SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ihe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_1
(HIV-1 PROTEASE)		 5ihe DNA POLYMERASE II
SMALL SUBUNIT
(Pyrococcus
abyssi) 		5 / 12 GLY A 500
ALA A 530
GLY A 534
GLY A 535
ILE A 458
 None
None
None
None
ACT  A 705 (-3.9A)
 0.80A 1hxbA-5iheA:
undetectable		 1hxbA-5iheA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ISM_B_NCAB305_0
(BONE MARROW STROMAL
CELL ANTIGEN 1)		 5ihe DNA POLYMERASE II
SMALL SUBUNIT
(Pyrococcus
abyssi) 		4 / 7 HIS A 497
SER A 359
ASP A 360
PHE A 463
 ZN  A 703 ( 3.5A)
None
FE  A 702 ( 3.0A)
None
 1.27A 1ismB-5iheA:
undetectable		 1ismB-5iheA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOM_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 5ihe DNA POLYMERASE II
SMALL SUBUNIT
(Pyrococcus
abyssi) 		5 / 11 ALA A 372
LEU A 377
PHE A 376
ILE A 401
LEU A 399
 None
 1.17A 1jomA-5iheA:
undetectable		 1jomA-5iheA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_1
(GLYCINE
N-METHYLTRANSFERASE)		 5ihe DNA POLYMERASE II
SMALL SUBUNIT
(Pyrococcus
abyssi) 		3 / 3 ARG A 570
ASP A 304
ASN A 332
 None
 0.88A 1nbhA-5iheA:
undetectable		 1nbhA-5iheA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_1
(GLYCINE
N-METHYLTRANSFERASE)		 5ihe DNA POLYMERASE II
SMALL SUBUNIT
(Pyrococcus
abyssi) 		3 / 3 ARG A 570
ASP A 304
ASN A 332
 None
 0.87A 1nbhD-5iheA:
undetectable		 1nbhD-5iheA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE1_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 5ihe DNA POLYMERASE II
SMALL SUBUNIT
(Pyrococcus
abyssi) 		3 / 3 ASP A 404
HIS A 451
HIS A 362
 ZN  A 703 (-2.7A)
D5M  A 701 (-4.1A)
FE  A 702 ( 3.4A)
 0.66A 1oe1A-5iheA:
undetectable		 1oe1A-5iheA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE3_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 5ihe DNA POLYMERASE II
SMALL SUBUNIT
(Pyrococcus
abyssi) 		3 / 3 ASP A 404
HIS A 451
HIS A 362
 ZN  A 703 (-2.7A)
D5M  A 701 (-4.1A)
FE  A 702 ( 3.4A)
 0.64A 1oe3A-5iheA:
undetectable		 1oe3A-5iheA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_2
(ASPARTYLPROTEASE)		 5ihe DNA POLYMERASE II
SMALL SUBUNIT
(Pyrococcus
abyssi) 		5 / 9 LEU A 488
VAL A 199
GLY A 447
ILE A 401
ILE A 486
 None
 1.01A 1ohrB-5iheA:
undetectable		 1ohrB-5iheA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVS_B_MK1B902_1
(POL POLYPROTEIN)		 5ihe DNA POLYMERASE II
SMALL SUBUNIT
(Pyrococcus
abyssi) 		5 / 12 GLY A 500
ALA A 530
GLY A 534
GLY A 535
ILE A 458
 None
None
None
None
ACT  A 705 (-3.9A)
 0.89A 2avsA-5iheA:
undetectable		 2avsA-5iheA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_1
(POL POLYPROTEIN)		 5ihe DNA POLYMERASE II
SMALL SUBUNIT
(Pyrococcus
abyssi) 		5 / 12 GLY A 500
ALA A 530
GLY A 534
GLY A 535
ILE A 458
 None
None
None
None
ACT  A 705 (-3.9A)
 0.83A 2avvA-5iheA:
undetectable		 2avvA-5iheA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_1
(POL POLYPROTEIN)		 5ihe DNA POLYMERASE II
SMALL SUBUNIT
(Pyrococcus
abyssi) 		5 / 12 GLY A 500
ALA A 530
GLY A 534
GLY A 535
