SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ijl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1B02_A_C2FA281_0
(PROTEIN (THYMIDYLATE
SYNTHASE))		 5ijl DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
abyssi) 		5 / 11 ALA A 968
ILE A 991
LEU A 995
LEU A 920
GLY A 919
 None
 0.99A 1b02A-5ijlA:
undetectable		 1b02A-5ijlA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KNY_B_KANB559_1
(KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE)		 5ijl DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
abyssi) 		4 / 8 GLU A 487
LYS A 505
GLU A 491
GLU A 502
 None
 1.08A 1knyA-5ijlA:
undetectable
1knyB-5ijlA:
undetectable		 1knyA-5ijlA:
12.48
1knyB-5ijlA:
12.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5R_A_RBFA859_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5ijl DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
abyssi) 		5 / 11 ASN A 457
LEU A 512
ALA A 456
TYR A1013
PHE A 482
 None
 1.24A 1l5rA-5ijlA:
undetectable		 1l5rA-5ijlA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRG_A_ADNA300_1
(ALPHA-MOMORCHARIN)		 5ijl DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
abyssi) 		5 / 9 TYR A  98
ILE A  85
GLY A  87
ILE A  84
ALA A 102
 None
 1.18A 1mrgA-5ijlA:
undetectable		 1mrgA-5ijlA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRQ_A_STRA501_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 5ijl DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
abyssi) 		5 / 11 LEU A 589
VAL A 603
ILE A 577
LEU A 617
LEU A 614
 None
 1.35A 1mrqA-5ijlA:
undetectable		 1mrqA-5ijlA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBK_A_RAPA225_1
(FKBP25)		 5ijl DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
abyssi) 		5 / 12 LEU A 260
ILE A 218
TYR A 143
ALA A 117
ILE A 147
 None
 1.00A 1pbkA-5ijlA:
undetectable		 1pbkA-5ijlA:
7.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S1X_A_NVPA999_1
(REVERSE
TRANSCRIPTASE)		 5ijl DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
abyssi) 		4 / 8 LEU A 771
VAL A 673
GLY A 788
LEU A 806
 None
 0.96A 1s1xA-5ijlA:
undetectable		 1s1xA-5ijlA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UUJ_B_ACTB1077_0
(PLATELET-ACTIVATING
FACTOR
ACETYLHYDROLASE IB
ALPHA SUBUNIT)		 5ijl DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
abyssi) 		3 / 3 ARG A 416
TYR A 535
LYS A 515
 None
 1.02A 1uujB-5ijlA:
undetectable		 1uujB-5ijlA:
6.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 5ijl DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
abyssi) 		3 / 3 LYS A 259
ASP A 956
ASP A 958
 None
 1.10A 2br4A-5ijlA:
undetectable		 2br4A-5ijlA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2001_1
(SERUM ALBUMIN)		 5ijl DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
abyssi) 		5 / 11 ILE A 122
VAL A 161
GLY A 162
LEU A 107
SER A 150
 None
 1.04A 2bxeA-5ijlA:
undetectable		 2bxeA-5ijlA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2001_1
(SERUM ALBUMIN)		 5ijl DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
abyssi) 		5 / 12 ILE A 122
VAL A 161
GLY A 162
LEU A 107
SER A 150
 None
 1.06A 2bxeB-5ijlA:
undetectable		 2bxeB-5ijlA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_B_SCKB951_1
(ACETYLCHOLINESTERASE)		 5ijl DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
abyssi) 		4 / 8 TYR A  10
ASP A 872
TYR A 850
HIS A 832
 None
 1.40A 2ha2B-5ijlA:
undetectable		 2ha2B-5ijlA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1001_0
(ALDEHYDE
DEHYDROGENASE A)		 5ijl DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
abyssi) 		4 / 7 LEU A 770
PHE A 675
ILE A 765
PHE A 703
 None
 0.86A 2opxA-5ijlA:
undetectable		 2opxA-5ijlA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_0
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 5ijl DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
abyssi) 		5 / 12 ALA A 961
PRO A 922
ILE A 119
ALA A 987
LEU A 977
 None
 1.06A 2plwA-5ijlA:
undetectable		 2plwA-5ijlA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEO_A_LNRA200_1
(D7R4 PROTEIN)		 5ijl DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
abyssi) 		5 / 12 GLU A 590
ARG A 587
HIS A 596
VAL A 414
GLU A 432
 None
 1.13A 2qeoA-5ijlA:
undetectable		 2qeoA-5ijlA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_C_SALC1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 5ijl DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
abyssi) 		4 / 7 THR A 992
ILE A 928
GLY A 927
ILE A 114
 None
 0.78A 2y7wC-5ijlA:
undetectable		 2y7wC-5ijlA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YY8_B_SAMB500_0
