SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ihw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_1
(AMINOMETHYLTRANSFERA
SE)		 5ihw SERINE-ASPARTATE
REPEAT-CONTAINING
PROTEIN E
(Staphylococcus
aureus) 		3 / 3 ASP A 342
GLU A 449
TYR A 554
 None
 0.85A 1wsvA-5ihwA:
undetectable		 1wsvA-5ihwA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_1
(UNCHARACTERIZED
PROTEIN)		 5ihw SERINE-ASPARTATE
REPEAT-CONTAINING
PROTEIN E
(Staphylococcus
aureus) 		3 / 3 THR A 447
LYS A 364
GLU A 449
 None
 1.00A 3ijdB-5ihwA:
undetectable		 3ijdB-5ihwA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_A_SAMA226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5ihw SERINE-ASPARTATE
REPEAT-CONTAINING
PROTEIN E
(Staphylococcus
aureus) 		6 / 12 GLY A 470
ASN A 532
ALA A 565
GLY A 484
LEU A 481
ILE A 479
 None
 1.32A 3ku1A-5ihwA:
undetectable		 3ku1A-5ihwA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_G_SAMG226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5ihw SERINE-ASPARTATE
REPEAT-CONTAINING
PROTEIN E
(Staphylococcus
aureus) 		5 / 12 ASN A 532
ALA A 565
GLY A 484
LEU A 481
ILE A 479
 None
 1.02A 3ku1G-5ihwA:
undetectable		 3ku1G-5ihwA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_B_GJZB506_1
(CHOLESTEROL
24-HYDROXYLASE)		 5ihw SERINE-ASPARTATE
REPEAT-CONTAINING
PROTEIN E
(Staphylococcus
aureus) 		4 / 6 PHE A 438
ILE A 564
ALA A 565
ALA A 469
 None
 0.87A 3mdrB-5ihwA:
undetectable		 3mdrB-5ihwA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_B_EAAB214_1
(GLUTATHIONE
S-TRANSFERASE P)		 5ihw SERINE-ASPARTATE
REPEAT-CONTAINING
PROTEIN E
(Staphylococcus
aureus) 		4 / 8 VAL A 473
GLY A 567
ILE A 452
GLY A 583
 None
 0.64A 3n9jB-5ihwA:
undetectable		 3n9jB-5ihwA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_B_NCAB1536_0
(DIPHTHERIA TOXIN)		 5ihw SERINE-ASPARTATE
REPEAT-CONTAINING
PROTEIN E
(Staphylococcus
aureus) 		4 / 5 HIS A 304
GLY A 306
TYR A 390
GLU A 310
 None
 1.45A 4ae1B-5ihwA:
4.8		 4ae1B-5ihwA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		 5ihw SERINE-ASPARTATE
REPEAT-CONTAINING
PROTEIN E
(Staphylococcus
aureus) 		5 / 10 ILE A 564
THR A 486
GLY A 470
GLY A 567
SER A 585
 None
 1.14A 4bwlC-5ihwA:
undetectable		 4bwlC-5ihwA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5ihw SERINE-ASPARTATE
REPEAT-CONTAINING
PROTEIN E
(Staphylococcus
aureus) 		4 / 8 ASN A 533
GLY A 470
PHE A 438
ILE A 564
 None
 0.96A 4fglD-5ihwA:
undetectable		 4fglD-5ihwA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA610_0
(SERUM ALBUMIN)		 5ihw SERINE-ASPARTATE
REPEAT-CONTAINING
PROTEIN E
(Staphylococcus
aureus) 		3 / 3 TYR A 497
LYS A 549
LYS A 495
 None
 1.24A 5dbyA-5ihwA:
undetectable		 5dbyA-5ihwA:
18.06