ILE A 458
 None
None
None
None
ACT  A 705 (-3.9A)
 0.83A 2avvD-5iheA:
undetectable		 2avvD-5iheA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_A_BEZA352_0
(D-AMINO-ACID OXIDASE)		 5ihe DNA POLYMERASE II
SMALL SUBUNIT
(Pyrococcus
abyssi) 		4 / 6 LEU A 431
TYR A 428
ILE A 471
GLY A 449
 None
 0.89A 2du8A-5iheA:
undetectable		 2du8A-5iheA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDW_B_017B401_1
(PROTEASE)		 5ihe DNA POLYMERASE II
SMALL SUBUNIT
(Pyrococcus
abyssi) 		5 / 11 LEU A 488
VAL A 199
GLY A 447
ILE A 401
ILE A 486
 None
 0.96A 2idwA-5iheA:
undetectable		 2idwA-5iheA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNP_A_ROCA401_2
(PROTEASE)		 5ihe DNA POLYMERASE II
SMALL SUBUNIT
(Pyrococcus
abyssi) 		5 / 11 LEU A 613
ILE A 401
ILE A 442
VAL A 601
VAL A 599
 None
 0.87A 2nnpB-5iheA:
undetectable		 2nnpB-5iheA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_A_CUA1338_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 5ihe DNA POLYMERASE II
SMALL SUBUNIT
(Pyrococcus
abyssi) 		3 / 3 ASP A 404
HIS A 451
HIS A 362
 ZN  A 703 (-2.7A)
D5M  A 701 (-4.1A)
FE  A 702 ( 3.4A)
 0.67A 2xxgA-5iheA:
undetectable		 2xxgA-5iheA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XXG_C_CUC1339_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 5ihe DNA POLYMERASE II
SMALL SUBUNIT
(Pyrococcus
abyssi) 		3 / 3 ASP A 404
HIS A 451
HIS A 362
 ZN  A 703 (-2.7A)
D5M  A 701 (-4.1A)
FE  A 702 ( 3.4A)
 0.69A 2xxgC-5iheA:
undetectable		 2xxgC-5iheA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_3
(HIV-1 PROTEASE)		 5ihe DNA POLYMERASE II
SMALL SUBUNIT
(Pyrococcus
abyssi) 		5 / 12 GLY A 500
ALA A 530
GLY A 534
GLY A 535
ILE A 458
 None
None
None
None
ACT  A 705 (-3.9A)
 0.86A 3cyxB-5iheA:
undetectable		 3cyxB-5iheA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKQ_A_ROCA100_2
(PROTEASE)		 5ihe DNA POLYMERASE II
SMALL SUBUNIT
(Pyrococcus
abyssi) 		5 / 9 LEU A 488
VAL A 199
GLY A 447
ILE A 401
ILE A 486
 None
 1.03A 3ekqB-5iheA:
undetectable		 3ekqB-5iheA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_B_H3PB552_1
(GLUTAMATE
DEHYDROGENASE)		 5ihe DNA POLYMERASE II
SMALL SUBUNIT
(Pyrococcus
abyssi) 		3 / 3 TYR A 412
TYR A 163
ILE A 409
 None
 0.79A 3eteA-5iheA:
undetectable
3eteB-5iheA:
undetectable		 3eteA-5iheA:
22.77
3eteB-5iheA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GY3_A_PNTA246_0
(CATIONIC TRYPSIN)		 5ihe DNA POLYMERASE II
SMALL SUBUNIT
(Pyrococcus
abyssi) 		5 / 11 HIS A 562
GLN A 557
ASP A 452
GLY A 403
GLY A 449
 FE  A 702 ( 3.4A)
None
None
None
None
 1.07A 3gy3A-5iheA:
undetectable		 3gy3A-5iheA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB1_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 5ihe DNA POLYMERASE II
SMALL SUBUNIT
(Pyrococcus
abyssi) 		5 / 12 ILE A 446
GLY A 447
ALA A 454
ILE A 495
ALA A 484
 None
 1.04A 3jb1A-5iheA:
undetectable		 3jb1A-5iheA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_D_CGED501_1
(CYTOCHROME P450 2B4)		 5ihe DNA POLYMERASE II
SMALL SUBUNIT
(Pyrococcus
