SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ikj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_A_EAAA224_1
(GLUTATHIONE
TRANSFERASE)		 5ikj CRYPTIC LOCI
REGULATOR 2
CRYPTIC LOCI
REGULATOR PROTEIN 1
(Schizosaccharomy
ces
pombe) 		5 / 12 TYR A 522
PHE A 521
LEU B1183
LEU A 508
VAL A 511
 None
None
None
CL  B1301 ( 4.7A)
None
 1.16A 1gseA-5ikjA:
undetectable		 1gseA-5ikjA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_B_AG2B7011_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 5ikj CRYPTIC LOCI
REGULATOR 2
CRYPTIC LOCI
REGULATOR PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 5 GLU B1226
ARG A 232
ASP A 382
LEU A 383
 None
 1.06A 1n13B-5ikjB:
undetectable
1n13C-5ikjB:
undetectable		 1n13B-5ikjB:
19.66
1n13C-5ikjB:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_L_AG2L7014_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 5ikj CRYPTIC LOCI
REGULATOR 2
CRYPTIC LOCI
REGULATOR PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 7 ASP A 382
LEU A 383
GLU B1226
ARG A 232
 None
 1.06A 1n13I-5ikjA:
undetectable
1n13L-5ikjA:
undetectable		 1n13I-5ikjA:
5.88
1n13L-5ikjA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_1
(PROTEASE)		 5ikj CRYPTIC LOCI
REGULATOR 2
CRYPTIC LOCI
REGULATOR PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 7 ASP A 223
GLY A 370
PRO B1221
ILE B1225
 None
 0.65A 1n49A-5ikjA:
undetectable		 1n49A-5ikjA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_2
(PROTEASE)		 5ikj CRYPTIC LOCI
REGULATOR 2
CRYPTIC LOCI
REGULATOR PROTEIN 1
(Schizosaccharomy
ces
pombe) 		4 / 6 ASP A 223
GLY A 370
PRO B1221
ILE B1225
 None
 0.62A 1n49D-5ikjA:
undetectable		 1n49D-5ikjA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_2
(DIPEPTIDYL PEPTIDASE
IV)		 5ikj CRYPTIC LOCI
REGULATOR 2
(Schizosaccharomy
ces
pombe) 		3 / 3 PHE A 489
TYR A 279
TYR A 277
 None
 0.86A 1x70B-5ikjA:
undetectable		 1x70B-5ikjA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRD_A_MIYA2001_1
(ACRB)		 5ikj CRYPTIC LOCI
REGULATOR 2
(Schizosaccharomy
ces
pombe) 		5 / 9 PHE A 372
GLY A 374
ILE A 319
ALA A 510
VAL A 511
 None
 1.08A 2drdA-5ikjA:
undetectable		 2drdA-5ikjA:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_A_ADNA1501_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 5ikj CRYPTIC LOCI
REGULATOR 2
(Schizosaccharomy
ces
pombe) 		4 / 7 GLU A 312
LYS A 282
PRO A 247
ALA A 248
 None
 1.06A 2ejgA-5ikjA:
undetectable		 2ejgA-5ikjA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_B_ADNB1502_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 5ikj CRYPTIC LOCI
REGULATOR 2
(Schizosaccharomy
ces
pombe) 		4 / 7 GLU A 312
LYS A 282
PRO A 247
ALA A 248
 None
 1.09A 2ejgB-5ikjA:
undetectable		 2ejgB-5ikjA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5ikj CRYPTIC LOCI
REGULATOR 2
(Schizosaccharomy
ces
pombe) 		4 / 7 GLY A 374
THR A 322
PHE A 477
PHE A 416
 None
 1.22A 2qx4A-5ikjA:
undetectable
2qx4B-5ikjA:
undetectable		 2qx4A-5ikjA:
17.64
2qx4B-5ikjA:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_0
(MODIFICATION
METHYLASE HHAI)		 5ikj CRYPTIC LOCI
REGULATOR 2
CRYPTIC LOCI
REGULATOR PROTEIN 1
(Schizosaccharomy
ces
pombe;
Schizosaccharomy
ces
pombe) 		5 / 12 PHE A 342
GLY B1227
ASP A 344
ILE A 122
TYR A 225
 None
 1.18A 3eeoA-5ikjA:
undetectable		 3eeoA-5ikjA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTP_A_017A201_1
(HIV-1 PROTEASE)		 5ikj CRYPTIC LOCI
REGULATOR 2
CRYPTIC LOCI
REGULATOR PROTEIN 1
(Schizosaccharomy
ces
pombe) 		5 / 10 ASP A 223
GLY A 370
PRO B1221
LEU B1224
ILE B1225
 None
 0.85A 3ttpA-5ikjA:
undetectable		 3ttpA-5ikjA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTP_A_017A201_2
