SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5im2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA803_0
(FERROCHELATASE)		 5im2 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
(Rhodoferax
ferrireducens) 		4 / 5 LEU A 253
PRO A 254
LEU A 257
ILE A  61
 None
 0.85A 2qd4A-5im2A:
undetectable		 2qd4A-5im2A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_A_DX4A270_0
(PTERIDINE REDUCTASE
1)		 5im2 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
(Rhodoferax
ferrireducens) 		4 / 6 ARG A 103
PHE A 101
ASP A 137
TYR A  79
 None
 1.47A 3jqaA-5im2A:
undetectable		 3jqaA-5im2A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_A_DX4A270_0
(PTERIDINE REDUCTASE
1)		 5im2 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
(Rhodoferax
ferrireducens) 		4 / 6 PHE A 101
ASP A 137
TYR A  79
PRO A 102
 None
 1.41A 3jqaA-5im2A:
undetectable		 3jqaA-5im2A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_B_DX4B270_0
(PTERIDINE REDUCTASE
1)		 5im2 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
(Rhodoferax
ferrireducens) 		4 / 6 ARG A 103
PHE A 101
ASP A 137
TYR A  79
 None
 1.46A 3jqaB-5im2A:
undetectable		 3jqaB-5im2A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_B_DX4B270_0
(PTERIDINE REDUCTASE
1)		 5im2 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
(Rhodoferax
ferrireducens) 		4 / 6 PHE A 101
ASP A 137
TYR A  79
PRO A 102
 None
 1.42A 3jqaB-5im2A:
undetectable		 3jqaB-5im2A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_C_DX4C270_0
(PTERIDINE REDUCTASE
1)		 5im2 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
(Rhodoferax
ferrireducens) 		4 / 6 ARG A 103
PHE A 101
ASP A 137
TYR A  79
 None
 1.48A 3jqaC-5im2A:
undetectable		 3jqaC-5im2A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQA_D_DX4D270_0
(PTERIDINE REDUCTASE
1)		 5im2 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
(Rhodoferax
ferrireducens) 		4 / 6 ARG A 103
PHE A 101
ASP A 137
TYR A  79
 None
 1.48A 3jqaD-5im2A:
undetectable		 3jqaD-5im2A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_B_CGEB501_1
(CYTOCHROME P450 2B4)		 5im2 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
(Rhodoferax
ferrireducens) 		4 / 8 ILE A 261
ALA A 142
THR A 269
VAL A  53
 None
 0.89A 3me6B-5im2A:
undetectable		 3me6B-5im2A:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5im2 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
(Rhodoferax
ferrireducens) 		5 / 12 GLN A 277
GLY A 147
ILE A 195
ALA A 208
ALA A 207
 BEZ  A 401 (-3.9A)
None
None
None
None
 0.84A 3sudC-5im2A:
undetectable		 3sudC-5im2A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5im2 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
(Rhodoferax
ferrireducens) 		5 / 12 GLN A 277
GLY A 147
ILE A 195
ALA A 208
ALA A 207
 BEZ  A 401 (-3.9A)
None
None
None
None
 0.83A 3sueA-5im2A:
undetectable		 3sueA-5im2A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5im2 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
(Rhodoferax
ferrireducens) 		5 / 12 GLN A 277
GLY A 147
ILE A 195
ALA A 208
ALA A 207
 BEZ  A 401 (-3.9A)
None
None
None
None
 0.94A 3sufB-5im2A:
undetectable		 3sufB-5im2A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5im2 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
(Rhodoferax
ferrireducens) 		4 / 4 LEU A 253
PRO A 254
LEU A 257
ILE A  61
 None
 0.95A 4f4dB-5im2A:
undetectable		 4f4dB-5im2A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_B_ACTB1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 5im2 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
(Rhodoferax
ferrireducens) 		4 / 5 ARG A 174
GLY A  99
ALA A  98
GLY A  95
 None
 0.95A 4u9uB-5im2A:
undetectable		 4u9uB-5im2A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 5im2 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
(Rhodoferax
ferrireducens) 		4 / 6 ASP A  80
ALA A  76
THR A  92
TYR A  79
 None
 1.15A 4w5qA-5im2A:
undetectable		 4w5qA-5im2A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5R_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 5im2 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
(Rhodoferax
ferrireducens) 		4 / 6 ASP A  80
ALA A  76
THR A  92
TYR A  79
 None
 1.20A 4w5rA-5im2A:
undetectable		 4w5rA-5im2A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 5im2 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
(Rhodoferax
ferrireducens) 		4 / 6 ASP A  80
ALA A  76
THR A  92
TYR A  79
 None
 1.16A 4w5tA-5im2A:
undetectable		 4w5tA-5im2A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA906_0
