SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ip7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK4_A_T44A1008_1
(SERUM ALBUMIN)		 5ip7 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB11
(Saccharomyces
cerevisiae) 		5 / 10 ASP K  82
ALA K  86
GLU K  79
ASN K  29
VAL K  56
 None
 1.48A 1hk4A-5ip7K:
2.1		 1hk4A-5ip7K:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK5_A_T44A1008_1
(SERUM ALBUMIN)		 5ip7 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB11
(Saccharomyces
cerevisiae) 		5 / 10 ASP K  82
ALA K  86
GLU K  79
ASN K  29
VAL K  56
 None
 1.49A 1hk5A-5ip7K:
2.3		 1hk5A-5ip7K:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZ4_A_BEZA784_0
(MALT REGULATORY
PROTEIN)		 5ip7 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB3
(Saccharomyces
cerevisiae) 		4 / 6 HIS C 131
LEU C  44
LEU C  72
PRO C  71
 None
 1.23A 1hz4A-5ip7C:
undetectable		 1hz4A-5ip7C:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_E_RBFE505_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 5ip7 DNA-DIRECTED RNA
POLYMERASES I, II,
AND III SUBUNIT
RPABC5
(Saccharomyces
cerevisiae) 		5 / 12 ILE J   2
GLY J  15
TRP J  18
LEU J  41
ILE J  50
 None
 1.26A 1kyvD-5ip7J:
undetectable
1kyvE-5ip7J:
undetectable		 1kyvD-5ip7J:
14.20
1kyvE-5ip7J:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q6I_B_FK5B401_1
(FKBP-TYPE
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKPA)		 5ip7 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB11
DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB3
(Saccharomyces
cerevisiae) 		5 / 10 ASP K  39
ARG C  35
VAL C 255
ILE C 258
PHE K  71
 None
 1.42A 1q6iB-5ip7K:
undetectable		 1q6iB-5ip7K:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YI4_A_ADNA306_1
(PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 5ip7 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB3
(Saccharomyces
cerevisiae) 		5 / 10 LEU C 147
ILE C  63
LEU C  58
ASP C 117
ILE C 144
 None
 1.11A 1yi4A-5ip7C:
undetectable		 1yi4A-5ip7C:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_1
(POL POLYPROTEIN)		 5ip7 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB9
(Saccharomyces
cerevisiae) 		5 / 12 ARG I 118
VAL I 102
ILE I  62
GLY I  57
ILE I 109
 None
 0.90A 2avvD-5ip7I:
undetectable		 2avvD-5ip7I:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA502_1
(CYTOCHROME P450 2B4)		 5ip7 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB3
(Saccharomyces
cerevisiae) 		5 / 12 LEU C  72
ILE C  70
ILE C 144
LEU C 101
THR C 100
 None
 1.07A 2bdmA-5ip7C:
undetectable		 2bdmA-5ip7C:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMY_B_SAMB328_0
(PROTEIN
(CYTOSINE-SPECIFIC
METHYLTRANSFERASE
HHAI))		 5ip7 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB3
DNA-DIRECTED RNA
POLYMERASES I, II,
AND III SUBUNIT
RPABC5
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 12 GLY J  11
ASP J  55
ILE J   2
LEU C 143
VAL C 235
 None
 1.08A 2hmyB-5ip7J:
undetectable		 2hmyB-5ip7J:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD2_A_CHDA2_0
(FERROCHELATASE)		 5ip7 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB3
(Saccharomyces
cerevisiae) 		4 / 8 LEU C 155
ARG C  66
PRO C 132
VAL C 142
 None
 0.92A 2qd2A-5ip7C:
undetectable		 2qd2A-5ip7C:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XRH_A_NIOA200_1
(PROTEIN HP0721)		 5ip7 DNA-DIRECTED RNA
POLYMERASES I, II,
AND III SUBUNIT
RPABC1
(Saccharomyces
cerevisiae) 		4 / 7 GLY E 189
ILE E 109
ARG E  26
LEU E 186
 None
 0.89A 2xrhA-5ip7E:
undetectable		 2xrhA-5ip7E:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_D_VD3D2001_1
(VITAMIN D
HYDROXYLASE)		 5ip7 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB11
DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB3
(Saccharomyces
cerevisiae) 		5 / 12 ILE K  46
LEU K  50
ASN K  29
ILE K  33
LEU C 262
 None
 1.14A 3a50D-5ip7K:
undetectable		 3a50D-5ip7K:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDX_A_RITA100_2
(PROTEASE)		 5ip7 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB11
DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB3
