SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5igp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MOG_A_RBFA200_1
(DODECIN)		 5igp MACROLIDE
2'-PHOSPHOTRANSFERAS
E
(Escherichia
coli) 		3 / 3 PHE A 272
TRP A 183
GLU A 268
 None
 1.10A 1mogA-5igpA:
undetectable		 1mogA-5igpA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_C_T3C601_1
(TRANSTHYRETIN)		 5igp MACROLIDE
2'-PHOSPHOTRANSFERAS
E
(Escherichia
coli) 		4 / 6 LEU A 270
ALA A 234
LEU A 236
VAL A 203
 None
ERY  A 402 ( 3.2A)
None
None
 1.17A 1sn5A-5igpA:
undetectable		 1sn5A-5igpA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_X_CPFX1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 5igp MACROLIDE
2'-PHOSPHOTRANSFERAS
E
(Escherichia
coli) 		4 / 4 ARG A  37
GLY A  33
GLU A  31
SER A 221
 None
None
None
GDP  A 401 ( 4.7A)
 1.20A 2xctS-5igpA:
undetectable
2xctU-5igpA:
undetectable		 2xctS-5igpA:
19.85
2xctU-5igpA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_A_ACTA501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 5igp MACROLIDE
2'-PHOSPHOTRANSFERAS
E
(Escherichia
coli) 		4 / 7 ASP A 219
VAL A  50
ARG A  52
ILE A  38
 GDP  A 401 (-2.6A)
GDP  A 401 (-4.6A)
GDP  A 401 (-4.5A)
GDP  A 401 (-4.2A)
 0.95A 2yfbA-5igpA:
undetectable		 2yfbA-5igpA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_B_ACTB501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 5igp MACROLIDE
2'-PHOSPHOTRANSFERAS
E
(Escherichia
coli) 		4 / 6 ASP A 219
VAL A  50
ARG A  52
ILE A  38
 GDP  A 401 (-2.6A)
GDP  A 401 (-4.6A)
GDP  A 401 (-4.5A)
GDP  A 401 (-4.2A)
 0.98A 2yfbB-5igpA:
undetectable		 2yfbB-5igpA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB8_0
(GRAMICIDIN D)		 5igp MACROLIDE
2'-PHOSPHOTRANSFERAS
E
(Escherichia
coli) 		3 / 3 VAL A  92
VAL A  50
TRP A  84
 None
GDP  A 401 (-4.6A)
None
 0.86A 3l8lA-5igpA:
undetectable
3l8lB-5igpA:
undetectable		 3l8lA-5igpA:
5.43
3l8lB-5igpA:
4.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_D_DVAD8_0
(GRAMICIDIN D)		 5igp MACROLIDE
2'-PHOSPHOTRANSFERAS
E
(Escherichia
coli) 		3 / 3 VAL A  92
VAL A  50
TRP A  84
 None
GDP  A 401 (-4.6A)
None
 0.94A 3l8lC-5igpA:
undetectable
3l8lD-5igpA:
undetectable		 3l8lC-5igpA:
5.43
3l8lD-5igpA:
4.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B7N_A_ZMRA601_2
(NEURAMINIDASE)		 5igp MACROLIDE
2'-PHOSPHOTRANSFERAS
E
(Escherichia
coli) 		3 / 3 ARG A 176
ARG A 179
TRP A 180
 None
 1.29A 4b7nA-5igpA:
undetectable		 4b7nA-5igpA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_C_ZMRC1470_2
(NEURAMINIDASE)		 5igp MACROLIDE
2'-PHOSPHOTRANSFERAS
E
(Escherichia
coli) 		3 / 3 ARG A 176
ARG A 179
TRP A 180
 None
 1.35A 4cpzC-5igpA:
undetectable		 4cpzC-5igpA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_E_ZMRE1471_2
(NEURAMINIDASE)		 5igp MACROLIDE
2'-PHOSPHOTRANSFERAS
E
(Escherichia
coli) 		3 / 3 ARG A 176
ARG A 179
TRP A 180
 None
 1.24A 4cpzE-5igpA:
undetectable		 4cpzE-5igpA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_F_ZMRF1470_2
(NEURAMINIDASE)		 5igp MACROLIDE
