SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5igu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 5igu MACROLIDE
2'-PHOSPHOTRANSFERAS
E II
(Escherichia
coli) 		4 / 7 VAL A  98
GLY A  97
THR A 215
ASP A 211
 None
 0.80A 2a1mA-5iguA:
undetectable		 2a1mA-5iguA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V32_A_BEZA1222_0
(PEROXIREDOXIN 6)		 5igu MACROLIDE
2'-PHOSPHOTRANSFERAS
E II
(Escherichia
coli) 		4 / 8 PRO A 274
VAL A 275
SER A 276
ARG A 162
 None
 0.91A 2v32A-5iguA:
undetectable
2v32B-5iguA:
undetectable		 2v32A-5iguA:
20.79
2v32B-5iguA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_E_BEZE1222_0
(PEROXIREDOXIN 6.)		 5igu MACROLIDE
2'-PHOSPHOTRANSFERAS
E II
(Escherichia
coli) 		4 / 7 PRO A 274
VAL A 275
SER A 276
ARG A 162
 None
 0.84A 2v41E-5iguA:
undetectable
2v41F-5iguA:
undetectable		 2v41E-5iguA:
20.79
2v41F-5iguA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YOE_C_FL7C1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 5igu MACROLIDE
2'-PHOSPHOTRANSFERAS
E II
(Escherichia
coli) 		4 / 8 GLY A 243
ASN A 235
ILE A 208
VAL A 130
 None
 0.96A 2yoeB-5iguA:
undetectable
2yoeC-5iguA:
undetectable		 2yoeB-5iguA:
20.70
2yoeC-5iguA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5igu MACROLIDE
2'-PHOSPHOTRANSFERAS
E II
(Escherichia
coli) 		5 / 12 LEU A 269
PHE A 232
HIS A 135
LEU A 131
LEU A 217
 None
 1.46A 3adsA-5iguA:
undetectable		 3adsA-5iguA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W9N_C_CCSC1548_0
(ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE)		 5igu MACROLIDE
2'-PHOSPHOTRANSFERAS
E II
(Escherichia
coli) 		3 / 3 ALA A  91
TRP A  46
VAL A  47
 None
 0.34A 4w9nC-5iguA:
undetectable		 4w9nC-5iguA:
20.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5igu MACROLIDE
2'-PHOSPHOTRANSFERAS
E II
(Escherichia
coli) 		6 / 12 ARG A 237
ALA A 238
SER A 276
ILE A 277
TYR A 289
MET A 292
 None
 0.89A 5igvA-5iguA:
30.9		 5igvA-5iguA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5igu MACROLIDE
2'-PHOSPHOTRANSFERAS
E II
(Escherichia
coli) 		5 / 12 ASP A 200
GLU A 222
ARG A 237
ALA A 238
SER A 276
 None
 0.74A 5igvA-5iguA:
30.9		 5igvA-5iguA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IGW_A_CTYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5igu MACROLIDE
2'-PHOSPHOTRANSFERAS
E II
(Escherichia
coli) 		6 / 12 ARG A 237
SER A 276
ILE A 277
PHE A 280
TYR A 289
MET A 292
 None
 0.94A 5igwA-5iguA:
31.4		 5igwA-5iguA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IGW_A_CTYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5igu MACROLIDE
2'-PHOSPHOTRANSFERAS
E II
(Escherichia
coli) 		5 / 12 HIS A 202
ILE A 277
PHE A 280
TYR A 289
MET A 292
 None
 1.30A 5igwA-5iguA:
31.4		 5igwA-5iguA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IGY_A_ERYA403_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5igu MACROLIDE
2'-PHOSPHOTRANSFERAS
E II
(Escherichia
coli) 		4 / 6 ASP A 200
ILE A 233
ARG A 237
TYR A 273
 None
 0.46A 5igyA-5iguA:
31.0		 5igyA-5iguA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IGZ_A_SPRA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5igu MACROLIDE
2'-PHOSPHOTRANSFERAS
E II
(Escherichia
coli) 		6 / 9 ARG A 237
ILE A 277
GLU A 279
PHE A 280
VAL A 283
GLU A 288
 None
 0.61A 5igzA-5iguA:
