SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ig8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_0
(FTSJ)		 5ig8 ATP GRASP LIGASE
(Microcystis
aeruginosa) 		5 / 12 ALA A 282
GLY A 301
GLY A 302
LEU A 172
LEU A 135
 None
 0.92A 1eizA-5ig8A:
undetectable		 1eizA-5ig8A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_0
(FTSJ)		 5ig8 ATP GRASP LIGASE
(Microcystis
aeruginosa) 		5 / 12 ALA A 282
GLY A 301
GLY A 302
LEU A 172
LEU A 135
 None
 0.90A 1ej0A-5ig8A:
undetectable		 1ej0A-5ig8A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOB_A_PNNA1311_1
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 5ig8 ATP GRASP LIGASE
(Microcystis
aeruginosa) 		3 / 3 ARG A  80
ARG A  79
ILE A 125
 None
 0.80A 1uobA-5ig8A:
undetectable		 1uobA-5ig8A:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZG_A_NCAA302_0
(ADP-RIBOSYL CYCLASE
1)		 5ig8 ATP GRASP LIGASE
(Microcystis
aeruginosa) 		4 / 7 LYS A  30
LEU A 323
ASP A 321
SER A  75
 None
 1.50A 3dzgA-5ig8A:
undetectable		 3dzgA-5ig8A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_C_SAMC1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 5ig8 ATP GRASP LIGASE
(Microcystis
aeruginosa) 		5 / 12 ILE A 214
THR A 288
VAL A 294
ILE A 144
PRO A 146
 None
 0.92A 3kpdC-5ig8A:
undetectable		 3kpdC-5ig8A:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_A_ADNA506_2
(ADENOSYLHOMOCYSTEINA
SE)		 5ig8 ATP GRASP LIGASE
(Microcystis
aeruginosa) 		3 / 3 GLN A 217
THR A 288
LEU A 261
 None
 0.75A 3ondA-5ig8A:
undetectable		 3ondA-5ig8A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_B_ADNB507_2
(ADENOSYLHOMOCYSTEINA
SE)		 5ig8 ATP GRASP LIGASE
(Microcystis
aeruginosa) 		3 / 3 GLN A 217
THR A 288
LEU A 261
 None
 0.75A 3ondB-5ig8A:
undetectable		 3ondB-5ig8A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G7A_B_AZMB302_1
(CARBONATE
DEHYDRATASE)		 5ig8 ATP GRASP LIGASE
(Microcystis
aeruginosa) 		5 / 11 GLU A 297
VAL A 209
LEU A 173
THR A 189
THR A 174
 None
 0.92A 4g7aB-5ig8A:
undetectable		 4g7aB-5ig8A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_A_LURA201_1
(TRANSTHYRETIN)		 5ig8 ATP GRASP LIGASE
(Microcystis
aeruginosa) 		3 / 3 LYS A 127
LEU A 133
ALA A 128
 None
 0.68A 4iizA-5ig8A:
undetectable		 4iizA-5ig8A:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UOV_B_AZMB299_1
(CARBONATE
DEHYDRATASE)		 5ig8 ATP GRASP LIGASE
(Microcystis
aeruginosa) 		5 / 11 GLU A 297
VAL A 209
LEU A 173
THR A 189
THR A 174
 None
 1.17A 4uovB-5ig8A:
undetectable		 4uovB-5ig8A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4USW_A_ACTA1470_0
(ADENYLATE CYCLASE
TYPE 10)		 5ig8 ATP GRASP LIGASE
(Microcystis
aeruginosa) 		4 / 6 LYS A 131
LEU A 132
LEU A 172
VAL A 209
 None
 1.12A 4uswA-5ig8A:
undetectable		 4uswA-5ig8A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5S_B_AZMB302_1
(CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE))		 5ig8 ATP GRASP LIGASE
(Microcystis
aeruginosa) 		5 / 11 GLU A 297
VAL A 209
LEU A 173
THR A 189
THR A 174
 None
 1.16A 4x5sB-5ig8A:
undetectable		 4x5sB-5ig8A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XIW_E_AZME402_1
(CARBONIC ANHYDRASE,
ALPHA TYPE)		 5ig8 ATP GRASP LIGASE
(Microcystis
aeruginosa) 		5 / 11 GLU A 297
VAL A 209
LEU A 173
THR A 189
THR A 174
 None
 0.94A 4xiwE-5ig8A:
undetectable		 4xiwE-5ig8A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XIW_F_AZMF402_1
(CARBONIC ANHYDRASE,
ALPHA TYPE)		 5ig8 ATP GRASP LIGASE
(Microcystis
aeruginosa) 		5 / 11 GLU A 297
VAL A 209
LEU A 173
THR A 189
THR A 174
 None
 0.88A 4xiwF-5ig8A:
undetectable		 4xiwF-5ig8A:
22.52