2'-PHOSPHOTRANSFERAS
E
(Escherichia
coli) 		3 / 3 ARG A 176
ARG A 179
TRP A 180
 None
 1.32A 4cpzF-5igpA:
undetectable		 4cpzF-5igpA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_G_ZMRG1471_2
(NEURAMINIDASE)		 5igp MACROLIDE
2'-PHOSPHOTRANSFERAS
E
(Escherichia
coli) 		3 / 3 ARG A 176
ARG A 179
TRP A 180
 None
 1.29A 4cpzG-5igpA:
undetectable		 4cpzG-5igpA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CPZ_H_ZMRH1470_2
(NEURAMINIDASE)		 5igp MACROLIDE
2'-PHOSPHOTRANSFERAS
E
(Escherichia
coli) 		3 / 3 ARG A 176
ARG A 179
TRP A 180
 None
 1.38A 4cpzH-5igpA:
undetectable		 4cpzH-5igpA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVR_A_SALA203_1
(3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE)		 5igp MACROLIDE
2'-PHOSPHOTRANSFERAS
E
(Escherichia
coli) 		4 / 7 ASP A 219
HIS A 198
VAL A  69
GLU A  66
 GDP  A 401 (-2.6A)
None
None
None
 1.12A 4hvrA-5igpA:
undetectable		 4hvrA-5igpA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MS4_A_2C0A501_1
(GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1)		 5igp MACROLIDE
2'-PHOSPHOTRANSFERAS
E
(Escherichia
coli) 		4 / 8 SER A 221
HIS A 205
TYR A  36
ILE A  38
 GDP  A 401 ( 4.7A)
GDP  A 401 (-4.4A)
None
GDP  A 401 (-4.2A)
 1.21A 4ms4A-5igpA:
undetectable		 4ms4A-5igpA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 5igp MACROLIDE
2'-PHOSPHOTRANSFERAS
E
(Escherichia
coli) 		4 / 6 ASP A 187
GLU A 268
VAL A 159
ALA A 160
 None
 0.96A 4nkvC-5igpA:
undetectable		 4nkvC-5igpA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W9N_C_CCSC1548_0
(ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE)		 5igp MACROLIDE
2'-PHOSPHOTRANSFERAS
E
(Escherichia
coli) 		3 / 3 ALA A  93
TRP A  49
VAL A  50
 None
None
GDP  A 401 (-4.6A)
 0.25A 4w9nC-5igpA:
undetectable		 4w9nC-5igpA:
24.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 5igp MACROLIDE
2'-PHOSPHOTRANSFERAS
E
(Escherichia
coli) 		12 / 12 MET A 103
ILE A 105
ASP A 200
TYR A 202
VAL A 203
ALA A 234
MET A 237
VAL A 238
GLY A 273
THR A 276
PHE A 280
TYR A 289
 ERY  A 402 (-2.2A)
ERY  A 402 ( 4.4A)
ERY  A 402 (-2.4A)
ERY  A 402 (-2.7A)
None
ERY  A 402 ( 3.2A)
ERY  A 402 ( 3.0A)
ERY  A 402 ( 4.7A)
ERY  A 402 ( 3.6A)
ERY  A 402 ( 3.8A)
ERY  A 402 ( 3.6A)
None
 0.48A 5igiA-5igpA:
47.5		 5igiA-5igpA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IGI_A_ZITA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 5igp MACROLIDE
2'-PHOSPHOTRANSFERAS
E
(Escherichia
coli) 		6 / 6 PRO A 112
HIS A 205
GLU A 222
ALA A 233
LEU A 270
TYR A 277
 ERY  A 402 ( 4.1A)
GDP  A 401 (-4.4A)
ERY  A 402 ( 3.9A)
ERY  A 402 ( 3.9A)
None
ERY  A 402 ( 4.5A)
 0.00A 5igiA-5igpA:
47.5		 5igiA-5igpA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IGJ_A_CTYA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 5igp MACROLIDE
2'-PHOSPHOTRANSFERAS
E
(Escherichia
coli) 		12 / 12 MET A 103
ILE A 105
ASP A 200
TYR A 202
VAL A 203
GLU A 222
ALA A 233
ALA A 234
MET A 237
VAL A 238
GLY A 273
THR A 276
 ERY  A 402 (-2.2A)
ERY  A 402 ( 4.4A)
ERY  A 402 (-2.4A)
