SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ikp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A7Y_A_DVAA2_0
(ACTINOMYCIN D)		 5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens) 		4 / 4 THR A 240
PRO A 229
THR A 228
PRO A 231
 None
 1.31A 1a7yA-5ikpA:
undetectable
1a7yC-5ikpA:
undetectable		 1a7yA-5ikpA:
1.22
1a7yC-5ikpA:
1.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1C8L_A_CFFA940_1
(PROTEIN (GLYCOGEN
PHOSPHORYLASE))		 5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens) 		4 / 6 HIS A 571
ALA A 610
GLY A 612
TYR A 613
 None
 0.72A 1c8lA-5ikpA:
undetectable		 1c8lA-5ikpA:
83.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1GFZ_A_CFFA940_1
(GLYCOGEN
PHOSPHORYLASE)		 5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens) 		4 / 6 HIS A 571
ALA A 610
GLY A 612
TYR A 613
 None
 0.76A 1gfzA-5ikpA:
49.3		 1gfzA-5ikpA:
83.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTB_A_PZQA901_0
(GLUTATHIONE
S-TRANSFERASE)		 5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens) 		3 / 3 GLN A 539
TYR A 791
ARG A 792
 None
 0.91A 1gtbA-5ikpA:
undetectable		 1gtbA-5ikpA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		 5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens) 		3 / 3 ASP A 564
PHE A 681
VAL A 567
 None
 0.68A 1kijB-5ikpA:
undetectable		 1kijB-5ikpA:
18.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1L5Q_A_CFFA863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens) 		4 / 6 HIS A 571
ALA A 610
GLY A 612
TYR A 613
 None
 0.84A 1l5qA-5ikpA:
undetectable		 1l5qA-5ikpA:
81.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1L5Q_B_CFFB1863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens) 		4 / 6 HIS A 571
ALA A 610
GLY A 612
TYR A 613
 None
 0.84A 1l5qB-5ikpA:
52.7		 1l5qB-5ikpA:
81.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1L5R_A_RBFA859_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens) 		5 / 11 TYR A 573
ALA A 610
GLY A 612
TYR A 613
PHE A 771
 None
 0.26A 1l5rA-5ikpA:
52.0		 1l5rA-5ikpA:
81.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1L7X_A_CFFA863_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens) 		4 / 6 HIS A 571
ALA A 610
GLY A 612
TYR A 613
 None
 0.87A 1l7xA-5ikpA:
52.1		 1l7xA-5ikpA:
81.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1L7X_A_CFFA864_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens) 		3 / 3 TRP A 174
HIS A 614
LYS A 617
 None
 0.44A 1l7xA-5ikpA:
52.1		 1l7xA-5ikpA:
81.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1868_0
(FPRA)		 5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens) 		3 / 3 ALA A 442
HIS A 443
VAL A 446
 None
 0.00A 1lqtB-5ikpA:
3.8		 1lqtB-5ikpA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1425_0
(FPRA)		 5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens) 		3 / 3 ALA A 442
HIS A 443
VAL A 446
 None
 0.00A 1lquB-5ikpA:
3.6		 1lquB-5ikpA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_B_SAMB200_0
(METHIONINE REPRESSOR)		 5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens) 		5 / 11 GLU A 730
PHE A 774
GLU A 737
LEU A 735
PRO A 736
 None
 1.35A 1mjqA-5ikpA:
undetectable
1mjqB-5ikpA:
undetectable		 1mjqA-5ikpA:
9.05
1mjqB-5ikpA:
9.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens) 		5 / 11 PHE A 749
PHE A 598
LEU A 640
VAL A 642
VAL A 636
 None
 1.38A 1q23I-5ikpA:
undetectable		 1q23I-5ikpA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_B_SAMB2501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens) 		4 / 7 TYR A 374
GLU A 819
THR A 483
VAL A 463
 None
 1.21A 1tv8B-5ikpA:
undetectable		 1tv8B-5ikpA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TV8_B_SAMB2501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens) 		4 / 7 TYR A 374
THR A 816
GLU A 823
VAL A 463
 None
 1.15A 1tv8B-5ikpA:
undetectable		 1tv8B-5ikpA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPM_A_SAMA300_0
(PROTEIN
