SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5iic'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E06_A_IPBA600_0
(ODORANT-BINDING
PROTEIN)		 5iic MALTOSE-BINDING
PERIPLASMIC
PROTEIN,VITELLINE
ENVELOPE SPERM LYSIN
RECEPTOR
(Escherichia
coli;
Haliotis
rufescens) 		4 / 6 VAL A3977
VAL A4019
ILE A4029
ASN A4236
 None
 0.91A 1e06A-5iicA:
undetectable		 1e06A-5iicA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MAA_B_DMEB996_1
(ACETYLCHOLINESTERASE)		 5iic MALTOSE-BINDING
PERIPLASMIC
PROTEIN,VITELLINE
ENVELOPE SPERM LYSIN
RECEPTOR
(Escherichia
coli;
Haliotis
rufescens) 		4 / 6 GLU A4183
ILE A3980
TYR A3986
GLY A3988
 None
 1.14A 1maaB-5iicA:
undetectable
1maaD-5iicA:
undetectable		 1maaB-5iicA:
20.04
1maaD-5iicA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_2
(ISOLEUCYL-TRNA
SYNTHETASE)		 5iic MALTOSE-BINDING
PERIPLASMIC
PROTEIN,VITELLINE
ENVELOPE SPERM LYSIN
RECEPTOR
(Escherichia
coli;
Haliotis
rufescens) 		3 / 3 GLU A4080
TRP A4199
LYS A4242
 MAL  A4501 (-2.7A)
MAL  A4501 ( 3.7A)
None
 1.34A 1qu2A-5iicA:
undetectable		 1qu2A-5iicA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RV7_B_AB1B1001_1
(PROTEASE)		 5iic MALTOSE-BINDING
PERIPLASMIC
PROTEIN,VITELLINE
ENVELOPE SPERM LYSIN
RECEPTOR
(Escherichia
coli;
Haliotis
rufescens) 		5 / 11 ALA A4338
VAL A4150
LEU A4429
THR A4426
ALA A4427
 None
 1.01A 1rv7A-5iicA:
undetectable
1rv7B-5iicA:
undetectable		 1rv7A-5iicA:
11.29
1rv7B-5iicA:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2888_0
(AMINOMETHYLTRANSFERA
SE)		 5iic MALTOSE-BINDING
PERIPLASMIC
PROTEIN,VITELLINE
ENVELOPE SPERM LYSIN
RECEPTOR
(Escherichia
coli;
Haliotis
rufescens) 		5 / 10 LEU A4161
LEU A4164
ILE A4130
GLU A4122
LEU A4120
 None
None
None
MAL  A4501 (-3.8A)
None
 1.21A 1wopA-5iicA:
undetectable		 1wopA-5iicA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q83_B_ADNB2_1
(YTAA PROTEIN)		 5iic MALTOSE-BINDING
PERIPLASMIC
PROTEIN,VITELLINE
ENVELOPE SPERM LYSIN
RECEPTOR
(Escherichia
coli;
Haliotis
rufescens) 		4 / 6 ILE A4077
PRO A4026
LEU A4012
ILE A4029
 None
 0.98A 2q83B-5iicA:
undetectable		 2q83B-5iicA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_A_SALA1303_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5iic MALTOSE-BINDING
PERIPLASMIC
PROTEIN,VITELLINE
ENVELOPE SPERM LYSIN
RECEPTOR
(Escherichia
coli;
Haliotis
rufescens) 		4 / 7 PRO A4380
ILE A4372
PRO A4403
GLY A4404
 None
 0.99A 2y7kA-5iicA:
7.6		 2y7kA-5iicA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_A_PM6A301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 5iic MALTOSE-BINDING
PERIPLASMIC
PROTEIN,VITELLINE
ENVELOPE SPERM LYSIN
RECEPTOR
(Escherichia
coli;
Haliotis
rufescens) 		4 / 6 PHE A4227
ALA A4131
LEU A4216
PRO A4128
 None
 0.91A 3bgdA-5iicA:
undetectable		 3bgdA-5iicA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_1
(PHOSPHOLIPASE A2)		 5iic MALTOSE-BINDING
PERIPLASMIC
PROTEIN,VITELLINE
ENVELOPE SPERM LYSIN
RECEPTOR
(Escherichia
coli;
Haliotis
rufescens) 		4 / 7 VAL A4079
GLY A4269
PRO A4198
LYS A4274
 None
 0.75A 3bjwC-5iicA:
undetectable		 3bjwC-5iicA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_1
(PHOSPHOLIPASE A2)		 5iic MALTOSE-BINDING
PERIPLASMIC
PROTEIN,VITELLINE
ENVELOPE SPERM LYSIN
RECEPTOR
(Escherichia
coli;
Haliotis
rufescens) 		4 / 8 VAL A4079
GLY A4269
