SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ik8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_B_SAMB105_0
(PROTEIN (MET
REPRESSOR))		 5ik8 LAMININ SUBUNIT
ALPHA-2
(Mus
musculus) 		5 / 11 LEU A3105
LEU A3107
ALA A2946
PHE A3061
GLY A3063
 None
 1.32A 1cmaA-5ik8A:
undetectable
1cmaB-5ik8A:
undetectable		 1cmaA-5ik8A:
13.39
1cmaB-5ik8A:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_A_SAMA105_0
(MET REPRESSOR)		 5ik8 LAMININ SUBUNIT
ALPHA-2
(Mus
musculus) 		5 / 10 ALA A2946
PHE A3061
GLY A3063
LEU A3105
LEU A3107
 None
 1.34A 1cmcA-5ik8A:
undetectable
1cmcB-5ik8A:
undetectable		 1cmcA-5ik8A:
13.39
1cmcB-5ik8A:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_B_SAMB105_0
(MET REPRESSOR)		 5ik8 LAMININ SUBUNIT
ALPHA-2
(Mus
musculus) 		5 / 10 LEU A3105
LEU A3107
ALA A2946
PHE A3061
GLY A3063
 None
 1.34A 1cmcA-5ik8A:
undetectable
1cmcB-5ik8A:
undetectable		 1cmcA-5ik8A:
13.39
1cmcB-5ik8A:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_A_SAMA200_0
(METHIONINE REPRESSOR)		 5ik8 LAMININ SUBUNIT
ALPHA-2
(Mus
musculus) 		5 / 11 LEU A3105
LEU A3107
ALA A2946
PHE A3061
GLY A3063
 None
 1.35A 1mjqA-5ik8A:
undetectable
1mjqB-5ik8A:
undetectable		 1mjqA-5ik8A:
13.39
1mjqB-5ik8A:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_C_SAMC199_0
(METHIONINE REPRESSOR)		 5ik8 LAMININ SUBUNIT
ALPHA-2
(Mus
musculus) 		5 / 10 LEU A3105
LEU A3107
ALA A2946
PHE A3061
GLY A3063
 None
 1.35A 1mjqC-5ik8A:
undetectable
1mjqD-5ik8A:
undetectable		 1mjqC-5ik8A:
13.39
1mjqD-5ik8A:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_I_SAMI199_0
(METHIONINE REPRESSOR)		 5ik8 LAMININ SUBUNIT
ALPHA-2
(Mus
musculus) 		5 / 11 LEU A3105
LEU A3107
ALA A2946
PHE A3061
GLY A3063
 None
 1.35A 1mjqI-5ik8A:
undetectable
1mjqJ-5ik8A:
undetectable		 1mjqI-5ik8A:
13.39
1mjqJ-5ik8A:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_J_FUAJ711_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5ik8 LAMININ SUBUNIT
ALPHA-2
(Mus
musculus) 		5 / 11 PHE A2940
PHE A3080
LEU A3089
VAL A2960
VAL A3060
 None
 1.13A 1q23J-5ik8A:
undetectable		 1q23J-5ik8A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_B_SAMB302_0
(HEMK PROTEIN)		 5ik8 LAMININ SUBUNIT
ALPHA-2
(Mus
musculus) 		5 / 12 ILE A2986
GLY A2985
GLY A3073
VAL A2976
SER A2977
 None
 0.95A 1sg9B-5ik8A:
undetectable		 1sg9B-5ik8A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WD9_C_IBPC1570_1
(ACYL-COENZYME A
SYNTHETASE ACSM2A,
MITOCHONDRIAL)		 5ik8 LAMININ SUBUNIT
ALPHA-2
(Mus
musculus) 		5 / 10 THR A2892
GLY A2884
GLY A2796
GLN A2813
THR A2899
 None
 1.24A 2wd9C-5ik8A:
undetectable		 2wd9C-5ik8A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 5ik8 LAMININ SUBUNIT
ALPHA-2
(Mus
musculus) 		3 / 3 GLY A2975
GLY A3073
GLY A2985
 None
 0.42A 3bogC-5ik8A:
undetectable		 3bogC-5ik8A:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB303_0
(DISULFIDE
INTERCHANGE PROTEIN)		 5ik8 LAMININ SUBUNIT
ALPHA-2
(Mus
musculus) 		4 / 4 LEU A2974
ALA A2948
VAL A2949
PRO A3059
 None
 1.03A 3gv1B-5ik8A:
undetectable		 3gv1B-5ik8A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HKU_A_TORA300_2
(CARBONIC ANHYDRASE 2)		 5ik8 LAMININ SUBUNIT
ALPHA-2
(Mus
musculus) 		3 / 3 GLU A2987
HIS A2996
THR A3075
 None
 0.80A 3hkuA-5ik8A:
undetectable		 3hkuA-5ik8A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5ik8 LAMININ SUBUNIT
ALPHA-2
(Mus
musculus) 		5 / 12 TYR A2820
GLY A2817
GLY A2796
SER A2795
LEU A2798
 None