(Saccharomyces
cerevisiae) 		6 / 11 ARG K  47
ALA K  86
ASP K  85
ASP K  82
ILE C 258
ILE K  75
 None
 1.35A 3ndxB-5ip7K:
undetectable		 3ndxB-5ip7K:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_C_478C200_2
(HIV-1 PROTEASE)		 5ip7 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB9
(Saccharomyces
cerevisiae) 		5 / 11 ARG I 118
VAL I 102
ILE I  62
GLY I  57
ILE I 109
 None
 1.01A 3oxvD-5ip7I:
undetectable		 3oxvD-5ip7I:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_B_SAMB801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 5ip7 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB3
(Saccharomyces
cerevisiae) 		5 / 11 GLY C  68
ASP C  60
VAL C  51
TYR C 114
LEU C 153
 None
 1.27A 3v8vB-5ip7C:
undetectable		 3v8vB-5ip7C:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C66_A_H4CA1168_0
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 5ip7 DNA-DIRECTED RNA
POLYMERASES I, II,
AND III SUBUNIT
RPABC1
(Saccharomyces
cerevisiae) 		5 / 9 PRO E 151
VAL E 184
LEU E 188
LEU E 190
ILE E 198
 None
 1.34A 4c66A-5ip7E:
undetectable		 4c66A-5ip7E:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5ip7 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB3
(Saccharomyces
cerevisiae) 		4 / 8 ILE C  63
ARG C  66
PRO C 132
VAL C 142
 None
 0.92A 4f4dB-5ip7C:
undetectable		 4f4dB-5ip7C:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5ip7 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB3
(Saccharomyces
cerevisiae) 		4 / 7 LEU C 155
ARG C  66
PRO C 132
VAL C 142
 None
 1.09A 4klrA-5ip7C:
undetectable		 4klrA-5ip7C:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KT0_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 5ip7 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB3
(Saccharomyces
cerevisiae) 		5 / 11 SER C 109
LEU C 147
GLY C 105
ILE C  46
LEU C  72
 None
 0.97A 4kt0A-5ip7C:
undetectable
4kt0J-5ip7C:
undetectable		 4kt0A-5ip7C:
16.11
4kt0J-5ip7C:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5ip7 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB3
(Saccharomyces
cerevisiae) 		4 / 6 ASN C 206
GLU C 177
TYR C 180
GLU C 179
 None
 1.25A 4mi4A-5ip7C:
undetectable		 4mi4A-5ip7C:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5ip7 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB3
(Saccharomyces
cerevisiae) 		4 / 7 ASN C 206
GLU C 177
TYR C 180
GLU C 179
 None
 1.26A 4mi4A-5ip7C:
undetectable
4mi4C-5ip7C:
undetectable		 4mi4A-5ip7C:
20.45
4mi4C-5ip7C:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 5ip7 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB3
(Saccharomyces
cerevisiae) 		4 / 8 ASN C 206
GLU C 177
TYR C 180
GLU C 179
 None
 1.20A 4mj8A-5ip7C:
undetectable
4mj8C-5ip7C:
undetectable		 4mj8A-5ip7C:
22.45
4mj8C-5ip7C:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P68_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 5ip7 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB11
DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB3
(Saccharomyces
cerevisiae) 		5 / 11 ASP K  39
PHE K  71
SER C 257
ILE C 258
ILE K  46
 None
 1.46A 4p68A-5ip7K:
undetectable		 4p68A-5ip7K:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE0_A_40LA1101_0
(PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM)		 5ip7 DNA-DIRECTED RNA
POLYMERASES I, II,
AND III SUBUNIT
RPABC1
(Saccharomyces
cerevisiae) 		5 / 12 PRO E 151
ILE E 198
VAL E 195
ILE E 178
ASP E 182
 None
 1.49A 4xe0A-5ip7E:
undetectable		 4xe0A-5ip7E:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 5ip7 DNA-DIRECTED RNA
POLYMERASES I, II,
AND III SUBUNIT
RPABC1
(Saccharomyces
cerevisiae) 		3 / 3 ARG E  55
PRO E  53
ASN E   5
 None
 1.09A 5jwaA-5ip7E:
undetectable
5jwaH-5ip7E:
undetectable		 5jwaA-5ip7E:
18.27
5jwaH-5ip7E:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_1_PQN1842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 5ip7 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB3
(Saccharomyces
cerevisiae) 		5 / 10 SER C 109
LEU C 147
GLY C 105
ILE C  46
LEU C  72
 None
 0.92A 5oy01-5ip7C:
undetectable
5oy07-5ip7C:
undetectable		 5oy01-5ip7C:
15.95
5oy07-5ip7C:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_A_DAHA60_1
(PUTATIVE CYTOCHROME
C)		 5ip7 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB3
(Saccharomyces
cerevisiae) 		4 / 6 HIS C 131
ASN C 123
VAL C 121
LEU C  99
 None
 1.38A 5xdhA-5ip7C:
undetectable
5xdhC-5ip7C:
undetectable		 5xdhA-5ip7C:
12.98
5xdhC-5ip7C:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_B_DAHB60_1
(PUTATIVE CYTOCHROME
C)		 5ip7 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB3
(Saccharomyces
cerevisiae) 		4 / 5 HIS C 131
ASN C 123
VAL C 121
LEU C  99
 None
 1.34A 5xdhB-5ip7C:
undetectable		 5xdhB-5ip7C:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_D_DAHD60_1
(PUTATIVE CYTOCHROME
C)		 5ip7 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB3
(Saccharomyces
cerevisiae) 		4 / 5 HIS C 131
ASN C 123
VAL C 121
LEU C  99
 None
 1.34A 5xdhD-5ip7C:
undetectable		 5xdhD-5ip7C:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AGG_Z_AG2Z503_0
(TRNA(ILE2)
2-AGMATINYLCYTIDINE
SYNTHETASE TIAS)		 5ip7 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB9
(Saccharomyces
cerevisiae) 		4 / 5 GLU I  82
ASN I  83
VAL I 102
CYH I 103
 None
None
None
ZN  I 202 (-2.4A)
 1.49A 6aggZ-5ip7I:
undetectable		 6aggZ-5ip7I:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8F_A_ACTA803_0
(UNCHARACTERIZED
PROTEIN)		 5ip7 DNA-DIRECTED RNA
POLYMERASES I, II,
AND III SUBUNIT
RPABC5
(Saccharomyces
cerevisiae) 		3 / 3 GLU J  32
LEU J  51
ARG J  47
 None
 0.81A 6d8fA-5ip7J:
undetectable		 6d8fA-5ip7J:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5ip7 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB3
DNA-DIRECTED RNA
POLYMERASES I, II,
AND III SUBUNIT
RPABC5
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 10 LEU C 118
SER C 115
ASP J  16
ILE C  46
GLY C  68
 None
 1.42A 6dlzA-5ip7C:
undetectable
6dlzD-5ip7C:
undetectable		 6dlzA-5ip7C:
14.29
6dlzD-5ip7C:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5ip7 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB3
DNA-DIRECTED RNA
POLYMERASES I, II,
AND III SUBUNIT
RPABC5
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 10 SER C 237
LEU C 118
SER C 115
ASP J  16
ILE C  46
 None
 1.46A 6dlzA-5ip7C:
undetectable
6dlzD-5ip7C:
undetectable		 6dlzA-5ip7C:
14.29
6dlzD-5ip7C:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5ip7 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB3
DNA-DIRECTED RNA
POLYMERASES I, II,
AND III SUBUNIT
RPABC5
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 10 SER C 237
LEU C 118
SER C 115
ASP J  16
ILE C  46
 None
 1.40A 6dlzB-5ip7C:
undetectable
6dlzC-5ip7C:
undetectable		 6dlzB-5ip7C:
14.29
6dlzC-5ip7C:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5ip7 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB3
DNA-DIRECTED RNA
POLYMERASES I, II,
AND III SUBUNIT
RPABC5
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 10 ILE C  46
GLY C  68
LEU C 118
SER C 115
ASP J  16
 None
 1.41A 6dlzB-5ip7C:
undetectable
6dlzC-5ip7C:
undetectable		 6dlzB-5ip7C:
14.29
6dlzC-5ip7C:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5ip7 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB3
DNA-DIRECTED RNA
POLYMERASES I, II,
AND III SUBUNIT
RPABC5
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 10 ILE C  46
SER C 237
LEU C 118
SER C 115
ASP J  16
 None
 1.46A 6dlzB-5ip7C:
undetectable
6dlzC-5ip7C:
undetectable		 6dlzB-5ip7C:
14.29
6dlzC-5ip7C:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DLZ_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5ip7 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB3
DNA-DIRECTED RNA
POLYMERASES I, II,
AND III SUBUNIT
RPABC5
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 11 ILE C  46
SER C 237
LEU C 118
SER C 115
ASP J  16
 None
 1.40A 6dlzA-5ip7C:
undetectable
6dlzD-5ip7C:
undetectable		 6dlzA-5ip7C:
14.29
6dlzD-5ip7C:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5ip7 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB3
DNA-DIRECTED RNA
POLYMERASES I, II,
AND III SUBUNIT
RPABC5
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 10 LEU C 118
