SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ijz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K6C_B_MK1B902_1
(POL POLYPROTEIN)		 5ijz NADP-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		5 / 10 ARG A  96
VAL A 376
ILE A 124
GLY A 125
GLY A 126
 NAP  A 501 (-4.0A)
AKG  A 502 (-4.1A)
None
None
None
 0.84A 1k6cA-5ijzA:
undetectable		 1k6cA-5ijzA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_B_DIFB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ijz NADP-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		5 / 9 LEU A 122
LEU A 401
VAL A 376
GLY A 374
ALA A 373
 None
None
AKG  A 502 (-4.1A)
None
None
 1.25A 1pxxB-5ijzA:
1.0		 1pxxB-5ijzA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_D_DIFD3701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 5ijz NADP-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		5 / 10 LEU A 122
LEU A 401
VAL A 376
GLY A 374
ALA A 373
 None
None
AKG  A 502 (-4.1A)
None
None
 1.25A 1pxxD-5ijzA:
0.9		 1pxxD-5ijzA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVS_B_MK1B902_1
(POL POLYPROTEIN)		 5ijz NADP-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		5 / 12 ARG A  96
VAL A 376
ILE A 124
GLY A 125
GLY A 126
 NAP  A 501 (-4.0A)
AKG  A 502 (-4.1A)
None
None
None
 0.80A 2avsA-5ijzA:
undetectable		 2avsA-5ijzA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_1
(POL POLYPROTEIN)		 5ijz NADP-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		5 / 12 ARG A  96
VAL A 376
ILE A 124
GLY A 125
GLY A 126
 NAP  A 501 (-4.0A)
AKG  A 502 (-4.1A)
None
None
None
 0.86A 2avvD-5ijzA:
undetectable		 2avvD-5ijzA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_B_MK1B902_1
(PROTEASE)		 5ijz NADP-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		5 / 12 ARG A  96
VAL A 376
ILE A 124
GLY A 125
GLY A 126
 NAP  A 501 (-4.0A)
AKG  A 502 (-4.1A)
None
None
None
 0.87A 2r5pA-5ijzA:
undetectable		 2r5pA-5ijzA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5P_D_MK1D902_1
(PROTEASE)		 5ijz NADP-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		5 / 12 ARG A  96
VAL A 376
ILE A 124
GLY A 125
GLY A 126
 NAP  A 501 (-4.0A)
AKG  A 502 (-4.1A)
None
None
None
 0.86A 2r5pC-5ijzA:
undetectable		 2r5pC-5ijzA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		 5ijz NADP-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		5 / 12 PHE A 365
VAL A 426
ALA A 429
ALA A 343
VAL A 342
 None
 1.12A 3czhA-5ijzA:
undetectable		 3czhA-5ijzA:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE201_1
(PROTEIN S100-A4)		 5ijz NADP-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		4 / 7 PHE A 434
GLY A 433
PHE A 115
PHE A 111
 None
 0.93A 3ko0D-5ijzA:
undetectable
3ko0E-5ijzA:
undetectable		 3ko0D-5ijzA:
14.91
3ko0E-5ijzA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3005_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5ijz NADP-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		4 / 8 ASN A 372
THR A 212
ALA A 377
ARG A 208
 NAP  A 501 (-3.7A)
NAP  A 501 (-3.3A)
None
NAP  A 501 ( 3.1A)
 0.78A 3kp6A-5ijzA:
undetectable		 3kp6A-5ijzA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_2
(TYROSINE-PROTEIN
KINASE BTK)		 5ijz NADP-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		4 / 5 PHE A 365
ILE A 224
ASN A 347
PHE A 341
 None
None
AKG  A 502 ( 3.6A)
None
 1.38A 3octA-5ijzA:
undetectable		 3octA-5ijzA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BUP_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 5ijz NADP-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		3 / 3 HIS A  25
GLU A  23
ASN A 102
 None
 0.95A 4bupB-5ijzA:
0.4		 4bupB-5ijzA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTZ_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 8C8)		 5ijz NADP-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		4 / 6 PHE A 358
ALA A 331
ALA A 317
LEU A 326
 None
 1.09A 4dtzB-5ijzA:
undetectable		 4dtzB-5ijzA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F84_A_SAMA501_0
(GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E)		 5ijz NADP-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		5 / 12 GLY A 129
GLY A  93
VAL A  82
GLN A 113
VAL A 101
 None
AKG  A 502 (-3.4A)
None
AKG  A 502 (-2.9A)
None
 1.15A 4f84A-5ijzA:
3.9		 4f84A-5ijzA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_2
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 5ijz NADP-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		4 / 4 LEU A  14
LEU A  54
GLN A  26
GLU A  33
 None
 1.22A 4i41A-5ijzA:
undetectable		 4i41A-5ijzA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIL_A_RBFA401_2
(MEMBRANE LIPOPROTEIN
TPN38(B))		 5ijz NADP-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		4 / 8 PRO A  99
VAL A 101
GLN A 323
ILE A 169
 None
None
None
NAP  A 501 (-4.1A)
 1.05A 4iilA-5ijzA:
5.0		 4iilA-5ijzA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A206_1
(UNCHARACTERIZED
PROTEIN)		 5ijz NADP-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		5 / 10 PHE A 146
TYR A 178
GLY A 173
PHE A  97
LEU A  95
 None
 1.49A 4kouA-5ijzA:
undetectable		 4kouA-5ijzA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_B_SAMB601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 5ijz NADP-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		5 / 12 GLY A 130
GLY A 129
ASP A 168
ILE A  62
ASN A 102
 None
None
NAP  A 501 (-2.6A)
None
None
 0.80A 4obwB-5ijzA:
4.0		 4obwB-5ijzA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA602_1
(SERUM ALBUMIN)		 5ijz NADP-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		5 / 9 PHE A 262
ALA A 245
ALA A 248
LEU A 280
VAL A 277
 None
 1.27A 4or0A-5ijzA:
undetectable		 4or0A-5ijzA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP9_A_ASCA501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)		 5ijz NADP-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		5 / 12 THR A 415
TYR A 419
ASP A 439
ALA A 438
ILE A 431
 None
 1.11A 4rp9A-5ijzA:
undetectable		 4rp9A-5ijzA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XNX_A_41XA707_1
(TRANSPORTER)		 5ijz NADP-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		5 / 11 ASP A 398
ALA A 248
VAL A 217
TYR A 218
GLY A 213
 None
 1.21A 4xnxA-5ijzA:
undetectable		 4xnxA-5ijzA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP1_A_LDPA708_1
(DOPAMINE
TRANSPORTER, ISOFORM
B)		 5ijz NADP-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		5 / 10 ASP A 398
ALA A 248
VAL A 217
TYR A 218
GLY A 213
 None
 1.19A 4xp1A-5ijzA:
undetectable		 4xp1A-5ijzA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_A_SAMA301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5ijz NADP-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		5 / 12 ALA A 166
GLY A 204
THR A 201
GLU A 382
SER A 379
 AKG  A 502 (-3.3A)
None
None
None
AKG  A 502 (-2.5A)
 1.22A 5hfjA-5ijzA:
undetectable		 5hfjA-5ijzA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_A_SAMA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 5ijz NADP-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		3 / 3 HIS A  25
GLU A  23
ASN A 102
 None
 0.88A 5wbvA-5ijzA:
undetectable		 5wbvA-5ijzA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WBV_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
KMT5B)		 5ijz NADP-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		3 / 3 HIS A  25
GLU A  23
ASN A 102
 None
 0.89A 5wbvB-5ijzA:
0.1		 5wbvB-5ijzA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FI4_B_DVAB8_0
(14-3-3 PROTEIN SIGMA
PRO-SEP-LEU-PRO-DVA)		 5ijz NADP-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		4 / 5 SER A 379
VAL A 376
ASN A 117
PRO A 165
 AKG  A 502 (-2.5A)
AKG  A 502 (-4.1A)
None
None
 1.39A 6fi4A-5ijzA:
undetectable
6fi4B-5ijzA:
undetectable		 6fi4A-5ijzA:
20.90
6fi4B-5ijzA:
7.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_1
(-)		 5ijz NADP-SPECIFIC
GLUTAMATE
DEHYDROGENASE
(Corynebacterium
glutamicum) 		5 / 12 GLY A  94
GLY A  93
VAL A 376
ASN A 117
GLY A 126
 AKG  A 502 (-3.7A)
AKG  A 502 (-3.4A)
AKG  A 502 (-4.1A)
None
None
 1.17A 6gneA-5ijzA:
3.1		 6gneA-5ijzA:
21.76