SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5igq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_B_THAB2_1
(LIVER
CARBOXYLESTERASE I)		 5igq E3 UBIQUITIN-PROTEIN
LIGASE RFWD2
(Homo
sapiens) 		5 / 11 LEU A 664
GLY A 658
VAL A 614
LEU A 622
LEU A 716
 None
 1.16A 1mx1B-5igqA:
undetectable		 1mx1B-5igqA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_B_ACTB1108_0
(C5A PEPTIDASE)		 5igq E3 UBIQUITIN-PROTEIN
LIGASE RFWD2
(Homo
sapiens) 		4 / 6 LEU A 486
GLY A 500
ASN A 465
ILE A 445
 None
 0.75A 1xf1B-5igqA:
undetectable		 1xf1B-5igqA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R2V_C_ACTC36_0
(GCN4 LEUCINE ZIPPER)		 5igq E3 UBIQUITIN-PROTEIN
LIGASE RFWD2
(Homo
sapiens) 		5 / 10 ALA A 556
ASN A 557
ALA A 536
GLU A 553
ALA A 554
 None
 1.35A 2r2vC-5igqA:
undetectable
2r2vF-5igqA:
undetectable
2r2vG-5igqA:
undetectable		 2r2vC-5igqA:
7.46
2r2vF-5igqA:
7.46
2r2vG-5igqA:
7.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_A_C2FA315_0
(UNCHARACTERIZED
PROTEIN)		 5igq E3 UBIQUITIN-PROTEIN
LIGASE RFWD2
(Homo
sapiens) 		5 / 11 THR A 410
ILE A 717
THR A 724
VAL A 453
ILE A 454
 None
 1.40A 3ijdA-5igqA:
undetectable		 3ijdA-5igqA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_A_FLRA700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5igq E3 UBIQUITIN-PROTEIN
LIGASE RFWD2
(Homo
sapiens) 		5 / 12 VAL A 447
LEU A 486
GLY A 440
ALA A 439
SER A 426
 None
 1.07A 3rr3A-5igqA:
undetectable		 3rr3A-5igqA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_B_FLRB700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5igq E3 UBIQUITIN-PROTEIN
LIGASE RFWD2
(Homo
sapiens) 		5 / 12 VAL A 447
LEU A 486
GLY A 440
ALA A 439
SER A 426
 None
 1.06A 3rr3B-5igqA:
undetectable		 3rr3B-5igqA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_C_FLRC700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5igq E3 UBIQUITIN-PROTEIN
LIGASE RFWD2
(Homo
sapiens) 		5 / 12 VAL A 447
LEU A 486
GLY A 440
ALA A 439
SER A 426
 None
 1.06A 3rr3C-5igqA:
undetectable		 3rr3C-5igqA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RR3_D_FLRD700_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5igq E3 UBIQUITIN-PROTEIN
LIGASE RFWD2
(Homo
sapiens) 		5 / 12 VAL A 447
LEU A 486
GLY A 440
ALA A 439
SER A 426
 None
 1.06A 3rr3D-5igqA:
undetectable		 3rr3D-5igqA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_E_CLME221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5igq E3 UBIQUITIN-PROTEIN
LIGASE RFWD2
(Homo
sapiens) 		3 / 3 PHE A 573
CYH A 575
HIS A 581
 None
 1.16A 3u9fF-5igqA:
undetectable		 3u9fF-5igqA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5igq E3 UBIQUITIN-PROTEIN
LIGASE RFWD2
(Homo
sapiens) 		3 / 3 PHE A 573
CYH A 575
HIS A 581
 None
 1.18A 3u9fG-5igqA:
undetectable		 3u9fG-5igqA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_K_CLMK221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5igq E3 UBIQUITIN-PROTEIN
LIGASE RFWD2
(Homo
sapiens) 		3 / 3 PHE A 573
CYH A 575
HIS A 581
 None
 1.14A 3u9fL-5igqA:
undetectable		 3u9fL-5igqA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_R_CLMR221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5igq E3 UBIQUITIN-PROTEIN
LIGASE RFWD2
(Homo
sapiens) 		3 / 3 PHE A 573
CYH A 575
HIS A 581
 None
 1.14A 3u9fS-5igqA:
undetectable		 3u9fS-5igqA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IAQ_A_2GMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 1B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 5igq E3 UBIQUITIN-PROTEIN
LIGASE RFWD2
(Homo
sapiens) 		4 / 6 ILE A 473
VAL A 495
SER A 426
ASP A 535
 None
 1.06A 4iaqA-5igqA:
undetectable		 4iaqA-5igqA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YSH_B_GLYB401_0
(GLYCINE OXIDASE)		 5igq E3 UBIQUITIN-PROTEIN
LIGASE RFWD2
(Homo
sapiens) 		4 / 6 PHE A 595
LYS A 629
GLY A 628
TYR A 582
 None
 1.21A 4yshB-5igqA:
undetectable		 4yshB-5igqA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA303_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5igq E3 UBIQUITIN-PROTEIN
LIGASE RFWD2
(Homo
sapiens) 		3 / 3 GLU A 449
TYR A 450
ARG A 706
 None
 0.64A 5uunA-5igqA:
undetectable		 5uunA-5igqA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_B_ACTB305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 5igq E3 UBIQUITIN-PROTEIN
LIGASE RFWD2
(Homo
sapiens) 		3 / 3 GLU A 449
TYR A 450
ARG A 706
 None
 0.61A 5uunB-5igqA:
undetectable		 5uunB-5igqA:
21.01