SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5iob'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICU_D_NIOD223_1
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 5iob BETA-GLUCOSIDASE-REL
ATED GLYCOSIDASES
(Corynebacterium
glutamicum) 		4 / 5 GLY A 234
SER A 291
THR A 297
PHE A 232
 None
 1.36A 1icuC-5iobA:
undetectable
1icuD-5iobA:
undetectable		 1icuC-5iobA:
22.22
1icuD-5iobA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_G_AG2G7003_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 5iob BETA-GLUCOSIDASE-REL
ATED GLYCOSIDASES
(Corynebacterium
glutamicum) 		4 / 6 LEU A  76
ASP A 346
GLY A 314
ARG A 302
 None
 0.77A 1mt1G-5iobA:
undetectable
1mt1J-5iobA:
undetectable		 1mt1G-5iobA:
10.45
1mt1J-5iobA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_H_AG2H7012_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN)		 5iob BETA-GLUCOSIDASE-REL
ATED GLYCOSIDASES
(Corynebacterium
glutamicum) 		4 / 6 ARG A 302
LEU A  76
ASP A 346
GLY A 314
 None
 0.78A 1n13H-5iobA:
undetectable
1n13K-5iobA:
undetectable		 1n13H-5iobA:
14.04
1n13K-5iobA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N13_J_AG2J7013_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 5iob BETA-GLUCOSIDASE-REL
ATED GLYCOSIDASES
(Corynebacterium
glutamicum) 		4 / 7 LEU A  76
ASP A 346
GLY A 314
ARG A 302
 None
 0.79A 1n13G-5iobA:
undetectable
1n13J-5iobA:
undetectable		 1n13G-5iobA:
10.45
1n13J-5iobA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5iob BETA-GLUCOSIDASE-REL
ATED GLYCOSIDASES
(Corynebacterium
glutamicum) 		4 / 8 ALA A  90
GLN A  86
ASP A 105
ILE A 100
 None
 0.91A 1p7lD-5iobA:
undetectable		 1p7lD-5iobA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5iob BETA-GLUCOSIDASE-REL
ATED GLYCOSIDASES
(Corynebacterium
glutamicum) 		4 / 8 ALA A  90
GLN A  86
ASP A 105
ILE A 100
 None
 0.91A 1p7lC-5iobA:
undetectable		 1p7lC-5iobA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5iob BETA-GLUCOSIDASE-REL
ATED GLYCOSIDASES
(Corynebacterium
glutamicum) 		4 / 8 ALA A  90
GLN A  86
ASP A 105
ILE A 100
 None
 0.93A 1rg9A-5iobA:
undetectable		 1rg9A-5iobA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5iob BETA-GLUCOSIDASE-REL
ATED GLYCOSIDASES
(Corynebacterium
glutamicum) 		4 / 8 ALA A  90
GLN A  86
ASP A 105
ILE A 100
 None
 0.90A 1rg9D-5iobA:
undetectable		 1rg9D-5iobA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 5iob BETA-GLUCOSIDASE-REL
ATED GLYCOSIDASES
(Corynebacterium
glutamicum) 		4 / 8 ALA A  90
GLN A  86
ASP A 105
ILE A 100
 None
 0.91A 1rg9C-5iobA:
undetectable		 1rg9C-5iobA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RK3_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 5iob BETA-GLUCOSIDASE-REL
ATED GLYCOSIDASES
(Corynebacterium
glutamicum) 		5 / 12 TYR A 298
LEU A 321
VAL A 337
SER A 340
VAL A  79
 None
 1.47A 1rk3A-5iobA:
undetectable		 1rk3A-5iobA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1U70_A_MTXA187_2
(DIHYDROFOLATE
REDUCTASE)		 5iob BETA-GLUCOSIDASE-REL
ATED GLYCOSIDASES
(Corynebacterium
glutamicum) 		4 / 4 SER A 358
ILE A 360
VAL A  79
