SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ioj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5ioj HALOALKYLPHOSPHORUS
HYDROLASE
(Sphingobium
sp.
TCM1) 		5 / 9 VAL A 149
GLY A 563
THR A 522
ILE A 131
SER A 525
 None
 1.33A 1gtnL-5iojA:
undetectable
1gtnM-5iojA:
undetectable		 1gtnL-5iojA:
8.40
1gtnM-5iojA:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_O_TRPO81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 5ioj HALOALKYLPHOSPHORUS
HYDROLASE
(Sphingobium
sp.
TCM1) 		5 / 10 GLY A 271
HIS A 286
THR A 202
HIS A 258
ALA A 232
 None
 1.23A 1gtnO-5iojA:
undetectable
1gtnP-5iojA:
undetectable		 1gtnO-5iojA:
8.40
1gtnP-5iojA:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1502_0
(FERROCHELATASE)		 5ioj HALOALKYLPHOSPHORUS
HYDROLASE
(Sphingobium
sp.
TCM1) 		4 / 8 MET A 203
ARG A 192
LEU A 190
GLY A 136
 None
 0.98A 1hrkA-5iojA:
undetectable		 1hrkA-5iojA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_B_CHDB2502_0
(FERROCHELATASE)		 5ioj HALOALKYLPHOSPHORUS
HYDROLASE
(Sphingobium
sp.
TCM1) 		4 / 8 MET A 203
ARG A 192
LEU A 190
GLY A 136
 None
 1.01A 1hrkB-5iojA:
undetectable		 1hrkB-5iojA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDU_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 5ioj HALOALKYLPHOSPHORUS
HYDROLASE
(Sphingobium
sp.
TCM1) 		5 / 11 LEU A 333
ALA A 406
GLY A 413
GLY A 409
VAL A 342
 None
 1.01A 1sduA-5iojA:
undetectable		 1sduA-5iojA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 5ioj HALOALKYLPHOSPHORUS
HYDROLASE
(Sphingobium
sp.
TCM1) 		4 / 6 ARG A 226
ILE A 223
GLY A 222
ALA A 231
 None
 1.00A 1wmqA-5iojA:
undetectable		 1wmqA-5iojA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 5ioj HALOALKYLPHOSPHORUS
HYDROLASE
(Sphingobium
sp.
TCM1) 		4 / 6 ARG A 226
ILE A 223
GLY A 222
ALA A 231
 None
 1.00A 1wmqB-5iojA:
undetectable		 1wmqB-5iojA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 5ioj HALOALKYLPHOSPHORUS
HYDROLASE
(Sphingobium
sp.
TCM1) 		4 / 6 ARG A 226
ILE A 223
GLY A 222
ALA A 231
 None
 1.00A 1wrqB-5iojA:
undetectable		 1wrqB-5iojA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PLW_A_SAMA203_0
(RIBOSOMAL RNA
METHYLTRANSFERASE,
PUTATIVE)		 5ioj HALOALKYLPHOSPHORUS
HYDROLASE
(Sphingobium
sp.
TCM1) 		5 / 12 GLY A 122
PRO A  93
GLY A  94
ILE A 499
LEU A 577
 None
 1.10A 2plwA-5iojA:
undetectable		 2plwA-5iojA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_B_FUAB2002_1
(SERUM ALBUMIN)		 5ioj HALOALKYLPHOSPHORUS
HYDROLASE
(Sphingobium
sp.
TCM1) 		4 / 9 ILE A 419
ARG A 417
ALA A 331
VAL A 360
 None
 1.04A 2vufB-5iojA:
undetectable		 2vufB-5iojA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1357_1
(PROSTAGLANDIN
REDUCTASE 2)		 5ioj HALOALKYLPHOSPHORUS
HYDROLASE
(Sphingobium
sp.
TCM1) 		4 / 6 LEU A 243
ASN A 241
LYS A 246
ASP A 238
 None
 1.38A 2w98A-5iojA:
undetectable
2w98B-5iojA:
undetectable		 2w98A-5iojA:
22.04
2w98B-5iojA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 5ioj HALOALKYLPHOSPHORUS
HYDROLASE
(Sphingobium
sp.
TCM1) 		5 / 12 PHE A 557
ALA A 558
THR A 129
GLY A 135
LEU A 534
 None
 1.34A 3aodC-5iojA:
undetectable		 3aodC-5iojA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_A_BCZA468_1
(NEURAMINIDASE)		 5ioj HALOALKYLPHOSPHORUS
HYDROLASE
(Sphingobium
sp.
