SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5iig'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1873_0
(FPRA)		 5iig VACUOLAR TRANSPORTER
CHAPERONE 4
(Saccharomyces
cerevisiae) 		3 / 3 ASP A  89
ASP A 377
LYS A 428
 None
 1.10A 1lqtB-5iigA:
undetectable		 1lqtB-5iigA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1430_0
(FPRA)		 5iig VACUOLAR TRANSPORTER
CHAPERONE 4
(Saccharomyces
cerevisiae) 		3 / 3 ASP A  89
ASP A 377
LYS A 428
 None
 1.07A 1lquB-5iigA:
undetectable		 1lquB-5iigA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q13_A_TESA501_1
(PROSTAGLANDIN-E2
9-REDUCTASE)		 5iig VACUOLAR TRANSPORTER
CHAPERONE 4
(Saccharomyces
cerevisiae) 		4 / 6 HIS A 461
GLU A 451
PRO A 452
VAL A 424
 None
 1.29A 1q13A-5iigA:
undetectable		 1q13A-5iigA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 5iig VACUOLAR TRANSPORTER
CHAPERONE 4
(Saccharomyces
cerevisiae) 		4 / 6 ASP A 389
ASP A 469
ASN A 468
GLU A 385
 None
 1.21A 1rjdA-5iigA:
undetectable		 1rjdA-5iigA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 5iig VACUOLAR TRANSPORTER
CHAPERONE 4
(Saccharomyces
cerevisiae) 		4 / 6 ASP A 389
ASP A 469
ASN A 468
GLU A 385
 None
 1.21A 1rjdB-5iigA:
undetectable		 1rjdB-5iigA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 5iig VACUOLAR TRANSPORTER
CHAPERONE 4
(Saccharomyces
cerevisiae) 		4 / 6 ASP A 389
ASP A 469
ASN A 468
GLU A 385
 None
 1.20A 1rjdC-5iigA:
undetectable		 1rjdC-5iigA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V54_J_CHDJ3060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE I
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 5iig VACUOLAR TRANSPORTER
CHAPERONE 4
(Saccharomyces
cerevisiae) 		4 / 6 ARG A 356
MET A 382
THR A 381
LEU A 380
 None
 0.94A 1v54A-5iigA:
2.0
1v54J-5iigA:
undetectable		 1v54A-5iigA:
20.84
1v54J-5iigA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYR_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5iig VACUOLAR TRANSPORTER
CHAPERONE 4
(Saccharomyces
cerevisiae) 		4 / 6 ARG A 356
MET A 382
THR A 381
LEU A 380
 None
 0.94A 2dyrA-5iigA:
undetectable
2dyrJ-5iigA:
undetectable		 2dyrA-5iigA:
20.84
2dyrJ-5iigA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_J_CHDJ101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5iig VACUOLAR TRANSPORTER
CHAPERONE 4
(Saccharomyces
cerevisiae) 		4 / 6 ARG A 356
MET A 382
THR A 381
LEU A 380
 None
 0.97A 2dysA-5iigA:
undetectable
2dysJ-5iigA:
undetectable		 2dysA-5iigA:
20.84
2dysJ-5iigA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_W_CHDW101_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5iig VACUOLAR TRANSPORTER
CHAPERONE 4
(Saccharomyces
cerevisiae) 		4 / 6 ARG A 356
MET A 382
THR A 381
LEU A 380
 None
 0.86A 2dysN-5iigA:
3.4
2dysW-5iigA:
undetectable		 2dysN-5iigA:
20.84
2dysW-5iigA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5iig VACUOLAR TRANSPORTER
CHAPERONE 4
(Saccharomyces
cerevisiae) 		4 / 6 ARG A 356
MET A 382
THR A 381
LEU A 380
 None
 0.93A 2eijA-5iigA:
3.5
2eijJ-5iigA:
undetectable		 2eijA-5iigA:
20.84
2eijJ-5iigA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5iig VACUOLAR TRANSPORTER
CHAPERONE 4
(Saccharomyces
cerevisiae) 		4 / 6 ARG A 356
MET A 382
THR A 381
LEU A 380
 None
 0.92A 2eilA-5iigA:
2.8
2eilJ-5iigA:
undetectable		 2eilA-5iigA:
20.84
