SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ij6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S19_A_MC9A500_0
(VITAMIN D3 RECEPTOR)		 5ij6 LIPOATE--PROTEIN
LIGASE
(Enterococcus
faecalis) 		5 / 12 LEU A 271
ILE A 283
TYR A 305
VAL A 303
LEU A 314
 None
 1.16A 1s19A-5ij6A:
undetectable		 1s19A-5ij6A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BFP_A_H4BA1290_1
(PTERIDINE REDUCTASE
1)		 5ij6 LIPOATE--PROTEIN
LIGASE
(Enterococcus
faecalis) 		4 / 8 PHE A 323
TYR A 287
LEU A 281
LEU A 300
 None
 1.03A 2bfpA-5ij6A:
undetectable		 2bfpA-5ij6A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DG9_A_RAPA501_1
(FK506-BINDING
PROTEIN 1A)		 5ij6 LIPOATE--PROTEIN
LIGASE
(Enterococcus
faecalis) 		5 / 11 PHE A 317
GLU A 295
ILE A 283
ILE A 278
PHE A 331
 None
 1.05A 2dg9A-5ij6A:
undetectable		 2dg9A-5ij6A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIM_W_CHDW1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ij6 LIPOATE--PROTEIN
LIGASE
(Enterococcus
faecalis) 		4 / 7 LEU A 109
PHE A 132
LEU A 150
PHE A  84
 None
 1.01A 2eimP-5ij6A:
undetectable
2eimW-5ij6A:
undetectable		 2eimP-5ij6A:
20.78
2eimW-5ij6A:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_C_CHDC1265_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ij6 LIPOATE--PROTEIN
LIGASE
(Enterococcus
faecalis) 		4 / 5 PHE A  84
PHE A  34
LEU A 206
PHE A 210
 None
 1.33A 2y69C-5ij6A:
undetectable
2y69J-5ij6A:
undetectable		 2y69C-5ij6A:
20.78
2y69J-5ij6A:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_P_CHDP1265_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ij6 LIPOATE--PROTEIN
LIGASE
(Enterococcus
faecalis) 		4 / 5 PHE A  84
PHE A  34
LEU A 206
PHE A 210
 None
 1.31A 2y69P-5ij6A:
undetectable
2y69W-5ij6A:
undetectable		 2y69P-5ij6A:
20.78
2y69W-5ij6A:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ij6 LIPOATE--PROTEIN
LIGASE
(Enterococcus
faecalis) 		4 / 5 PHE A  84
PHE A  34
LEU A 206
PHE A 210
 None
 1.34A 3abmC-5ij6A:
undetectable
3abmJ-5ij6A:
undetectable		 3abmC-5ij6A:
20.78
3abmJ-5ij6A:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABM_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 5ij6 LIPOATE--PROTEIN
LIGASE
(Enterococcus
faecalis) 		4 / 5 PHE A  84
PHE A  34
LEU A 206
PHE A 210
 None
 1.28A 3abmP-5ij6A:
undetectable
3abmW-5ij6A:
undetectable		 3abmP-5ij6A:
20.78
3abmW-5ij6A:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS4_A_AZMA702_1
(CARBONIC ANHYDRASE 2)		 5ij6 LIPOATE--PROTEIN
LIGASE
(Enterococcus
faecalis) 		4 / 7 VAL A 154
TYR A  76
GLU A  38
PRO A  39
 None
 1.17A 3hs4A-5ij6A:
undetectable		 3hs4A-5ij6A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_B_RITB600_2
(CYTOCHROME P450 3A4)		 5ij6 LIPOATE--PROTEIN
LIGASE
(Enterococcus
faecalis) 		5 / 9 ILE A  36
LEU A 205
PHE A  84
LEU A  21
GLU A  18
 None
 1.16A 3nxuB-5ij6A:
undetectable		 3nxuB-5ij6A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_C_9PLC501_1
(CYTOCHROME P450 2E1)		 5ij6 LIPOATE--PROTEIN
LIGASE
(Enterococcus
faecalis) 		4 / 5 PHE A  34
PHE A  86
THR A 102
LEU A 150
 None
 1.15A 3t3zC-5ij6A:
undetectable		 3t3zC-5ij6A:
24.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TEH_B_DAHB786_1
(PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN)		 5ij6 LIPOATE--PROTEIN