abyssi) 		5 / 9 PHE A 463
PHE A 445
ALA A 477
THR A 443
VAL A 199
 None
 1.28A 3me6D-5iheA:
undetectable		 3me6D-5iheA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU9_A_478A401_2
(PROTEASE)		 5ihe DNA POLYMERASE II
SMALL SUBUNIT
(Pyrococcus
abyssi) 		5 / 10 ALA A 315
ASP A 314
GLY A 271
ILE A 270
VAL A 311
 None
 1.09A 3nu9B-5iheA:
undetectable		 3nu9B-5iheA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OY4_B_017B200_1
(HIV-1 PROTEASE)		 5ihe DNA POLYMERASE II
SMALL SUBUNIT
(Pyrococcus
abyssi) 		5 / 11 LEU A 488
VAL A 199
GLY A 447
ILE A 401
ILE A 486
 None
 0.96A 3oy4A-5iheA:
undetectable		 3oy4A-5iheA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_A_CP6A602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5ihe DNA POLYMERASE II
SMALL SUBUNIT
(Pyrococcus
abyssi) 		5 / 12 VAL A 599
ALA A 597
PHE A 376
LEU A 435
ILE A 358
 None
 1.20A 3qfxA-5iheA:
undetectable		 3qfxA-5iheA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QFX_B_CP6B702_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 5ihe DNA POLYMERASE II
SMALL SUBUNIT
(Pyrococcus
abyssi) 		5 / 12 VAL A 599
ALA A 597
PHE A 376
LEU A 435
ILE A 358
 None
 1.20A 3qfxB-5iheA:
undetectable		 3qfxB-5iheA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5ihe DNA POLYMERASE II
SMALL SUBUNIT
(Pyrococcus
abyssi) 		4 / 8 SER A 394
GLU A 389
ILE A 392
TRP A 379
 None
 0.98A 4d33A-5iheA:
undetectable		 4d33A-5iheA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5ihe DNA POLYMERASE II
SMALL SUBUNIT
(Pyrococcus
abyssi) 		4 / 8 SER A 394
GLU A 389
ILE A 392
TRP A 379
 None
 1.03A 4d39A-5iheA:
undetectable		 4d39A-5iheA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D9H_A_ADNA301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 5ihe DNA POLYMERASE II
SMALL SUBUNIT
(Pyrococcus
abyssi) 		5 / 11 GLY A 517
VAL A 521
GLU A 522
ASP A 565
VAL A 567
 None
 1.23A 4d9hA-5iheA:
undetectable		 4d9hA-5iheA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DCM_A_SAMA401_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE G)		 5ihe DNA POLYMERASE II
SMALL SUBUNIT
(Pyrococcus
abyssi) 		5 / 11 GLY A 403
GLY A 559
ILE A 495
ASP A 360
ASN A 482
 None
None
None
FE  A 702 ( 3.0A)
ACT  A 705 (-3.1A)
 1.12A 4dcmA-5iheA:
undetectable		 4dcmA-5iheA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQH_B_017B101_1
(WILD-TYPE HIV-1
PROTEASE DIMER)		 5ihe DNA POLYMERASE II
SMALL SUBUNIT
(Pyrococcus
abyssi) 		5 / 11 LEU A 488
VAL A 199
GLY A 447
ILE A 401
ILE A 486
 None
 0.96A 4dqhA-5iheA:
undetectable		 4dqhA-5iheA:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_A_ACTA304_0
(GLUTATHIONE
TRANSFERASE GTE1)		 5ihe DNA POLYMERASE II
SMALL SUBUNIT
(Pyrococcus
abyssi) 		4 / 5 ALA A 496
ILE A 458
LEU A 547
ASN A 482
 ACT  A 705 ( 3.8A)
ACT  A 705 (-3.9A)
None
ACT  A 705 (-3.1A)
 1.20A 4g19A-5iheA:
undetectable		 4g19A-5iheA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K38_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME
KP18CYS PEPTIDE)		 5ihe DNA POLYMERASE II
