SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5imy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7A_B_PFLB4002_1
(SERUM ALBUMIN)		 5imy VAGINOLYSIN
(Gardnerella
vaginalis) 		4 / 6 PHE A 295
LEU A 221
VAL A 238
GLN A 236
 None
 1.07A 1e7aB-5imyA:
undetectable		 1e7aB-5imyA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_D_DVAD6_0
(GRAMICIDIN A)		 5imy VAGINOLYSIN
(Gardnerella
vaginalis) 		4 / 4 VAL A 484
TRP A 481
ALA A 418
VAL A 471
 None
 1.41A 1gmkC-5imyA:
undetectable
1gmkD-5imyA:
undetectable		 1gmkC-5imyA:
3.34
1gmkD-5imyA:
3.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ILQ_C_ACAC7_1
(INTERLEUKIN-8
PRECURSOR
INTERLEUKIN-8
RECEPTOR A)		 5imy VAGINOLYSIN
(Gardnerella
vaginalis) 		4 / 6 ASP A 129
ASP A 213
MET A 131
PRO A 132
 None
 1.40A 1ilqA-5imyA:
undetectable
1ilqC-5imyA:
undetectable		 1ilqA-5imyA:
9.59
1ilqC-5imyA:
3.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5imy VAGINOLYSIN
(Gardnerella
vaginalis) 		4 / 8 SER A 133
PHE A 121
ASN A 126
ASP A 124
 None
 1.29A 1p6kA-5imyA:
undetectable		 1p6kA-5imyA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5imy VAGINOLYSIN
(Gardnerella
vaginalis) 		4 / 8 SER A 133
PHE A 121
ASN A 126
ASP A 124
 None
 1.27A 1p6kB-5imyA:
undetectable		 1p6kB-5imyA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5imy VAGINOLYSIN
(Gardnerella
vaginalis) 		4 / 8 SER A 133
PHE A 121
ASN A 126
ASP A 124
 None
 1.24A 1rs6A-5imyA:
undetectable		 1rs6A-5imyA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5imy VAGINOLYSIN
(Gardnerella
vaginalis) 		4 / 8 SER A 133
PHE A 121
ASN A 126
ASP A 124
 None
 1.24A 1rs6B-5imyA:
undetectable		 1rs6B-5imyA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5imy VAGINOLYSIN
(Gardnerella
vaginalis) 		4 / 8 SER A 133
PHE A 121
ASN A 126
ASP A 124
 None
 1.30A 1zzqA-5imyA:
undetectable		 1zzqA-5imyA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5imy VAGINOLYSIN
(Gardnerella
vaginalis) 		4 / 8 SER A 133
PHE A 121
ASN A 126
ASP A 124
 None
 1.29A 1zzqB-5imyA:
undetectable		 1zzqB-5imyA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 5imy VAGINOLYSIN
(Gardnerella
vaginalis) 		4 / 8 SER A 133
PHE A 121
ASN A 126
ASP A 124
 None
 1.30A 1zzuB-5imyA:
undetectable		 1zzuB-5imyA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6P_B_TA1B502_1
(TUBULIN BETA CHAIN)		 5imy VAGINOLYSIN
(Gardnerella
vaginalis) 		5 / 12 VAL A 308
GLU A 309
SER A 197
PHE A 240
GLY A 314
 None
 1.21A 3j6pB-5imyA:
undetectable		 3j6pB-5imyA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_2
(GENOME POLYPROTEIN)		 5imy VAGINOLYSIN
(Gardnerella
vaginalis) 		3 / 3 PHE A 210
TYR A 195
LEU A 389
 None
 0.69A 3keeB-5imyA:
undetectable		 3keeB-5imyA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_MTLB870_0
(NITRIC OXIDE
SYNTHASE)		 5imy VAGINOLYSIN
(Gardnerella
vaginalis) 		4 / 8 SER A 133
PHE A 121
ASN A 126
ASP A 124
 None
 1.28A 3n62B-5imyA:
undetectable		 3n62B-5imyA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 5imy VAGINOLYSIN
(Gardnerella
vaginalis) 		3 / 3 PHE A 210
TYR A 195
LEU A 389
 None
 0.64A 3sueB-5imyA:
undetectable		 3sueB-5imyA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_A_NCAA300_0
(PROTOGLOBIN)		 5imy VAGINOLYSIN
(Gardnerella
vaginalis) 		4 / 7 TYR A 292
VAL A 335
PHE A 214
ILE A 223
 None
 0.92A 3zjqA-5imyA:
undetectable		 3zjqA-5imyA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZJQ_B_NCAB300_0
(PROTOGLOBIN)		 5imy VAGINOLYSIN
(Gardnerella
vaginalis) 		4 / 7 TYR A 292
VAL A 335
PHE A 214
ILE A 223
 None
 0.91A 3zjqB-5imyA:
undetectable		 3zjqB-5imyA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ARC_A_LEUA1001_0
(LEUCINE--TRNA LIGASE)		 5imy VAGINOLYSIN
(Gardnerella
vaginalis) 		4 / 7 LEU A 206
SER A 199
TYR A 395
HIS A 229
 None
 1.34A 4arcA-5imyA:
undetectable		 4arcA-5imyA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KRH_B_SAMB900_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
2)		 5imy VAGINOLYSIN
(Gardnerella
vaginalis) 		4 / 4 ILE A 135
SER A 136
ASP A 124
ASP A 129
 None
 1.40A 4krhB-5imyA:
undetectable		 4krhB-5imyA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QKN_A_JMSA602_1
(ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE FTO)		 5imy VAGINOLYSIN
(Gardnerella
vaginalis) 		4 / 8 PRO A 252
LEU A 120
VAL A 249
SER A 283
 None
 1.20A 4qknA-5imyA:
undetectable		 4qknA-5imyA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEA_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 5imy VAGINOLYSIN
(Gardnerella
vaginalis) 		4 / 5 LEU A 492
TYR A 403
LYS A 460
GLU A 426
 None
 1.19A 5weaA-5imyA:
undetectable		 5weaA-5imyA:
19.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FZB_B_SRYB301_1
(STREPTOMYCIN
3''-ADENYLYLTRANSFER
ASE)		 5imy VAGINOLYSIN
(Gardnerella
vaginalis) 		5 / 12 ASP A 224
ASP A 394
HIS A 229
ILE A 396
THR A 398
 None
 1.46A 6fzbB-5imyA:
undetectable		 6fzbB-5imyA:
11.98