(UPF0106 PROTEIN
PH0461)		 5ijl DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
abyssi) 		5 / 11 LEU A 528
LYS A 643
ILE A 474
GLU A 466
ALA A 470
 None
 1.09A 2yy8A-5ijlA:
undetectable
2yy8B-5ijlA:
undetectable		 2yy8A-5ijlA:
10.40
2yy8B-5ijlA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A27_A_SAMA250_1
(UNCHARACTERIZED
PROTEIN MJ1557)		 5ijl DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
abyssi) 		3 / 3 MET A 211
GLU A 187
ASN A 239
 None
 1.09A 3a27A-5ijlA:
undetectable		 3a27A-5ijlA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_A_DGXA1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 5ijl DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
abyssi) 		3 / 3 TRP A 540
VAL A 603
ARG A 599
 None
 0.91A 3b0wA-5ijlA:
undetectable		 3b0wA-5ijlA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_B_SALB258_1
(TRANSCRIPTIONAL
REGULATOR)		 5ijl DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
abyssi) 		5 / 11 ALA A 921
PHE A 947
ILE A 918
PRO A 988
GLY A 927
 None
 1.29A 3bpxA-5ijlA:
0.8
3bpxB-5ijlA:
undetectable		 3bpxA-5ijlA:
9.58
3bpxB-5ijlA:
9.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL5_B_1UNB201_2
(PROTEASE)		 5ijl DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
abyssi) 		5 / 12 GLY A 880
ALA A 879
GLY A 941
ILE A 874
VAL A 962
 None
 0.90A 3el5B-5ijlA:
undetectable		 3el5B-5ijlA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_B_0LIB2_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 5ijl DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
abyssi) 		4 / 7 LEU A 247
VAL A  55
ILE A 122
ARG A  50
 None
 1.31A 3ik3B-5ijlA:
undetectable		 3ik3B-5ijlA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB1_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 5ijl DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
abyssi) 		5 / 12 ILE A 838
ALA A 879
ALA A 938
ILE A 873
ALA A 943
 None
 1.06A 3jb1A-5ijlA:
undetectable		 3jb1A-5ijlA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 5ijl DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
abyssi) 		5 / 12 ALA A 968
ILE A 991
LEU A 995
LEU A 920
GLY A 919
 None
 1.11A 3k2hA-5ijlA:
undetectable		 3k2hA-5ijlA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB513_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 5ijl DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
abyssi) 		5 / 12 ALA A 968
ILE A 991
LEU A 995
LEU A 920
GLY A 919
 None
 1.11A 3k2hB-5ijlA:
3.7		 3k2hB-5ijlA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_F_LFXF0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 5ijl DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
abyssi) 		4 / 5 SER A 158
ARG A 242
GLY A 243
GLU A 187
 None
 1.30A 3k9fA-5ijlA:
undetectable
3k9fB-5ijlA:
undetectable
3k9fC-5ijlA:
undetectable		 3k9fA-5ijlA:
19.74
3k9fB-5ijlA:
19.74
3k9fC-5ijlA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 5ijl DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
abyssi) 		5 / 12 ARG A 647
GLY A 593
LEU A 589
SER A 413
GLU A 403
 None
 0.91A 3kkzA-5ijlA:
undetectable		 3kkzA-5ijlA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_B_SAMB302_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 5ijl DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
abyssi) 		5 / 12 ARG A 647
GLY A 593
LEU A 589
SER A 413
GLU A 403
 None
 0.89A 3kkzB-5ijlA:
undetectable		 3kkzB-5ijlA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LZV_A_017A200_2
(HIV-1 PROTEASE)		 5ijl DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
abyssi) 		6 / 11 ASP A  46
ALA A  48
VAL A  68
ILE A 109
GLY A 113
ILE A 114
 None
 1.31A 3lzvB-5ijlA:
undetectable		 3lzvB-5ijlA:
8.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUJ_B_478B401_1
(PROTEASE)		 5ijl DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
abyssi) 		6 / 10 ASP A  46
ALA A  48
VAL A  68
ILE A 109
GLY A 113
ILE A 114
 None
 1.30A 3nujA-5ijlA:
undetectable		 3nujA-5ijlA:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5P_A_TACA7101_1
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 5ijl DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
abyssi) 		5 / 12 PRO A 608
ASN A 619
TYR A 607
TYR A 536
ILE A 522
 None
 1.29A 3q5pA-5ijlA:
undetectable		 3q5pA-5ijlA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5R_A_KANA2002_1
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 5ijl DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
abyssi) 		5 / 11 PRO A 608
ASN A 619
TYR A 607
TYR A 536
ILE A 522
 None
