SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5im5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2AOH_C_FRDC305_1 (POL POLYPROTEIN PEPTIDE INHIBITOR)	5im5	DESIGNED KETO-HYDROXYGLUTARAT E-ALDOLASE/KETO-DEOX Y-PHOSPHOGLUCONATE ALDOLASE (Vibrionales bacterium SWAT-3)	4 / 5	LEU P 56 GLY P 36 PRO P 15 ALA P 40	None	0.96A	2aohA-5im5P: undetectable	2aohA-5im5P: 19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3GCS_A_BAXA401_2 (MITOGEN-ACTIVATED PROTEIN KINASE 14)	5im5	DESIGNED KETO-HYDROXYGLUTARAT E-ALDOLASE/KETO-DEOX Y-PHOSPHOGLUCONATE ALDOLASE (Vibrionales bacterium SWAT-3)	4 / 6	VAL P 87 LEU P 154 ILE P 103 ILE P 70	None	0.95A	3gcsA-5im5P: undetectable	3gcsA-5im5P: 20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3UVV_B_9CRB501_1 (RETINOIC ACID RECEPTOR RXR-ALPHA)	5im5	DESIGNED KETO-HYDROXYGLUTARAT E-ALDOLASE/KETO-DEOX Y-PHOSPHOGLUCONATE ALDOLASE (Vibrionales bacterium SWAT-3)	5 / 12	ILE P 53 ALA P 52 PHE P 44 ALA P 48 ILE P 105	None	1.26A	3uvvB-5im5P: undetectable	3uvvB-5im5P: 23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3W67_C_VIVC301_0 (ALPHA-TOCOPHEROL TRANSFER PROTEIN)	5im5	DESIGNED KETO-HYDROXYGLUTARAT E-ALDOLASE/KETO-DEOX Y-PHOSPHOGLUCONATE ALDOLASE (Vibrionales bacterium SWAT-3)	5 / 12	ILE P 196 TRP P 193 LEU P 55 ALA P 40 ILE P 19	None	1.15A	3w67C-5im5P: undetectable	3w67C-5im5P: 19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DU2_A_LDPA501_1 (CYTOCHROME P450 BM3 VARIANT B7)	5im5	DESIGNED KETO-HYDROXYGLUTARAT E-ALDOLASE/KETO-DEOX Y-PHOSPHOGLUCONATE ALDOLASE (Vibrionales bacterium SWAT-3)	4 / 7	ALA P 67 PHE P 44 ALA P 49 ALA P 82	None	0.91A	4du2A-5im5P: undetectable	4du2A-5im5P: 22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4LBG_B_ADNB402_1 (PROBABLE SUGAR KINASE PROTEIN)	5im5	DESIGNED KETO-HYDROXYGLUTARAT E-ALDOLASE/KETO-DEOX Y-PHOSPHOGLUCONATE ALDOLASE (Vibrionales bacterium SWAT-3)	5 / 9	THR P 69 ALA P 49 ILE P 25 ALA P 18 ILE P 17	None	1.10A	4lbgB-5im5P: undetectable	4lbgB-5im5P: 21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XV2_B_P06B801_2 (SERINE/THREONINE-PRO TEIN KINASE B-RAF)	5im5	DESIGNED KETO-HYDROXYGLUTARAT E-ALDOLASE/KETO-DEOX Y-PHOSPHOGLUCONATE ALDOLASE (Vibrionales bacterium SWAT-3)	4 / 4	GLY P 110 VAL P 108 PHE P 44 ILE P 70	None	1.15A	4xv2B-5im5P: undetectable	4xv2B-5im5P: 22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6HCO_A_FY5A1003_0 (ATP-BINDING CASSETTE SUB-FAMILY G MEMBER 2)	5im5	DESIGNED KETO-HYDROXYGLUTARAT E-ALDOLASE/KETO-DEOX Y-PHOSPHOGLUCONATE ALDOLASE (Vibrionales bacterium SWAT-3)	5 / 11	THR P 157 PHE P 131 THR P 43 ILE P 107 VAL P 88	None	1.21A	6hcoA-5im5P: undetectable 6hcoB-5im5P: undetectable	6hcoA-5im5P: 15.69 6hcoB-5im5P: 15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6NCS_A_ACTA303_0 (N-ACETYLNEURAMINIC ACID (SIALIC ACID) SYNTHETASE)	5im5	DESIGNED KETO-HYDROXYGLUTARAT E-ALDOLASE/KETO-DEOX Y-PHOSPHOGLUCONATE ALDOLASE (Vibrionales bacterium SWAT-3)	3 / 3	ILE P 203 THR P 200 PRO P 162	None	0.65A	6ncsA-5im5P: 15.0	6ncsA-5im5P: 21.74

