SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5iof'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_A_CHDA701_0
(FERROCHELATASE)		 5iof SULPHATE TRANSPORTER
(Deinococcus
geothermalis) 		4 / 8 MET A  85
LEU A 234
VAL A  52
GLY A  53
 None
 1.06A 2qd5A-5iofA:
undetectable		 2qd5A-5iofA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD5_B_CHDB1103_0
(FERROCHELATASE)		 5iof SULPHATE TRANSPORTER
(Deinococcus
geothermalis) 		4 / 8 MET A  85
LEU A 234
VAL A  52
GLY A  53
 None
 0.99A 2qd5B-5iofA:
undetectable		 2qd5B-5iofA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 5iof SULPHATE TRANSPORTER
(Deinococcus
geothermalis) 		5 / 12 ILE A  59
GLY A 281
ALA A 269
ALA A  82
VAL A  52
 None
 1.13A 2yvlB-5iofA:
undetectable		 2yvlB-5iofA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_C_SAMC604_0
(HYPOTHETICAL PROTEIN)		 5iof SULPHATE TRANSPORTER
(Deinococcus
geothermalis) 		5 / 12 ILE A  59
GLY A 281
ALA A 269
ALA A  82
VAL A  52
 None
 1.11A 2yvlC-5iofA:
undetectable		 2yvlC-5iofA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YY8_B_SAMB500_0
(UPF0106 PROTEIN
PH0461)		 5iof SULPHATE TRANSPORTER
(Deinococcus
geothermalis) 		5 / 11 LEU A 135
VAL A 132
GLY A 130
ILE A 139
ALA A 136
 None
 1.01A 2yy8A-5iofA:
undetectable
2yy8B-5iofA:
undetectable		 2yy8A-5iofA:
18.52
2yy8B-5iofA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GN8_A_DEXA247_2
(GLUCOCORTICOID
RECEPTOR 2)		 5iof SULPHATE TRANSPORTER
(Deinococcus
geothermalis) 		3 / 3 MET A 279
MET A 310
PHE A  42
 None
 0.86A 3gn8A-5iofA:
undetectable		 3gn8A-5iofA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IW1_A_ASDA1223_1
(CYTOCHROME P450
CYP125)		 5iof SULPHATE TRANSPORTER
(Deinococcus
geothermalis) 		5 / 12 ILE A 290
GLN A 287
PRO A  37
ILE A 139
VAL A 335
 None
 1.23A 3iw1A-5iofA:
undetectable		 3iw1A-5iofA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 5iof SULPHATE TRANSPORTER
(Deinococcus
geothermalis) 		5 / 12 ILE A 249
THR A 245
VAL A 292
ILE A  74
SER A  75
 None
 1.16A 3kpbA-5iofA:
undetectable		 3kpbA-5iofA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 5iof SULPHATE TRANSPORTER
(Deinococcus
geothermalis) 		5 / 12 ILE A 249
THR A 245
VAL A 292
ILE A  74
SER A  75
 None
 1.16A 3kpbC-5iofA:
undetectable		 3kpbC-5iofA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_D_SAMD1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 5iof SULPHATE TRANSPORTER
(Deinococcus
geothermalis) 		5 / 10 ILE A 249
THR A 245
VAL A 292
ILE A  74
SER A  75
 None
 1.16A 3kpbD-5iofA:
undetectable		 3kpbD-5iofA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 5iof SULPHATE TRANSPORTER
(Deinococcus
geothermalis) 		5 / 12 GLY A 267
ARG A 118
LEU A 240
GLY A 238
ALA A 117
 None
 1.00A 3sufA-5iofA:
undetectable		 3sufA-5iofA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_A_9PLA1_1
(CYTOCHROME P450 2A13)		 5iof SULPHATE TRANSPORTER
(Deinococcus
geothermalis) 		5 / 9 PHE A  42
ALA A 142
ALA A 336
THR A 339
LEU A  83
 None
 1.02A 3t3sA-5iofA:
undetectable		 3t3sA-5iofA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_2
(ADENOSINE KINASE,
PUTATIVE)		 5iof SULPHATE TRANSPORTER
(Deinococcus
geothermalis) 		4 / 5 LEU A 345
GLY A 343
MET A 359