(ADENINE-SPECIFIC
METHYLTRANSFERASE
DPNII 1))		 5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens) 		5 / 12 GLY A 454
ALA A 456
PHE A 471
ASP A 470
PRO A 381
 None
 1.10A 2dpmA-5ikpA:
undetectable		 2dpmA-5ikpA:
16.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ECP_A_ACRA992_1
(MALTODEXTRIN
PHOSPHORYLASE)		 5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens) 		8 / 10 ASN A 133
LEU A 136
TYR A 280
ARG A 292
ASP A 339
HIS A 341
HIS A 571
ALA A 610
 None
 0.71A 2ecpA-5ikpA:
47.1		 2ecpA-5ikpA:
43.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ECP_A_ACRA992_1
(MALTODEXTRIN
PHOSPHORYLASE)		 5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens) 		6 / 10 ASN A 133
LEU A 136
TYR A 280
ASP A 339
HIS A 341
ARG A 569
 None
None
None
None
None
PLP  A 901 (-4.1A)
 1.19A 2ecpA-5ikpA:
47.1		 2ecpA-5ikpA:
43.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ECP_B_ACRB992_1
(MALTODEXTRIN
PHOSPHORYLASE)		 5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens) 		5 / 10 ASN A 133
LEU A 136
ASP A 339
HIS A 341
ARG A 569
 None
None
None
None
PLP  A 901 (-4.1A)
 1.18A 2ecpB-5ikpA:
47.1		 2ecpB-5ikpA:
43.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ECP_B_ACRB992_1
(MALTODEXTRIN
PHOSPHORYLASE)		 5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens) 		8 / 10 ASN A 133
LEU A 136
TYR A 280
ARG A 292
ASP A 339
HIS A 341
HIS A 571
ALA A 610
 None
 0.70A 2ecpB-5ikpA:
47.1		 2ecpB-5ikpA:
43.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens) 		3 / 3 LEU A 243
LEU A 198
MET A 197
 None
 0.86A 2itzA-5ikpA:
undetectable		 2itzA-5ikpA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A131_1
(FATTY ACID-BINDING
PROTEIN, LIVER)		 5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens) 		5 / 12 ILE A 335
LEU A 337
CYH A 372
LEU A 353
THR A 368
 None
 1.27A 2jn3A-5ikpA:
undetectable		 2jn3A-5ikpA:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M9Q_B_BEZB251_0
(SERINE PROTEASE
INHIBITOR
SERINE PROTEASE
SUBUNIT NS2B, SERINE
PROTEASE NS3)		 5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens) 		5 / 9 ILE A 308
ILE A 307
PHE A 326
THR A 371
LEU A 353
 None
 1.17A 2m9qA-5ikpA:
undetectable		 2m9qA-5ikpA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO5_A_CHDA131_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens) 		5 / 12 ILE A 308
ILE A 335
LEU A 337
CYH A 372
THR A 368
 None
 1.16A 2qo5A-5ikpA:
undetectable		 2qo5A-5ikpA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W3A_B_TOPB1189_1
(DIHYDROFOLATE
REDUCTASE)		 5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens) 		5 / 10 PHE A 548
PHE A 545
THR A 602
ILE A 643
LEU A 645
 None
 1.17A 2w3aB-5ikpA:
undetectable		 2w3aB-5ikpA:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WM3_A_NFLA1301_1
(NMRA-LIKE FAMILY
DOMAIN CONTAINING
PROTEIN 1)		 5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens) 		4 / 6 LEU A 117
PHE A  31
LEU A  55
ASP A  50
 None
 0.80A 2wm3A-5ikpA:
4.7		 2wm3A-5ikpA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZB7_A_NCAA901_0
(PROSTAGLANDIN
REDUCTASE 2)		 5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens) 		4 / 5 ILE A 745
MET A 615
LEU A 765
LEU A 577
 None
 1.15A 2zb7A-5ikpA:
2.6		 2zb7A-5ikpA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZS9_A_PAUA603_0
(PANTOTHENATE KINASE)		 5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens) 		4 / 6 VAL A 455
ASP A 339
TYR A  84
ASN A 484
 None
 1.47A 2zs9A-5ikpA:
undetectable		 2zs9A-5ikpA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWM_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens) 		3 / 3 SER A 561
GLU A 550
ASP A 638
 None
 0.84A 3bwmA-5ikpA:
undetectable		 3bwmA-5ikpA:
12.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DD1_A_CFFA903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens) 		4 / 6 HIS A 571
ALA A 610
GLY A 612
TYR A 613
 None
 0.77A 3dd1A-5ikpA:
51.3		 3dd1A-5ikpA:
