SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ijx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB8_0
(GRAMICIDIN A)		 5ijx TYROSINE--TRNA
LIGASE,
MITOCHONDRIAL
(Coccidioides
posadasii) 		3 / 3 TRP A 310
VAL A 278
TRP A 271
 None
 1.00A 1c4dA-5ijxA:
undetectable
1c4dB-5ijxA:
undetectable		 1c4dA-5ijxA:
9.73
1c4dB-5ijxA:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 5ijx TYROSINE--TRNA
LIGASE,
MITOCHONDRIAL
(Coccidioides
posadasii) 		6 / 11 GLY A 116
HIS A 125
HIS A 128
GLY A 284
ASP A 286
GLN A 287
 TYR  A 501 (-3.6A)
None
None
None
None
TYR  A 501 (-2.8A)
 0.76A 1jzsA-5ijxA:
undetectable		 1jzsA-5ijxA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JZS_A_MRCA1301_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 5ijx TYROSINE--TRNA
LIGASE,
MITOCHONDRIAL
(Coccidioides
posadasii) 		6 / 11 HIS A 125
HIS A 128
GLY A 284
ASP A 286
GLN A 287
LEU A 330
 None
None
None
None
TYR  A 501 (-2.8A)
None
 0.86A 1jzsA-5ijxA:
undetectable		 1jzsA-5ijxA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PG2_A_ADNA552_1
(METHIONYL-TRNA
SYNTHETASE)		 5ijx TYROSINE--TRNA
LIGASE,
MITOCHONDRIAL
(Coccidioides
posadasii) 		5 / 11 ALA A 115
HIS A 125
GLY A 127
HIS A 128
GLY A 284
 None
 0.95A 1pg2A-5ijxA:
8.2		 1pg2A-5ijxA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PG2_A_ADNA552_1
(METHIONYL-TRNA
SYNTHETASE)		 5ijx TYROSINE--TRNA
LIGASE,
MITOCHONDRIAL
(Coccidioides
posadasii) 		5 / 11 HIS A 125
GLY A 127
HIS A 128
GLY A 284
ASP A 286
 None
 0.45A 1pg2A-5ijxA:
8.2		 1pg2A-5ijxA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 5ijx TYROSINE--TRNA
LIGASE,
MITOCHONDRIAL
(Coccidioides
posadasii) 		5 / 12 GLY A 127
HIS A 128
GLY A 284
ASP A 286
GLN A 287
 None
None
None
None
TYR  A 501 (-2.8A)
 0.68A 1qu2A-5ijxA:
undetectable		 1qu2A-5ijxA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_1
(ISOLEUCYL-TRNA
SYNTHETASE)		 5ijx TYROSINE--TRNA
LIGASE,
MITOCHONDRIAL
(Coccidioides
posadasii) 		5 / 12 HIS A 125
GLY A 127
HIS A 128
GLY A 284
ASP A 286
 None
 0.93A 1qu2A-5ijxA:
undetectable		 1qu2A-5ijxA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C49_B_ADNB1301_1
(SUGAR KINASE MJ0406)		 5ijx TYROSINE--TRNA
LIGASE,
MITOCHONDRIAL
(Coccidioides
posadasii) 		4 / 7 ASP A 118
GLY A 150
GLY A 151
ASN A 214
 TYR  A 501 (-2.9A)
TYR  A 501 ( 3.8A)
None
TYR  A 501 ( 4.4A)
 0.69A 2c49B-5ijxA:
undetectable		 2c49B-5ijxA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JC9_A_ADNA1498_1
(CYTOSOLIC PURINE
5'-NUCLEOTIDASE)		 5ijx TYROSINE--TRNA
LIGASE,
MITOCHONDRIAL
(Coccidioides
posadasii) 		4 / 5 PHE A 192
ARG A 187
MET A 129
MET A 133
 None
 1.43A 2jc9A-5ijxA:
0.0		 2jc9A-5ijxA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_A_ADNA601_1