TCM1) 		3 / 3 ASP A 289
ARG A 297
ARG A 211
 None
 1.00A 3k37A-5iojA:
7.9		 3k37A-5iojA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_B_SAMB302_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 5ioj HALOALKYLPHOSPHORUS
HYDROLASE
(Sphingobium
sp.
TCM1) 		5 / 12 GLY A 284
GLY A 279
GLY A 277
GLU A 336
ALA A 334
 None
 1.00A 3kkzB-5iojA:
undetectable		 3kkzB-5iojA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_F_TFPF202_1
(PROTEIN S100-A4)		 5ioj HALOALKYLPHOSPHORUS
HYDROLASE
(Sphingobium
sp.
TCM1) 		5 / 11 GLU A 325
SER A 263
ILE A 328
ASP A 289
SER A 291
 None
 1.48A 3ko0E-5iojA:
undetectable
3ko0F-5iojA:
undetectable
3ko0G-5iojA:
undetectable
3ko0H-5iojA:
undetectable		 3ko0E-5iojA:
10.29
3ko0F-5iojA:
10.29
3ko0G-5iojA:
10.29
3ko0H-5iojA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO202_1
(PROTEIN S100-A4)		 5ioj HALOALKYLPHOSPHORUS
HYDROLASE
(Sphingobium
sp.
TCM1) 		5 / 11 SER A 263
ILE A 328
GLU A 325
ASP A 289
SER A 291
 None
 1.48A 3ko0O-5iojA:
undetectable
3ko0P-5iojA:
undetectable
3ko0Q-5iojA:
undetectable
3ko0R-5iojA:
undetectable		 3ko0O-5iojA:
10.29
3ko0P-5iojA:
10.29
3ko0Q-5iojA:
10.29
3ko0R-5iojA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_Q_TFPQ202_1
(PROTEIN S100-A4)		 5ioj HALOALKYLPHOSPHORUS
HYDROLASE
(Sphingobium
sp.
TCM1) 		5 / 10 ASP A 289
SER A 291
SER A 263
ILE A 328
GLU A 325
 None
 1.40A 3ko0O-5iojA:
undetectable
3ko0P-5iojA:
undetectable
3ko0Q-5iojA:
undetectable
3ko0R-5iojA:
undetectable		 3ko0O-5iojA:
10.29
3ko0P-5iojA:
10.29
3ko0Q-5iojA:
10.29
3ko0R-5iojA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT202_1
(PROTEIN S100-A4)		 5ioj HALOALKYLPHOSPHORUS
HYDROLASE
(Sphingobium
sp.
TCM1) 		5 / 11 ASP A 289
SER A 291
GLU A 325
SER A 263
ILE A 328
 None
 1.48A 3ko0Q-5iojA:
undetectable
3ko0R-5iojA:
undetectable
3ko0S-5iojA:
undetectable
3ko0T-5iojA:
undetectable		 3ko0Q-5iojA:
10.29
3ko0R-5iojA:
10.29
3ko0S-5iojA:
10.29
3ko0T-5iojA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M0W_C_P77C203_1
(PROTEIN S100-A4)		 5ioj HALOALKYLPHOSPHORUS
HYDROLASE
(Sphingobium
sp.
TCM1) 		5 / 10 ASP A 289
SER A 291
SER A 263
ILE A 328
GLU A 325
 None
 1.45A 3m0wC-5iojA:
undetectable
3m0wD-5iojA:
undetectable
3m0wE-5iojA:
undetectable
3m0wF-5iojA:
undetectable		 3m0wC-5iojA:
10.24
3m0wD-5iojA:
10.24
3m0wE-5iojA:
10.24
3m0wF-5iojA:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA609_0
(GBAA_1210 PROTEIN)		 5ioj HALOALKYLPHOSPHORUS
HYDROLASE
(Sphingobium
sp.
TCM1) 		3 / 3 LYS A 428
VAL A 430
HIS A 401
 None
 1.12A 3tj7A-5iojA:
undetectable		 3tj7A-5iojA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_A_ACTA860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5ioj HALOALKYLPHOSPHORUS
HYDROLASE
(Sphingobium
sp.
TCM1) 		4 / 5 GLY A 156
ILE A 158
VAL A 200
SER A 220
 None
 0.86A 4d33A-5iojA:
undetectable		 4d33A-5iojA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D33_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5ioj HALOALKYLPHOSPHORUS
HYDROLASE
(Sphingobium
sp.
TCM1) 		4 / 5 GLY A 156
ILE A 158
VAL A 200
SER A 220
 None
 0.90A 4d33B-5iojA:
undetectable		 4d33B-5iojA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D39_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE,
ENDOTHELIAL)		 5ioj HALOALKYLPHOSPHORUS
HYDROLASE
(Sphingobium
sp.
