SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ikn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 5ikn DNA PRIMASE/HELICASE
(Escherichia
virus
T7) 		4 / 7 VAL D 459
VAL D 310
ILE D 422
LEU D 502
 None
 0.87A 1iepB-5iknD:
undetectable		 1iepB-5iknD:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_4
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 5ikn THIOREDOXIN-1
(Escherichia
coli) 		4 / 5 LEU K  94
CYH K  35
ALA K  29
CYH K  32
 None
 1.04A 1mz9D-5iknK:
undetectable		 1mz9D-5iknK:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_A_GBNA502_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 5ikn DNA PRIMASE/HELICASE
(Escherichia
virus
T7) 		4 / 8 ARG D 359
GLY D 330
THR D 331
ALA D 332
 None
 0.66A 2a1hA-5iknD:
undetectable
2a1hB-5iknD:
undetectable		 2a1hA-5iknD:
21.26
2a1hB-5iknD:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_A_LPRA705_1
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 5ikn DNA PRIMASE/HELICASE
(Escherichia
virus
T7) 		5 / 12 HIS D 180
ALA D 184
GLU D 159
HIS D 136
TYR D 111
 None
 1.31A 2c6nA-5iknD:
undetectable		 2c6nA-5iknD:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 5ikn DNA PRIMASE/HELICASE
(Escherichia
virus
T7) 		3 / 3 ARG D 124
ASN D  70
THR D 133
 None
 0.78A 2q63A-5iknD:
undetectable		 2q63A-5iknD:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_A_REAA1445_1
(PUTATIVE CYTOCHROME
P450 120)		 5ikn DNA PRIMASE/HELICASE
(Escherichia
virus
T7) 		5 / 12 THR D 188
ALA D 219
LEU D 223
PHE D 196
GLY D 158
 None
 1.05A 2ve3A-5iknD:
undetectable		 2ve3A-5iknD:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B302_1
(THIOPURINE
S-METHYLTRANSFERASE)		 5ikn THIOREDOXIN-1
(Escherichia
coli) 		4 / 7 PHE K 102
LEU K  80
LEU K  53
LEU K  24
 None
 0.85A 3bgdB-5iknK:
undetectable		 3bgdB-5iknK:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_A_ADNA300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 5ikn DNA PRIMASE/HELICASE
(Escherichia
virus
T7) 		5 / 11 ALA D 326
VAL D 420
GLY D 330
LEU D 339
THR D 390
 None
 1.16A 3kw2A-5iknD:
undetectable		 3kw2A-5iknD:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_B_ADNB300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 5ikn DNA PRIMASE/HELICASE
(Escherichia
virus
T7) 		5 / 11 ALA D 326
VAL D 420
GLY D 330
LEU D 339
THR D 390
 None
 1.20A 3kw2B-5iknD:
undetectable		 3kw2B-5iknD:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_F_ASWF101_1
(DNA TOPOISOMERASE
2-BETA)		 5ikn DNA PRIMASE/HELICASE
(Escherichia
virus
T7) 		4 / 6 PRO D 469
ARG D 479
GLY D 478
GLU D 476
 None
 1.08A 4g0uA-5iknD:
7.1		 4g0uA-5iknD:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_B_CHDB102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5ikn THIOREDOXIN-1
(Escherichia
coli) 		5 / 11 LEU K 103
LEU K  24
LEU K  99
GLU K  44
LEU K  42
 None
 0.99A 4wg0B-5iknK:
undetectable
4wg0C-5iknK:
undetectable
4wg0D-5iknK:
undetectable		 4wg0B-5iknK:
7.62
4wg0C-5iknK:
7.62
4wg0D-5iknK:
7.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_D_CHDD102_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5ikn THIOREDOXIN-1
(Escherichia
coli) 		5 / 11 LEU K 103
LEU K  24
LEU K  99
GLU K  44
LEU K  42
 None
 0.98A 4wg0D-5iknK:
undetectable
4wg0E-5iknK:
undetectable
4wg0F-5iknK:
undetectable		 4wg0D-5iknK:
7.62
4wg0E-5iknK:
7.62
4wg0F-5iknK:
7.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_F_CHDF103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5ikn THIOREDOXIN-1
(Escherichia
coli) 		5 / 11 LEU K 103
LEU K  24
LEU K  99
GLU K  44
LEU K  42
 None
 0.97A 4wg0F-5iknK:
undetectable
4wg0G-5iknK:
undetectable
4wg0H-5iknK:
undetectable		 4wg0F-5iknK:
7.62
4wg0G-5iknK:
7.62
4wg0H-5iknK:
7.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_I_CHDI103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5ikn THIOREDOXIN-1
(Escherichia
coli) 		5 / 11 GLU K  44
LEU K  42
LEU K  99
LEU K 103
LEU K  24
 None
 1.01A 4wg0G-5iknK:
undetectable
4wg0H-5iknK:
undetectable
4wg0I-5iknK:
undetectable		 4wg0G-5iknK:
7.62
4wg0H-5iknK:
7.62
4wg0I-5iknK:
7.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_J_CHDJ103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 5ikn THIOREDOXIN-1
(Escherichia
coli) 		5 / 11 LEU K 103
LEU K  24
LEU K  99
GLU K  44
LEU K  42
 None
 1.17A 4wg0J-5iknK:
undetectable
4wg0K-5iknK:
undetectable
4wg0L-5iknK:
undetectable		 4wg0J-5iknK:
7.62
4wg0K-5iknK:
7.62
4wg0L-5iknK:
7.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_1
(ESTROGEN RECEPTOR)		 5ikn DNA PRIMASE/HELICASE
(Escherichia
virus
T7) 		5 / 12 MET D 309
THR D 311
ILE D 442
GLY D 488
LEU D 486
 None
 1.02A 5gs4A-5iknD:
undetectable		 5gs4A-5iknD:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGK_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5ikn DNA PRIMASE/HELICASE
(Escherichia
virus
T7) 		3 / 3 VAL D 123
TYR D 106
GLN D 107
 None
 0.66A 5qgkA-5iknD:
undetectable		 5qgkA-5iknD:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGR_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5ikn DNA PRIMASE/HELICASE
(Escherichia
virus
T7) 		3 / 3 VAL D 123
TYR D 106
GLN D 107
 None
 0.63A 5qgrA-5iknD:
undetectable		 5qgrA-5iknD:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGT_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 5ikn DNA PRIMASE/HELICASE
(Escherichia
virus
T7) 		3 / 3 VAL D 123
TYR D 106
GLN D 107
 None
 0.68A 5qgtA-5iknD:
undetectable		 5qgtA-5iknD:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YJS_A_SALA603_0
(VICILIN-LIKE
ANTIMICROBIAL
PEPTIDES 2-2)		 5ikn DNA PRIMASE/HELICASE
(Escherichia
virus
T7) 		5 / 11 ASN D 296
VAL D 516
PHE D 321
MET D 533
GLY D 531
 None
 1.50A 5yjsA-5iknD:
undetectable		 5yjsA-5iknD:
11.19