SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ip9'

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	11GS_A_EAAA211_1 (GLUTATHIONE S-TRANSFERASE)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	4 / 7	TYR B 859 VAL B 968 ARG B 942 GLY B 947	None	0.84A	11gsA-5ip9B: undetectable	11gsA-5ip9B: 10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1AM6_A_HAEA555_1 (CARBONIC ANHYDRASE)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	4 / 7	LEU B 603 THR B 599 THR B 602 TRP B 561	None	1.02A	1am6A-5ip9B: undetectable	1am6A-5ip9B: 13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1AXW_B_MTXB733_1 (THYMIDYLATE SYNTHASE)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	5 / 11	ILE B 911 ASP B 896 LEU B 898 GLY B 897 VAL B 952	None	1.42A	1axwB-5ip9B: undetectable	1axwB-5ip9B: 11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1D4Y_A_TPVA501_1 (PROTEIN (HIV-1 PROTEASE))	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Saccharomyces cerevisiae)	5 / 10	LEU A1105 ASP A1373 ILE A 864 GLY A1065 VAL A1384	None	1.10A	1d4yA-5ip9A: undetectable	1d4yA-5ip9A: 4.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DFO_A_FFOA1002_0 (SERINE HYDROXYMETHYLTRANSFE RASE)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	5 / 12	LEU A 340 GLY A 338 LEU B1203 PRO B1197 PHE B1158	None	1.15A	1dfoA-5ip9A: undetectable	1dfoA-5ip9A: 13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DFO_B_FFOB2002_1 (SERINE HYDROXYMETHYLTRANSFE RASE)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	5 / 12	LEU A 340 GLY A 338 LEU B1203 PRO B1197 PHE B1158	None	1.15A	1dfoB-5ip9A: undetectable	1dfoB-5ip9A: 13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DFO_C_FFOC3002_1 (SERINE HYDROXYMETHYLTRANSFE RASE)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	5 / 12	LEU A 340 GLY A 338 LEU B1203 PRO B1197 PHE B1158	None	1.14A	1dfoC-5ip9A: undetectable	1dfoC-5ip9A: 13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DFO_D_FFOD4002_1 (SERINE HYDROXYMETHYLTRANSFE RASE)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	5 / 12	LEU A 340 GLY A 338 LEU B1203 PRO B1197 PHE B1158	None	1.15A	1dfoD-5ip9A: undetectable	1dfoD-5ip9A: 13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DGM_A_ADNA375_1 (ADENOSINE KINASE)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	5 / 9	ASN B 383 ILE B 382 GLY B 379 LEU B 254 TYR B 380	None	1.34A	1dgmA-5ip9B: undetectable	1dgmA-5ip9B: 14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DHJ_B_MTXB361_1 (DIHYDROFOLATE REDUCTASE)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	6 / 12	ILE B 282 ILE B 334 LEU B 273 PRO B 274 ILE B 285 THR B 268	None	1.43A	1dhjB-5ip9B: undetectable	1dhjB-5ip9B: 8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FE2_A_LAXA700_2 (PROSTAGLANDIN ENDOPEROXIDE H SYNTHASE-1)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	5 / 12	LEU B 361 PHE B 581 GLY B 584 GLY B 588 LEU B 566	None	0.93A	1fe2A-5ip9B: undetectable	1fe2A-5ip9B: 18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FM9_A_9CRA201_1 (RETINOIC ACID RECEPTOR RXR-ALPHA)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Saccharomyces cerevisiae)	5 / 12	ILE A1072 ALA A1069 ALA A1068 LEU A1370 LEU A 841	None	0.95A	1fm9A-5ip9A: undetectable	1fm9A-5ip9A: 9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1FML_B_RTLB501_0 (RETINOL DEHYDRATASE)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Saccharomyces cerevisiae)	5 / 12	ILE A 274 LEU A 296 LEU A 295 LEU A 270 ILE A 269	None	1.13A	1fmlB-5ip9A: undetectable	1fmlB-5ip9A: 11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IGX_A_EPAA700_1 (PROSTAGLANDIN ENDOPEROXIDE H SYNTHASE-1)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	5 / 12	LEU B 361 PHE B 581 GLY B 584 GLY B 588 LEU B 566	None	0.90A	1igxA-5ip9B: undetectable	1igxA-5ip9B: 18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IKE_A_HSMA190_1 (NITROPHORIN 4)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	3 / 3	ASP B 427 LEU B 420 LEU B 424	None	0.56A	1ikeA-5ip9B: undetectable	1ikeA-5ip9B: 9.