SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5iip'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3IA4_C_MTXC164_2 (DIHYDROFOLATE REDUCTASE)	5iip	GLYCINE BETAINE/CARNITINE/CH OLINE ABC TRANSPORTER%2C ATP-BINDING PROTEIN%2C PUTATIVE (Staphylococcus aureus)	4 / 4	ILE A 261 ARG A 278 ILE A 282 THR A 266	None	1.12A	3ia4C-5iipA: undetectable	3ia4C-5iipA: 20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OEZ_A_STIA601_2 (PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC)	5iip	GLYCINE BETAINE/CARNITINE/CH OLINE ABC TRANSPORTER%2C ATP-BINDING PROTEIN%2C PUTATIVE (Staphylococcus aureus)	4 / 5	VAL A 344 ILE A 256 MET A 274 ARG A 350	None	1.32A	3oezA-5iipA: undetectable	3oezA-5iipA: 23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3PYY_B_STIB4_2 (V-ABL ABELSON MURINE LEUKEMIA VIRAL ONCOGENE HOMOLOG 1 ISOFORM B VARIANT)	5iip	GLYCINE BETAINE/CARNITINE/CH OLINE ABC TRANSPORTER%2C ATP-BINDING PROTEIN%2C PUTATIVE (Staphylococcus aureus)	4 / 5	VAL A 344 ILE A 256 MET A 274 ARG A 350	None	1.43A	3pyyB-5iipA: undetectable	3pyyB-5iipA: 22.15

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3IA4_C_MTXC164_2","DIHYDROFOLATE REDUCTASE","5iip","GLYCINE BETAINE\/CARNITINE\/CHOLINE ABC TRANSPORTER%2C ATP-BINDING PROTEIN%2C PUTATIVE","Staphylococcus aureus",4,"ILE A 261;ARG A 278;ILE A 282;THR A 266","None","1.12A","3ia4C-5iipA:undetectable","3ia4C-5iipA:20.67"],["3OEZ_A_STIA601_2","PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC","5iip","GLYCINE BETAINE\/CARNITINE\/CHOLINE ABC TRANSPORTER%2C ATP-BINDING PROTEIN%2C PUTATIVE","Staphylococcus aureus",4,"VAL A 344;ILE A 256;MET A 274;ARG A 350","None","1.32A","3oezA-5iipA:undetectable","3oezA-5iipA:23.18"],["3PYY_B_STIB4_2","V-ABL ABELSON MURINE LEUKEMIA VIRAL ONCOGENE HOMOLOG 1 ISOFORM B VARIANT","5iip","GLYCINE BETAINE\/CARNITINE\/CHOLINE ABC TRANSPORTER%2C ATP-BINDING PROTEIN%2C PUTATIVE","Staphylococcus aureus",4,"VAL A 344;ILE A 256;MET A 274;ARG A 350","None","1.43A","3pyyB-5iipA:undetectable","3pyyB-5iipA:22.15"]]