(METHIONYL-TRNA
SYNTHETASE)		 5ijx TYROSINE--TRNA
LIGASE,
MITOCHONDRIAL
(Coccidioides
posadasii) 		5 / 11 ALA A 115
HIS A 125
GLY A 127
HIS A 128
GLY A 284
 None
 1.03A 2x1lA-5ijxA:
7.3		 2x1lA-5ijxA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_A_ADNA601_1
(METHIONYL-TRNA
SYNTHETASE)		 5ijx TYROSINE--TRNA
LIGASE,
MITOCHONDRIAL
(Coccidioides
posadasii) 		5 / 11 HIS A 125
GLY A 127
HIS A 128
GLY A 284
ASP A 286
 None
 0.51A 2x1lA-5ijxA:
7.3		 2x1lA-5ijxA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_B_ADNB601_1
(METHIONYL-TRNA
SYNTHETASE)		 5ijx TYROSINE--TRNA
LIGASE,
MITOCHONDRIAL
(Coccidioides
posadasii) 		5 / 12 ALA A 115
HIS A 125
GLY A 127
HIS A 128
GLY A 284
 None
 1.00A 2x1lB-5ijxA:
7.3		 2x1lB-5ijxA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_B_ADNB601_1
(METHIONYL-TRNA
SYNTHETASE)		 5ijx TYROSINE--TRNA
LIGASE,
MITOCHONDRIAL
(Coccidioides
posadasii) 		5 / 12 HIS A 125
GLY A 127
HIS A 128
GLY A 284
ASP A 286
 None
 0.48A 2x1lB-5ijxA:
7.3		 2x1lB-5ijxA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_C_ADNC601_1
(METHIONYL-TRNA
SYNTHETASE)		 5ijx TYROSINE--TRNA
LIGASE,
MITOCHONDRIAL
(Coccidioides
posadasii) 		5 / 11 ALA A 115
HIS A 125
GLY A 127
HIS A 128
GLY A 284
 None
 1.02A 2x1lC-5ijxA:
7.3		 2x1lC-5ijxA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_C_ADNC601_1
(METHIONYL-TRNA
SYNTHETASE)		 5ijx TYROSINE--TRNA
LIGASE,
MITOCHONDRIAL
(Coccidioides
posadasii) 		5 / 11 HIS A 125
GLY A 127
HIS A 128
GLY A 284
ASP A 286
 None
 0.51A 2x1lC-5ijxA:
7.3		 2x1lC-5ijxA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_A_ADNA353_1
(ADENOSINE KINASE)		 5ijx TYROSINE--TRNA
LIGASE,
MITOCHONDRIAL
(Coccidioides
posadasii) 		5 / 12 ASP A 118
GLY A 150
GLY A 151
SER A 152
ASN A 214
 TYR  A 501 (-2.9A)
TYR  A 501 ( 3.8A)
None
None
TYR  A 501 ( 4.4A)
 0.88A 3uboA-5ijxA:
2.4		 3uboA-5ijxA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1005_1
(HEMOLYTIC LECTIN
CEL-III)		 5ijx TYROSINE--TRNA
LIGASE,
MITOCHONDRIAL
(Coccidioides
posadasii) 		3 / 3 ASP A 243
GLY A 289
TYR A 244
 None
 0.65A 3w9tC-5ijxA:
undetectable		 3w9tC-5ijxA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG503_1
(HEMOLYTIC LECTIN
CEL-III)		 5ijx TYROSINE--TRNA
LIGASE,
MITOCHONDRIAL
(Coccidioides
posadasii) 		3 / 3 ASP A 243
GLY A 289
TYR A 244
 None
 0.65A 3w9tG-5ijxA:
undetectable		 3w9tG-5ijxA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1002_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 5ijx TYROSINE--TRNA
LIGASE,
MITOCHONDRIAL
(Coccidioides
posadasii) 		3 / 3 ASN A 214
TRP A 217
ASP A 118
 TYR  A 501 ( 4.4A)
None
TYR  A 501 (-2.9A)
 0.81A 4a7tA-5ijxA:
undetectable
4a7tF-5ijxA:
undetectable		 4a7tA-5ijxA:
17.55
