None
None
None
PO4  A 401 (-4.8A)
None
0.83A 5mafA-5ig1A:
29.7
5mafA-5ig1A:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OWR_A_1N1A401_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)
5ig1 CAMK/CAMK2 PROTEIN
KINASE

(Salpingoeca
rosetta)
4 / 8 ALA A  45
GLU A  65
LEU A 147
ASP A 161
None
0.60A 5owrA-5ig1A:
23.9
5owrA-5ig1A:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UJX_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)
5ig1 CAMK/CAMK2 PROTEIN
KINASE

(Salpingoeca
rosetta)
6 / 12 ILE A 209
PHE A 103
ILE A 124
LEU A 146
ILE A 206
THR A 289
None
1.45A 5ujxA-5ig1A:
undetectable
5ujxA-5ig1A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF9_B_NIOB401_1
(CASEIN KINASE II
SUBUNIT ALPHA')
5ig1 CAMK/CAMK2 PROTEIN
KINASE

(Salpingoeca
rosetta)
4 / 7 VAL A  32
LYS A  47
PHE A  94
ASP A 161
None
0.76A 5yf9B-5ig1A:
26.2
5yf9B-5ig1A:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_B_1E8B1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
5ig1 CAMK/CAMK2 PROTEIN
KINASE

(Salpingoeca
rosetta)
6 / 12 GLY A  25
VAL A  32
ALA A  45
LYS A  47
LEU A  92
THR A 160
None
0.87A 5yu9B-5ig1A:
22.8
5yu9B-5ig1A:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
5ig1 CAMK/CAMK2 PROTEIN
KINASE

(Salpingoeca
rosetta)
5 / 12 VAL A  32
ALA A  45
LEU A  92
GLY A 100
THR A 160
None
0.76A 5yu9C-5ig1A:
22.3
5yu9C-5ig1A:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YU9_C_1E8C1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
5ig1 CAMK/CAMK2 PROTEIN
KINASE

(Salpingoeca
rosetta)
5 / 12 VAL A  32
ALA A  45
LYS A  47
LEU A  92
THR A 160
None
0.79A 5yu9C-5ig1A:
22.3
5yu9C-5ig1A:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)
5ig1 CAMK/CAMK2 PROTEIN
KINASE

(Salpingoeca
rosetta)
6 / 12 ILE A 209
PHE A 103
ILE A 124
LEU A 146
ILE A 206
THR A 289
None
1.40A 5z6jA-5ig1A:
undetectable
5z6jA-5ig1A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)
5ig1 CAMK/CAMK2 PROTEIN
KINASE

(Salpingoeca
rosetta)
6 / 12 ILE A 209
PHE A 103
ILE A 124
LEU A 146
ILE A 206
THR A 289
None
1.41A 5z6kA-5ig1A:
undetectable
5z6kA-5ig1A:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)
5ig1 CAMK/CAMK2 PROTEIN
KINASE

(Salpingoeca
rosetta)
6 / 12 ILE A 209
PHE A 103
ILE A 124
LEU A 146
ILE A 206
THR A 289
None
1.42A 7dfrA-5ig1A:
undetectable
7dfrA-5ig1A:
18.31