SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5imt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_A_URFA1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 5imt INTERMEDILYSIN
(Streptococcus
intermedius) 		4 / 6 ASN A 397
ILE A  68
ASN A  65
SER A 269
 None
 1.16A 1h7xA-5imtA:
undetectable		 1h7xA-5imtA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_B_URFB1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 5imt INTERMEDILYSIN
(Streptococcus
intermedius) 		4 / 6 ASN A 397
ILE A  68
ASN A  65
SER A 269
 None
 1.16A 1h7xB-5imtA:
undetectable		 1h7xB-5imtA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_C_URFC1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 5imt INTERMEDILYSIN
(Streptococcus
intermedius) 		4 / 6 ASN A 397
ILE A  68
ASN A  65
SER A 269
 None
 1.16A 1h7xC-5imtA:
undetectable		 1h7xC-5imtA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_D_URFD1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 5imt INTERMEDILYSIN
(Streptococcus
intermedius) 		4 / 6 ASN A 397
ILE A  68
ASN A  65
SER A 269
 None
 1.17A 1h7xD-5imtA:
undetectable		 1h7xD-5imtA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5imt INTERMEDILYSIN
(Streptococcus
intermedius) 		4 / 8 SER A 119
ARG A 254
ASN A 252
ASP A 226
 None
 1.32A 1p6kA-5imtA:
undetectable		 1p6kA-5imtA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_A_PXLA1003_1
(PYRIDOXINE KINASE)		 5imt INTERMEDILYSIN
(Streptococcus
intermedius) 		4 / 8 VAL A 293
LEU A 134
PRO A 145
TYR A 389
 None
 1.08A 2ddwA-5imtA:
undetectable		 2ddwA-5imtA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 5imt INTERMEDILYSIN
(Streptococcus
intermedius) 		4 / 6 TYR A  67
PRO A 292
ILE A  78
ASN A 287
 None
 1.34A 2wekB-5imtA:
undetectable		 2wekB-5imtA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 5imt INTERMEDILYSIN
(Streptococcus
intermedius) 		5 / 11 VAL A 324
THR A 343
ILE A 345
LYS A 369
LEU A 368
 None
 1.40A 3bexC-5imtA:
undetectable
3bexD-5imtA:
undetectable		 3bexC-5imtA:
17.57
3bexD-5imtA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BEX_D_PAUD248_0
(TYPE III
PANTOTHENATE KINASE)		 5imt INTERMEDILYSIN
(Streptococcus
intermedius) 		5 / 10 LYS A 369
LEU A 368
VAL A 324
THR A 343
ILE A 345
 None
 1.38A 3bexC-5imtA:
undetectable
3bexD-5imtA:
undetectable		 3bexC-5imtA:
17.57
3bexD-5imtA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_C_PAUC248_0
(TYPE III
PANTOTHENATE KINASE)		 5imt INTERMEDILYSIN
(Streptococcus
intermedius) 		5 / 11 VAL A 324
THR A 343
ILE A 345
LYS A 369
LEU A 368
 None
 1.35A 3bf1C-5imtA:
undetectable
3bf1D-5imtA:
undetectable		 3bf1C-5imtA:
17.57
3bf1D-5imtA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF1_F_PAUF248_0
(TYPE III
PANTOTHENATE KINASE)		 5imt INTERMEDILYSIN
(Streptococcus
intermedius) 		5 / 11 LYS A 369
LEU A 368
VAL A 324
THR A 343
ILE A 345
 None
 1.38A 3bf1E-5imtA:
undetectable
3bf1F-5imtA:
undetectable		 3bf1E-5imtA:
17.57
3bf1F-5imtA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP5_B_KANB2002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 5imt INTERMEDILYSIN
(Streptococcus
intermedius) 		3 / 3 ALA A  94
ARG A  92
LYS A 107
 ZN  A 607 ( 4.1A)
ZN  A 607 ( 4.9A)