PRO A4198
LYS A4274
 None
 0.70A 3bjwA-5iicA:
undetectable		 3bjwA-5iicA:
14.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_1
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 5iic MALTOSE-BINDING
PERIPLASMIC
PROTEIN,VITELLINE
ENVELOPE SPERM LYSIN
RECEPTOR
(Escherichia
coli;
Haliotis
rufescens) 		10 / 12 ASP A3983
LYS A3984
LYS A4011
GLU A4013
GLU A4014
ALA A4032
ASP A4034
ARG A4035
GLU A4080
TRP A4199
 MAL  A4501 (-3.0A)
MAL  A4501 (-2.7A)
None
None
None
MAL  A4501 (-3.3A)
MAL  A4501 (-2.3A)
MAL  A4501 (-3.7A)
MAL  A4501 (-2.7A)
MAL  A4501 ( 3.7A)
 0.98A 3jyrA-5iicA:
56.3		 3jyrA-5iicA:
72.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_1
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 5iic MALTOSE-BINDING
PERIPLASMIC
PROTEIN,VITELLINE
ENVELOPE SPERM LYSIN
RECEPTOR
(Escherichia
coli;
Haliotis
rufescens) 		10 / 12 ASP A3983
LYS A3984
LYS A4011
GLU A4013
GLU A4014
ALA A4032
ASP A4034
GLU A4080
PRO A4123
TRP A4199
 MAL  A4501 (-3.0A)
MAL  A4501 (-2.7A)
None
None
None
MAL  A4501 (-3.3A)
MAL  A4501 (-2.3A)
MAL  A4501 (-2.7A)
MAL  A4501 (-2.8A)
MAL  A4501 ( 3.7A)
 0.76A 3jyrA-5iicA:
56.3		 3jyrA-5iicA:
72.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3JYR_A_ACRA371_2
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 5iic MALTOSE-BINDING
PERIPLASMIC
PROTEIN,VITELLINE
ENVELOPE SPERM LYSIN
RECEPTOR
(Escherichia
coli;
Haliotis
rufescens) 		6 / 7 ASN A3981
TRP A4031
GLU A4122
TYR A4124
MET A4299
TRP A4309
 MAL  A4501 (-4.0A)
MAL  A4501 (-3.8A)
MAL  A4501 (-3.8A)
MAL  A4501 (-3.0A)
MAL  A4501 ( 3.4A)
MAL  A4501 ( 3.0A)
 0.35A 3jyrA-5iicA:
56.3		 3jyrA-5iicA:
72.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 5iic MALTOSE-BINDING
PERIPLASMIC
PROTEIN,VITELLINE
ENVELOPE SPERM LYSIN
RECEPTOR
(Escherichia
coli;
Haliotis
rufescens) 		5 / 11 GLN A4018
ALA A4238
GLY A4023
THR A4022
ALA A4021
 None
 1.15A 3mg0H-5iicA:
undetectable
3mg0I-5iicA:
undetectable		 3mg0H-5iicA:
21.34
3mg0I-5iicA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_B_RTZB1_1
(CYTOCHROME P450 2D6)		 5iic MALTOSE-BINDING
PERIPLASMIC
PROTEIN,VITELLINE
ENVELOPE SPERM LYSIN
RECEPTOR
(Escherichia
coli;
Haliotis
rufescens) 		5 / 12 PHE A4125
GLY A4269
LEU A4268
GLU A4080
ALA A4200
 MAL  A4501 ( 4.7A)
None
None
MAL  A4501 (-2.7A)
None
 0.81A 3tbgB-5iicA:
undetectable		 3tbgB-5iicA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD1_1
(CYTOCHROME P450 2D6)		 5iic MALTOSE-BINDING
PERIPLASMIC
PROTEIN,VITELLINE
ENVELOPE SPERM LYSIN
RECEPTOR
(Escherichia
coli;
Haliotis
rufescens) 		5 / 12 PHE A4125
GLY A4269
LEU A4268
GLU A4080
ALA A4200
 MAL  A4501 ( 4.7A)
None
None
MAL  A4501 (-2.7A)
None
 0.79A 3tbgD-5iicA:
undetectable		 3tbgD-5iicA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_D_SAMD401_1
(MNMC2)		 5iic MALTOSE-BINDING
PERIPLASMIC
PROTEIN,VITELLINE
ENVELOPE SPERM LYSIN
RECEPTOR
(Escherichia
coli;
Haliotis
rufescens) 		4 / 5 GLU A4277
ASP A4283
ASP A4256
ASN A4263
 None
 1.37A 3vywD-5iicA:
undetectable		 3vywD-5iicA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_G_TMQG202_1
(DIHYDROFOLATE
REDUCTASE)		 5iic MALTOSE-BINDING
PERIPLASMIC
PROTEIN,VITELLINE
ENVELOPE SPERM LYSIN
RECEPTOR
(Escherichia
coli;
Haliotis
rufescens) 		5 / 12 ILE A4235
ALA A4074
LEU A3989
VAL A3992
ILE A4028
 None
 1.10A 4m2xG-5iicA:
undetectable		 4m2xG-5iicA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 5iic MALTOSE-BINDING
PERIPLASMIC
PROTEIN,VITELLINE
ENVELOPE SPERM LYSIN
RECEPTOR
(Escherichia
coli;
Haliotis
rufescens) 		4 / 5 ASN A4236
ALA A4020
GLY A4025
ASP A3983
 None
None
None
MAL  A4501 (-3.0A)
 1.01A 4n48A-5iicA:
undetectable		 4n48A-5iicA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IL1_A_SAMA601_0
(METTL3)		 5iic MALTOSE-BINDING
PERIPLASMIC
PROTEIN,VITELLINE
ENVELOPE SPERM LYSIN
RECEPTOR
(Escherichia
coli;
Haliotis
rufescens) 		5 / 12 ILE A4317
ARG A4323
LEU A4422
LYS A4011
GLU A4122
 None
None
None
None
MAL  A4501 (-3.8A)
 1.37A 5il1A-5iicA:
undetectable		 5il1A-5iicA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 5iic MALTOSE-BINDING
PERIPLASMIC
PROTEIN,VITELLINE
ENVELOPE SPERM LYSIN
RECEPTOR
(Escherichia
coli;
Haliotis
rufescens) 		5 / 12 ILE A4317
ARG A4323
LEU A4422
LYS A4011
GLU A4122
 None
None
None
None
MAL  A4501 (-3.8A)
 1.35A 5k7uA-5iicA:
undetectable		 5k7uA-5iicA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5iic MALTOSE-BINDING
PERIPLASMIC
PROTEIN,VITELLINE
ENVELOPE SPERM LYSIN
RECEPTOR
(Escherichia
coli;
Haliotis
rufescens) 		5 / 12 GLN A4018
ALA A4238
GLY A4023
THR A4022
ALA A4021
 None
 1.17A 5l66H-5iicA:
undetectable
5l66I-5iicA:
undetectable		 5l66H-5iicA:
21.04
5l66I-5iicA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 5iic MALTOSE-BINDING
PERIPLASMIC
PROTEIN,VITELLINE
ENVELOPE SPERM LYSIN
RECEPTOR
(Escherichia
coli;
Haliotis
rufescens) 		5 / 12 GLN A4018
ALA A4238
GLY A4023
THR A4022
ALA A4021
 None
 1.17A 5l66V-5iicA:
undetectable
5l66W-5iicA:
undetectable		 5l66V-5iicA:
21.04
5l66W-5iicA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_B_TESB502_1
(-)		 5iic MALTOSE-BINDING
PERIPLASMIC
PROTEIN,VITELLINE
ENVELOPE SPERM LYSIN
RECEPTOR
(Escherichia
coli;
Haliotis
rufescens) 		5 / 12 LEU A4439
VAL A4425
ILE A4381
MET A4390
LEU A4378
 None
 1.07A 5og9B-5iicA:
undetectable		 5og9B-5iicA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIW_D_LOCD503_2
(TUBULIN BETA CHAIN)		 5iic MALTOSE-BINDING
PERIPLASMIC
PROTEIN,VITELLINE
ENVELOPE SPERM LYSIN
RECEPTOR
(Escherichia
coli;
Haliotis
rufescens) 		5 / 12 LEU A4108
LEU A4091
THR A4214
ILE A4101
LYS A4096
 None
 1.26A 5xiwD-5iicA:
undetectable		 5xiwD-5iicA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YBB_B_SAMB601_0
(TYPE I
RESTRICTION-MODIFICA
TION SYSTEM
METHYLTRANSFERASE
SUBUNIT)		 5iic MALTOSE-BINDING
PERIPLASMIC
PROTEIN,VITELLINE
ENVELOPE SPERM LYSIN
RECEPTOR
(Escherichia
coli;
Haliotis
rufescens) 		5 / 12 THR A4194
PRO A4226
LEU A4231
ASN A4196
PRO A4198
 None
 1.50A 5ybbB-5iicA:
undetectable		 5ybbB-5iicA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_B_9SCB601_1
(SERUM ALBUMIN)		 5iic MALTOSE-BINDING
PERIPLASMIC
PROTEIN,VITELLINE
ENVELOPE SPERM LYSIN
RECEPTOR
(Escherichia
coli;
Haliotis
rufescens) 		4 / 6 ASN A4318
TYR A4310
LEU A4422
SER A4440
 None
 1.41A 6a7pB-5iicA:
1.3		 6a7pB-5iicA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA603_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 5iic MALTOSE-BINDING
PERIPLASMIC
PROTEIN,VITELLINE
ENVELOPE SPERM LYSIN
RECEPTOR
(Escherichia
coli;
Haliotis
rufescens) 		3 / 3 TYR A4124
ASN A4196
LEU A4082
 MAL  A4501 (-3.0A)
None
None
 0.82A 6b58A-5iicA:
undetectable		 6b58A-5iicA:
21.38