 1.22A 3ou7A-5ik8A:
undetectable		 3ou7A-5ik8A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 5ik8 LAMININ SUBUNIT
ALPHA-2
(Mus
musculus) 		5 / 12 TYR A2820
GLY A2817
GLY A2796
SER A2795
LEU A2798
 None
 1.21A 3ou7D-5ik8A:
undetectable		 3ou7D-5ik8A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3R_A_9PLA501_1
(CYTOCHROME P450 2A6)		 5ik8 LAMININ SUBUNIT
ALPHA-2
(Mus
musculus) 		5 / 11 VAL A3024
PHE A3080
ILE A3084
THR A2966
LEU A2993
 None
 1.10A 3t3rA-5ik8A:
undetectable		 3t3rA-5ik8A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TOP_B_ACRB1_2
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 5ik8 LAMININ SUBUNIT
ALPHA-2
(Mus
musculus) 		4 / 5 PRO A2753
ILE A3084
TRP A3021
PHE A2931
 None
None
None
EDO  A4009 ( 4.4A)
 1.19A 3topB-5ik8A:
undetectable		 3topB-5ik8A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		 5ik8 LAMININ SUBUNIT
ALPHA-2
(Mus
musculus) 		4 / 7 ILE A3084
ILE A2986
LEU A3089
VAL A3099
 None
 0.83A 3ua5B-5ik8A:
undetectable		 3ua5B-5ik8A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PBH_A_BEZA401_0
(TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE)		 5ik8 LAMININ SUBUNIT
ALPHA-2
(Mus
musculus) 		5 / 12 THR A2892
HIS A2806
THR A2811
ALA A2802
LEU A2886
 None
 1.45A 4pbhA-5ik8A:
undetectable		 4pbhA-5ik8A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 5ik8 LAMININ SUBUNIT
ALPHA-2
(Mus
musculus) 		5 / 12 VAL A3110
PHE A3080
LEU A3087
PHE A2962
GLY A3063
 EDO  A4009 (-4.3A)
None
None
None
None
 1.44A 4pevC-5ik8A:
undetectable		 4pevC-5ik8A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 5ik8 LAMININ SUBUNIT
ALPHA-2
(Mus
musculus) 		5 / 12 ALA A2946
THR A3056
VAL A2954
LEU A2974
LEU A3074
 None
 1.31A 4qzuA-5ik8A:
undetectable		 4qzuA-5ik8A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_A_ADNA303_1
(5'/3'-NUCLEOTIDASE
SURE)		 5ik8 LAMININ SUBUNIT
ALPHA-2
(Mus
musculus) 		5 / 10 GLY A2885
TYR A2882
ALA A2802
LEU A2886
LEU A2797
 None
 0.97A 4xj7A-5ik8A:
undetectable
4xj7B-5ik8A:
undetectable		 4xj7A-5ik8A:
22.51
4xj7B-5ik8A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MM4_B_TA1B501_1
(TUBULIN BETA CHAIN)		 5ik8 LAMININ SUBUNIT
ALPHA-2
(Mus
musculus) 		5 / 10 LEU A2783
ALA A2771
SER A2923
THR A2811
PRO A2887
 None
 1.29A 5mm4B-5ik8A:
undetectable		 5mm4B-5ik8A:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MM4_B_TA1B501_1
(TUBULIN BETA CHAIN)		 5ik8 LAMININ SUBUNIT
ALPHA-2
(Mus
musculus) 		5 / 10 LEU A2783
SER A2923
THR A2811
PRO A2887
LEU A2886
 None
 1.23A 5mm4B-5ik8A:
undetectable		 5mm4B-5ik8A:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MM4_B_TA1B501_1
(TUBULIN BETA CHAIN)		 5ik8 LAMININ SUBUNIT
ALPHA-2
(Mus
musculus) 		5 / 10 LEU A2875
SER A2923
THR A2811
PRO A2887
LEU A2886
 None
 1.08A 5mm4B-5ik8A:
undetectable		 5mm4B-5ik8A:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 5ik8 LAMININ SUBUNIT
ALPHA-2
(Mus
musculus) 		4 / 7 PHE A2799
THR A2866
ILE A2848
GLY A2855
 None
 0.99A 5nzyA-5ik8A:
undetectable		 5nzyA-5ik8A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 5ik8 LAMININ SUBUNIT
ALPHA-2
(Mus
musculus) 		3 / 3 LYS A3095
PRO A3096
LYS A3088
 None
 1.27A 5y9yA-5ik8A:
undetectable		 5y9yA-5ik8A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DIF_B_TPVB201_0
(HIV-1 PROTEASE)		 5ik8 LAMININ SUBUNIT
ALPHA-2
(Mus
musculus) 		5 / 12 ALA A2862
ASP A2861
ASP A2860
ILE A2856
ILE A2834
 None
 1.13A 6difA-5ik8A:
undetectable		 6difA-5ik8A:
12.63