SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5iku'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FE2_A_LAXA700_1
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 5iku COLLAGENASE
(Hathewaya
histolytica) 		5 / 10 VAL A1006
PHE A 952
VAL A 954
VAL A 993
LEU A1004
 None
 1.24A 1fe2A-5ikuA:
undetectable		 1fe2A-5ikuA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_C_ACHC323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 5iku COLLAGENASE
(Hathewaya
histolytica) 		4 / 8 PHE A 835
GLU A 780
TYR A 885
LEU A 827
 None
CA  A2004 (-2.2A)
None
None
 1.11A 3rqwC-5ikuA:
undetectable
3rqwD-5ikuA:
undetectable		 3rqwC-5ikuA:
19.52
3rqwD-5ikuA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_J_ACHJ323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 5iku COLLAGENASE
(Hathewaya
histolytica) 		4 / 8 GLU A 780
TYR A 885
LEU A 827
PHE A 835
 CA  A2004 (-2.2A)
None
None
None
 1.10A 3rqwF-5ikuA:
undetectable
3rqwJ-5ikuA:
undetectable		 3rqwF-5ikuA:
19.52
3rqwJ-5ikuA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_A_BEZA507_0
(BETA-LACTAMASE VIM-2)		 5iku COLLAGENASE
(Hathewaya
histolytica) 		3 / 3 THR A 836
HIS A 877
ASN A 834
 None
 0.81A 5n4tA-5ikuA:
undetectable		 5n4tA-5ikuA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 5iku COLLAGENASE
(Hathewaya
histolytica) 		4 / 7 PHE A 815
THR A 836
ILE A 825
GLY A 852
 None
 1.00A 5nzyA-5ikuA:
undetectable		 5nzyA-5ikuA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6G2P_A_TRPA502_0
(FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA)		 5iku COLLAGENASE
(Hathewaya
histolytica) 		4 / 7 TYR A 994
LEU A 946
TYR A 996
VAL A 978
 None
 1.27A 6g2pA-5ikuA:
undetectable		 6g2pA-5ikuA:
19.51