81.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DD1_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens) 		4 / 6 HIS A 571
ALA A 610
GLY A 612
TYR A 613
 None
 0.81A 3dd1B-5ikpA:
undetectable		 3dd1B-5ikpA:
81.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DDS_A_CFFA904_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens) 		4 / 6 HIS A 571
ALA A 610
GLY A 612
TYR A 613
 None
 0.82A 3ddsA-5ikpA:
51.2		 3ddsA-5ikpA:
81.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DDS_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens) 		4 / 6 HIS A 571
ALA A 610
GLY A 612
TYR A 613
 None
 0.79A 3ddsB-5ikpA:
52.0		 3ddsB-5ikpA:
81.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DDW_A_CFFA903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens) 		4 / 6 HIS A 571
ALA A 610
GLY A 612
TYR A 613
 None
 0.83A 3ddwA-5ikpA:
undetectable		 3ddwA-5ikpA:
81.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DDW_B_CFFB903_1
(GLYCOGEN
PHOSPHORYLASE, LIVER
FORM)		 5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens) 		4 / 6 HIS A 571
ALA A 610
GLY A 612
TYR A 613
 None
 0.82A 3ddwB-5ikpA:
55.0		 3ddwB-5ikpA:
81.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_A_V2HA602_0
(CYTOCHROME P450 2R1)		 5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens) 		5 / 12 ALA A 364
GLU A 348
VAL A 333
ILE A 308
THR A 371
 None
 1.17A 3dl9A-5ikpA:
undetectable		 3dl9A-5ikpA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K9F_H_LFXH0_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens) 		4 / 6 SER A 146
GLY A 809
GLU A 701
GLU A 702
 None
 0.94A 3k9fA-5ikpA:
undetectable
3k9fB-5ikpA:
undetectable
3k9fD-5ikpA:
1.2		 3k9fA-5ikpA:
20.98
3k9fB-5ikpA:
20.98
3k9fD-5ikpA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA1_1
(CYTOCHROME P450 2D6)		 5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens) 		5 / 12 LEU A 279
GLY A 137
LEU A 139
PHE A  89
SER A  86
 None
 1.25A 3tbgA-5ikpA:
undetectable		 3tbgA-5ikpA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC1_1
(CYTOCHROME P450 2D6)		 5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens) 		5 / 12 LEU A 279
GLY A 137
LEU A 139
PHE A  89
SER A  86
 None
 1.23A 3tbgC-5ikpA:
undetectable		 3tbgC-5ikpA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_B_SALB404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens) 		4 / 7 ALA A  54
TYR A  51
ARG A  49
ALA A  46
 None
 1.06A 3twpB-5ikpA:
undetectable		 3twpB-5ikpA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA804_1
(CATALASE-PEROXIDASE)		 5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens) 		3 / 3 ASN A 270
GLU A 273
ARG A 277
 None
 0.91A 3wxoA-5ikpA:
undetectable		 3wxoA-5ikpA:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_C_MIYC392_1
(TETX2 PROTEIN)		 5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens) 		5 / 12 GLU A 348
VAL A 333
ILE A 335
ILE A 352
GLU A 357
 None
 1.43A 4a99A-5ikpA:
undetectable
4a99C-5ikpA:
undetectable		 4a99A-5ikpA:
19.41
4a99C-5ikpA:
19.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4BQF_B_QPSB951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens) 		4 / 8 TRP A 361
ARG A 398
GLU A 401
ARG A 409
 None
 0.66A 4bqfB-5ikpA:
48.4		 4bqfB-5ikpA:
45.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_A_MTLA870_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens) 		4 / 8 ASN A 440
GLU A 385
ASN A 376
ASP A 339
 None
 1.11A 4d39A-5ikpA:
undetectable		 4d39A-5ikpA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4H1N_A_CGEA505_1
(CYTOCHROME P450 2B4)		 5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens) 		5 / 11 ILE A 406
ILE A 402
ALA A 343
ILE A 439
VAL A 430
 None
 1.19A 4h1nA-5ikpA:
undetectable		 4h1nA-5ikpA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4II8_A_010A210_0
(LYSOZYME C)		 5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens) 		4 / 7 GLU A 366
ASP A 362
ILE A 406
TRP A 365
 None
 1.19A 4ii8A-5ikpA:
undetectable		 4ii8A-5ikpA:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M5M_A_DX4A401_0
(2-AMINO-4-HYDROXY-6-
HYDROXYMETHYLDIHYDRO
PTERIDINE
PYROPHOSPHOKINASE)		 5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens) 		4 / 8 THR A 237
LEU A 150
ASN A 235
ARG A 489
 None
 1.10A 4m5mA-5ikpA:
undetectable		 4m5mA-5ikpA:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_A_8PRA603_1
(TRANSPORTER)		 5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens) 		5 / 12 VAL A 452
TYR A 374
PHE A 471
PHE A 479
GLY A 454
 None
 1.38A 4mm4A-5ikpA:
undetectable		 4mm4A-5ikpA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_1
(NEURAMINIDASE)		 5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens) 		3 / 3 ARG A 649
GLU A 552
ARG A  93
 None
 0.99A 4mwvA-5ikpA:
undetectable		 4mwvA-5ikpA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGF_A_ADNA502_1
(ADENOSYLHOMOCYSTEINA
SE)		 5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens) 		5 / 12 LEU A 521
LEU A 492
ASN A 496
GLY A 498
PHE A 530
 None
 1.33A 4pgfA-5ikpA:
2.4		 4pgfA-5ikpA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_ACTA608_0
(SERUM ALBUMIN)		 5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens) 		3 / 3 LYS A  29
ARG A  33
HIS A  34
 None
 1.23A 4zbrA-5ikpA:
undetectable		 4zbrA-5ikpA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C0O_H_SAMH301_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
TRMI)		 5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens) 		5 / 12 ALA A 140
GLY A 132
GLY A 137
GLY A 135
LEU A 131
 None
None
None
PLP  A 901 ( 3.8A)
None
 1.06A 5c0oH-5ikpA:
2.4		 5c0oH-5ikpA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_F_MFXF2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens) 		4 / 6 SER A 245
ASP A 181
ARG A 184
GLY A 186
 None
 0.79A 5cdqA-5ikpA:
undetectable
5cdqC-5ikpA:
undetectable
5cdqD-5ikpA:
1.9		 5cdqA-5ikpA:
22.75
5cdqC-5ikpA:
22.75
5cdqD-5ikpA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4N_C_ACTC201_0
(NITROGEN REGULATORY
PROTEIN P-II)		 5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens) 		4 / 5 VAL A 584
VAL A 629
GLY A 627
PHE A 750
 None
 1.01A 5d4nA-5ikpA:
undetectable
5d4nC-5ikpA:
undetectable		 5d4nA-5ikpA:
8.19
5d4nC-5ikpA:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_H_FK5H201_1
(FK506-BINDING
PROTEIN 1)		 5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens) 		4 / 8 TYR A  84
PHE A 143
ILE A 824
TRP A 825
 None
 0.93A 5hw8H-5ikpA:
undetectable		 5hw8H-5ikpA:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JI0_D_BRLD501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens) 		5 / 12 GLN A 295
HIS A 341
LEU A  85
LEU A 279
TYR A 280
 None
 1.35A 5ji0D-5ikpA:
undetectable		 5ji0D-5ikpA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_1
(METHYLTRANSFERASE)		 5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens) 		4 / 7 LEU A 652
ILE A 125
GLU A 124
ASP A 128
 None
 0.95A 5n5dA-5ikpA:
undetectable		 5n5dA-5ikpA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWV_A_ACAA18_2
(SCRFP-TAG,GP41)		 5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens) 		4 / 7 ASP A 128
TRP A 182
ALA A 129
LEU A 131
 None
 1.09A 5nwvA-5ikpA:
undetectable		 5nwvA-5ikpA:
3.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VNC_C_GCSC801_1
(GLYCOGEN [STARCH]
SYNTHASE ISOFORM 2)		 5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens) 		7 / 10 GLY A 135
HIS A 377
VAL A 455
ASN A 484
LYS A 574
GLU A 672
GLY A 675
 PLP  A 901 ( 3.8A)
None
None
None
PLP  A 901 (-3.3A)
None
PLP  A 901 (-3.3A)
 0.86A 5vncC-5ikpA:
16.2		 5vncC-5ikpA:
6.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_B_CHDB401_0
(BILE SALT HYDROLASE)		 5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens) 		5 / 10 LEU A 396
LEU A 349
LEU A 337
ALA A 343
LEU A 444
 None
 1.25A 5y7pB-5ikpA:
undetectable		 5y7pB-5ikpA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_H_CHDH401_0
