SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ijg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWK_A_117A2_1
(HMG-COA REDUCTASE)		 5ijg CYS/MET METABOLISM
PYRIDOXAL-PHOSPHATE-
DEPENDENT ENZYME
(Brucella
melitensis) 		4 / 8 SER A 128
VAL A 191
ASN A 217
ASP A 216
 None
None
None
PLP  A 501 (-3.0A)
 1.27A 1hwkA-5ijgA:
2.0		 1hwkA-5ijgA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACTB601_0
(ACETYLCHOLINESTERASE)		 5ijg CYS/MET METABOLISM
PYRIDOXAL-PHOSPHATE-
DEPENDENT ENZYME
(Brucella
melitensis) 		4 / 7 GLY A 351
GLY A 350
ALA A 353
ALA A 354
 None
 0.60A 2ha4B-5ijgA:
2.0		 2ha4B-5ijgA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO4_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 5ijg CYS/MET METABOLISM
PYRIDOXAL-PHOSPHATE-
DEPENDENT ENZYME
(Brucella
melitensis) 		5 / 12 LEU A 332
ILE A 329
ALA A 195
VAL A 196
ASP A 155
 None
 1.15A 2qo4A-5ijgA:
undetectable		 2qo4A-5ijgA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO6_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 5ijg CYS/MET METABOLISM
PYRIDOXAL-PHOSPHATE-
DEPENDENT ENZYME
(Brucella
melitensis) 		5 / 12 LEU A 332
ILE A 329
ALA A 195
VAL A 196
ASP A 155
 None
 1.15A 2qo6A-5ijgA:
undetectable		 2qo6A-5ijgA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2I_D_QPSD1060_1
(ALPHA-1,4-GLUCAN
LYASE ISOZYME 1)		 5ijg CYS/MET METABOLISM
PYRIDOXAL-PHOSPHATE-
DEPENDENT ENZYME
(Brucella
melitensis) 		5 / 10 THR A 182
SER A 327
VAL A 157
GLY A 156
GLN A 336
 None
 1.29A 2x2iD-5ijgA:
undetectable		 2x2iD-5ijgA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_1
(CYTOCHROME P450 2R1)		 5ijg CYS/MET METABOLISM
PYRIDOXAL-PHOSPHATE-
DEPENDENT ENZYME
(Brucella
melitensis) 		5 / 12 LEU A 139
ALA A 214
GLY A 134
VAL A 119
ILE A 125
 None
 0.87A 3c6gA-5ijgA:
undetectable		 3c6gA-5ijgA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_K_SAMK302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 5ijg CYS/MET METABOLISM
PYRIDOXAL-PHOSPHATE-
DEPENDENT ENZYME
(Brucella
melitensis) 		5 / 12 LEU A 420
SER A 342
ILE A 404
LEU A 365
LEU A 362
 None
 1.23A 3cjtK-5ijgA:
undetectable		 3cjtK-5ijgA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JAY_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 5ijg CYS/MET METABOLISM
PYRIDOXAL-PHOSPHATE-
DEPENDENT ENZYME
(Brucella
melitensis) 		3 / 3 ARG A 326
ASP A 328
ASP A 324
 None
 0.84A 3jayA-5ijgA:
3.3		 3jayA-5ijgA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_1
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 5ijg CYS/MET METABOLISM
PYRIDOXAL-PHOSPHATE-
DEPENDENT ENZYME
(Brucella
melitensis) 		4 / 6 TYR A 132
GLY A 134
THR A 135
LEU A 131
 PLP  A 501 (-3.5A)
None
None
None
 0.98A 3ps9A-5ijgA:
undetectable		 3ps9A-5ijgA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_B_CLMB221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5ijg CYS/MET METABOLISM
PYRIDOXAL-PHOSPHATE-
DEPENDENT ENZYME
(Brucella
melitensis) 		5 / 12 SER A 100
LEU A 234
PHE A 118
VAL A 260
PHE A 104
 None
 1.41A 3u9fB-5ijgA:
undetectable