None
 0.99A 3kp5B-5imtA:
undetectable		 3kp5B-5imtA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 5imt INTERMEDILYSIN
(Streptococcus
intermedius) 		5 / 12 ASN A 342
ILE A 345
THR A 343
VAL A 306
ILE A 321
 None
 1.23A 3kpbA-5imtA:
undetectable		 3kpbA-5imtA:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 5imt INTERMEDILYSIN
(Streptococcus
intermedius) 		4 / 4 ASN A 287
SER A 269
LEU A  64
THR A 290
 None
 1.34A 4an2A-5imtA:
undetectable		 4an2A-5imtA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSE_A_H4BA804_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5imt INTERMEDILYSIN
(Streptococcus
intermedius) 		4 / 7 ARG A 509
TRP A 437
PHE A 472
GLU A 438
 None
PGE  A 601 ( 4.5A)
PGE  A 601 (-4.3A)
None
 1.03A 4jseA-5imtA:
undetectable
4jseB-5imtA:
undetectable		 4jseA-5imtA:
20.39
4jseB-5imtA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JSE_B_H4BB802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 5imt INTERMEDILYSIN
(Streptococcus
intermedius) 		4 / 7 TRP A 437
PHE A 472
GLU A 438
ARG A 509
 PGE  A 601 ( 4.5A)
PGE  A 601 (-4.3A)
None
None
 1.07A 4jseA-5imtA:
undetectable
4jseB-5imtA:
undetectable		 4jseA-5imtA:
20.39
4jseB-5imtA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UIN_H_QI9H1226_0
(FAB 314.3)		 5imt INTERMEDILYSIN
(Streptococcus
intermedius) 		5 / 12 HIS A 425
GLY A 485
ARG A 432
PHE A 433
GLY A 459
 None
 1.27A 4uinH-5imtA:
undetectable
4uinL-5imtA:
undetectable		 4uinH-5imtA:
17.92
4uinL-5imtA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2Q_A_ACTA1728_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9)		 5imt INTERMEDILYSIN
(Streptococcus
intermedius) 		3 / 3 ASN A 297
SER A 299
ARG A 205
 CU  A 609 (-4.2A)
CU  A 609 (-3.2A)
None
 0.95A 5b2qA-5imtA:
undetectable		 5b2qA-5imtA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M35_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5imt INTERMEDILYSIN
(Streptococcus
intermedius) 		3 / 3 MET A 206
GLN A 207
ARG A 205
 SO4  A 602 (-4.9A)
None
None
 1.12A 5m35B-5imtA:
undetectable		 5m35B-5imtA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M36_A_BEZA303_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5imt INTERMEDILYSIN
(Streptococcus
intermedius) 		3 / 3 MET A 206
GLN A 207
ARG A 205
 SO4  A 602 (-4.9A)
None
None
 1.09A 5m36A-5imtA:
undetectable		 5m36A-5imtA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FN9_A_BEZA302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5imt INTERMEDILYSIN
(Streptococcus
intermedius) 		3 / 3 MET A 206
GLN A 207
ARG A 205
 SO4  A 602 (-4.9A)
None
None
 1.14A 6fn9A-5imtA:
undetectable		 6fn9A-5imtA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNA_B_BEZB302_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5imt INTERMEDILYSIN
(Streptococcus
intermedius) 		3 / 3 MET A 206
GLN A 207
ARG A 205
 SO4  A 602 (-4.9A)
None
None
 1.14A 6fnaB-5imtA:
undetectable		 6fnaB-5imtA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FNB_A_BEZA301_0
(14-3-3 PROTEIN
ZETA/DELTA)		 5imt INTERMEDILYSIN
(Streptococcus
intermedius) 		3 / 3 MET A 206
GLN A 207
ARG A 205
 SO4  A 602 (-4.9A)
None
None
 1.12A 6fnbA-5imtA:
undetectable		 6fnbA-5imtA:
18.48