2eilJ-5iigA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 5iig VACUOLAR TRANSPORTER
CHAPERONE 4
(Saccharomyces
cerevisiae) 		4 / 5 ARG A 356
MET A 382
THR A 381
LEU A 380
 None
 0.88A 2eimJ-5iigA:
undetectable		 2eimJ-5iigA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 5iig VACUOLAR TRANSPORTER
CHAPERONE 4
(Saccharomyces
cerevisiae) 		4 / 5 ARG A 356
MET A 382
THR A 381
LEU A 380
 None
 0.84A 2eimW-5iigA:
undetectable		 2eimW-5iigA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5iig VACUOLAR TRANSPORTER
CHAPERONE 4
(Saccharomyces
cerevisiae) 		4 / 6 ARG A 356
MET A 382
THR A 381
LEU A 380
 None
 0.86A 2einN-5iigA:
undetectable
2einW-5iigA:
undetectable		 2einN-5iigA:
20.84
2einW-5iigA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA502_1
(CYTOCHROME P450 2C8)		 5iig VACUOLAR TRANSPORTER
CHAPERONE 4
(Saccharomyces
cerevisiae) 		5 / 12 SER A 375
ILE A 374
VAL A 441
VAL A 450
ILE A 208
 None
 0.96A 2nnhA-5iigA:
2.1		 2nnhA-5iigA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA426_0
(FERROCHELATASE)		 5iig VACUOLAR TRANSPORTER
CHAPERONE 4
(Saccharomyces
cerevisiae) 		4 / 4 LEU A 219
PRO A 220
LEU A 366
ARG A 371
 None
 1.47A 2qd2A-5iigA:
undetectable		 2qd2A-5iigA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 5iig VACUOLAR TRANSPORTER
CHAPERONE 4
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 390
ASP A 392
ASP A 469
LEU A 467
ASN A 468
 None
 1.17A 2zw9B-5iigA:
undetectable		 2zw9B-5iigA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5iig VACUOLAR TRANSPORTER
CHAPERONE 4
(Saccharomyces
cerevisiae) 		4 / 6 ARG A 356
MET A 382
THR A 381
LEU A 380
 None
 0.96A 2zxwA-5iigA:
2.2
2zxwJ-5iigA:
undetectable		 2zxwA-5iigA:
20.84
2zxwJ-5iigA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 5iig VACUOLAR TRANSPORTER
CHAPERONE 4
(Saccharomyces
cerevisiae) 		4 / 5 ARG A 356
MET A 382
THR A 381
LEU A 380
 None
 0.98A 3ag1J-5iigA:
undetectable		 3ag1J-5iigA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG1_W_CHDW1059_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 1)		 5iig VACUOLAR TRANSPORTER
CHAPERONE 4
(Saccharomyces
cerevisiae) 		4 / 6 ARG A 356
MET A 382
THR A 381
LEU A 380
 None
 0.96A 3ag1N-5iigA:
2.9
3ag1W-5iigA:
undetectable		 3ag1N-5iigA:
20.84
3ag1W-5iigA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 5iig VACUOLAR TRANSPORTER
CHAPERONE 4
(Saccharomyces
cerevisiae) 		4 / 5 ARG A 356
MET A 382
THR A 381
LEU A 380
 None
 0.93A 3ag2J-5iigA:
undetectable		 3ag2J-5iigA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_J_CHDJ60_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1)		 5iig VACUOLAR TRANSPORTER
CHAPERONE 4
(Saccharomyces
cerevisiae) 		4 / 5 ARG A 356
MET A 382
THR A 381
LEU A 380
 None
 0.97A 3ag4J-5iigA:
undetectable		 3ag4J-5iigA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 5iig VACUOLAR TRANSPORTER
CHAPERONE 4
(Saccharomyces
cerevisiae) 		4 / 6 ARG A 356
MET A 382
THR A 381
LEU A 380
 None
 0.96A 3asnA-5iigA:
3.5
3asnJ-5iigA:
undetectable		 3asnA-5iigA:
20.84
3asnJ-5iigA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_J_CHDJ60_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 5iig VACUOLAR TRANSPORTER
CHAPERONE 4
(Saccharomyces
cerevisiae) 		4 / 6 ARG A 356
MET A 382
THR A 381
LEU A 380
 None
 0.95A 3asoA-5iigA:
2.3
3asoJ-5iigA:
undetectable		 3asoA-5iigA:
20.84
