SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ihx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BDW_B_DVAB8_0
(GRAMICIDIN A)		 5ihx TYROSINE--TRNA
LIGASE,
MITOCHONDRIAL
(Aspergillus
nidulans) 		3 / 3 VAL A 153
VAL A 158
TRP A 154
 None
 0.92A 1bdwA-5ihxA:
undetectable
1bdwB-5ihxA:
undetectable		 1bdwA-5ihxA:
4.60
1bdwB-5ihxA:
4.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 5ihx TYROSINE--TRNA
LIGASE,
MITOCHONDRIAL
(Aspergillus
nidulans) 		5 / 11 GLY A 129
HIS A 138
HIS A 141
GLY A 297
ASP A 299
 TYR  A 501 (-3.5A)
None
None
None
None
 0.92A 1jzsA-5ihxA:
undetectable		 1jzsA-5ihxA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 5ihx TYROSINE--TRNA
LIGASE,
MITOCHONDRIAL
(Aspergillus
nidulans) 		6 / 11 GLY A 129
HIS A 141
GLY A 297
ASP A 299
GLN A 300
LEU A 341
 TYR  A 501 (-3.5A)
None
None
None
TYR  A 501 (-2.9A)
None
 0.78A 1jzsA-5ihxA:
undetectable		 1jzsA-5ihxA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PG2_A_ADNA552_1
(METHIONYL-TRNA
SYNTHETASE)		 5ihx TYROSINE--TRNA
LIGASE,
MITOCHONDRIAL
(Aspergillus
nidulans) 		5 / 11 HIS A 138
GLY A 140
HIS A 141
GLY A 297
ASP A 299
 None
 0.58A 1pg2A-5ihxA:
7.5		 1pg2A-5ihxA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 5ihx TYROSINE--TRNA
LIGASE,
MITOCHONDRIAL
(Aspergillus
nidulans) 		5 / 12 GLY A 140
HIS A 141
GLY A 297
ASP A 299
GLN A 300
 None
None
None
None
TYR  A 501 (-2.9A)
 0.75A 1qu2A-5ihxA:
4.3		 1qu2A-5ihxA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9D_J_ACTJ1116_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 5ihx TYROSINE--TRNA
LIGASE,
MITOCHONDRIAL
(Aspergillus
nidulans) 		4 / 8 LYS A 387
GLU A 383
ILE A 397
ILE A 394
 None
 0.98A 2j9dJ-5ihxA:
undetectable
2j9dK-5ihxA:
undetectable
2j9dL-5ihxA:
undetectable		 2j9dJ-5ihxA:
17.01
2j9dK-5ihxA:
17.01
2j9dL-5ihxA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_A_ADNA601_1
(METHIONYL-TRNA
SYNTHETASE)		 5ihx TYROSINE--TRNA
LIGASE,
MITOCHONDRIAL
(Aspergillus
nidulans) 		5 / 11 HIS A 138
GLY A 140
HIS A 141
GLY A 297
ASP A 299
 None
 0.71A 2x1lA-5ihxA:
8.1		 2x1lA-5ihxA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_B_ADNB601_1
(METHIONYL-TRNA
SYNTHETASE)		 5ihx TYROSINE--TRNA
LIGASE,
MITOCHONDRIAL
(Aspergillus
nidulans) 		6 / 12 HIS A 138
GLY A 140
HIS A 141
GLY A 297
ASP A 299
LEU A 342
 None
 0.90A 2x1lB-5ihxA:
8.1		 2x1lB-5ihxA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_C_ADNC601_1
(METHIONYL-TRNA
SYNTHETASE)		 5ihx TYROSINE--TRNA
LIGASE,
MITOCHONDRIAL
(Aspergillus
nidulans) 		5 / 11 HIS A 138
GLY A 140
HIS A 141
GLY A 297
ASP A 299
 None
 0.76A 2x1lC-5ihxA:
8.2		 2x1lC-5ihxA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_B_CTCB1385_0
(TETX2 PROTEIN)		 5ihx TYROSINE--TRNA
LIGASE,
MITOCHONDRIAL
(Aspergillus
nidulans) 		4 / 8 PHE A 306
GLY A 309
PRO A 251
GLY A 254
 None
 0.87A 2y6rB-5ihxA:
undetectable		 2y6rB-5ihxA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SMT_A_ACTA1001_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD3)		 5ihx TYROSINE--TRNA
LIGASE,
MITOCHONDRIAL
(Aspergillus
nidulans) 		4 / 5 LEU A 156
GLY A 151
PHE A  95
PHE A 119
 None
 1.19A 3smtA-5ihxA:
undetectable		 3smtA-5ihxA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1002_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 5ihx TYROSINE--TRNA
LIGASE,
MITOCHONDRIAL
(Aspergillus
nidulans) 		3 / 3 ASN A 227
TRP A 230
ASP A 131
 TYR  A 501 ( 4.6A)
None
TYR  A 501 (-2.9A)
 0.87A 4a7tA-5ihxA:
undetectable
4a7tF-5ihxA:
undetectable		 4a7tA-5ihxA:
17.94
4a7tF-5ihxA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_A_FK5A205_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 5ihx TYROSINE--TRNA
LIGASE,
MITOCHONDRIAL
(Aspergillus
nidulans) 		4 / 4 THR A 318
ARG A 241
GLU A 238
VAL A 319
 None
 1.48A 4odoC-5ihxA:
undetectable		 4odoC-5ihxA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA601_1
(SERUM ALBUMIN)		 5ihx TYROSINE--TRNA
LIGASE,
MITOCHONDRIAL
(Aspergillus
nidulans) 		5 / 12 VAL A 118
PHE A 337
LEU A  99
VAL A 124
LEU A 156
 None
 1.38A 4po0A-5ihxA:
undetectable		 4po0A-5ihxA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1R_A_STRA600_1
(CYTOCHROME P450 3A4)		 5ihx TYROSINE--TRNA
LIGASE,
MITOCHONDRIAL
(Aspergillus
nidulans) 		4 / 5 PHE A 421
PHE A 373
PHE A 374
VAL A 139
 None
 0.86A 5a1rA-5ihxA:
undetectable		 5a1rA-5ihxA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA602_1
(CHITINASE)		 5ihx TYROSINE--TRNA
LIGASE,
MITOCHONDRIAL
(Aspergillus
nidulans) 		3 / 3 TRP A 281
GLU A 238
ASP A 323
 None
 1.05A 5gqbA-5ihxA:
undetectable		 5gqbA-5ihxA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_C_SAMC301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5ihx TYROSINE--TRNA
LIGASE,
MITOCHONDRIAL
(Aspergillus
nidulans) 		5 / 12 ALA A 310
PRO A 276
THR A 173
PHE A 306
GLY A 302
 None
 1.29A 5hfjC-5ihxA:
undetectable		 5hfjC-5ihxA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_B_SAMB301_0
(PANTOTHENATE
SYNTHETASE)		 5ihx TYROSINE--TRNA
LIGASE,
MITOCHONDRIAL
(Aspergillus
nidulans) 		5 / 12 HIS A 138
GLY A 140
HIS A 141
GLY A 297
ASP A 299
 None
 1.06A 5hg0B-5ihxA:
7.8		 5hg0B-5ihxA:
22.19