 1.26A 3q5rA-5ijlA:
undetectable		 3q5rA-5ijlA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5ijl DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
abyssi) 		5 / 12 GLY A 983
ASP A 986
GLY A 145
ALA A 117
SER A 158
 None
 1.29A 3sueD-5ijlA:
undetectable		 3sueD-5ijlA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_B_MIYB2001_1
(TETX2 PROTEIN)		 5ijl DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
abyssi) 		4 / 8 PHE A 704
HIS A 711
GLY A 713
GLY A  32
 None
 0.71A 3v3nB-5ijlA:
undetectable		 3v3nB-5ijlA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_C_MIYC2001_1
(TETX2 PROTEIN)		 5ijl DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
abyssi) 		4 / 8 PHE A 704
HIS A 711
GLY A 713
GLY A  32
 None
 0.69A 3v3nC-5ijlA:
undetectable		 3v3nC-5ijlA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_C_ACTC502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 5ijl DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
abyssi) 		3 / 3 PRO A  35
ASP A  34
GLU A 800
 None
 0.86A 3v4tC-5ijlA:
undetectable		 3v4tC-5ijlA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_0
(METHYLTRANSFERASE
WBDD)		 5ijl DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
abyssi) 		5 / 12 GLY A  49
ALA A  44
ILE A  64
VAL A  51
ILE A 109
 None
 1.01A 4aztA-5ijlA:
undetectable		 4aztA-5ijlA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_A_REAA501_1
(RETINOIC ACID
RECEPTOR BETA)		 5ijl DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
abyssi) 		5 / 11 PHE A 972
LEU A  54
ILE A 119
SER A  36
LEU A 920
 None
 1.21A 4dm8A-5ijlA:
undetectable		 4dm8A-5ijlA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FU9_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 5ijl DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
abyssi) 		3 / 3 GLN A 871
THR A 993
THR A 992
 None
 0.68A 4fu9A-5ijlA:
undetectable		 4fu9A-5ijlA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUF_A_ACTA310_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 5ijl DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
abyssi) 		3 / 3 GLN A 871
THR A 993
THR A 992
 None
 0.67A 4fufA-5ijlA:
undetectable		 4fufA-5ijlA:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_A_SAMA401_0
(METHYLTRANSFERASE
MPPJ)		 5ijl DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
abyssi) 		5 / 12 GLY A  56
ARG A 104
ILE A  64
ALA A  61
ALA A  77
 None
 1.11A 4kicA-5ijlA:
undetectable		 4kicA-5ijlA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_1
(NEURAMINIDASE)		 5ijl DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
abyssi) 		3 / 3 ARG A 647
ASP A 438
ARG A 416
 None
 0.98A 4mx0A-5ijlA:
undetectable		 4mx0A-5ijlA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_E_SPME202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5ijl DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
abyssi) 		4 / 5 GLU A 487
GLU A 486
GLU A 488
GLU A 492
 None
 1.34A 4r87E-5ijlA:
undetectable		 4r87E-5ijlA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDA_A_DEXA1985_2
(MINERALOCORTICOID
RECEPTOR)		 5ijl DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
abyssi) 		4 / 6 LEU A 249
TRP A 272
LEU A 209
PHE A 278
 None
 1.09A 4udaA-5ijlA:
undetectable		 4udaA-5ijlA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XYZ_A_ACTA103_0
(POLYUBIQUITIN-C)		 5ijl DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
abyssi) 		4 / 4 LEU A 964
ILE A 932
HIS A 915
VAL A 917
 None
 1.01A 4xyzA-5ijlA:
undetectable		 4xyzA-5ijlA:
6.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YBN_A_ACTA303_0
(FLAVIN-NUCLEOTIDE-BI
NDING PROTEIN)		 5ijl DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
abyssi) 		3 / 3 VAL A  39
TYR A  22
ALA A  25
 None
 0.29A 4ybnA-5ijlA:
undetectable		 4ybnA-5ijlA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YVP_B_GBMB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 5ijl DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
abyssi) 		5 / 12 LEU A 589
VAL A 603
ILE A 577
LEU A 617
LEU A 614
 None
 1.33A 4yvpB-5ijlA:
undetectable		 4yvpB-5ijlA:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_E_SAME301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 5ijl DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
abyssi) 		5 / 12 ALA A 370
PRO A 369
GLY A 437
GLY A 404
LEU A 436
 None
 1.17A 5c0oE-5ijlA:
undetectable		 5c0oE-5ijlA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D75_A_FK5A301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3)		 5ijl DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
