SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ig2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_A_TESA325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 5ig2 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Paraburkholderia
phymatum) 		4 / 7 LEU A 147
HIS A 266
THR A 167
TYR A 251
 None
 1.13A 1afsA-5ig2A:
undetectable		 1afsA-5ig2A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AFS_B_TESB325_1
(3-ALPHA-HYDROXYSTERO
ID DEHYDROGENASE)		 5ig2 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Paraburkholderia
phymatum) 		4 / 7 LEU A 147
HIS A 266
THR A 167
TYR A 251
 None
 1.14A 1afsB-5ig2A:
undetectable		 1afsB-5ig2A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5ig2 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Paraburkholderia
phymatum) 		5 / 9 VAL A  34
GLY A  59
ALA A  76
ILE A  58
THR A  62
 None
 0.89A 1gtnL-5ig2A:
undetectable
1gtnM-5ig2A:
undetectable		 1gtnL-5ig2A:
15.59
1gtnM-5ig2A:
15.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3003_1
(SERUM ALBUMIN)		 5ig2 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Paraburkholderia
phymatum) 		4 / 6 ILE A 155
LYS A 160
ALA A 162
VAL A 110
 None
NAD  A 301 (-2.9A)
None
None
 0.87A 1hk1A-5ig2A:
undetectable		 1hk1A-5ig2A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_2
(ANGIOTENSIN
CONVERTING ENZYME)		 5ig2 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Paraburkholderia
phymatum) 		4 / 4 SER A 143
VAL A 163
PHE A  18
VAL A 237
 ACT  A 302 ( 2.7A)
None
NAD  A 301 (-4.1A)
None
 1.13A 1o86A-5ig2A:
undetectable		 1o86A-5ig2A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5ig2 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Paraburkholderia
phymatum) 		4 / 6 GLY A 131
ILE A 128
GLN A 132
VAL A 181
 None
 0.92A 1rs7B-5ig2A:
undetectable		 1rs7B-5ig2A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_B_DVAB8_0
(GRAMICIDIN A)		 5ig2 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Paraburkholderia
phymatum) 		4 / 5 VAL A 118
GLY A 117
VAL A 115
TRP A 109
 None
 0.98A 1tkqB-5ig2A:
undetectable		 1tkqB-5ig2A:
4.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAY_A_ADNA1001_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 5ig2 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Paraburkholderia
phymatum) 		7 / 11 GLY A  13
ALA A  14
ASP A  63
VAL A  64
ALA A  91
VAL A  93
VAL A 113
 NAD  A 301 (-3.4A)
None
NAD  A 301 (-3.7A)
NAD  A 301 (-3.5A)
NAD  A 301 (-3.4A)
None
NAD  A 301 (-4.1A)
 1.31A 1uayA-5ig2A:
25.6		 1uayA-5ig2A:
28.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAY_A_ADNA1001_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 5ig2 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Paraburkholderia
phymatum) 		7 / 11 GLY A  13
ASP A  37
ASP A  63
VAL A  64
ALA A  91
VAL A  93
VAL A 113
 NAD  A 301 (-3.4A)
NAD  A 301 (-2.9A)
NAD  A 301 (-3.7A)
NAD  A 301 (-3.5A)
NAD  A 301 (-3.4A)
None
NAD  A 301 (-4.1A)
 0.44A 1uayA-5ig2A:
25.6		 1uayA-5ig2A:
28.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAY_A_ADNA1001_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 5ig2 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Paraburkholderia
phymatum) 		7 / 11 GLY A  13
SER A  16
ASP A  37
VAL A  64
ALA A  91
VAL A  93
VAL A 113
 NAD  A 301 (-3.4A)
NAD  A 301 (-2.6A)
NAD  A 301 (-2.9A)
NAD  A 301 (-3.5A)
NAD  A 301 (-3.4A)
None
NAD  A 301 (-4.1A)
 0.55A 1uayA-5ig2A:
25.6		 1uayA-5ig2A:
28.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAY_B_ADNB1002_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 5ig2 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Paraburkholderia
phymatum) 		7 / 10 GLY A  13
ALA A  14
ASP A  63
VAL A  64
ALA A  91
VAL A  93
VAL A 113
 NAD  A 301 (-3.4A)
None
NAD  A 301 (-3.7A)
NAD  A 301 (-3.5A)
NAD  A 301 (-3.4A)
None
NAD  A 301 (-4.1A)
 1.30A 1uayB-5ig2A:
25.9		 1uayB-5ig2A:
28.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAY_B_ADNB1002_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 5ig2 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Paraburkholderia
phymatum) 		7 / 10 GLY A  13
ASP A  37
ASP A  63
VAL A  64
ALA A  91
VAL A  93
VAL A 113
 NAD  A 301 (-3.4A)
NAD  A 301 (-2.9A)
NAD  A 301 (-3.7A)
NAD  A 301 (-3.5A)
NAD  A 301 (-3.4A)
None
NAD  A 301 (-4.1A)
 0.40A 1uayB-5ig2A:
25.9		 1uayB-5ig2A:
28.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAY_B_ADNB1002_1
(TYPE II
3-HYDROXYACYL-COA
DEHYDROGENASE)		 5ig2 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Paraburkholderia
phymatum) 		7 / 10 GLY A  13
SER A  16
ASP A  37
VAL A  64
ALA A  91
VAL A  93
VAL A 113
 NAD  A 301 (-3.4A)
NAD  A 301 (-2.6A)
NAD  A 301 (-2.9A)
NAD  A 301 (-3.5A)
NAD  A 301 (-3.4A)
None
NAD  A 301 (-4.1A)
 0.56A 1uayB-5ig2A:
25.9		 1uayB-5ig2A:
28.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_A_NFZA1219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5ig2 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Paraburkholderia
phymatum) 		4 / 8 PHE A  88
ASN A  89
GLY A 121
THR A  62
 None
 1.03A 1ykiA-5ig2A:
undetectable
1ykiB-5ig2A:
undetectable		 1ykiA-5ig2A:
22.43
1ykiB-5ig2A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_B_NFZB2219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5ig2 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Paraburkholderia
phymatum) 		4 / 8 THR A  62
PHE A  88
ASN A  89
GLY A 121
 None
 1.04A 1ykiA-5ig2A:
undetectable
1ykiB-5ig2A:
undetectable		 1ykiA-5ig2A:
22.43
1ykiB-5ig2A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_C_NFZC3219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5ig2 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Paraburkholderia
phymatum) 		4 / 8 PHE A  88
ASN A  89
GLY A 121
THR A  62
 None
 1.04A 1ykiC-5ig2A:
undetectable
1ykiD-5ig2A:
undetectable		 1ykiC-5ig2A:
22.43
1ykiD-5ig2A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YKI_D_NFZD4219_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5ig2 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Paraburkholderia
phymatum) 		4 / 8 THR A  62
PHE A  88
ASN A  89
GLY A 121
 None
 1.02A 1ykiC-5ig2A:
undetectable
1ykiD-5ig2A:
undetectable		 1ykiC-5ig2A:
22.43
1ykiD-5ig2A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_B_SAMB301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5ig2 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Paraburkholderia
phymatum) 		5 / 12 GLY A  13
ASP A  37
ARG A 200
ASP A  63
ASN A  90
 NAD  A 301 (-3.4A)
NAD  A 301 (-2.9A)
NAD  A 301 (-3.2A)
NAD  A 301 (-3.7A)
NAD  A 301 (-3.3A)
 1.12A 2bm9B-5ig2A:
6.0		 2bm9B-5ig2A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_E_SAME301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5ig2 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Paraburkholderia
phymatum) 		5 / 12 GLY A  13
ASP A  37
ASP A  63
ASN A  90
ALA A  91
 NAD  A 301 (-3.4A)
NAD  A 301 (-2.9A)
NAD  A 301 (-3.7A)
NAD  A 301 (-3.3A)
NAD  A 301 (-3.4A)
 0.95A 2bm9E-5ig2A:
5.9		 2bm9E-5ig2A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLC_A_CHDA332_0
(CHOLOYLGLYCINE
HYDROLASE)		 5ig2 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Paraburkholderia
phymatum) 		5 / 12 ILE A  11
ALA A 238
ILE A 195
THR A 141
LEU A 186
 None
None
NAD  A 301 (-3.6A)
NAD  A 301 (-3.9A)
None
 1.12A 2rlcA-5ig2A:
undetectable		 2rlcA-5ig2A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRZ_A_ACTA1467_0
(DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE)		 5ig2 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Paraburkholderia
phymatum) 		4 / 5 ARG A 202
ASP A 106
ILE A 155
GLU A 199
 None
 1.03A 2xrzA-5ig2A:
2.9
2xrzB-5ig2A:
3.2		 2xrzA-5ig2A:
23.12
2xrzB-5ig2A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBU_D_ADND504_1
(UNCHARACTERIZED
CONSERVED PROTEIN)		 5ig2 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Paraburkholderia