3u9fC-5ijgA:
undetectable		 3u9fB-5ijgA:
17.95
3u9fC-5ijgA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_D_CLMD221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5ijg CYS/MET METABOLISM
PYRIDOXAL-PHOSPHATE-
DEPENDENT ENZYME
(Brucella
melitensis) 		5 / 12 SER A 100
LEU A 234
PHE A 118
VAL A 260
PHE A 104
 None
 1.41A 3u9fD-5ijgA:
undetectable
3u9fE-5ijgA:
undetectable		 3u9fD-5ijgA:
17.95
3u9fE-5ijgA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_G_CLMG221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5ijg CYS/MET METABOLISM
PYRIDOXAL-PHOSPHATE-
DEPENDENT ENZYME
(Brucella
melitensis) 		5 / 12 SER A 100
LEU A 234
PHE A 118
VAL A 260
PHE A 104
 None
 1.41A 3u9fG-5ijgA:
undetectable
3u9fH-5ijgA:
undetectable		 3u9fG-5ijgA:
17.95
3u9fH-5ijgA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_N_CLMN221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5ijg CYS/MET METABOLISM
PYRIDOXAL-PHOSPHATE-
DEPENDENT ENZYME
(Brucella
melitensis) 		5 / 11 SER A 100
LEU A 234
PHE A 118
VAL A 260
PHE A 104
 None
 1.37A 3u9fN-5ijgA:
undetectable
3u9fO-5ijgA:
undetectable		 3u9fN-5ijgA:
17.95
3u9fO-5ijgA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_S_CLMS221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5ijg CYS/MET METABOLISM
PYRIDOXAL-PHOSPHATE-
DEPENDENT ENZYME
(Brucella
melitensis) 		5 / 12 PHE A 104
SER A 100
LEU A 234
PHE A 118
VAL A 260
 None
 1.40A 3u9fP-5ijgA:
undetectable
3u9fS-5ijgA:
undetectable		 3u9fP-5ijgA:
17.95
3u9fS-5ijgA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_C_ADNC401_2
(ADENOSINE KINASE)		 5ijg CYS/MET METABOLISM
PYRIDOXAL-PHOSPHATE-
DEPENDENT ENZYME
(Brucella
melitensis) 		4 / 5 ASN A 185
LEU A 219
SER A 189
LEU A 320
 None
 1.13A 4n09C-5ijgA:
undetectable		 4n09C-5ijgA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NED_A_PFNA709_1
(LACTOTRANSFERRIN)		 5ijg CYS/MET METABOLISM
PYRIDOXAL-PHOSPHATE-
DEPENDENT ENZYME
(Brucella
melitensis) 		4 / 6 VAL A 212
SER A 259
ALA A 102
PHE A 104
 None
 1.22A 4nedA-5ijgA:
undetectable		 4nedA-5ijgA:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 5ijg CYS/MET METABOLISM
PYRIDOXAL-PHOSPHATE-
DEPENDENT ENZYME
(Brucella
melitensis) 		5 / 11 ILE A 404
ALA A 378
VAL A 314
HIS A 311
LEU A 420
 None
 1.12A 4nqaA-5ijgA:
undetectable		 4nqaA-5ijgA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA602_1
(SERUM ALBUMIN)		 5ijg CYS/MET METABOLISM
PYRIDOXAL-PHOSPHATE-
DEPENDENT ENZYME
(Brucella
melitensis) 		5 / 9 ALA A 253
ALA A 110
LYS A 265
SER A 100
LEU A 255
 None
 1.14A 4or0A-5ijgA:
undetectable		 4or0A-5ijgA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5O_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5ijg CYS/MET METABOLISM
PYRIDOXAL-PHOSPHATE-
DEPENDENT ENZYME
(Brucella
melitensis) 		4 / 7 ARG A 197
PRO A 211
ILE A 213
ASP A 233
 None
 0.85A 4w5oA-5ijgA:
2.9		 4w5oA-5ijgA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 5ijg CYS/MET METABOLISM
PYRIDOXAL-PHOSPHATE-
DEPENDENT ENZYME
(Brucella
melitensis) 		5 / 12 VAL A 399
LEU A 424
LEU A 359