ASN A 133
 None
 1.28A 3uq6B-5iofA:
undetectable		 3uq6B-5iofA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_1
(ADENOSINE KINASE)		 5iof SULPHATE TRANSPORTER
(Deinococcus
geothermalis) 		5 / 12 LEU A  35
GLY A 298
GLY A  72
ALA A 305
GLY A  68
 None
 1.00A 4n09B-5iofA:
undetectable		 4n09B-5iofA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_D_ADND401_1
(ADENOSINE KINASE)		 5iof SULPHATE TRANSPORTER
(Deinococcus
geothermalis) 		5 / 12 LEU A  35
GLY A 298
GLY A  72
ALA A 305
GLY A  68
 None
 0.98A 4n09D-5iofA:
undetectable		 4n09D-5iofA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5iof SULPHATE TRANSPORTER
(Deinococcus
geothermalis) 		5 / 11 ALA A  82
ALA A  46
MET A 284
GLY A 281
ALA A  77
 None
 1.01A 4qvlK-5iofA:
undetectable
4qvlL-5iofA:
undetectable		 4qvlK-5iofA:
20.15
4qvlL-5iofA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5iof SULPHATE TRANSPORTER
(Deinococcus
geothermalis) 		5 / 11 ALA A  82
ALA A  46
MET A 284
GLY A 281
ALA A  77
 None
 1.02A 4qvlK-5iofA:
undetectable
4qvlL-5iofA:
undetectable		 4qvlK-5iofA:
20.15
4qvlL-5iofA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5iof SULPHATE TRANSPORTER
(Deinococcus
geothermalis) 		5 / 11 ALA A  82
ALA A  46
MET A 284
GLY A 281
ALA A  77
 None
 1.01A 4qvlY-5iofA:
undetectable
4qvlZ-5iofA:
undetectable		 4qvlY-5iofA:
20.15
4qvlZ-5iofA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5iof SULPHATE TRANSPORTER
(Deinococcus
geothermalis) 		5 / 11 ALA A  82
ALA A  46
MET A 284
GLY A 281
ALA A  77
 None
 1.02A 4qvlY-5iofA:
undetectable
4qvlZ-5iofA:
undetectable		 4qvlY-5iofA:
20.15
4qvlZ-5iofA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5iof SULPHATE TRANSPORTER
(Deinococcus
geothermalis) 		5 / 11 ALA A  82
ALA A  46
MET A 284
GLY A 281
ALA A  77
 None
 0.99A 4qw1K-5iofA:
undetectable
4qw1L-5iofA:
undetectable		 4qw1K-5iofA:
20.15
4qw1L-5iofA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5iof SULPHATE TRANSPORTER
(Deinococcus
geothermalis) 		5 / 11 ALA A  82
ALA A  46
MET A 284
GLY A 281
ALA A  77
 None
 1.01A 4qw1K-5iofA:
undetectable
4qw1L-5iofA:
undetectable		 4qw1K-5iofA:
20.15
4qw1L-5iofA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5iof SULPHATE TRANSPORTER
(Deinococcus
geothermalis) 		5 / 10 ALA A  82
ALA A  46
MET A 284
GLY A 281
ALA A  77
 None
 0.98A 4qw1Y-5iofA:
undetectable
4qw1Z-5iofA:
undetectable		 4qw1Y-5iofA:
20.15
4qw1Z-5iofA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5iof SULPHATE TRANSPORTER
(Deinococcus
geothermalis) 		5 / 10 ALA A  82
ALA A  46
MET A 284
GLY A 281
ALA A  77
 None
 1.01A 4qw1Y-5iofA:
undetectable
4qw1Z-5iofA:
undetectable		 4qw1Y-5iofA:
20.15
4qw1Z-5iofA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5iof SULPHATE TRANSPORTER
(Deinococcus
geothermalis) 		5 / 10 ALA A  82
ALA A  46
MET A 284
GLY A 281
ALA A  77
 None
 1.01A 4qw3K-5iofA:
undetectable
4qw3L-5iofA:
undetectable		 4qw3K-5iofA:
20.15
4qw3L-5iofA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5iof SULPHATE TRANSPORTER
(Deinococcus
geothermalis) 		5 / 10 ALA A  82
ALA A  46
MET A 284
GLY A 281
ALA A  77
 None
 1.00A 4qw3Y-5iofA:
undetectable
4qw3Z-5iofA:
undetectable		 4qw3Y-5iofA:
20.15