phymatum) 		3 / 3 PHE A  18
ASN A  90
PHE A  22
 NAD  A 301 (-4.1A)
NAD  A 301 (-3.3A)
None
 1.06A 2zbuD-5ig2A:
2.8		 2zbuD-5ig2A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMF_A_SAMA388_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 5ig2 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Paraburkholderia
phymatum) 		5 / 12 GLY A  13
ALA A  21
ASP A  63
VAL A  64
VAL A 113
 NAD  A 301 (-3.4A)
None
NAD  A 301 (-3.7A)
NAD  A 301 (-3.5A)
NAD  A 301 (-4.1A)
 0.97A 3dmfA-5ig2A:
6.8		 3dmfA-5ig2A:
26.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMF_A_SAMA388_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 5ig2 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Paraburkholderia
phymatum) 		5 / 12 GLY A  13
GLY A  15
ASP A  63
VAL A  64
VAL A 113
 NAD  A 301 (-3.4A)
NAD  A 301 ( 4.2A)
NAD  A 301 (-3.7A)
NAD  A 301 (-3.5A)
NAD  A 301 (-4.1A)
 0.87A 3dmfA-5ig2A:
6.8		 3dmfA-5ig2A:
26.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_B_SAMB801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 5ig2 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Paraburkholderia
phymatum) 		5 / 11 GLY A  15
ASP A  37
ASP A  39
ASP A  63
ASN A  90
 NAD  A 301 ( 4.2A)
NAD  A 301 (-2.9A)
None
NAD  A 301 (-3.7A)
NAD  A 301 (-3.3A)
 1.26A 3v8vB-5ig2A:
7.5		 3v8vB-5ig2A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_B_SAMB801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 5ig2 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Paraburkholderia
phymatum) 		5 / 11 GLY A  15
ASP A  37
ASP A  39
ASP A  63
VAL A  64
 NAD  A 301 ( 4.2A)
NAD  A 301 (-2.9A)
None
NAD  A 301 (-3.7A)
NAD  A 301 (-3.5A)
 0.78A 3v8vB-5ig2A:
7.5		 3v8vB-5ig2A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5ig2 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Paraburkholderia
phymatum) 		4 / 6 GLY A 131
ILE A 128
GLN A 132
VAL A 181
 None
 0.89A 4d39B-5ig2A:
undetectable		 4d39B-5ig2A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KCN_A_ACTA803_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5ig2 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Paraburkholderia
phymatum) 		4 / 6 GLY A 131
ILE A 128
GLN A 132
VAL A 181
 None
 0.98A 4kcnA-5ig2A:
undetectable		 4kcnA-5ig2A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_B_ASDB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 5ig2 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Paraburkholderia
phymatum) 		4 / 7 TYR A 156
VAL A 110
TRP A 109
LEU A 223
 ACT  A 302 ( 4.1A)
None
None
None
 1.13A 4xo7B-5ig2A:
2.3		 4xo7B-5ig2A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z7F_C_FOLC201_0
(FOLATE ECF
TRANSPORTER)		 5ig2 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Paraburkholderia
phymatum) 		5 / 12 ALA A  27
PHE A  22
PHE A 242
THR A 239
LEU A  86
 None
 1.36A 4z7fC-5ig2A:
undetectable		 4z7fC-5ig2A:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_H_6V8H305_0
(PROTEASOME SUBUNIT
BETA TYPE-3
PROTEASOME SUBUNIT
BETA TYPE-7)		 5ig2 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Paraburkholderia
phymatum) 		5 / 11 ALA A 238
THR A 241
GLU A 243
ALA A  23
GLY A  26
 None
 1.12A 5lf7H-5ig2A:
undetectable
5lf7I-5ig2A:
undetectable		 5lf7H-5ig2A:
23.26
5lf7I-5ig2A:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODQ_A_ACTA703_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 5ig2 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Paraburkholderia
phymatum) 		4 / 6 ARG A 214
ALA A 218
PHE A  98
GLU A 101
 None
 0.97A 5odqA-5ig2A:
3.8		 5odqA-5ig2A:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_A_HISA402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 5ig2 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR
(Paraburkholderia
phymatum) 		5 / 10 GLY A 117
THR A  62
VAL A  10
ALA A  36
LEU A  87
 None
 0.86A 6czmA-5ig2A:
undetectable
6czmC-5ig2A:
undetectable		 6czmA-5ig2A:
24.18
6czmC-5ig2A:
24.18