SER C 115
ASP J  16
ILE C  46
GLY C  68
 None
 1.42A 6dm1A-5ip7C:
undetectable
6dm1D-5ip7C:
undetectable		 6dm1A-5ip7C:
14.29
6dm1D-5ip7C:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_A_CYZA1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5ip7 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB3
DNA-DIRECTED RNA
POLYMERASES I, II,
AND III SUBUNIT
RPABC5
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 10 SER C 237
LEU C 118
SER C 115
ASP J  16
ILE C  46
 None
 1.46A 6dm1A-5ip7C:
undetectable
6dm1D-5ip7C:
undetectable		 6dm1A-5ip7C:
14.29
6dm1D-5ip7C:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5ip7 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB3
DNA-DIRECTED RNA
POLYMERASES I, II,
AND III SUBUNIT
RPABC5
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 10 SER C 237
LEU C 118
SER C 115
ASP J  16
ILE C  46
 None
 1.39A 6dm1B-5ip7C:
undetectable
6dm1C-5ip7C:
undetectable		 6dm1B-5ip7C:
14.29
6dm1C-5ip7C:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5ip7 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB3
DNA-DIRECTED RNA
POLYMERASES I, II,
AND III SUBUNIT
RPABC5
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 10 ILE C  46
GLY C  68
LEU C 118
SER C 115
ASP J  16
 None
 1.42A 6dm1B-5ip7C:
undetectable
6dm1C-5ip7C:
undetectable		 6dm1B-5ip7C:
14.29
6dm1C-5ip7C:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_C_CYZC1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5ip7 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB3
DNA-DIRECTED RNA
POLYMERASES I, II,
AND III SUBUNIT
RPABC5
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 10 ILE C  46
SER C 237
LEU C 118
SER C 115
ASP J  16
 None
 1.46A 6dm1B-5ip7C:
undetectable
6dm1C-5ip7C:
undetectable		 6dm1B-5ip7C:
14.29
6dm1C-5ip7C:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM1_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5ip7 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB3
DNA-DIRECTED RNA
POLYMERASES I, II,
AND III SUBUNIT
RPABC5
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 11 ILE C  46
SER C 237
LEU C 118
SER C 115
ASP J  16
 None
 1.39A 6dm1A-5ip7C:
undetectable
6dm1D-5ip7C:
undetectable		 6dm1A-5ip7C:
14.29
6dm1D-5ip7C:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_B_CYZB1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5ip7 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB3
DNA-DIRECTED RNA
POLYMERASES I, II,
AND III SUBUNIT
RPABC5
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 10 SER C 237
LEU C 118
SER C 115
ASP J  16
ILE C  46
 None
 1.38A 6dm2B-5ip7C:
undetectable
6dm2C-5ip7C:
undetectable		 6dm2B-5ip7C:
14.29
6dm2C-5ip7C:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DM2_D_CYZD1302_0
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT)		 5ip7 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB3
DNA-DIRECTED RNA
POLYMERASES I, II,
AND III SUBUNIT
RPABC5
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		5 / 10 ILE C  46
SER C 237
LEU C 118
SER C 115
ASP J  16
 None
 1.39A 6dm2A-5ip7C:
undetectable
6dm2D-5ip7C:
undetectable		 6dm2A-5ip7C:
14.29
6dm2D-5ip7C:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_ACTA813_0
(GEPHYRIN)		 5ip7 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB11
(Saccharomyces
cerevisiae) 		3 / 3 THR K  77
ALA K  86
LYS K  88
 None
 0.75A 6fgcA-5ip7K:
undetectable		 6fgcA-5ip7K:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_1
(TYROSINE-PROTEIN
KINASE ABL1)		 5ip7 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB3
DNA-DIRECTED RNA
POLYMERASES I, II,
AND III SUBUNIT
RPABC5
(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		4 / 6 LEU J  24
TYR J  21
VAL C 235
GLY J  33
 None
 0.94A 6hd4B-5ip7J:
undetectable		 6hd4B-5ip7J:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I0Y_A_TRPA3001_0
(23S RIBOSOMAL RNA
TRYPTOPHANASE OPERON
LEADER PEPTIDE)		 5ip7 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB3
(Saccharomyces
cerevisiae) 		3 / 3 TRP C 170
ILE C  46
ASP C  47
 None
 0.71A 6i0y7-5ip7C:
undetectable		 6i0y7-5ip7C:
7.76