SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5iml'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_N_ACTN803_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 5iml NANOBODY
(Camelidae) 		4 / 6 ARG B  71
GLY B  34
TYR B 111
TRP B 100
 None
 1.39A 1kf6M-5imlB:
undetectable
1kf6N-5imlB:
undetectable		 1kf6M-5imlB:
13.71
1kf6N-5imlB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOB_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 5iml NANOBODY
(Camelidae) 		5 / 12 THR B  57
PHE B  36
GLY B  32
ARG B  71
LEU B   3
 None
 1.48A 3aobC-5imlB:
1.5		 3aobC-5imlB:
8.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 5iml NANOBODY
(Camelidae) 		6 / 12 ALA B  23
MET B  33
ARG B  71
ASN B  76
VAL B  78
ALA B  97
 None
 0.84A 3qxtA-5imlB:
23.7		 3qxtA-5imlB:
76.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXT_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 5iml NANOBODY
(Camelidae) 		7 / 12 LEU B   3
ALA B  23
MET B  33
ARG B  71
VAL B  78
ALA B  97
TYR B 113
 None
 0.64A 3qxtB-5imlB:
24.0		 3qxtB-5imlB:
76.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5iml NANOBODY
(Camelidae) 		6 / 12 ALA B  23
MET B  33
ASN B  73
VAL B  78
ALA B  97
TYR B 113
 None
 0.72A 3qxvA-5imlB:
23.7		 3qxvA-5imlB:
75.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5iml NANOBODY
(Camelidae) 		6 / 12 MET B  33
ARG B  71
ASN B  73
VAL B  78
ALA B  97
TYR B 113
 None
 0.30A 3qxvA-5imlB:
23.7		 3qxvA-5imlB:
75.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5iml NANOBODY
(Camelidae) 		5 / 12 MET B  33
ARG B  71
VAL B  78
ALA B  97
TYR B 113
 None
 0.35A 3qxvB-5imlB:
23.7		 3qxvB-5imlB:
75.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_C_MTXC2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5iml NANOBODY
(Camelidae) 		6 / 11 ALA B  23
MET B  33
ARG B  71
ASN B  73
VAL B  78
ALA B  97
 None
 0.72A 3qxvC-5imlB:
24.1		 3qxvC-5imlB:
75.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_D_MTXD2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5iml NANOBODY
(Camelidae) 		6 / 12 ALA B  23
MET B  33
ARG B  71
VAL B  78
ALA B  97
TYR B 113
 None
 0.75A 3qxvD-5imlB:
23.6		 3qxvD-5imlB:
75.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_E_MTXE2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5iml NANOBODY
(Camelidae) 		5 / 12 ALA B  23
MET B  33
ARG B  71
ALA B  97
TYR B 113
 None
 0.82A 3qxvE-5imlB:
19.9		 3qxvE-5imlB:
75.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3QXV_E_MTXE2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 5iml NANOBODY
(Camelidae) 		5 / 12 MET B  33
ARG B  71
VAL B  78
ALA B  97
TYR B 113
 None
 0.43A 3qxvE-5imlB:
19.9		 3qxvE-5imlB:
75.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_C_ACTC1113_0
(BLR5658 PROTEIN)		 5iml NANOBODY
(Camelidae) 		4 / 4 ASN B  76
ALA B  23
GLY B  25
THR B  27
 None
 1.39A 4bboC-5imlB:
undetectable		 4bboC-5imlB:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KHP_A_PARA1606_1
(16S RIBOSOMAL RNA
30S RIBOSOMAL
PROTEIN S9
30S RIBOSOMAL
PROTEIN S10)		 5iml NANOBODY
(Camelidae) 		3 / 3 TYR B  58
ARG B  51
SER B  56
 None
 1.11A 4khpI-5imlB:
undetectable
4khpJ-5imlB:
undetectable		 4khpI-5imlB:
19.71
4khpJ-5imlB:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RFQ_A_SAMA401_1
(HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG)		 5iml NANOBODY
(Camelidae) 		4 / 4 THR B  27
GLY B  98
ASP B 112
SER B  30
 None
 0.89A 4rfqA-5imlB:
undetectable		 4rfqA-5imlB:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA607_1
(PHIAB6 TAILSPIKE)		 5iml NANOBODY
(Camelidae) 		3 / 3 THR B  27
SER B  30
TYR B  31
 None
 0.74A 5jsdA-5imlB:
undetectable		 5jsdA-5imlB:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB618_1
(PHIAB6 TAILSPIKE)		 5iml NANOBODY
(Camelidae) 		3 / 3 THR B  27
SER B  30
TYR B  31
 None
 0.75A 5jsdB-5imlB:
undetectable		 5jsdB-5imlB:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_C_1GNC608_1
(PHIAB6 TAILSPIKE)		 5iml NANOBODY
(Camelidae) 		3 / 3 THR B  27
SER B  30
TYR B  31
 None
 0.74A 5jsdC-5imlB:
undetectable		 5jsdC-5imlB:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_A_1GNA608_1
(PHIAB6 TAILSPIKE)		 5iml NANOBODY
(Camelidae) 		3 / 3 THR B  27
SER B  30
TYR B  31
 None
 0.76A 5jseA-5imlB:
2.4		 5jseA-5imlB:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_B_1GNB611_1
(PHIAB6 TAILSPIKE)		 5iml NANOBODY
(Camelidae) 		3 / 3 THR B  27
SER B  30
TYR B  31
 None
 0.74A 5jseB-5imlB:
undetectable		 5jseB-5imlB:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_C_1GNC611_1
(PHIAB6 TAILSPIKE)		 5iml NANOBODY
(Camelidae) 		3 / 3 THR B  27
SER B  30
TYR B  31
 None
 0.74A 5jseC-5imlB:
undetectable		 5jseC-5imlB:
9.82