(PROTEIN ARGONAUTE-2)		 5im2 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
(Rhodoferax
ferrireducens) 		4 / 6 ASP A  80
ALA A  76
THR A  92
TYR A  79
 None
 1.16A 4z4cA-5im2A:
undetectable		 4z4cA-5im2A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5im2 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
(Rhodoferax
ferrireducens) 		4 / 6 ASP A  80
ALA A  76
THR A  92
TYR A  79
 None
 1.13A 4z4fA-5im2A:
undetectable		 4z4fA-5im2A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 5im2 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
(Rhodoferax
ferrireducens) 		4 / 5 ASP A  80
ALA A  76
THR A  92
TYR A  79
 None
 1.16A 4z4gA-5im2A:
undetectable		 4z4gA-5im2A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA905_0
(PROTEIN ARGONAUTE-2)		 5im2 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
(Rhodoferax
ferrireducens) 		4 / 5 ASP A  80
ALA A  76
THR A  92
TYR A  79
 None
 1.15A 4z4hA-5im2A:
undetectable		 4z4hA-5im2A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 5im2 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
(Rhodoferax
ferrireducens) 		4 / 6 ASP A  80
ALA A  76
THR A  92
TYR A  79
 None
 1.10A 4z4iA-5im2A:
undetectable		 4z4iA-5im2A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERS_A_ACTA803_0
(GEPHYRIN)		 5im2 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
(Rhodoferax
ferrireducens) 		3 / 3 THR A 114
ALA A 118
ASN A 115
 None
 0.59A 5ersA-5im2A:
undetectable		 5ersA-5im2A:
22.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IM2_A_BEZA401_0
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL)		 5im2 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
(Rhodoferax
ferrireducens) 		12 / 12 PHE A  34
MET A  35
VAL A  41
TRP A  91
ILE A  93
HIS A 146
PRO A 172
LEU A 192
LEU A 209
VAL A 213
PHE A 241
GLN A 277
 BEZ  A 401 ( 4.1A)
BEZ  A 401 ( 2.9A)
None
None
BEZ  A 401 (-4.9A)
BEZ  A 401 ( 4.2A)
BEZ  A 401 (-4.3A)
BEZ  A 401 ( 3.8A)
BEZ  A 401 (-4.5A)
BEZ  A 401 ( 3.9A)
BEZ  A 401 ( 4.9A)
BEZ  A 401 (-3.9A)
 0.00A 5im2A-5im2A:
59.8		 5im2A-5im2A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5IM2_A_BEZA401_1
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL)		 5im2 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
(Rhodoferax
ferrireducens) 		4 / 4 TYR A  96
ARG A 170
PRO A 210
GLU A 212
 BEZ  A 401 (-4.8A)
BEZ  A 401 (-2.8A)
BEZ  A 401 (-3.8A)
BEZ  A 401 (-3.6A)
 0.03A 5im2A-5im2A:
59.8		 5im2A-5im2A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LUR_B_STRB201_1
(AVIDIN)		 5im2 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
(Rhodoferax
ferrireducens) 		5 / 11 TYR A  79
ALA A  82
VAL A  86
THR A  97
PHE A 101
 None
 1.35A 5lurB-5im2A:
undetectable		 5lurB-5im2A:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_1
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 5im2 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
(Rhodoferax
ferrireducens) 		3 / 3 THR A 173
GLU A 108
HIS A 146
 None
None
BEZ  A 401 ( 4.2A)
 0.88A 5xioA-5im2A:
undetectable		 5xioA-5im2A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_B_HFGB1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5im2 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
(Rhodoferax
ferrireducens) 		3 / 3 THR A 173
GLU A 108
HIS A 146
 None
None
BEZ  A 401 ( 4.2A)
 0.85A 5xiqB-5im2A:
undetectable		 5xiqB-5im2A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_1
(PROLYL-TRNA
SYNTHETASE (PRORS))		 5im2 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
(Rhodoferax
ferrireducens) 		3 / 3 THR A 173
GLU A 108
HIS A 146
 None
None
BEZ  A 401 ( 4.2A)
 0.88A 5xiqD-5im2A:
undetectable		 5xiqD-5im2A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_0
(NS3 PROTEASE)		 5im2 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
(Rhodoferax
ferrireducens) 		5 / 12 GLY A 149
VAL A 213
ILE A 339
GLY A 234
ALA A 116
 None
BEZ  A 401 ( 3.9A)
None
None
None
 1.17A 6c2mB-5im2A:
undetectable		 6c2mB-5im2A:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_0
(NS3 PROTEASE)		 5im2 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
(Rhodoferax
ferrireducens) 		5 / 12 GLN A 277
GLY A 147
ILE A 195
ALA A 208
ALA A 207
 BEZ  A 401 (-3.9A)
None
None
None
None
 0.71A 6c2mD-5im2A:
undetectable		 6c2mD-5im2A:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_A_HISA402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 5im2 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
(Rhodoferax
ferrireducens) 		5 / 10 GLY A 181
LEU A 183
VAL A 176
ALA A 208
LEU A 236
 None
 0.88A 6czmA-5im2A:
4.7
6czmC-5im2A:
4.4		 6czmA-5im2A:
22.74
6czmC-5im2A:
22.74