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1K74_A_9CRA463_1 (RETINOIC ACID RECEPTOR RXR-ALPHA)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Saccharomyces cerevisiae)	5 / 12	ILE A1072 ALA A1069 ALA A1068 LEU A1370 LEU A 841	None	0.93A	1k74A-5ip9A: undetectable	1k74A-5ip9A: 9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1LIN_A_TFPA154_1 (CALMODULIN)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Saccharomyces cerevisiae)	4 / 7	GLU A 205 GLU A 293 LEU A 276 GLU A 280	None	1.13A	1linA-5ip9A: undetectable	1linA-5ip9A: 6.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1MJQ_H_SAMH200_0 (METHIONINE REPRESSOR)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Saccharomyces cerevisiae)	5 / 10	HIS A  92 PHE A  91 GLY A  94 LEU A 208 PRO A 231	None	1.49A	1mjqG-5ip9A: undetectable 1mjqH-5ip9A: undetectable	1mjqG-5ip9A: 5.74 1mjqH-5ip9A: 5.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1N2X_A_SAMA401_1 (S-ADENOSYL-METHYLTRA NSFERASE MRAW)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Saccharomyces cerevisiae)	4 / 4	HIS A 906 ASP A 909 SER A 917 ASP A 905	None	1.48A	1n2xA-5ip9A: undetectable	1n2xA-5ip9A: 13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1NP1_B_HSMB304_1 (NITROPHORIN 1)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	3 / 3	ASP B 427 LEU B 420 LEU B 424	None	0.57A	1np1B-5ip9B: undetectable	1np1B-5ip9B: 10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1OSV_B_CHCB201_2 (BILE ACID RECEPTOR)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Saccharomyces cerevisiae)	4 / 5	HIS A1367 ARG A1366 ILE A 511 HIS A 451	None	1.29A	1osvB-5ip9A: undetectable	1osvB-5ip9A: 8.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1PHG_A_MYTA422_1 (CYTOCHROME P450-CAM)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Saccharomyces cerevisiae)	5 / 11	VAL A1311 GLY A1310 THR A1308 VAL A1118 ILE A1327	None	1.14A	1phgA-5ip9A: undetectable	1phgA-5ip9A: 13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1Q72_H_COCH401_1 (FAB M82G2, HEAVY CHAIN FAB M82G2, LIGHT CHAIN)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	5 / 10	GLN A   4 GLY A   3 HIS A  80 HIS B1161 PHE B1180	None None ZN  A1802 (-3.1A) None None	1.45A	1q72H-5ip9A: 1.3 1q72L-5ip9A: 1.7	1q72H-5ip9A: 8.53 1q72L-5ip9A: 8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1QCA_A_FUAA221_1 (TYPE III CHLORAMPHENICOL ACETYLTRANSFERASE)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	4 / 7	THR B 272 SER B 252 PHE B 360 LEU B 385	None	1.08A	1qcaA-5ip9B: undetectable	1qcaA-5ip9B: 10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1R5L_A_VIVA301_0 (PROTEIN (ALPHA-TOCOPHEROL TRANSFER PROTEIN))	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	5 / 12	ILE B1055 ILE B1012 VAL B1052 ILE A 666 ILE B1017	None	1.33A	1r5lA-5ip9B: undetectable	1r5lA-5ip9B: 12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1SBR_A_VIBA501_1 (YKOF)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	4 / 8	PHE B 360 LEU B 254 ILE B 222 ILE B 240	None	0.74A	1sbrA-5ip9B: undetectable	1sbrA-5ip9B: 11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1U18_B_HSMB402_1 (NITROPHORIN 1)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	4 / 5	GLU B 691 THR B 599 LEU B 603 LEU B 600	None	1.05A	