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2AOH_C_FRDC305_1","POL POLYPROTEIN;PEPTIDE INHIBITOR","5im5","DESIGNED KETO-HYDROXYGLUTARATE-ALDOLASE\/KETO-DEOXY-PHOSPHOGLUCONATE ALDOLASE","Vibrionales bacterium SWAT-3",4,"LEU P  56;GLY P  36;PRO P  15;ALA P  40","None","0.96A","2aohA-5im5P:undetectable","2aohA-5im5P:19.91"],["3GCS_A_BAXA401_2","MITOGEN-ACTIVATED PROTEIN KINASE 14","5im5","DESIGNED KETO-HYDROXYGLUTARATE-ALDOLASE\/KETO-DEOXY-PHOSPHOGLUCONATE ALDOLASE","Vibrionales bacterium SWAT-3",4,"VAL P  87;LEU P 154;ILE P 103;ILE P  70","None","0.95A","3gcsA-5im5P:undetectable","3gcsA-5im5P:20.98"],["3UVV_B_9CRB501_1","RETINOIC ACID RECEPTOR RXR-ALPHA","5im5","DESIGNED KETO-HYDROXYGLUTARATE-ALDOLASE\/KETO-DEOXY-PHOSPHOGLUCONATE ALDOLASE","Vibrionales bacterium SWAT-3",5,"ILE P  53;ALA P  52;PHE P  44;ALA P  48;ILE P 105","None","1.26A","3uvvB-5im5P:undetectable","3uvvB-5im5P:23.27"],["3W67_C_VIVC301_0","ALPHA-TOCOPHEROL TRANSFER PROTEIN","5im5","DESIGNED KETO-HYDROXYGLUTARATE-ALDOLASE\/KETO-DEOXY-PHOSPHOGLUCONATE ALDOLASE","Vibrionales bacterium SWAT-3",5,"ILE P 196;TRP P 193;LEU P  55;ALA P  40;ILE P  19","None","1.15A","3w67C-5im5P:undetectable","3w67C-5im5P:19.86"],["4DU2_A_LDPA501_1","CYTOCHROME P450 BM3 VARIANT B7","5im5","DESIGNED KETO-HYDROXYGLUTARATE-ALDOLASE\/KETO-DEOXY-PHOSPHOGLUCONATE ALDOLASE","Vibrionales bacterium SWAT-3",4,"ALA P  67;PHE P  44;ALA P  49;ALA P  82","None","0.91A","4du2A-5im5P:undetectable","4du2A-5im5P:22.08"],["4LBG_B_ADNB402_1","PROBABLE SUGAR KINASE PROTEIN","5im5","DESIGNED KETO-HYDROXYGLUTARATE-ALDOLASE\/KETO-DEOXY-PHOSPHOGLUCONATE ALDOLASE","Vibrionales bacterium SWAT-3",5,"THR P  69;ALA P  49;ILE P  25;ALA P  18;ILE P  17","None","1.10A","4lbgB-5im5P:undetectable","4lbgB-5im5P:21.39"],["4XV2_B_P06B801_2","SERINE\/THREONINE-PROTEIN KINASE B-RAF","5im5","DESIGNED KETO-HYDROXYGLUTARATE-ALDOLASE\/KETO-DEOXY-PHOSPHOGLUCONATE ALDOLASE","Vibrionales bacterium SWAT-3",4,"GLY P 110;VAL P 108;PHE P  44;ILE P  70","None","1.15A","4xv2B-5im5P:undetectable","4xv2B-5im5P:22.52"],["6HCO_A_FY5A1003_0","ATP-BINDING CASSETTE SUB-FAMILY G MEMBER 2","5im5","DESIGNED KETO-HYDROXYGLUTARATE-ALDOLASE\/KETO-DEOXY-PHOSPHOGLUCONATE ALDOLASE","Vibrionales bacterium SWAT-3",5,"THR P 157;PHE P 131;THR P  43;ILE P 107;VAL P  88","None","1.21A","6hcoA-5im5P:undetectable;6hcoB-5im5P:undetectable","6hcoA-5im5P:15.69;6hcoB-5im5P:15.69"],["6NCS_A_ACTA303_0","N-ACETYLNEURAMINIC ACID (SIALIC ACID) SYNTHETASE","5im5","DESIGNED KETO-HYDROXYGLUTARATE-ALDOLASE\/KETO-DEOXY-PHOSPHOGLUCONATE ALDOLASE","Vibrionales bacterium SWAT-3",3,"ILE P 203;THR P 200;PRO P 162","None","0.65A","6ncsA-5im5P:15.0","6ncsA-5im5P:21.74"]]