4a7tF-5ijxA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 5ijx TYROSINE--TRNA
LIGASE,
MITOCHONDRIAL
(Coccidioides
posadasii) 		4 / 8 LEU A 330
THR A 328
VAL A 117
GLY A 127
 None
None
TYR  A 501 ( 4.0A)
None
 0.83A 4eq4B-5ijxA:
undetectable		 4eq4B-5ijxA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_2
(GLUCOCORTICOID
RECEPTOR)		 5ijx TYROSINE--TRNA
LIGASE,
MITOCHONDRIAL
(Coccidioides
posadasii) 		3 / 3 MET A 295
MET A 239
TYR A 288
 None
 0.91A 4p6xI-5ijxA:
undetectable		 4p6xI-5ijxA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4USW_A_ACTA1470_0
(ADENYLATE CYCLASE
TYPE 10)		 5ijx TYROSINE--TRNA
LIGASE,
MITOCHONDRIAL
(Coccidioides
posadasii) 		4 / 6 LEU A  83
LEU A  91
VAL A  92
PHE A  85
 None
 1.27A 4uswA-5ijxA:
undetectable		 4uswA-5ijxA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPM_A_BO2A801_1
(LON PROTEASE)		 5ijx TYROSINE--TRNA
LIGASE,
MITOCHONDRIAL
(Coccidioides
posadasii) 		5 / 12 THR A 354
LEU A 359
GLY A 416
SER A 419
ALA A 420
 None
 1.14A 4ypmA-5ijxA:
undetectable		 4ypmA-5ijxA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBQ_A_DIFA601_1
(SERUM ALBUMIN)		 5ijx TYROSINE--TRNA
LIGASE,
MITOCHONDRIAL
(Coccidioides
posadasii) 		5 / 11 VAL A  92
ASN A  93
LEU A 330
GLY A 283
LEU A 130
 None
 1.31A 4zbqA-5ijxA:
undetectable		 4zbqA-5ijxA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_C_SAMC301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5ijx TYROSINE--TRNA
LIGASE,
MITOCHONDRIAL
(Coccidioides
posadasii) 		5 / 12 ALA A 297
PRO A 263
THR A 160
PHE A 293
GLY A 289
 None
 1.33A 5hfjC-5ijxA:
2.9		 5hfjC-5ijxA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_H_SAMH301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5ijx TYROSINE--TRNA
LIGASE,
MITOCHONDRIAL
(Coccidioides
posadasii) 		5 / 12 ALA A 297
PRO A 263
THR A 160
PHE A 293
GLY A 289
 None
 1.41A 5hfjH-5ijxA:
2.9		 5hfjH-5ijxA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HG0_B_SAMB301_0
(PANTOTHENATE
SYNTHETASE)		 5ijx TYROSINE--TRNA
LIGASE,
MITOCHONDRIAL
(Coccidioides
posadasii) 		5 / 12 HIS A 125
GLY A 127
HIS A 128
GLY A 284
ASP A 286
 None
 0.94A 5hg0B-5ijxA:
7.2		 5hg0B-5ijxA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA503_1
(CYTOCHROME P450 2C9)		 5ijx TYROSINE--TRNA
LIGASE,
MITOCHONDRIAL
(Coccidioides
posadasii) 		5 / 12 ILE A 264
PHE A 293
LEU A 292
LEU A 302
LEU A 230
 None
 1.22A 5xxiA-5ijxA:
undetectable		 5xxiA-5ijxA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA607_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 5ijx TYROSINE--TRNA
LIGASE,
MITOCHONDRIAL
(Coccidioides
posadasii) 		4 / 4 GLY A 294
ARG A 242
ASN A 290
LEU A 292
 None
 1.33A 6b58A-5ijxA:
undetectable		 6b58A-5ijxA:
20.68