SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ikk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_D_PPFD412_1
(PHOSPHONOACETATE
HYDROLASE)		 5ikk HISTONE DEACETYLASE
CLR3
(Schizosaccharomy
ces
pombe) 		4 / 8 ASP A 234
HIS A 195
ILE A 334
HIS A 236
 ZN  A 701 ( 1.7A)
ZN  A 701 (-2.9A)
None
ZN  A 701 ( 3.1A)
 1.00A 1ei6D-5ikkA:
2.1		 1ei6D-5ikkA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1502_0
(FERROCHELATASE)		 5ikk HISTONE DEACETYLASE
CLR3
(Schizosaccharomy
ces
pombe) 		4 / 8 MET A 309
PRO A 317
VAL A 359
GLY A 357
 None
 0.98A 1hrkA-5ikkA:
4.1		 1hrkA-5ikkA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2502_0
(FERROCHELATASE)		 5ikk HISTONE DEACETYLASE
CLR3
(Schizosaccharomy
ces
pombe) 		4 / 8 MET A 309
PRO A 317
VAL A 359
GLY A 357
 None
 0.96A 1hrkB-5ikkA:
4.0		 1hrkB-5ikkA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_2
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 5ikk HISTONE DEACETYLASE
CLR3
(Schizosaccharomy
ces
pombe) 		4 / 7 VAL A  97
CYH A 324
ARG A  83
CYH A  60
 None
None
EDO  A 710 ( 3.7A)
None
 1.27A 1t46A-5ikkA:
undetectable		 1t46A-5ikkA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TMX_B_BEZB882_0
(HYDROXYQUINOL
1,2-DIOXYGENASE)		 5ikk HISTONE DEACETYLASE
CLR3
(Schizosaccharomy
ces
pombe) 		5 / 12 LEU A 363
PRO A 191
HIS A  77
HIS A  68
VAL A  84
 None
None
ZN  A 703 (-2.8A)
ZN  A 703 (-3.2A)
None
 1.17A 1tmxB-5ikkA:
undetectable		 1tmxB-5ikkA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q7L_A_TESA155_1
(ANDROGEN RECEPTOR)		 5ikk HISTONE DEACETYLASE
CLR3
(Schizosaccharomy
ces
pombe) 		5 / 12 LEU A 587
ASN A 586
LEU A 584
GLY A 583
VAL A 559
 None
 1.41A 2q7lA-5ikkA:
undetectable		 2q7lA-5ikkA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_A_SALA257_1
(TRANSCRIPTIONAL
REGULATOR)		 5ikk HISTONE DEACETYLASE
CLR3
(Schizosaccharomy
ces
pombe) 		4 / 8 ALA A 170
CYH A 174
ILE A 321
THR A 213
 None
 0.87A 3bpxA-5ikkA:
undetectable
3bpxB-5ikkA:
undetectable		 3bpxA-5ikkA:
11.94
3bpxB-5ikkA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		 5ikk HISTONE DEACETYLASE
CLR3
(Schizosaccharomy
ces
pombe) 		4 / 8 ASP A 234
HIS A 236
ASP A 327
GLY A 365
 ZN  A 701 ( 1.7A)
ZN  A 701 ( 3.1A)
ZN  A 701 (-2.5A)
ZN  A 701 ( 4.5A)
 0.25A 3c0zB-5ikkA:
43.4		 3c0zB-5ikkA:
26.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 5ikk HISTONE DEACETYLASE
CLR3
(Schizosaccharomy
ces
pombe) 		4 / 4 LEU A 282
GLY A 281
GLY A 283
THR A 285
 None
None
None
K  A 702 ( 4.7A)
 0.94A 3si7A-5ikkA:
2.0		 3si7A-5ikkA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T01_A_PPFA503_1
(PHOSPHONOACETATE
HYDROLASE)		 5ikk HISTONE DEACETYLASE
CLR3
(Schizosaccharomy
ces
pombe) 		4 / 7 ASP A 234
HIS A 195
ILE A 334
HIS A 236
 ZN  A 701 ( 1.7A)
ZN  A 701 (-2.9A)
None
ZN  A 701 ( 3.1A)
 1.03A 3t01A-5ikkA:
undetectable		 3t01A-5ikkA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BZ6_A_SHHA700_1
(HISTONE DEACETYLASE
8)		 5ikk HISTONE DEACETYLASE
CLR3
(Schizosaccharomy
ces
pombe) 		5 / 10 ASP A 234
HIS A 236
ASP A 327
GLY A 365
TYR A 367
 ZN  A 701 ( 1.7A)
ZN  A 701 ( 3.1A)
ZN  A 701 (-2.5A)
ZN  A 701 ( 4.5A)
EDO  A 710 (-4.6A)
 0.71A 4bz6A-5ikkA:
32.0		 4bz6A-5ikkA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HXY_B_ACAB502_1
(PLM1)		 5ikk HISTONE DEACETYLASE
CLR3
(Schizosaccharomy
ces
pombe) 		4 / 7 VAL A 585
SER A 628
TYR A 624
LEU A 609
 None
 1.26A 4hxyB-5ikkA:
undetectable		 4hxyB-5ikkA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDQ_A_BEZA306_0
(GLYCOSIDE HYDROLASE
FAMILY PROTEIN)		 5ikk HISTONE DEACETYLASE
CLR3
(Schizosaccharomy
ces
pombe) 		3 / 3 ARG A 591
ASP A 561
TRP A 560
 None
 1.22A 4xdqA-5ikkA:
undetectable		 4xdqA-5ikkA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_B_ASDB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 5ikk HISTONE DEACETYLASE
CLR3
(Schizosaccharomy
ces
pombe) 		4 / 7 VAL A 308
ILE A 404
TRP A 290
LEU A 339
 None
 1.23A 4xo7B-5ikkA:
undetectable		 4xo7B-5ikkA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSU_B_SAMB1304_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2)		 5ikk HISTONE DEACETYLASE
CLR3
(Schizosaccharomy
ces
pombe) 		3 / 3 ASN A 602
TYR A 624
CYH A 599
 None
 0.84A 5lsuB-5ikkA:
undetectable		 5lsuB-5ikkA:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_1
(REGULATORY PROTEIN
TETR)		 5ikk HISTONE DEACETYLASE
CLR3
(Schizosaccharomy
ces
pombe) 		4 / 7 GLY A 325
ILE A 235
ASP A 332
TYR A 367
 None
None
None
EDO  A 710 (-4.6A)
 1.06A 5vlmC-5ikkA:
undetectable		 5vlmC-5ikkA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH0_A_017A101_1
(PROTEASE)		 5ikk HISTONE DEACETYLASE
CLR3
(Schizosaccharomy
ces
pombe) 		5 / 12 GLY A 357
ALA A 355
ASP A 318
VAL A 231
VAL A 320
 None
 1.08A 6dh0B-5ikkA:
undetectable		 6dh0B-5ikkA:
9.18