ERY  A 402 (-2.7A)
None
ERY  A 402 ( 3.9A)
ERY  A 402 ( 3.9A)
ERY  A 402 ( 3.2A)
ERY  A 402 ( 3.0A)
ERY  A 402 ( 4.7A)
ERY  A 402 ( 3.6A)
ERY  A 402 ( 3.8A)
 0.40A 5igjA-5igpA:
48.1		 5igjA-5igpA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IGJ_A_CTYA402_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 5igp MACROLIDE
2'-PHOSPHOTRANSFERAS
E
(Escherichia
coli) 		5 / 5 PRO A 112
HIS A 205
LEU A 270
TYR A 277
PHE A 280
 ERY  A 402 ( 4.1A)
GDP  A 401 (-4.4A)
None
ERY  A 402 ( 4.5A)
ERY  A 402 ( 3.6A)
 0.18A 5igjA-5igpA:
48.1		 5igjA-5igpA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IGP_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 5igp MACROLIDE
2'-PHOSPHOTRANSFERAS
E
(Escherichia
coli) 		12 / 12 MET A 103
ILE A 105
PRO A 112
VAL A 203
GLU A 222
ALA A 233
ALA A 234
VAL A 238
LEU A 270
GLY A 273
THR A 276
TYR A 277
 ERY  A 402 (-2.2A)
ERY  A 402 ( 4.4A)
ERY  A 402 ( 4.1A)
None
ERY  A 402 ( 3.9A)
ERY  A 402 ( 3.9A)
ERY  A 402 ( 3.2A)
ERY  A 402 ( 4.7A)
None
ERY  A 402 ( 3.6A)
ERY  A 402 ( 3.8A)
ERY  A 402 ( 4.5A)
 0.28A 5igpA-5igpA:
49.3		 5igpA-5igpA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IGP_A_ERYA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 5igp MACROLIDE
2'-PHOSPHOTRANSFERAS
E
(Escherichia
coli) 		4 / 4 ASP A 200
TYR A 202
MET A 237
PHE A 280
 ERY  A 402 (-2.4A)
ERY  A 402 (-2.7A)
ERY  A 402 ( 3.0A)
ERY  A 402 ( 3.6A)
 0.00A 5igpA-5igpA:
49.3		 5igpA-5igpA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IGT_A_ERYA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 5igp MACROLIDE
2'-PHOSPHOTRANSFERAS
E
(Escherichia
coli) 		5 / 5 MET A 103
ASP A 200
TYR A 202
MET A 237
PHE A 280
 ERY  A 402 (-2.2A)
ERY  A 402 (-2.4A)
ERY  A 402 (-2.7A)
ERY  A 402 ( 3.0A)
ERY  A 402 ( 3.6A)
 0.51A 5igtA-5igpA:
48.0		 5igtA-5igpA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_K_6V8K305_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		 5igp MACROLIDE
2'-PHOSPHOTRANSFERAS
E
(Escherichia
coli) 		5 / 11 ALA A 128
ALA A 130
GLY A 256
GLY A 255
ALA A 254
 None
 0.95A 5lf7K-5igpA:
undetectable
5lf7L-5igpA:
undetectable		 5lf7K-5igpA:
19.61
5lf7L-5igpA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_Y_6V8Y306_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-5)		 5igp MACROLIDE
2'-PHOSPHOTRANSFERAS
E
(Escherichia
coli) 		5 / 11 ALA A 128
ALA A 130
GLY A 256
GLY A 255
ALA A 254
 None
 0.96A 5lf7Y-5igpA:
undetectable
5lf7Z-5igpA:
undetectable		 5lf7Y-5igpA:
19.61
5lf7Z-5igpA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B89_A_NOVA403_1
(LIPOPOLYSACCHARIDE
EXPORT SYSTEM
ATP-BINDING PROTEIN
LPTB)		 5igp MACROLIDE
2'-PHOSPHOTRANSFERAS
E
(Escherichia
coli) 		5 / 10 LEU A 290
ALA A 293
GLU A  58
VAL A 166
ARG A 165
 None
 1.03A 6b89A-5igpA:
undetectable		 6b89A-5igpA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		 5igp MACROLIDE
2'-PHOSPHOTRANSFERAS
E
(Escherichia
coli) 		4 / 6 SER A 189
ARG A 269
ALA A 229
ALA A 155
 None
 0.94A 6ma6A-5igpA:
undetectable		 6ma6A-5igpA:
13.45