SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ija'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_3
(HIV-1 PROTEASE)		 5ija HYDROGENASE-SPECIFIC
MATURATION
ENDOPEPTIDASE
(Thermococcus
kodakarensis) 		5 / 12 VAL A  69
ILE A 142
ILE A  25
VAL A 132
ILE A 117
 None
 0.97A 1hxbB-5ijaA:
undetectable		 1hxbB-5ijaA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_B_MK1B902_1
(PROTEASE)		 5ija HYDROGENASE-SPECIFIC
MATURATION
ENDOPEPTIDASE
(Thermococcus
kodakarensis) 		5 / 12 VAL A  69
ILE A 142
ILE A  25
VAL A 132
ILE A 117
 None
 0.91A 2r5pA-5ijaA:
undetectable		 2r5pA-5ijaA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_D_MK1D902_1
(PROTEASE)		 5ija HYDROGENASE-SPECIFIC
MATURATION
ENDOPEPTIDASE
(Thermococcus
kodakarensis) 		5 / 12 VAL A  69
ILE A 142
ILE A  25
VAL A 132
ILE A 117
 None
 0.91A 2r5pC-5ijaA:
undetectable		 2r5pC-5ijaA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKX_B_1UNB201_2
(PROTEASE)		 5ija HYDROGENASE-SPECIFIC
MATURATION
ENDOPEPTIDASE
(Thermococcus
kodakarensis) 		5 / 11 VAL A  69
ILE A 142
ILE A  25
VAL A 132
ILE A 117
 None
 0.90A 3ekxB-5ijaA:
undetectable		 3ekxB-5ijaA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JVY_B_017B401_2
(GAG-POL POLYPROTEIN)		 5ija HYDROGENASE-SPECIFIC
MATURATION
ENDOPEPTIDASE
(Thermococcus
kodakarensis) 		5 / 12 VAL A  69
ILE A 142
ILE A  25
VAL A 132
ILE A 117
 None
 0.90A 3jvyB-5ijaA:
undetectable		 3jvyB-5ijaA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_1
(HIV-1 PROTEASE)		 5ija HYDROGENASE-SPECIFIC
MATURATION
ENDOPEPTIDASE
(Thermococcus
kodakarensis) 		5 / 12 VAL A  69
ILE A 142
ILE A  25
VAL A 132
ILE A 117
 None
 0.87A 3k4vC-5ijaA:
undetectable		 3k4vC-5ijaA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDU_D_ROCD100_1
(PROTEASE)		 5ija HYDROGENASE-SPECIFIC
MATURATION
ENDOPEPTIDASE
(Thermococcus
kodakarensis) 		5 / 12 VAL A  69
ILE A 142
ILE A  25
VAL A 132
ILE A 117
 None
 0.87A 3nduC-5ijaA:
undetectable		 3nduC-5ijaA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NK7_A_SAMA770_0
(23S RRNA
METHYLTRANSFERASE)		 5ija HYDROGENASE-SPECIFIC
MATURATION
ENDOPEPTIDASE
(Thermococcus
kodakarensis) 		5 / 12 LEU A   6
GLY A  37
GLU A  11
GLY A   9
ILE A   5
 None
 1.07A 3nk7A-5ijaA:
undetectable		 3nk7A-5ijaA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU3_B_478B401_2
(PROTEASE)		 5ija HYDROGENASE-SPECIFIC
MATURATION
ENDOPEPTIDASE
(Thermococcus
kodakarensis) 		6 / 11 GLY A  17
ALA A  18
ASP A  57
GLY A  23
ILE A  25
ILE A 117
 None
 1.48A 3nu3B-5ijaA:
undetectable		 3nu3B-5ijaA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUO_B_478B478_2
(PROTEASE)		 5ija HYDROGENASE-SPECIFIC
MATURATION
ENDOPEPTIDASE
(Thermococcus
kodakarensis) 		6 / 9 GLY A  17
ALA A  18
ASP A  57
GLY A  23
ILE A  25
ILE A 117
 None
 1.49A 3nuoB-5ijaA:
undetectable		 3nuoB-5ijaA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_3
(PROTEASE)		 5ija HYDROGENASE-SPECIFIC
MATURATION
ENDOPEPTIDASE
(Thermococcus
kodakarensis) 		5 / 12 VAL A  69
ILE A 142
ILE A  25
VAL A 132
ILE A 117
 None
 0.95A 3pwrB-5ijaA:
undetectable		 3pwrB-5ijaA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_B_478B101_2
(HIV-1 PROTEASE)		 5ija HYDROGENASE-SPECIFIC
MATURATION
ENDOPEPTIDASE
(Thermococcus
kodakarensis) 		6 / 9 GLY A  17
ALA A  18
ASP A  57
GLY A  23
ILE A  25
ILE A 117
 None
 1.48A 4rvjB-5ijaA:
undetectable		 4rvjB-5ijaA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVJ_D_478D101_2
(HIV-1 PROTEASE)		 5ija HYDROGENASE-SPECIFIC
MATURATION
ENDOPEPTIDASE
(Thermococcus
kodakarensis) 		6 / 9 GLY A  17
ALA A  18
ASP A  57
GLY A  23
ILE A  25
ILE A 117
 None
 1.49A 4rvjD-5ijaA:
undetectable		 4rvjD-5ijaA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3C_B_AC2B301_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 5ija HYDROGENASE-SPECIFIC
MATURATION
ENDOPEPTIDASE
(Thermococcus
kodakarensis) 		5 / 10 GLY A 116
VAL A  69
GLU A  68
ASP A  57
ILE A 115
 None
 1.23A 5i3cB-5ijaA:
7.4		 5i3cB-5ijaA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIF_B_TPVB201_1
(HIV-1 PROTEASE)		 5ija HYDROGENASE-SPECIFIC
MATURATION
ENDOPEPTIDASE
(Thermococcus
kodakarensis) 		5 / 12 VAL A  69
ILE A 142
ILE A  25
VAL A 132
ILE A 117
 None
 0.82A 6difB-5ijaA:
undetectable		 6difB-5ijaA:
18.92