SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5int'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_1_T441128_1
(TRANSTHYRETIN)		 5int PHOSPHOPANTOTHENOYLC
YSTEINE
DECARBOXYLASE
(Bacillus
anthracis) 		4 / 5 LYS A 340
GLU A 339
ALA A 342
LEU A 310
 None
 1.14A 1eta1-5intA:
undetectable		 1eta1-5intA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETB_1_T441128_1
(TRANSTHYRETIN)		 5int PHOSPHOPANTOTHENOYLC
YSTEINE
DECARBOXYLASE
(Bacillus
anthracis) 		4 / 6 LYS A 340
GLU A 339
ALA A 342
LEU A 310
 None
 1.15A 1etb1-5intA:
undetectable		 1etb1-5intA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2503_0
(FERROCHELATASE)		 5int PHOSPHOPANTOTHENOYLC
YSTEINE
DECARBOXYLASE
(Bacillus
anthracis) 		4 / 4 LEU A 376
PRO A 377
LEU A 379
ARG A 386
 None
 0.95A 1hrkB-5intA:
4.1		 1hrkB-5intA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA703_0
(FERROCHELATASE)		 5int PHOSPHOPANTOTHENOYLC
YSTEINE
DECARBOXYLASE
(Bacillus
anthracis) 		4 / 4 LEU A 376
PRO A 377
LEU A 379
ARG A 386
 None
 0.81A 2hrcA-5intA:
3.2		 2hrcA-5intA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_B_CHDB1604_0
(FERROCHELATASE)		 5int PHOSPHOPANTOTHENOYLC
YSTEINE
DECARBOXYLASE
(Bacillus
anthracis) 		4 / 4 LEU A 376
PRO A 377
LEU A 379
ARG A 386
 None
 0.96A 2hrcB-5intA:
4.0		 2hrcB-5intA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5int PHOSPHOPANTOTHENOYLC
YSTEINE
DECARBOXYLASE
(Bacillus
anthracis) 		4 / 4 LEU A 376
PRO A 377
LEU A 379
ARG A 386
 None
 0.95A 2pnjB-5intA:
4.1		 2pnjB-5intA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA803_0
(FERROCHELATASE)		 5int PHOSPHOPANTOTHENOYLC
YSTEINE
DECARBOXYLASE
(Bacillus
anthracis) 		4 / 5 LEU A 376
PRO A 377
LEU A 379
ARG A 386
 None
 0.82A 2qd4A-5intA:
4.2		 2qd4A-5intA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB927_0
(FERROCHELATASE)		 5int PHOSPHOPANTOTHENOYLC
YSTEINE
DECARBOXYLASE
(Bacillus
anthracis) 		3 / 3 LEU A 376
PRO A 377
ARG A 386
 None
 0.50A 2qd4B-5intA:
4.0		 2qd4B-5intA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_B_CHDB1_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5int PHOSPHOPANTOTHENOYLC
YSTEINE
DECARBOXYLASE
(Bacillus
anthracis) 		4 / 4 LEU A 376
PRO A 377
LEU A 379
ARG A 386
 None
 0.70A 3hcoB-5intA:
3.9		 3hcoB-5intA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECNB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5int PHOSPHOPANTOTHENOYLC
YSTEINE
DECARBOXYLASE
(Bacillus
anthracis) 		5 / 9 THR A 247
GLY A 235
ALA A 194
THR A 273
ILE A 219
 None
 1.24A 3jusB-5intA:
undetectable		 3jusB-5intA:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 5int PHOSPHOPANTOTHENOYLC
YSTEINE
DECARBOXYLASE
(Bacillus
anthracis) 		5 / 9 ILE A 271
VAL A 269
ALA A 228
ALA A 223
ILE A 190
 None
 1.04A 4lbgB-5intA:
5.2		 4lbgB-5intA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_0
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 5int PHOSPHOPANTOTHENOYLC
YSTEINE
DECARBOXYLASE
(Bacillus
anthracis) 		5 / 12 GLY A 195
PRO A 196
GLY A 235
ILE A 271
GLY A 216
 None
 1.03A 4n48A-5intA:
3.3		 4n48A-5intA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_A_PARA500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 5int PHOSPHOPANTOTHENOYLC
YSTEINE
DECARBOXYLASE
(Bacillus
anthracis) 		5 / 10 SER A 211
PHE A 210
THR A 273
TYR A 217
GLY A 216
 None
 1.44A 4qb9A-5intA:
undetectable		 4qb9A-5intA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WOZ_F_MN9F401_0
(N-ACETYLNEURAMINATE
LYASE)		 5int PHOSPHOPANTOTHENOYLC
YSTEINE
DECARBOXYLASE
(Bacillus
anthracis) 		4 / 5 LEU A 307
ASP A 305
LEU A 319
THR A 193
 None
 1.24A 4wozF-5intA:
2.8
4wozH-5intA:
2.9		 4wozF-5intA:
21.41
4wozH-5intA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 5int PHOSPHOPANTOTHENOYLC
YSTEINE
DECARBOXYLASE
(Bacillus
anthracis) 		5 / 12 THR A 237
ALA A 218
ALA A 385
LEU A 389
GLY A 216
 None
 1.04A 5jglA-5intA:
5.4		 5jglA-5intA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_0
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 5int PHOSPHOPANTOTHENOYLC
YSTEINE
DECARBOXYLASE
(Bacillus
anthracis) 		5 / 12 THR A 237
ALA A 218
ALA A 385
LEU A 389
GLY A 216
 None
 1.08A 5jglB-5intA:
4.3		 5jglB-5intA:
24.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_A_9SCA601_1
(SERUM ALBUMIN)		 5int PHOSPHOPANTOTHENOYLC
YSTEINE
DECARBOXYLASE
(Bacillus
anthracis) 		4 / 5 ASN A 341
TYR A 264
VAL A 267
LEU A 191
 None
 1.25A 6a7pA-5intA:
undetectable		 6a7pA-5intA:
17.56