SMALL SUBUNIT
(Pyrococcus
abyssi) 		5 / 12 GLN A 557
SER A 577
LEU A 357
VAL A 599
LEU A 380
 None
 1.41A 4k38A-5iheA:
undetectable
4k38D-5iheA:
undetectable		 4k38A-5iheA:
21.53
4k38D-5iheA:
2.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K39_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 5ihe DNA POLYMERASE II
SMALL SUBUNIT
(Pyrococcus
abyssi) 		5 / 12 GLN A 557
SER A 577
LEU A 357
VAL A 599
LEU A 380
 None
 1.43A 4k39A-5iheA:
undetectable		 4k39A-5iheA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_A_TPVA500_2
(PROTEASE)		 5ihe DNA POLYMERASE II
SMALL SUBUNIT
(Pyrococcus
abyssi) 		5 / 10 LEU A 488
VAL A 199
GLY A 447
ILE A 401
ILE A 486
 None
 1.08A 4njuB-5iheA:
undetectable		 4njuB-5iheA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJU_C_TPVC500_2
(PROTEASE)		 5ihe DNA POLYMERASE II
SMALL SUBUNIT
(Pyrococcus
abyssi) 		5 / 10 LEU A 488
VAL A 199
GLY A 447
ILE A 401
ILE A 486
 None
 1.06A 4njuD-5iheA:
undetectable		 4njuD-5iheA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_A_ASCA501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 5ihe DNA POLYMERASE II
SMALL SUBUNIT
(Pyrococcus
abyssi) 		5 / 11 THR A 584
HIS A 562
GLN A 587
HIS A 451
ASP A 404
 None
FE  A 702 ( 3.4A)
None
D5M  A 701 (-4.1A)
ZN  A 703 (-2.7A)
 1.25A 4rp8A-5iheA:
0.0		 4rp8A-5iheA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_B_478B101_1
(HIV-1 PROTEASE)		 5ihe DNA POLYMERASE II
SMALL SUBUNIT
(Pyrococcus
abyssi) 		5 / 11 ILE A 458
GLY A 498
ILE A 501
PRO A 531
THR A 532
 ACT  A 705 (-3.9A)
ACT  A 705 (-3.5A)
None
None
None
 0.98A 4rvjA-5iheA:
undetectable		 4rvjA-5iheA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA610_0
(SERUM ALBUMIN)		 5ihe DNA POLYMERASE II
SMALL SUBUNIT
(Pyrococcus
abyssi) 		3 / 3 TYR A 335
LYS A 320
LYS A 333
 None
 1.15A 5dbyA-5iheA:
undetectable		 5dbyA-5iheA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5ihe DNA POLYMERASE II
SMALL SUBUNIT
(Pyrococcus
abyssi) 		4 / 4 LEU A 312
TYR A 569
PRO A 519
ILE A 501
 None
 1.32A 5esgA-5iheA:
undetectable		 5esgA-5iheA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G08_A_Z80A1187_1
(FREQUENIN 2)		 5ihe DNA POLYMERASE II
SMALL SUBUNIT
(Pyrococcus
abyssi) 		4 / 6 ILE A 401
PHE A 445
PHE A 376
TRP A 379
 None
 1.11A 5g08A-5iheA:
undetectable		 5g08A-5iheA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 5ihe DNA POLYMERASE II
SMALL SUBUNIT
(Pyrococcus
abyssi) 		3 / 3 ALA A 430
ASN A 433
LEU A 434
 None
 0.37A 5i1nB-5iheA:
undetectable		 5i1nB-5iheA:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 5ihe DNA POLYMERASE II
SMALL SUBUNIT
(Pyrococcus
abyssi) 		3 / 3 ALA A 430
ASN A 433
LEU A 434
 None
 0.40A 5i1oC-5iheA:
undetectable		 5i1oC-5iheA:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 5ihe DNA POLYMERASE II
SMALL SUBUNIT
(Pyrococcus
abyssi) 		3 / 3 ALA A 430
ASN A 433
LEU A 434
 None
 0.36A 5i1pA-5iheA:
undetectable		 5i1pA-5iheA:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_2
(PROTEASE E35D-SQV)		 5ihe DNA POLYMERASE II