1u18B-5ip9B: undetectable	1u18B-5ip9B: 9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1UDU_A_CIAA1003_1 (CGMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Saccharomyces cerevisiae)	5 / 11	SER A  60 ILE A  30 VAL A  32 ALA A  33 ILE A  35	None	1.21A	1uduA-5ip9A: undetectable	1uduA-5ip9A: 11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XF1_B_ACTB1108_0 (C5A PEPTIDASE)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	4 / 6	LEU B1026 GLY A 665 ASN A 742 ILE B 827	None	0.90A	1xf1B-5ip9B: undetectable	1xf1B-5ip9B: 22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XLS_A_9CRA801_1 (RETINOIC ACID RECEPTOR RXR-ALPHA)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Saccharomyces cerevisiae)	5 / 12	ILE A1072 ALA A1069 ALA A1068 LEU A1370 LEU A 841	None	0.92A	1xlsA-5ip9A: undetectable	1xlsA-5ip9A: 10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XLS_B_9CRB802_1 (RETINOIC ACID RECEPTOR RXR-ALPHA)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Saccharomyces cerevisiae)	5 / 12	ILE A1072 ALA A1069 ALA A1068 LEU A1370 LEU A 841	None	0.92A	1xlsB-5ip9A: undetectable	1xlsB-5ip9A: 10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XLS_C_9CRC803_1 (RETINOIC ACID RECEPTOR RXR-ALPHA)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Saccharomyces cerevisiae)	5 / 12	ILE A1072 ALA A1069 ALA A1068 LEU A1370 LEU A 841	None	0.92A	1xlsC-5ip9A: undetectable	1xlsC-5ip9A: 10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XLS_D_9CRD804_1 (RETINOIC ACID RECEPTOR RXR-ALPHA)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Saccharomyces cerevisiae)	5 / 12	ILE A1072 ALA A1069 ALA A1068 LEU A1370 LEU A 841	None	0.92A	1xlsD-5ip9A: undetectable	1xlsD-5ip9A: 10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XOT_A_VDNA101_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4B)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	5 / 12	LEU B1216 ILE A1429 SER B1155 MET B1152 ILE B1194	None	1.37A	1xotA-5ip9B: undetectable	1xotA-5ip9B: 16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XZX_X_T3X500_2 (THYROID HORMONE RECEPTOR BETA-1)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Saccharomyces cerevisiae)	3 / 3	PHE A1389 ARG A1422 ASN A 858	None	0.88A	1xzxX-5ip9A: undetectable	1xzxX-5ip9A: 10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1YA3_A_STRA1001_2 (MINERALOCORTICOID RECEPTOR)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	4 / 4	LEU B1037 LEU B1058 SER B1056 LEU B1030	None	1.06A	1ya3A-5ip9B: undetectable	1ya3A-5ip9B: 12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1YAJ_B_BEZB12_0 (CES1 PROTEIN)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	4 / 4	GLY B 467 SER B 475 VAL B 479 LEU B 416	None	1.30A	1yajB-5ip9B: undetectable	1yajB-5ip9B: 18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1Z11_A_8MOA501_0 (CYTOCHROME P450, FAMILY 2, SUBFAMILY A, POLYPEPTIDE 6)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	5 / 11	PHE B 758 ILE B1055 GLY B1054 ILE A 670 LEU A 805	None	0.87A	1z11A-5ip9B: undetectable	1z11A-5ip9B: 18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1Z11_B_8MOB501_0 (CYTOCHROME P450, FAMILY 2, SUBFAMILY A, POLYPEPTIDE 6)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	5 / 11	PHE B 758 ILE B1055 GLY B1054 ILE A 670 LEU A 805	None	0.92A	1z11B-5ip9B: undetectable	1z11B-5ip9B: 18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1Z11_C_8MOC501_0 (CYTOCHROME P450, FAMILY 2, SUBFAMILY A, POLYPEPTIDE 6)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	5 / 10	PHE B 758 ILE B1055 GLY B1054 ILE A 670 LEU A 805	None	0.89A	1z11C-5ip9B: undetectable	1z11C-5ip9B: 