(BILE SALT HYDROLASE)		 5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens) 		5 / 10 LEU A 396
LEU A 349
LEU A 337
ALA A 343
LEU A 444
 None
 1.24A 5y7pH-5ikpA:
undetectable		 5y7pH-5ikpA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXN_A_SAMA901_0
(DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2)		 5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens) 		5 / 12 LEU A 243
VAL A 333
ARG A 242
ILE A 307
ASP A 306
 None
None
AMP  A 902 ( 4.2A)
None
None
 1.49A 6bxnA-5ikpA:
undetectable		 6bxnA-5ikpA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_A_ACRA602_1
(-)		 5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens) 		6 / 12 GLY A 134
GLY A 135
ASP A 339
VAL A 455
ASN A 484
GLY A 675
 PLP  A 901 ( 4.1A)
PLP  A 901 ( 3.8A)
None
None
None
PLP  A 901 (-3.3A)
 0.77A 6gneA-5ikpA:
22.4		 6gneA-5ikpA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNE_B_ACRB602_1
(-)		 5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens) 		7 / 12 GLU A  88
GLY A 134
GLY A 135
ASP A 339
VAL A 455
ASN A 484
GLY A 675
 None
PLP  A 901 ( 4.1A)
PLP  A 901 ( 3.8A)
None
None
None
PLP  A 901 (-3.3A)
 0.77A 6gneB-5ikpA:
22.3		 6gneB-5ikpA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_1
(-)		 5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens) 		5 / 12 ASP A 339
HIS A 341
ASN A 484
GLU A 672
GLY A 675
 None
None
None
None
PLP  A 901 (-3.3A)
 0.62A 6gnfA-5ikpA:
21.3		 6gnfA-5ikpA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_A_QPSA602_2
(-)		 5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens) 		5 / 9 GLY A 134
GLY A 135
TYR A 280
HIS A 377
VAL A 455
 PLP  A 901 ( 4.1A)
PLP  A 901 ( 3.8A)
None
None
None
 0.67A 6gnfA-5ikpA:
21.4		 6gnfA-5ikpA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_1
(-)		 5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens) 		5 / 10 GLY A 135
LEU A 136
TYR A 280
HIS A 377
VAL A 455
 PLP  A 901 ( 3.8A)
None
None
None
None
 0.68A 6gnfC-5ikpA:
21.7		 6gnfC-5ikpA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNF_C_QPSC602_2
(-)		 5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens) 		5 / 12 ASP A 339
HIS A 341
ASN A 484
GLU A 672
GLY A 675
 None
None
None
None
PLP  A 901 (-3.3A)
 0.63A 6gnfC-5ikpA:
21.7		 6gnfC-5ikpA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_1
(-)		 5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens) 		5 / 12 GLY A 134
LEU A 136
ASP A 339
HIS A 341
ASN A 484
 PLP  A 901 ( 4.1A)
None
None
None
None
 0.73A 6gngA-5ikpA:
21.5		 6gngA-5ikpA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		 5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens) 		7 / 12 GLU A  88
GLY A 135
TYR A 280
HIS A 377
VAL A 455
GLU A 672
GLY A 675
 None
PLP  A 901 ( 3.8A)
None
None
None
None
PLP  A 901 (-3.3A)
 0.78A 6gngA-5ikpA:
21.5		 6gngA-5ikpA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		 5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens) 		5 / 12 TYR A 280
HIS A 377
VAL A 455
GLU A 672
GLY A 675
 None
None
None
None
PLP  A 901 (-3.3A)
 0.76A 6gngB-5ikpA:
21.5		 6gngB-5ikpA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_2
(-)		 5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens) 		5 / 12 GLU A  88
GLY A 134
GLY A 135
LEU A 136
HIS A 341
 None
PLP  A 901 ( 4.1A)
PLP  A 901 ( 3.8A)
None
None
 0.59A 6gngB-5ikpA:
21.6		 6gngB-5ikpA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HQB_A_PQNA2001_0
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens) 		5 / 10 GLY A 135
ARG A 138
ALA A 141
GLY A 132
LEU A 198
 PLP  A 901 ( 3.8A)
None
None
None
None
 1.21A 6hqbA-5ikpA:
undetectable
6hqbJ-5ikpA:
undetectable		 6hqbA-5ikpA:
7.88
6hqbJ-5ikpA:
4.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_1
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM
(Homo
sapiens) 		4 / 7 ILE A 403
GLU A 385
VAL A 430
TRP A 365
 None
 1.09A 6j20A-5ikpA:
undetectable		 6j20A-5ikpA:
19.45