TCM1) 		4 / 6 GLY A 156
ILE A 158
VAL A 200
SER A 220
 None
 0.92A 4d39B-5iojA:
undetectable		 4d39B-5iojA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2R_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		 5ioj HALOALKYLPHOSPHORUS
HYDROLASE
(Sphingobium
sp.
TCM1) 		4 / 4 HIS A 317
GLU A 273
HIS A 286
LEU A 234
 None
 1.38A 4m2rA-5iojA:
undetectable		 4m2rA-5iojA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAD_A_CLMA205_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 5ioj HALOALKYLPHOSPHORUS
HYDROLASE
(Sphingobium
sp.
TCM1) 		5 / 12 PHE A 490
PRO A 491
TYR A 514
GLY A 122
LEU A 573
 None
 1.42A 4oadA-5iojA:
undetectable		 4oadA-5iojA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1Y_A_017A106_2
(ASPARTYL PROTEASE)		 5ioj HALOALKYLPHOSPHORUS
HYDROLASE
(Sphingobium
sp.
TCM1) 		5 / 12 ALA A 383
ILE A 421
ILE A 362
VAL A 403
ILE A 419
 None
 0.92A 4q1yB-5iojA:
undetectable		 4q1yB-5iojA:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GQB_A_GCSA605_1
(CHITINASE)		 5ioj HALOALKYLPHOSPHORUS
HYDROLASE
(Sphingobium
sp.
TCM1) 		3 / 3 TRP A 531
ILE A 158
SER A 220
 None
 0.72A 5gqbA-5iojA:
undetectable		 5gqbA-5iojA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HQA_A_ACRA705_2
(ALPHA-GLUCOSIDASE)		 5ioj HALOALKYLPHOSPHORUS
HYDROLASE
(Sphingobium
sp.
TCM1) 		4 / 8 PHE A 152
GLU A 201
HIS A 545
THR A 129
 None
 1.43A 5hqaA-5iojA:
undetectable		 5hqaA-5iojA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 5ioj HALOALKYLPHOSPHORUS
HYDROLASE
(Sphingobium
sp.
TCM1) 		4 / 4 ASN A 308
ILE A 362
TYR A 361
PHE A 302
 None
 1.15A 5igvA-5iojA:
2.2		 5igvA-5iojA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 5ioj HALOALKYLPHOSPHORUS
HYDROLASE
(Sphingobium
sp.
TCM1) 		5 / 12 VAL A 275
HIS A 258
THR A 151
ARG A 226
GLY A 156
 None
 1.36A 5m50B-5iojA:
undetectable		 5m50B-5iojA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 5ioj HALOALKYLPHOSPHORUS
HYDROLASE
(Sphingobium
sp.
TCM1) 		5 / 12 VAL A 275
HIS A 258
THR A 151
ARG A 226
GLY A 156
 None
 1.36A 5m50E-5iojA:
undetectable		 5m50E-5iojA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 5ioj HALOALKYLPHOSPHORUS
HYDROLASE
(Sphingobium
sp.
TCM1) 		4 / 4 GLY A 473
ALA A 494
MET A 543
THR A 539
 None
 1.24A 5n0sB-5iojA:
undetectable		 5n0sB-5iojA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_0
(REGULATORY PROTEIN
TETR)		 5ioj HALOALKYLPHOSPHORUS
HYDROLASE
(Sphingobium
sp.
TCM1) 		5 / 12 ALA A 330
GLU A 424
LEU A 402
ILE A 419
ASP A 423
 None
 1.31A 5vlmG-5iojA:
undetectable		 5vlmG-5iojA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7F_A_SAMA301_0
(PUTATIVE
O-METHYLTRANSFERASE
RV1220C)		 5ioj HALOALKYLPHOSPHORUS
HYDROLASE
(Sphingobium
sp.
TCM1) 		5 / 12 GLY A 541
GLY A 473
VAL A 497
ILE A 346
ALA A 471
 None
 1.10A 5x7fA-5iojA:
undetectable		 5x7fA-5iojA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA811_0
(GEPHYRIN)		 5ioj HALOALKYLPHOSPHORUS
HYDROLASE
(Sphingobium
sp.
TCM1) 		3 / 3 LEU A 487
LEU A 577
ARG A 503
 None
 0.68A 6fgcA-5iojA:
undetectable		 6fgcA-5iojA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA810_0
(GEPHYRIN)		 5ioj HALOALKYLPHOSPHORUS
HYDROLASE
(Sphingobium
sp.
TCM1) 		3 / 3 LEU A 487
LEU A 577
ARG A 503
 None
 0.64A 6fgdA-5iojA:
undetectable		 6fgdA-5iojA:
22.02