THR A 318
 None
 1.13A 1u70A-5iobA:
undetectable		 1u70A-5iobA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WQ5_A_MIYA1120_1
(PHOSPHOLIPASE A2,
ACIDIC)		 5iob BETA-GLUCOSIDASE-REL
ATED GLYCOSIDASES
(Corynebacterium
glutamicum) 		4 / 7 LEU A 387
ALA A 273
GLY A 314
ARG A 302
 None
 0.88A 2wq5A-5iobA:
undetectable		 2wq5A-5iobA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBU_D_ADND504_1
(UNCHARACTERIZED
CONSERVED PROTEIN)		 5iob BETA-GLUCOSIDASE-REL
ATED GLYCOSIDASES
(Corynebacterium
glutamicum) 		3 / 3 PHE A 133
ASN A 182
PHE A 216
 None
 1.04A 2zbuD-5iobA:
undetectable		 2zbuD-5iobA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CSJ_B_CBLB211_0
(GLUTATHIONE
S-TRANSFERASE P)		 5iob BETA-GLUCOSIDASE-REL
ATED GLYCOSIDASES
(Corynebacterium
glutamicum) 		5 / 9 PHE A 216
PRO A 227
GLY A 171
ILE A 169
GLY A 219
 None
 1.41A 3csjB-5iobA:
undetectable		 3csjB-5iobA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_B_SALB306_1
(TRANSCRIPTIONAL
REGULATOR SLYA)		 5iob BETA-GLUCOSIDASE-REL
ATED GLYCOSIDASES
(Corynebacterium
glutamicum) 		4 / 6 THR A 214
SER A 268
LEU A 267
THR A 270
 None
 0.91A 3deuB-5iobA:
undetectable		 3deuB-5iobA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IB1_A_IMNA701_1
(LACTOTRANSFERRIN)		 5iob BETA-GLUCOSIDASE-REL
ATED GLYCOSIDASES
(Corynebacterium
glutamicum) 		4 / 4 PRO A 112
THR A 110
GLY A 173
THR A 172
 None
 1.02A 3ib1A-5iobA:
undetectable		 3ib1A-5iobA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NHX_A_ASDA126_1
(STEROID
DELTA-ISOMERASE)		 5iob BETA-GLUCOSIDASE-REL
ATED GLYCOSIDASES
(Corynebacterium
glutamicum) 		5 / 12 TYR A 372
LEU A 341
SER A  75
VAL A 315
ALA A 379
 None
 1.35A 3nhxA-5iobA:
undetectable		 3nhxA-5iobA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7V_A_SAMA992_0
(METHYLORNITHINE
SYNTHASE PYLB)		 5iob BETA-GLUCOSIDASE-REL
ATED GLYCOSIDASES
(Corynebacterium
glutamicum) 		5 / 12 GLY A 272
GLY A 314
LEU A 349
MET A  78
VAL A 181
 None
 1.19A 3t7vA-5iobA:
11.3		 3t7vA-5iobA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VT3_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 5iob BETA-GLUCOSIDASE-REL
ATED GLYCOSIDASES
(Corynebacterium
glutamicum) 		5 / 12 TYR A 298
LEU A 321
VAL A 337
SER A 340
VAL A  79
 None
 1.48A 3vt3A-5iobA:
undetectable		 3vt3A-5iobA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD507_1
(HEMOLYTIC LECTIN
CEL-III)		 5iob BETA-GLUCOSIDASE-REL
ATED GLYCOSIDASES
(Corynebacterium
glutamicum) 		4 / 5 ASP A 259
GLU A 254
TYR A 258
ASP A 190
 None
 1.25A 3w9tD-5iobA:
undetectable		 3w9tD-5iobA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 5iob BETA-GLUCOSIDASE-REL
ATED GLYCOSIDASES
(Corynebacterium
glutamicum) 		4 / 8 GLY A 178
VAL A 179
PHE A 127
ILE A  98
 None
 0.71A 4fglD-5iobA:
undetectable		 4fglD-5iobA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 5iob BETA-GLUCOSIDASE-REL
ATED GLYCOSIDASES
(Corynebacterium
glutamicum) 		5 / 12 GLY A 272
LEU A 349
PHE A  99
GLY A 101
THR A 226
 None
None
GOL  A 401 (-4.5A)
None
None
 1.30A 4ze1A-5iobA:
undetectable		 4ze1A-5iobA:
20.43