SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5il0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMY_B_SAMB328_0
(PROTEIN
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI))		 5il0 METTL3
(Homo
sapiens) 		5 / 12 PHE A 534
ASP A 377
ILE A 378
PRO A 397
LEU A 409
 None
 1.03A 2hmyB-5il0A:
4.8		 2hmyB-5il0A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRH_A_NIOA200_1
(PROTEIN HP0721)		 5il0 METTL3
(Homo
sapiens) 		4 / 7 GLY A 387
ILE A 545
ARG A 529
LEU A 422
 None
 0.94A 2xrhA-5il0A:
undetectable		 2xrhA-5il0A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_0
(MODIFICATION
METHYLASE HHAI)		 5il0 METTL3
(Homo
sapiens) 		5 / 12 PHE A 534
ASP A 377
ILE A 378
PRO A 397
LEU A 409
 None
 0.96A 3eeoA-5il0A:
5.1		 3eeoA-5il0A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_2
(GLUCOCORTICOID
RECEPTOR)		 5il0 METTL3
(Homo
sapiens) 		3 / 3 MET A 520
CYH A 483
PRO A 514
 None
 0.51A 3h52C-5il0A:
undetectable		 3h52C-5il0A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_A_C2FA314_0
(UNCHARACTERIZED
PROTEIN)		 5il0 METTL3
(Homo
sapiens) 		5 / 12 GLY A 548
LEU A 551
ILE A 531
LEU A 417
ILE A 419
 None
EDO  A 601 (-3.8A)
None
None
None
 1.09A 3ijdA-5il0A:
undetectable		 3ijdA-5il0A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJD_B_C2FB314_0
(UNCHARACTERIZED
PROTEIN)		 5il0 METTL3
(Homo
sapiens) 		5 / 12 GLY A 548
LEU A 551
ILE A 531
LEU A 417
ILE A 419
 None
EDO  A 601 (-3.8A)
None
None
None
 1.17A 3ijdB-5il0A:
undetectable		 3ijdB-5il0A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_A_SAMA301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 5il0 METTL3
(Homo
sapiens) 		5 / 12 ASP A 377
ASP A 395
PRO A 397
PHE A 534
GLY A 535
 None
 0.92A 5hfjA-5il0A:
13.6		 5hfjA-5il0A:
22.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IL1_A_SAMA601_0
(METTL3)		 5il0 METTL3
(Homo
sapiens) 		9 / 12 ASP A 377
ILE A 378
ARG A 379
LEU A 409
GLU A 532
PHE A 534
ARG A 536
ASN A 539
GLY A 548
 None
 1.09A 5il1A-5il0A:
32.6		 5il1A-5il0A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IL1_A_SAMA601_0
(METTL3)		 5il0 METTL3
(Homo
sapiens) 		9 / 12 ASP A 377
ILE A 378
ARG A 379
PRO A 397
LEU A 409
GLU A 532
PHE A 534
ASN A 539
GLY A 548
 None
 0.42A 5il1A-5il0A:
32.6		 5il1A-5il0A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5K7U_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 5il0 METTL3
(Homo
sapiens) 		7 / 12 ASP A 377
ILE A 378
ARG A 379
GLU A 532
ARG A 536
ASN A 539
GLY A 548
 None
 0.82A 5k7uA-5il0A:
35.0		 5k7uA-5il0A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5K7U_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 5il0 METTL3
(Homo
sapiens) 		9 / 12 ASP A 377
ILE A 378
ARG A 379
PRO A 397
LEU A 409
GLU A 532
PHE A 534
ASN A 539
GLY A 548
 None
 0.39A 5k7uA-5il0A:
35.0		 5k7uA-5il0A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5K7U_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 5il0 METTL3
(Homo
sapiens) 		3 / 3 ASP A 395
ASN A 549
GLN A 550
 None
 0.39A 5k7uA-5il0A:
35.0		 5k7uA-5il0A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L6E_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 5il0 METTL3
(Homo
sapiens) 		8 / 12 ILE A 378
ARG A 379
PRO A 397
LEU A 409
GLU A 532
PHE A 534
GLY A 535
GLY A 548
 None
 0.40A 5l6eA-5il0A:
32.3		 5l6eA-5il0A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L6E_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 5il0 METTL3
(Homo
sapiens) 		5 / 12 ILE A 378
HIS A 538
GLU A 532
GLY A 535
GLY A 548
 None
 0.97A 5l6eA-5il0A:
32.3		 5l6eA-5il0A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5L6E_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 5il0 METTL3
(Homo
sapiens) 		6 / 6 ASP A 377
ASP A 395
ARG A 536
ASN A 539
ASN A 549
GLN A 550
 None
 0.73A 5l6eA-5il0A:
32.3		 5l6eA-5il0A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_W_CHDW101_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 5il0 METTL3
(Homo
sapiens) 		3 / 3 ARG A 441
LEU A 484
PHE A 429
 None
 0.69A 6nknP-5il0A:
undetectable		 6nknP-5il0A:
19.63