SMALL SUBUNIT
(Pyrococcus
abyssi) 		5 / 9 LEU A 488
VAL A 199
GLY A 447
ILE A 401
ILE A 486
 None
 1.02A 5kqxB-5iheA:
undetectable		 5kqxB-5iheA:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NCD_D_ACTD301_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 5ihe DNA POLYMERASE II
SMALL SUBUNIT
(Pyrococcus
abyssi) 		4 / 4 ASP A 404
HIS A 497
HIS A 560
HIS A 451
 ZN  A 703 (-2.7A)
ZN  A 703 ( 3.5A)
ZN  A 703 ( 3.3A)
D5M  A 701 (-4.1A)
 1.49A 5ncdD-5iheA:
undetectable		 5ncdD-5iheA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NEL_C_ACTC302_0
(PEPTIDOGLYCAN
N-ACETYLGLUCOSAMINE
DEACETYLASE)		 5ihe DNA POLYMERASE II
SMALL SUBUNIT
(Pyrococcus
abyssi) 		4 / 6 ASP A 404
HIS A 362
HIS A 562
HIS A 497
 ZN  A 703 (-2.7A)
FE  A 702 ( 3.4A)
FE  A 702 ( 3.4A)
ZN  A 703 ( 3.5A)
 1.04A 5nelB-5iheA:
undetectable
5nelC-5iheA:
undetectable		 5nelB-5iheA:
19.87
5nelC-5iheA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TRQ_B_ACTB307_0
(WELO5)		 5ihe DNA POLYMERASE II
SMALL SUBUNIT
(Pyrococcus
abyssi) 		3 / 3 GLU A 502
HIS A 513
VAL A 561
 D5M  A 701 (-3.6A)
None
D5M  A 701 (-3.7A)
 0.81A 5trqB-5iheA:
undetectable		 5trqB-5iheA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA503_1
(CYTOCHROME P450 2C9)		 5ihe DNA POLYMERASE II
SMALL SUBUNIT
(Pyrococcus
abyssi) 		5 / 12 ILE A 356
PHE A 376
LEU A 374
PHE A 368
LEU A 399
 None
 1.24A 5xxiA-5iheA:
undetectable		 5xxiA-5iheA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_B_CHDB401_0
(BILE SALT HYDROLASE)		 5ihe DNA POLYMERASE II
SMALL SUBUNIT
(Pyrococcus
abyssi) 		5 / 10 ILE A 182
LEU A 377
LEU A 431
ALA A 432
LEU A 474
 None
 1.14A 5y7pB-5iheA:
undetectable		 5y7pB-5iheA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_D_CHDD401_0
(BILE SALT HYDROLASE)		 5ihe DNA POLYMERASE II
SMALL SUBUNIT
(Pyrococcus
abyssi) 		5 / 10 ILE A 182
LEU A 377
LEU A 431
ALA A 432
LEU A 474
 None
 1.16A 5y7pD-5iheA:
undetectable		 5y7pD-5iheA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_H_CHDH401_0
(BILE SALT HYDROLASE)		 5ihe DNA POLYMERASE II
SMALL SUBUNIT
(Pyrococcus
abyssi) 		5 / 10 ILE A 182
LEU A 377
LEU A 431
ALA A 432
LEU A 474
 None
 1.15A 5y7pH-5iheA:
undetectable		 5y7pH-5iheA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH3_A_017A101_1
(PROTEASE)		 5ihe DNA POLYMERASE II
SMALL SUBUNIT
(Pyrococcus
abyssi) 		5 / 12 LEU A 488
VAL A 199
GLY A 447
ILE A 401
ILE A 486
 None
 0.97A 6dh3B-5iheA:
undetectable		 6dh3B-5iheA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ1_B_AB1B201_0
(HIV-1 PROTEASE)		 5ihe DNA POLYMERASE II
SMALL SUBUNIT
(Pyrococcus
abyssi) 		5 / 12 GLY A 500
ALA A 530
GLY A 534
GLY A 535
ILE A 458
 None
None
None
None
ACT  A 705 (-3.9A)
 0.84A 6dj1A-5iheA:
undetectable		 6dj1A-5iheA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_A_GMJA301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 5ihe DNA POLYMERASE II
SMALL SUBUNIT
(Pyrococcus
abyssi) 		5 / 12 LEU A 435
ILE A 358
VAL A 396
LEU A 374
TYR A 177
 None
 1.06A 6djzA-5iheA:
undetectable		 6djzA-5iheA:
17.81