SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5imu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OQ5_A_CELA701_2
(CARBONIC ANHYDRASE
II)		 5imu TAT (TWIN-ARGININE
TRANSLOCATION)
PATHWAY SIGNAL
SEQUENCE CONTAINING
PROTEIN
(Mycobacterium
tuberculosis) 		4 / 4 HIS A 364
VAL A 357
THR A 399
LEU A 374
 None
 1.34A 1oq5A-5imuA:
undetectable		 1oq5A-5imuA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_B_PODB700_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 5imu TAT (TWIN-ARGININE
TRANSLOCATION)
PATHWAY SIGNAL
SEQUENCE CONTAINING
PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 393
ALA A 377
LEU A 374
ALA A 329
VAL A 333
 None
 1.12A 1sa1A-5imuA:
undetectable
1sa1B-5imuA:
undetectable		 1sa1A-5imuA:
18.40
1sa1B-5imuA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SA1_D_PODD701_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 5imu TAT (TWIN-ARGININE
TRANSLOCATION)
PATHWAY SIGNAL
SEQUENCE CONTAINING
PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 393
ALA A 377
LEU A 374
ALA A 329
VAL A 333
 None
 1.16A 1sa1C-5imuA:
undetectable
1sa1D-5imuA:
undetectable		 1sa1C-5imuA:
18.40
1sa1D-5imuA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DAU_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 5imu TAT (TWIN-ARGININE
TRANSLOCATION)
PATHWAY SIGNAL
SEQUENCE CONTAINING
PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 238
ALA A 297
LEU A 228
ALA A 218
TYR A 391
 None
 1.11A 3dauA-5imuA:
undetectable		 3dauA-5imuA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_B_URFB400_1
(URIDINE
PHOSPHORYLASE 1)		 5imu TAT (TWIN-ARGININE
TRANSLOCATION)
PATHWAY SIGNAL
SEQUENCE CONTAINING
PROTEIN
(Mycobacterium
tuberculosis) 		4 / 8 GLY A 348
LEU A 346
LEU A 345
ILE A 324
 None
 0.83A 3nbqB-5imuA:
undetectable		 3nbqB-5imuA:
26.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NBQ_C_URFC400_1
(URIDINE
PHOSPHORYLASE 1)		 5imu TAT (TWIN-ARGININE
TRANSLOCATION)
PATHWAY SIGNAL
SEQUENCE CONTAINING
PROTEIN
(Mycobacterium
tuberculosis) 		4 / 8 GLY A 348
LEU A 346
LEU A 345
ILE A 324
 None
 0.88A 3nbqC-5imuA:
undetectable		 3nbqC-5imuA:
26.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SO9_A_017A100_2
(HIV-1 PROTEASE)		 5imu TAT (TWIN-ARGININE
TRANSLOCATION)
PATHWAY SIGNAL
SEQUENCE CONTAINING
PROTEIN
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 260
ASP A 261
ASP A 232
GLY A 267
THR A 254
 None
 0.94A 3so9B-5imuA:
undetectable		 3so9B-5imuA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA510_1
(PROTON-GATED ION
CHANNEL)		 5imu TAT (TWIN-ARGININE
TRANSLOCATION)
PATHWAY SIGNAL
SEQUENCE CONTAINING
PROTEIN
(Mycobacterium
tuberculosis) 		5 / 9 ALA A 327
ILE A 324
ILE A 382
ALA A 343
LEU A 346
 None
 0.95A 5mvmA-5imuA:
2.4
5mvmE-5imuA:
2.4		 5mvmA-5imuA:
17.83
5mvmE-5imuA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 5imu TAT (TWIN-ARGININE
TRANSLOCATION)
PATHWAY SIGNAL
SEQUENCE CONTAINING
PROTEIN
(Mycobacterium
tuberculosis) 		5 / 10 ILE A 382
ALA A 343
LEU A 346
ALA A 327
ILE A 324
 None
 0.97A 5mvmD-5imuA:
2.4
5mvmE-5imuA:
2.4		 5mvmD-5imuA:
17.83
5mvmE-5imuA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB603_0
(ACETYLCHOLINESTERASE)		 5imu TAT (TWIN-ARGININE
TRANSLOCATION)
PATHWAY SIGNAL
SEQUENCE CONTAINING
PROTEIN
(Mycobacterium
tuberculosis) 		4 / 7 GLN A 201
ASP A 205
TRP A 216
TYR A 361
 None
 1.15A 5ov9B-5imuA:
undetectable		 5ov9B-5imuA:
19.02