34.1		 5igzA-5iguA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IH0_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5igu MACROLIDE
2'-PHOSPHOTRANSFERAS
E II
(Escherichia
coli) 		4 / 6 ARG A  49
PRO A  51
THR A  60
ILE A  90
 None
 0.42A 5ih0A-5iguA:
31.2		 5ih0A-5iguA:
99.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IH0_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5igu MACROLIDE
2'-PHOSPHOTRANSFERAS
E II
(Escherichia
coli) 		5 / 12 ARG A 237
ALA A 238
SER A 276
ILE A 277
PHE A 280
 None
 0.76A 5ih0A-5iguA:
31.2		 5ih0A-5iguA:
99.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IH0_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5igu MACROLIDE
2'-PHOSPHOTRANSFERAS
E II
(Escherichia
coli) 		5 / 12 ARG A 237
SER A 276
ILE A 277
PHE A 280
MET A 292
 None
 0.99A 5ih0A-5iguA:
31.2		 5ih0A-5iguA:
99.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IH0_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5igu MACROLIDE
2'-PHOSPHOTRANSFERAS
E II
(Escherichia
coli) 		5 / 12 GLU A 222
PHE A 234
ARG A 237
ALA A 238
SER A 276
 None
 0.50A 5ih0A-5iguA:
31.2		 5ih0A-5iguA:
99.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IWU_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5igu MACROLIDE
2'-PHOSPHOTRANSFERAS
E II
(Escherichia
coli) 		5 / 6 PHE A  37
VAL A  47
TYR A  92
MET A 207
ILE A 218
 None
 0.60A 5iwuA-5iguA:
31.5		 5iwuA-5iguA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IWU_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5igu MACROLIDE
2'-PHOSPHOTRANSFERAS
E II
(Escherichia
coli) 		5 / 12 HIS A 202
PHE A 234
ALA A 238
ILE A 277
PHE A 280
 None
 1.29A 5iwuA-5iguA:
31.5		 5iwuA-5iguA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IWU_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5igu MACROLIDE
2'-PHOSPHOTRANSFERAS
E II
(Escherichia
coli) 		5 / 12 HIS A 202
THR A 221
GLU A 222
PHE A 234
ALA A 238
 None
 1.08A 5iwuA-5iguA:
31.5		 5iwuA-5iguA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IWU_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5igu MACROLIDE
2'-PHOSPHOTRANSFERAS
E II
(Escherichia
coli) 		5 / 12 PHE A 234
ALA A 238
SER A 276
ILE A 277
PHE A 280
 None
 0.76A 5iwuA-5iguA:
31.5		 5iwuA-5iguA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IWU_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5igu MACROLIDE
2'-PHOSPHOTRANSFERAS
E II
(Escherichia
coli) 		5 / 12 THR A 221
GLU A 222
PHE A 234
ALA A 238
SER A 276
 None
 0.39A 5iwuA-5iguA:
31.5		 5iwuA-5iguA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IWU_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5igu MACROLIDE
2'-PHOSPHOTRANSFERAS
E II
(Escherichia
coli) 		4 / 6 ASP A 200
ILE A 233
ARG A 237
TYR A 273
 None
 0.42A 5iwuA-5iguA:
31.5		 5iwuA-5iguA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IWU_A_ERYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5igu MACROLIDE
2'-PHOSPHOTRANSFERAS
E II
(Escherichia
coli) 		4 / 6 ILE A 233
ARG A 237
TYR A 273
TYR A 289
 None
 0.88A 5iwuA-5iguA:
31.5		 5iwuA-5iguA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMF_A_6U9A1301_1
(ION TRANSPORT
PROTEIN)		 5igu MACROLIDE
2'-PHOSPHOTRANSFERAS
E II
(Escherichia
coli) 		5 / 6 GLY A 243
GLU A 245
PHE A 239
TYR A 236
ILE A 233
 None
 1.40A 5kmfA-5iguA:
undetectable
5kmfC-5iguA:
undetectable		 5kmfA-5iguA:
21.88
5kmfC-5iguA:
21.88