3asoJ-5iigA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3Q_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 5iig VACUOLAR TRANSPORTER
CHAPERONE 4
(Saccharomyces
cerevisiae) 		4 / 7 LEU A 425
LYS A 428
VAL A 372
LEU A 444
 None
 1.12A 4b3qA-5iigA:
3.2		 4b3qA-5iigA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5iig VACUOLAR TRANSPORTER
CHAPERONE 4
(Saccharomyces
cerevisiae) 		4 / 7 ARG A 356
MET A 382
THR A 381
LEU A 380
 None
 0.91A 5b1bN-5iigA:
3.0
5b1bW-5iigA:
undetectable		 5b1bN-5iigA:
20.84
5b1bW-5iigA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5iig VACUOLAR TRANSPORTER
CHAPERONE 4
(Saccharomyces
cerevisiae) 		4 / 7 ARG A 356
MET A 382
THR A 381
LEU A 380
 None
 0.85A 5b3sN-5iigA:
2.3
5b3sW-5iigA:
undetectable		 5b3sN-5iigA:
20.84
5b3sW-5iigA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5iig VACUOLAR TRANSPORTER
CHAPERONE 4
(Saccharomyces
cerevisiae) 		4 / 7 ARG A 356
MET A 382
THR A 381
LEU A 380
 None
 0.94A 5iy5N-5iigA:
3.5
5iy5W-5iigA:
undetectable		 5iy5N-5iigA:
20.84
5iy5W-5iigA:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS5_A_ASCA202_0
(CYTOCHROME C')		 5iig VACUOLAR TRANSPORTER
CHAPERONE 4
(Saccharomyces
cerevisiae) 		3 / 3 CYH A  63
LYS A  64
HIS A  67
 None
 0.72A 5js5A-5iigA:
undetectable		 5js5A-5iigA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWU_A_ACAA18_1
(WTFP-TAG,GP41)		 5iig VACUOLAR TRANSPORTER
CHAPERONE 4
(Saccharomyces
cerevisiae) 		5 / 12 ASN A 330
GLU A 331
GLU A 333
LEU A 335
GLU A 336
 None
 1.24A 5nwuA-5iigA:
undetectable		 5nwuA-5iigA:
5.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_J_CHDJ101_1
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5iig VACUOLAR TRANSPORTER
CHAPERONE 4
(Saccharomyces
cerevisiae) 		4 / 5 ARG A 356
MET A 382
THR A 381
LEU A 380
 None
 0.87A 5w97J-5iigA:
undetectable		 5w97J-5iigA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_J_CHDJ101_1
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5iig VACUOLAR TRANSPORTER
CHAPERONE 4
(Saccharomyces
cerevisiae) 		4 / 5 ARG A 356
MET A 382
THR A 381
LEU A 380
 None
 0.94A 5wauJ-5iigA:
undetectable		 5wauJ-5iigA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5iig VACUOLAR TRANSPORTER
CHAPERONE 4
(Saccharomyces
cerevisiae) 		4 / 5 ARG A 356
MET A 382
THR A 381
LEU A 380
 None
 1.12A 5x19J-5iigA:
undetectable		 5x19J-5iigA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5iig VACUOLAR TRANSPORTER
CHAPERONE 4
(Saccharomyces
cerevisiae) 		4 / 5 ARG A 356
MET A 382
THR A 381
LEU A 380
 None
 0.98A 5x1fW-5iigA:
undetectable		 5x1fW-5iigA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5iig VACUOLAR TRANSPORTER
CHAPERONE 4
(Saccharomyces
cerevisiae) 		4 / 5 ARG A 356
MET A 382
THR A 381
LEU A 380
 None
 0.96A 5z86J-5iigA:
undetectable		 5z86J-5iigA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKZ_A_SNPA414_0
(AROMATIC
PEROXYGENASE)		 5iig VACUOLAR TRANSPORTER
CHAPERONE 4
(Saccharomyces
cerevisiae) 		4 / 5 PHE A 459
VAL A 278
PRO A 353
VAL A 355
 None
 1.42A 6ekzA-5iigA:
undetectable		 6ekzA-5iigA:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW102_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5iig VACUOLAR TRANSPORTER
CHAPERONE 4
(Saccharomyces
cerevisiae) 		4 / 5 ARG A 356
MET A 382
THR A 381
LEU A 380
 None
 0.91A 6nknW-5iigA:
undetectable		 6nknW-5iigA:
9.17