SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5im4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C6Z_B_ROCB505_2
(PROTEIN (PROTEASE))		 5im4 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE
(Candida
albicans) 		5 / 12 GLY A  38
ALA A  39
ILE A 122
GLY A 124
ILE A  22
 None
 0.91A 1c6zB-5im4A:
undetectable		 1c6zB-5im4A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_2
(PROTEASE)		 5im4 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE
(Candida
albicans) 		6 / 11 GLY A 153
ALA A  39
ILE A  55
GLY A  21
ILE A  85
ILE A  88
 None
 1.38A 1n49B-5im4A:
undetectable		 1n49B-5im4A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_1
(PROTEASE)		 5im4 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE
(Candida
albicans) 		6 / 11 GLY A 153
ALA A  39
ILE A  55
GLY A  21
ILE A  85
ILE A  88
 None
 1.38A 1n49C-5im4A:
undetectable		 1n49C-5im4A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q9R_A_BEZA203_0
(PROTEIN OF UNKNOWN
FUNCTION)		 5im4 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE
(Candida
albicans) 		4 / 5 LEU A  35
GLY A  38
ILE A  22
ILE A  88
 None
 0.82A 2q9rA-5im4A:
undetectable		 2q9rA-5im4A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_A_DR7A100_1
(PROTEASE)		 5im4 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE
(Candida
albicans) 		5 / 11 GLY A  38
ALA A  39
ILE A 122
LEU A 126
ILE A  22
 None
 0.89A 3em4A-5im4A:
undetectable		 3em4A-5im4A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 5im4 PHOSPHOTRANSFERASE
SYSTEM,
MANNOSE/FRUCTOSE-SPE
CIFIC COMPONENT IIA
(Caldanaerobacter
subterraneus) 		4 / 4 LEU F  18
GLY F  17
GLY F  15
THR F  34
 None
 0.85A 3si7A-5im4F:
undetectable		 3si7A-5im4F:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_A_CYZA266_2
(GLUTAMATE RECEPTOR 2)		 5im4 PHOSPHOTRANSFERASE
SYSTEM,
MANNOSE/FRUCTOSE-SPE
CIFIC COMPONENT IIA
(Caldanaerobacter
subterraneus) 		4 / 5 ILE F 121
PRO F  97
LYS F 123
GLY F 122
 None
 1.17A 3tkdB-5im4F:
2.5		 3tkdB-5im4F:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_B_CYZB267_1
(GLUTAMATE RECEPTOR 2)		 5im4 PHOSPHOTRANSFERASE
SYSTEM,
MANNOSE/FRUCTOSE-SPE
CIFIC COMPONENT IIA
(Caldanaerobacter
subterraneus) 		4 / 5 ILE F 121
PRO F  97
LYS F 123
GLY F 122
 None
 1.17A 3tkdA-5im4F:
2.6		 3tkdA-5im4F:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_B_BEZB1000_0
(BENZOATE-COENZYME A
LIGASE)		 5im4 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE
(Candida
albicans) 		5 / 9 ALA A 156
ALA A  39
GLY A 149
ILE A  88
ILE A  22
 None
 1.08A 4eatB-5im4A:
3.3		 4eatB-5im4A:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_A_STRA604_1
(CYTOCHROME P450
21-HYDROXYLASE)		 5im4 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE
(Candida
albicans) 		5 / 12 SER A  61
VAL A  36
LEU A  35
ILE A  88
GLY A 124
 None
 0.98A 4y8wA-5im4A:
undetectable		 4y8wA-5im4A:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_B_STRB603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 5im4 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE
(Candida
albicans) 		5 / 12 SER A  61
VAL A  36
LEU A  35
ILE A  88
GLY A 124
 None
 0.98A 4y8wB-5im4A:
undetectable		 4y8wB-5im4A:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NJV_D_SAMD301_0
(NS5)		 5im4 PHOSPHOTRANSFERASE
SYSTEM,
MANNOSE/FRUCTOSE-SPE
CIFIC COMPONENT IIA
(Caldanaerobacter
subterraneus) 		5 / 12 GLY F  17
GLY F  36
GLY F  12
VAL F  46
ILE F   9
 None
 1.00A 5njvD-5im4F:
undetectable		 5njvD-5im4F:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NVP_A_ACAA18_1
(ENVELOPE
GLYCOPROTEIN,GP41)		 5im4 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE
(Candida
albicans) 		5 / 12 LYS A  69
GLU A  56
GLN A  75
GLU A  73
LEU A  70
 None
 1.32A 5nvpA-5im4A:
undetectable		 5nvpA-5im4A:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH6_A_017A104_0
(PROTEASE)		 5im4 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE
(Candida
albicans) 		5 / 12 GLY A  38
ALA A  39
ILE A 122
GLY A 124
ILE A  22
 None
 0.94A 6dh6A-5im4A:
undetectable		 6dh6A-5im4A:
22.50