SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5il6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN0_B_T44B602_1
(TRANSTHYRETIN)		 5il6 POLYKETIDE
SYNTHASE/NONRIBOSOMA
L PEPTIDE SYNTHETASE
HYBRID RZXB
(Pseudomonas
protegens) 		4 / 7 LEU A4606
ALA A4569
LEU A4637
ALA A4635
 None
 0.74A 1sn0B-5il6A:
undetectable
1sn0D-5il6A:
undetectable		 1sn0B-5il6A:
17.53
1sn0D-5il6A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN0_B_T44B602_1
(TRANSTHYRETIN)		 5il6 POLYKETIDE
SYNTHASE/NONRIBOSOMA
L PEPTIDE SYNTHETASE
HYBRID RZXB
(Pseudomonas
protegens) 		4 / 7 LEU A4637
ALA A4635
LEU A4606
ALA A4569
 None
 0.74A 1sn0B-5il6A:
undetectable
1sn0D-5il6A:
undetectable		 1sn0B-5il6A:
17.53
1sn0D-5il6A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TBF_A_VIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 5il6 POLYKETIDE
SYNTHASE/NONRIBOSOMA
L PEPTIDE SYNTHETASE
HYBRID RZXB
(Pseudomonas
protegens) 		5 / 9 LEU A4566
LEU A4637
VAL A4573
ALA A4575
LEU A4534
 None
 1.15A 1tbfA-5il6A:
undetectable		 1tbfA-5il6A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 5il6 POLYKETIDE
SYNTHASE/NONRIBOSOMA
L PEPTIDE SYNTHETASE
HYBRID RZXB
(Pseudomonas
protegens) 		5 / 12 VAL A4511
LEU A4624
ARG A4611
ARG A4519
LEU A4577
 None
 1.16A 5nd7B-5il6A:
undetectable		 5nd7B-5il6A:
21.61