4qw3Z-5iofA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_0
(RNA-DIRECTED RNA
POLYMERASE L)		 5iof SULPHATE TRANSPORTER
(Deinococcus
geothermalis) 		5 / 12 THR A 253
GLY A 296
SER A 301
LEU A 300
ALA A  65
 None
 1.13A 4uckB-5iofA:
undetectable		 4uckB-5iofA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_A_BQ1A1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 5iof SULPHATE TRANSPORTER
(Deinococcus
geothermalis) 		3 / 3 GLU A  38
ALA A  39
PHE A  42
 None
 0.42A 4v1fA-5iofA:
undetectable		 4v1fA-5iofA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_C_BQ1C1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 5iof SULPHATE TRANSPORTER
(Deinococcus
geothermalis) 		3 / 3 GLU A  38
ALA A  39
PHE A  42
 None
 0.47A 4v1fC-5iofA:
undetectable		 4v1fC-5iofA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5iof SULPHATE TRANSPORTER
(Deinococcus
geothermalis) 		5 / 11 ALA A  82
ALA A  46
MET A 284
GLY A 281
ALA A  77
 None
 0.99A 5bxnK-5iofA:
undetectable
5bxnL-5iofA:
undetectable		 5bxnK-5iofA:
20.15
5bxnL-5iofA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5iof SULPHATE TRANSPORTER
(Deinococcus
geothermalis) 		5 / 11 ALA A  82
ALA A  46
MET A 284
GLY A 281
ALA A  77
 None
 1.02A 5bxnK-5iofA:
undetectable
5bxnL-5iofA:
undetectable		 5bxnK-5iofA:
20.15
5bxnL-5iofA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 5iof SULPHATE TRANSPORTER
(Deinococcus
geothermalis) 		5 / 11 ALA A  82
ALA A  46
MET A 284
GLY A 281
ALA A  77
 None
 1.02A 5bxnY-5iofA:
undetectable
5bxnZ-5iofA:
undetectable		 5bxnY-5iofA:
20.15
5bxnZ-5iofA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_A_ILEA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 5iof SULPHATE TRANSPORTER
(Deinococcus
geothermalis) 		4 / 6 ALA A 361
THR A 362
VAL A 365
VAL A 381
 None
 1.01A 5eclA-5iofA:
undetectable		 5eclA-5iofA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G44_A_YTZA1512_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 5iof SULPHATE TRANSPORTER
(Deinococcus
geothermalis) 		5 / 9 LEU A  84
LEU A 234
ALA A  46
VAL A  48
ALA A 280
 None
 1.31A 5g44A-5iofA:
undetectable		 5g44A-5iofA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_C_DAHC60_1
(PUTATIVE CYTOCHROME
C)		 5iof SULPHATE TRANSPORTER
(Deinococcus
geothermalis) 		4 / 6 GLN A 287
MET A 175
ASN A 291
LEU A 179
 None
 1.35A 5xdhA-5iofA:
undetectable
5xdhC-5iofA:
undetectable		 5xdhA-5iofA:
13.25
5xdhC-5iofA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_A_SUEA1202_0
(NS3 PROTEASE)		 5iof SULPHATE TRANSPORTER
(Deinococcus
geothermalis) 		5 / 12 GLY A 267
ARG A 118
LEU A 240
GLY A 238
ALA A 117
 None
 1.11A 6c2mA-5iofA:
undetectable		 6c2mA-5iofA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5iof SULPHATE TRANSPORTER
(Deinococcus
geothermalis) 		5 / 11 PRO A 229
SER A 373
LEU A 107
SER A 235
LEU A 236
 None
 1.28A 6dlzA-5iofA:
undetectable
6dlzD-5iofA:
undetectable		 6dlzA-5iofA:
14.67
6dlzD-5iofA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5iof SULPHATE TRANSPORTER
(Deinococcus
geothermalis) 		5 / 11 PRO A 229
SER A 373
LEU A 107
SER A 235
LEU A 236
 None
 1.29A 6dm1A-5iofA:
undetectable
6dm1D-5iofA:
undetectable		 6dm1A-5iofA:
14.67
6dm1D-5iofA:
14.67