THR A 187
ALA A 378
 None
 1.20A 4x1kA-5ijgA:
undetectable
4x1kB-5ijgA:
3.0		 4x1kA-5ijgA:
24.65
4x1kB-5ijgA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVP_B_GBMB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 5ijg CYS/MET METABOLISM
PYRIDOXAL-PHOSPHATE-
DEPENDENT ENZYME
(Brucella
melitensis) 		5 / 12 LEU A 308
VAL A 314
ILE A 348
LEU A 365
LEU A 362
 None
 1.17A 4yvpB-5ijgA:
undetectable		 4yvpB-5ijgA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4E_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5ijg CYS/MET METABOLISM
PYRIDOXAL-PHOSPHATE-
DEPENDENT ENZYME
(Brucella
melitensis) 		4 / 7 ARG A 197
PRO A 211
ILE A 213
ASP A 233
 None
 0.84A 4z4eA-5ijgA:
undetectable		 4z4eA-5ijgA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 5ijg CYS/MET METABOLISM
PYRIDOXAL-PHOSPHATE-
DEPENDENT ENZYME
(Brucella
melitensis) 		4 / 7 ARG A 197
PRO A 211
ILE A 213
ASP A 233
 None
 0.81A 4z4gA-5ijgA:
2.9		 4z4gA-5ijgA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5ijg CYS/MET METABOLISM
PYRIDOXAL-PHOSPHATE-
DEPENDENT ENZYME
(Brucella
melitensis) 		4 / 5 ARG A 197
PRO A 211
ILE A 213
ASP A 233
 None
 0.85A 4z4hA-5ijgA:
3.0		 4z4hA-5ijgA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 5ijg CYS/MET METABOLISM
PYRIDOXAL-PHOSPHATE-
DEPENDENT ENZYME
(Brucella
melitensis) 		5 / 12 GLY A 244
TYR A 242
ILE A 250
GLY A 252
GLY A 221
 None
 0.99A 5d4uA-5ijgA:
4.7		 5d4uA-5ijgA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 5ijg CYS/MET METABOLISM
PYRIDOXAL-PHOSPHATE-
DEPENDENT ENZYME
(Brucella
melitensis) 		5 / 12 GLY A 244
TYR A 242
ILE A 250
GLY A 252
GLY A 221
 None
 0.98A 5d4uB-5ijgA:
2.4		 5d4uB-5ijgA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 5ijg CYS/MET METABOLISM
PYRIDOXAL-PHOSPHATE-
DEPENDENT ENZYME
(Brucella
melitensis) 		5 / 12 GLY A 244
TYR A 242
ILE A 250
GLY A 252
GLY A 221
 None
 0.99A 5d4uC-5ijgA:
4.6		 5d4uC-5ijgA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K50_A_ACTA1403_0
(L-THREONINE
3-DEHYDROGENASE)		 5ijg CYS/MET METABOLISM
PYRIDOXAL-PHOSPHATE-
DEPENDENT ENZYME
(Brucella
melitensis) 		4 / 5 SER A 259
VAL A 260
GLY A 256
ALA A 257
 None
 1.08A 5k50A-5ijgA:
undetectable		 5k50A-5ijgA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KB5_A_ADNA401_2
(ADENOSINE KINASE)		 5ijg CYS/MET METABOLISM
PYRIDOXAL-PHOSPHATE-
DEPENDENT ENZYME
(Brucella
melitensis) 		4 / 4 ASN A 185
LEU A 219
SER A 189
LEU A 320
 None
 1.16A 5kb5A-5ijgA:
undetectable		 5kb5A-5ijgA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 5ijg CYS/MET METABOLISM
PYRIDOXAL-PHOSPHATE-
DEPENDENT ENZYME
(Brucella
melitensis) 		4 / 7 THR A 240
LEU A 255
VAL A 264
GLU A  86
 PLP  A 501 (-3.3A)
None
None
None
 1.13A 5tudA-5ijgA:
undetectable		 5tudA-5ijgA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA608_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 5ijg CYS/MET METABOLISM
PYRIDOXAL-PHOSPHATE-
DEPENDENT ENZYME
(Brucella
melitensis) 		3 / 3 GLY A 372
THR A 374
GLU A 375
 None
 0.57A 6b58A-5ijgA:
undetectable		 6b58A-5ijgA:
22.15