abyssi) 		5 / 11 LEU A 260
ILE A 218
TYR A 143
ALA A 117
ILE A 147
 None
 1.06A 5d75A-5ijlA:
undetectable		 5d75A-5ijlA:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_B_SAMB601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 5ijl DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
abyssi) 		5 / 12 GLY A 819
ASP A 818
VAL A 815
VAL A 671
VAL A 789
 None
 1.17A 5dpdB-5ijlA:
undetectable		 5dpdB-5ijlA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EC8_A_SAMA301_0
(GENOME POLYPROTEIN)		 5ijl DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
abyssi) 		6 / 12 SER A 149
GLY A 243
GLY A 145
GLY A 982
THR A 223
ILE A 246
 None
 1.50A 5ec8A-5ijlA:
undetectable		 5ec8A-5ijlA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GPG_A_RAPA301_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP3)		 5ijl DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
abyssi) 		5 / 11 LEU A 260
ILE A 218
TYR A 143
ALA A 117
ILE A 147
 None
 0.93A 5gpgA-5ijlA:
undetectable		 5gpgA-5ijlA:
7.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEN_A_VDYA201_2
(CDL2.2)		 5ijl DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
abyssi) 		5 / 12 ILE A 561
VAL A 518
LEU A 594
PRO A 517
LEU A 555
 None
 0.99A 5ienA-5ijlA:
undetectable		 5ienA-5ijlA:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ijl DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
abyssi) 		5 / 12 HIS A 923
GLN A 199
GLY A 121
ALA A 117
LEU A 107
 None
 0.97A 5kirB-5ijlA:
undetectable		 5kirB-5ijlA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KOX_A_RFPA502_1
(PENTACHLOROPHENOL
4-MONOOXYGENASE)		 5ijl DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
abyssi) 		5 / 12 ARG A 351
GLY A 437
ILE A 649
GLY A 348
GLY A 349
 None
 0.94A 5koxA-5ijlA:
undetectable		 5koxA-5ijlA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		 5ijl DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
abyssi) 		4 / 6 ALA A 926
LEU A 989
SER A 116
THR A 924
 None
 1.28A 5l4iB-5ijlA:
undetectable		 5l4iB-5ijlA:
8.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_A_PFLA412_1
(PROTON-GATED ION
CHANNEL)		 5ijl DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
abyssi) 		5 / 10 TYR A 142
ILE A 216
TYR A 143
THR A 219
ILE A 218
 None
 0.91A 5mzrA-5ijlA:
undetectable		 5mzrA-5ijlA:
6.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_C_PFLC409_1
(PROTON-GATED ION
CHANNEL)		 5ijl DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
abyssi) 		5 / 10 TYR A 142
ILE A 216
TYR A 143
THR A 219
ILE A 218
 None
 0.91A 5mzrC-5ijlA:
undetectable		 5mzrC-5ijlA:
6.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUK_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 5ijl DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
abyssi) 		5 / 10 ALA A 123
ILE A 216
ILE A 218
VAL A 248
ALA A 144
 None
 1.19A 5nukA-5ijlA:
undetectable		 5nukA-5ijlA:
6.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X24_A_LSNA503_1
(CYTOCHROME P450 2C9)		 5ijl DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
abyssi) 		4 / 6 PHE A 816
GLY A 819
THR A 820
ASN A 971
 None
 0.95A 5x24A-5ijlA:
undetectable		 5x24A-5ijlA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA410_0
(UNCHARACTERIZED
PROTEIN KDOO)		 5ijl DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
abyssi) 		4 / 4 GLY A 593
LEU A 434
VAL A 414
GLU A 590
 None
 1.27A 5yw0A-5ijlA:
undetectable		 5yw0A-5ijlA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5ijl DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
abyssi) 		4 / 6 GLN A 672
PHE A 889
LEU A 893
PHE A 897
 None
 1.12A 5z84P-5ijlA:
undetectable
5z84W-5ijlA:
undetectable		 5z84P-5ijlA:
12.20
5z84W-5ijlA:
4.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5ijl DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
abyssi) 		4 / 6 GLN A 672
PHE A 889
LEU A 893
PHE A 897
 None
 1.11A 5zcoP-5ijlA:
undetectable
5zcoW-5ijlA:
undetectable		 5zcoP-5ijlA:
12.20
5zcoW-5ijlA:
4.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5ijl DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
abyssi) 		4 / 6 GLN A 672
PHE A 889
LEU A 893
PHE A 897
 None
 1.11A 5zcpP-5ijlA:
undetectable
5zcpW-5ijlA:
undetectable		 5zcpP-5ijlA:
12.20
5zcpW-5ijlA:
4.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JI6_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME)		 5ijl DNA POLYMERASE II
LARGE SUBUNIT
(Pyrococcus
abyssi) 		4 / 5 GLY A 930
LEU A 916
TYR A  10
GLN A 871
 None
 0.82A 6ji6A-5ijlA:
undetectable		 6ji6A-5ijlA:
12.42