SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ine'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_A_D16A414_1
(THYMIDYLATE SYNTHASE)		 5ine PRE-GLYCOPROTEIN
POLYPROTEIN GP
COMPLEX
(Lymphocytic
choriomeningitis
mammarenavirus) 		5 / 12 ILE A 351
ASN A 348
GLY A 246
PHE A 245
ALA A 253
 None
 1.11A 1hvyA-5ineA:
undetectable		 1hvyA-5ineA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_B_D16B415_1
(THYMIDYLATE SYNTHASE)		 5ine PRE-GLYCOPROTEIN
POLYPROTEIN GP
COMPLEX
(Lymphocytic
choriomeningitis
mammarenavirus) 		5 / 12 ILE A 351
ASN A 348
GLY A 246
PHE A 245
ALA A 253
 None
 1.15A 1hvyB-5ineA:
undetectable		 1hvyB-5ineA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZ1_A_SHHA2452_1
(HISTONE
DEACETYLASE-LIKE
AMIDOHYDROLASE)		 5ine PRE-GLYCOPROTEIN
POLYPROTEIN GP
COMPLEX
(Lymphocytic
choriomeningitis
mammarenavirus) 		5 / 11 LEU A 110
ILE A 101
HIS A 360
PHE A 199
GLY A 201
 None
 1.22A 1zz1A-5ineA:
undetectable		 1zz1A-5ineA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_A_SNLA1001_2
(MINERALOCORTICOID
RECEPTOR)		 5ine PRE-GLYCOPROTEIN
POLYPROTEIN GP
COMPLEX
(Lymphocytic
choriomeningitis
mammarenavirus) 		4 / 5 LEU A 329
ALA A 327
TRP A 270
MET A 290
 None
 1.17A 2oaxA-5ineA:
undetectable		 2oaxA-5ineA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_A_HSMA1160_1
(ALLERGEN ARG R 1)		 5ine PRE-GLYCOPROTEIN
POLYPROTEIN GP
COMPLEX
(Lymphocytic
choriomeningitis
mammarenavirus) 		4 / 6 SER A 275
TYR A 284
VAL A 304
ASP A 323
 None
 1.45A 2x45A-5ineA:
undetectable		 2x45A-5ineA:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 5ine PRE-GLYCOPROTEIN
POLYPROTEIN GP
COMPLEX
(Lymphocytic
choriomeningitis
mammarenavirus) 		5 / 12 ALA A 303
PRO A 281
GLY A 282
GLY A 283
ILE A 426
 None
 0.92A 3douA-5ineA:
undetectable		 3douA-5ineA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_A_ACRA720_1
(ALPHA-AMYLASE, SUSG)		 5ine PRE-GLYCOPROTEIN
POLYPROTEIN GP
COMPLEX
(Lymphocytic
choriomeningitis
mammarenavirus) 		4 / 7 TYR A 100
GLU A 236
TRP A 235
ASN A  90
 None
 1.35A 3k8mA-5ineA:
undetectable		 3k8mA-5ineA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K8M_B_ACRB820_1
(ALPHA-AMYLASE, SUSG)		 5ine PRE-GLYCOPROTEIN
POLYPROTEIN GP
COMPLEX
(Lymphocytic
choriomeningitis
mammarenavirus) 		4 / 7 TYR A 100
GLU A 236
TRP A 235
ASN A  90
 None
 1.38A 3k8mB-5ineA:
undetectable		 3k8mB-5ineA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA601_1
(SERUM ALBUMIN)		 5ine PRE-GLYCOPROTEIN
POLYPROTEIN GP
COMPLEX
(Lymphocytic
choriomeningitis
mammarenavirus) 		5 / 12 LEU A 340
GLY A 246
SER A 248
LEU A 251
SER A 140
 None
 1.30A 4ot2A-5ineA:
undetectable		 4ot2A-5ineA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPE_A_SAMA2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5ine PRE-GLYCOPROTEIN
POLYPROTEIN GP
COMPLEX
(Lymphocytic
choriomeningitis
mammarenavirus) 		5 / 12 LYS A  69
GLY A  70
ASP A  66
ASN A  63
ILE A 409
 None
 1.05A 4ypeA-5ineA:
undetectable		 4ypeA-5ineA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YPE_B_SAMB2304_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L)		 5ine PRE-GLYCOPROTEIN
POLYPROTEIN GP
COMPLEX
(Lymphocytic
choriomeningitis
mammarenavirus) 		5 / 11 LYS A  69
GLY A  70
ASP A  66
ASN A  63
ILE A 409
 None
 1.05A 4ypeB-5ineA:
undetectable		 4ypeB-5ineA:
19.65