18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2AB2_A_SNLA502_2 (MINERALOCORTICOID RECEPTOR)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	4 / 6	LEU B 386 LEU B 390 CYH B 317 LEU B 298	None	0.88A	2ab2A-5ip9B: undetectable	2ab2A-5ip9B: 13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ACL_G_REAG501_1 (RETINOIC ACID RECEPTOR RXR-ALPHA)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Saccharomyces cerevisiae)	5 / 12	ILE A1072 ALA A1069 ALA A1068 LEU A1370 LEU A 841	None	0.93A	2aclG-5ip9A: undetectable	2aclG-5ip9A: 9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2BXE_A_1FLA2001_1 (SERUM ALBUMIN)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Saccharomyces cerevisiae)	5 / 11	LEU A 374 ILE A 370 VAL A 364 GLY A 365 LEU A 489	None	1.42A	2bxeA-5ip9A: 3.9	2bxeA-5ip9A: 16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2DRD_A_MIYA2001_1 (ACRB)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	5 / 9	PHE A 662 GLY A 661 ILE B1085 ALA B 828 PHE B1069	None	1.18A	2drdA-5ip9A: 3.6	2drdA-5ip9A: 20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2E1Q_D_SALD5006_1 (XANTHINE DEHYDROGENASE/OXIDAS E)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Saccharomyces cerevisiae)	4 / 5	PHE A1402 THR A1385 LEU A1105 ALA A 844	None	1.44A	2e1qD-5ip9A: undetectable	2e1qD-5ip9A: 21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2E7F_A_C2FA3000_0 (5-METHYLTETRAHYDROFO LATE CORRINOID/IRON SULFUR PROTEIN METHYLTRANSFERASE)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Saccharomyces cerevisiae)	5 / 12	GLU A1411 ILE A 138 LEU A 113 GLY A 223 SER A1415	None	1.27A	2e7fA-5ip9A: undetectable	2e7fA-5ip9A: 9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2EZ7_A_DHIA301_0 (CARBONIC ANHYDRASE 2)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	4 / 6	ASN B 103 GLN B 958 THR B 454 PRO B 171	None	1.25A	2ez7A-5ip9B: undetectable	2ez7A-5ip9B: 13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2G70_A_SAMA2001_0 (PHENYLETHANOLAMINE N-METHYLTRANSFERASE)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	5 / 12	PHE A 444 VAL A 366 ALA B1107 PHE A 347 VAL A 442	None	1.45A	2g70A-5ip9A: undetectable	2g70A-5ip9A: 9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2G70_B_SAMB2002_0 (PHENYLETHANOLAMINE N-METHYLTRANSFERASE)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	5 / 12	PHE A 444 VAL A 366 ALA B1107 PHE A 347 VAL A 442	None	1.45A	2g70B-5ip9A: undetectable	2g70B-5ip9A: 9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2GSS_A_EAAA0_1 (GLUTATHIONE S-TRANSFERASE P1-1)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	4 / 8	TYR B 859 VAL B 968 ARG B 942 GLY B 947	None	0.85A	2gssA-5ip9B: undetectable	2gssA-5ip9B: 10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2GSS_B_EAAB0_1 (GLUTATHIONE S-TRANSFERASE P1-1)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	4 / 8	TYR B 859 VAL B 968 ARG B 942 GLY B 947	None	0.85A	2gssB-5ip9B: undetectable	2gssB-5ip9B: 10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2H79_A_T3A1_1 (THRA PROTEIN)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	5 / 12	ILE B 756 ILE B 755 ALA B 752 SER B 771 PHE B 814	None	1.03A	2h79A-5ip9B: undetectable	2h79A-5ip9B: 11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2HDN_H_TACH4888_1 (ELONGATION FACTOR EF-TU)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Saccharomyces cerevisiae)	4 / 7	VAL A1363 LEU A1105 SER A1361 PRO A1075	None	1.03A	2hdnF-5ip9A: undetectable 2hdnG-5ip9A: undetectable 2hdnH-5ip9A: undetectable	2hdnF-5ip9A: 13.62 2hdnG-5ip9A: 2.20 2hdnH-5ip9A: 13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2HS1_B_017B203_1 (HIV-1 PROTEASE)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	4 / 7	GLU B1132 MET B1152 ARG B1135 GLY A 342	None	0.91A	2hs1B-5ip9B: undetectable	2hs1B-5ip9B: 6.