LIGASE
(Enterococcus
faecalis) 		4 / 7 LEU A  15
GLY A  71
ALA A 136
PHE A 288
 None
None
LPA  A 401 ( 3.8A)
None
 0.99A 3tehB-5ij6A:
undetectable		 3tehB-5ij6A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSE_A_H4BA804_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5ij6 LIPOATE--PROTEIN
LIGASE
(Enterococcus
faecalis) 		4 / 7 ARG A 186
VAL A  82
PHE A 201
GLU A 199
 None
 1.38A 4jseA-5ij6A:
undetectable
4jseB-5ij6A:
undetectable		 4jseA-5ij6A:
20.45
4jseB-5ij6A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSE_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5ij6 LIPOATE--PROTEIN
LIGASE
(Enterococcus
faecalis) 		4 / 7 PHE A 201
GLU A 199
ARG A 186
VAL A  82
 None
 1.43A 4jseA-5ij6A:
undetectable
4jseB-5ij6A:
undetectable		 4jseA-5ij6A:
20.45
4jseB-5ij6A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOW_A_CFXA204_1
(UNCHARACTERIZED
PROTEIN)		 5ij6 LIPOATE--PROTEIN
LIGASE
(Enterococcus
faecalis) 		5 / 12 PHE A 319
GLY A 285
ASN A  46
PHE A 331
LEU A 335
 None
 1.41A 4kowA-5ij6A:
undetectable		 4kowA-5ij6A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M7T_A_SAMA503_0
(BTRN)		 5ij6 LIPOATE--PROTEIN
LIGASE
(Enterococcus
faecalis) 		5 / 11 TYR A 287
GLU A 259
TYR A 284
LEU A 281
LEU A 300
 None
 1.41A 4m7tA-5ij6A:
undetectable		 4m7tA-5ij6A:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_B_SAMB601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 5ij6 LIPOATE--PROTEIN
LIGASE
(Enterococcus
faecalis) 		5 / 12 ALA A 136
GLY A  44
GLY A  73
ASN A  46
ILE A 247
 LPA  A 401 ( 3.8A)
None
LPA  A 401 (-3.7A)
None
None
 1.04A 4n48B-5ij6A:
undetectable		 4n48B-5ij6A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1I_D_LOCD502_1
(TUBULIN BETA CHAIN)		 5ij6 LIPOATE--PROTEIN
LIGASE
(Enterococcus
faecalis) 		5 / 12 LEU A 189
LEU A 205
ALA A 108
ALA A 114
ILE A 105
 None
 1.14A 4x1iD-5ij6A:
undetectable		 4x1iD-5ij6A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_S_BEZS801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 5ij6 LIPOATE--PROTEIN
LIGASE
(Enterococcus
faecalis) 		4 / 6 PHE A 210
MET A   1
LEU A 205
LEU A 206
 None
 1.26A 5dzke-5ij6A:
undetectable
5dzks-5ij6A:
undetectable		 5dzke-5ij6A:
21.43
5dzks-5ij6A:
5.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_A_ACTA612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 5ij6 LIPOATE--PROTEIN
LIGASE
(Enterococcus
faecalis) 		3 / 3 LYS A  99
ASP A  97
ARG A 122
 None
 1.00A 5jwaA-5ij6A:
undetectable
5jwaH-5ij6A:
undetectable		 5jwaA-5ij6A:
22.74
5jwaH-5ij6A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5ij6 LIPOATE--PROTEIN
LIGASE
(Enterococcus
faecalis) 		4 / 5 LEU A 109
PHE A 132
LEU A 150
PHE A  84
 None
 0.96A 5x19C-5ij6A:
undetectable
5x19J-5ij6A:
undetectable		 5x19C-5ij6A:
20.78
5x19J-5ij6A:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8F_A_ACTA803_0
(UNCHARACTERIZED
PROTEIN)		 5ij6 LIPOATE--PROTEIN
LIGASE
(Enterococcus
faecalis) 		3 / 3 GLU A  52
LEU A  43
ARG A  68
 None
None
LPA  A 401 (-3.5A)
 0.68A 6d8fA-5ij6A:
undetectable		 6d8fA-5ij6A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 5ij6 LIPOATE--PROTEIN
LIGASE
(Enterococcus
faecalis) 		3 / 3 THR A 102
GLU A  18
ASN A 135
 None
 0.70A 6nj9K-5ij6A:
undetectable		 6nj9K-5ij6A:
20.63