SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ikf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_X_BRLX504_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 5ikf CHROMATIN REMODELING
FACTOR MIT1
CRYPTIC LOCI
REGULATOR PROTEIN 1
(Schizosaccharomy
ces
pombe) 		5 / 12 ILE A1316
GLY A1315
CYH A1314
LEU B 389
LEU B 398
 CL  A1503 ( 4.2A)
None
ZN  A1501 (-2.3A)
None
None
 1.40A 1fm6X-5ikfA:
undetectable		 1fm6X-5ikfA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BNN_B_FCNB1199_1
(EPOXIDASE)		 5ikf CHROMATIN REMODELING
FACTOR MIT1
CRYPTIC LOCI
REGULATOR PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 8 LEU B 414
HIS A1284
GLU A1281
ALA B 415
 None
 1.01A 2bnnA-5ikfB:
undetectable
2bnnB-5ikfB:
undetectable		 2bnnA-5ikfB:
21.88
2bnnB-5ikfB:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)		 5ikf CHROMATIN REMODELING
FACTOR MIT1
CRYPTIC LOCI
REGULATOR PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 7 LEU B 422
ASN B 419
GLU A1281
LEU A1325
 None
 1.21A 2w8yA-5ikfB:
undetectable		 2w8yA-5ikfB:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)		 5ikf CRYPTIC LOCI
REGULATOR PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 7 LEU B 398
ASN B 399
GLU B 390
LEU B 391
 None
 1.13A 2w8yA-5ikfB:
undetectable		 2w8yA-5ikfB:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIA_A_SAMA206_0
(UPF0217 PROTEIN
MJ1640)		 5ikf CHROMATIN REMODELING
FACTOR MIT1
(Schizosaccharomy
ces
pombe) 		4 / 6 LEU A1335
GLY A1337
LEU A1350
CYH A1347
 ZN  A1502 ( 4.8A)
None
None
ZN  A1502 (-2.3A)
 0.93A 3aiaA-5ikfA:
undetectable		 3aiaA-5ikfA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_D_SAMD301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 5ikf CHROMATIN REMODELING
FACTOR MIT1
(Schizosaccharomy
ces
pombe) 		5 / 12 SER A1244
THR A1245
SER A1326
ASP A1269
LEU A1286
 None
 1.18A 3iv6D-5ikfA:
undetectable		 3iv6D-5ikfA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O02_B_JN3B1_1
(CELL INVASION
PROTEIN SIPD)		 5ikf CHROMATIN REMODELING
FACTOR MIT1
CRYPTIC LOCI
REGULATOR PROTEIN 1
(Schizosaccharomy
ces
pombe) 		5 / 10 ILE B 364
PHE A1370
ALA A1376
LEU A1359
LEU A1380
 None
 1.24A 3o02A-5ikfB:
undetectable
3o02B-5ikfB:
undetectable		 3o02A-5ikfB:
21.52
3o02B-5ikfB:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5J_A_08HA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5ikf CHROMATIN REMODELING
FACTOR MIT1
(Schizosaccharomy
ces
pombe) 		4 / 7 PRO A1275
LEU A1286
LEU A1330
ILE A1279
 None
 0.99A 3u5jA-5ikfA:
undetectable		 3u5jA-5ikfA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 5ikf CHROMATIN REMODELING
FACTOR MIT1
CRYPTIC LOCI
REGULATOR PROTEIN 1
(Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe) 		3 / 3 ASP A1270
LYS B 357
LEU B 359
 None
 1.08A 4ptjA-5ikfA:
undetectable		 4ptjA-5ikfA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA603_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 5ikf CHROMATIN REMODELING
FACTOR MIT1
(Schizosaccharomy
ces
pombe) 		3 / 3 TYR A1357
ASN A1381
LEU A1384
 None
 0.78A 6b58A-5ikfA:
2.8		 6b58A-5ikfA:
17.99