(HIV-1 PROTEASE)		 5ikj CRYPTIC LOCI
REGULATOR 2
CRYPTIC LOCI
REGULATOR PROTEIN 1
(Schizosaccharomy
ces
pombe) 		5 / 10 ASP A 223
GLY A 370
PRO B1221
LEU B1224
ILE B1225
 None
 0.87A 3ttpB-5ikjA:
undetectable		 3ttpB-5ikjA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRJ_A_RAPA201_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
SERINE/THREONINE-PRO
TEIN KINASE MTOR)		 5ikj CRYPTIC LOCI
REGULATOR 2
(Schizosaccharomy
ces
pombe) 		4 / 8 LEU A 526
PHE A 291
ASP A 520
TYR A 522
 None
 1.03A 4drjB-5ikjA:
undetectable		 4drjB-5ikjA:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DX5_B_MIYB1103_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 5ikj CRYPTIC LOCI
REGULATOR 2
(Schizosaccharomy
ces
pombe) 		5 / 12 PHE A 372
GLY A 374
ILE A 319
ALA A 510
VAL A 511
 None
 0.80A 4dx5B-5ikjA:
0.0		 4dx5B-5ikjA:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_C_LYAC304_2
(FOLATE RECEPTOR BETA)		 5ikj CRYPTIC LOCI
REGULATOR 2
CRYPTIC LOCI
REGULATOR PROTEIN 1
(Schizosaccharomy
ces
pombe) 		3 / 3 TYR A 180
GLN B1231
TRP A   8
 None
 1.02A 4kn2C-5ikjA:
undetectable		 4kn2C-5ikjA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTP_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 5ikj CRYPTIC LOCI
REGULATOR 2
(Schizosaccharomy
ces
pombe) 		5 / 12 SER A 165
ASN A 189
SER A 184
TYR A 180
GLN A 210
 None
 1.23A 4rtpA-5ikjA:
undetectable		 4rtpA-5ikjA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U8V_B_MIYB1103_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 5ikj CRYPTIC LOCI
REGULATOR 2
(Schizosaccharomy
ces
pombe) 		5 / 12 PHE A 372
GLY A 374
ILE A 319
ALA A 510
VAL A 511
 None
 0.78A 4u8vB-5ikjA:
undetectable		 4u8vB-5ikjA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U8Y_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 5ikj CRYPTIC LOCI
REGULATOR 2
(Schizosaccharomy
ces
pombe) 		5 / 12 PHE A 372
GLY A 374
ILE A 319
ALA A 510
VAL A 511
 None
 0.82A 4u8yB-5ikjA:
undetectable		 4u8yB-5ikjA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U95_B_MIYB1102_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 5ikj CRYPTIC LOCI
REGULATOR 2
(Schizosaccharomy
ces
pombe) 		5 / 12 PHE A 372
GLY A 374
ILE A 319
ALA A 510
VAL A 511
 None
 0.83A 4u95B-5ikjA:
undetectable		 4u95B-5ikjA:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_E_SC2E1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 5ikj CRYPTIC LOCI
REGULATOR 2
(Schizosaccharomy
ces
pombe) 		3 / 3 VAL A 172
GLN A  46
CYH A  48
 None
 0.57A 5icxA-5ikjA:
undetectable
5icxE-5ikjA:
undetectable		 5icxA-5ikjA:
19.43
5icxE-5ikjA:
2.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ICX_F_SC2F1_1
(CETUXIMAB FAB LIGHT
CHAIN
MEDITOPE)		 5ikj CRYPTIC LOCI
REGULATOR 2
(Schizosaccharomy
ces
pombe) 		3 / 3 VAL A 172
GLN A  46
CYH A  48
 None
 0.92A 5icxC-5ikjA:
undetectable
5icxF-5ikjA:
undetectable		 5icxC-5ikjA:
19.43
5icxF-5ikjA:
2.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_D_CVID301_1
(REGULATORY PROTEIN
TETR)		 5ikj CRYPTIC LOCI
REGULATOR 2
(Schizosaccharomy
ces
pombe) 		4 / 8 GLY A 285
GLU A 514
ILE A 319
TRP A 301
 None
 1.06A 5vlmD-5ikjA:
undetectable		 5vlmD-5ikjA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_0
(NS3 PROTEASE)		 5ikj CRYPTIC LOCI
REGULATOR 2
(Schizosaccharomy
ces
pombe) 		5 / 12 PHE A 372
GLY A 234
VAL A 517
GLY A 374
ALA A 316
 None
 1.20A 6c2mB-5ikjA:
0.7		 6c2mB-5ikjA:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 5ikj CRYPTIC LOCI
REGULATOR 2
(Schizosaccharomy
ces
pombe) 		4 / 8 ILE A  66
GLN A  64
THR A 352
VAL A 353
 None
 1.17A 6fbvC-5ikjA:
undetectable		 6fbvC-5ikjA:
17.61