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2LBD_A_REAA500_1 (RETINOIC ACID RECEPTOR GAMMA)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	5 / 12	CYH B1166 LEU B1168 MET B1169 ILE B1162 LEU A1397	ZN  B1301 (-2.2A) None None None None	1.23A	2lbdA-5ip9B: undetectable	2lbdA-5ip9B: 12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2NYR_B_SVRB401_2 (NAD-DEPENDENT DEACETYLASE SIRTUIN-5)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	4 / 6	PHE A  19 ARG B1215 ASN B1211 LEU A  58	None	1.21A	2nyrA-5ip9A: undetectable	2nyrA-5ip9A: 10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2OGY_A_C2FA3000_0 (5-METHYLTETRAHYDROFO LATE CORRINOID/IRON SULFUR PROTEIN METHYLTRANSFERASE)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Saccharomyces cerevisiae)	5 / 12	GLU A1411 ILE A 138 LEU A 113 GLY A 223 SER A1415	None	1.27A	2ogyA-5ip9A: undetectable	2ogyA-5ip9A: 8.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QD3_A_CHDA502_0 (FERROCHELATASE)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	4 / 8	ARG A 344 SER A 454 GLY B1131 MET B1133	None	1.07A	2qd3A-5ip9A: undetectable	2qd3A-5ip9A: 11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QEB_A_HSMA145_1 (D7R4 PROTEIN)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	4 / 7	ILE B 609 ARG B 604 ASP B 694 GLU B 697	None	1.07A	2qebA-5ip9B: undetectable	2qebA-5ip9B: 8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QEB_B_HSMB145_1 (D7R4 PROTEIN)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	4 / 7	ILE B 609 ARG B 604 ASP B 694 GLU B 697	None	1.13A	2qebB-5ip9B: undetectable	2qebB-5ip9B: 8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2QMJ_A_ACRA1001_1 (MALTASE-GLUCOAMYLASE , INTESTINAL)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Saccharomyces cerevisiae)	5 / 12	ASP A 592 ILE A 612 ILE A 607 ARG A 590 ALA A 749	None	1.49A	2qmjA-5ip9A: undetectable	2qmjA-5ip9A: 19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2VCT_D_ASDD1223_1 (GLUTATHIONE S-TRANSFERASE A2)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	4 / 7	ILE B  95 LEU B 420 PHE B 417 PHE B  54	None	1.02A	2vctD-5ip9B: undetectable	2vctD-5ip9B: 10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2VCT_D_ASDD1223_1 (GLUTATHIONE S-TRANSFERASE A2)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	4 / 7	ILE B 301 GLY B 379 LEU B 289 PHE B 286	None	0.86A	2vctD-5ip9B: undetectable	2vctD-5ip9B: 10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2W98_B_P1ZB1356_1 (PROSTAGLANDIN REDUCTASE 2)	5ip9	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3 (Saccharomyces cerevisiae)	4 / 8	ILE H  59 PHE H 118 LEU H  38 LEU H  40	None	0.81A	2w98B-5ip9H: undetectable	2w98B-5ip9H: 17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2WEK_B_DIFB1376_1 (ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	4 / 7	GLY A 820 ALA A 817 MET A 818 LEU B 514	None	0.92A	2wekB-5ip9A: undetectable	2wekB-5ip9A: 11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XRH_A_NIOA200_1 (PROTEIN HP0721)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	4 / 7	GLY B 321 ILE B 297 ARG B 287 GLN B 325	None	1.00A	2xrhA-5ip9B: undetectable	2xrhA-5ip9B: 6.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2XYT_D_TC9D1206_1 (SOLUBLE ACETYLCHOLINE RECEPTOR)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Saccharomyces cerevisiae)	4 / 7	TYR A1362 TYR A1349 GLU A 870 TYR A1365	None	1.21A	2xytD-5ip9A: undetectable	2xytD-5ip9A: 9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2YA7_C_ZMRC1776_2 (NEURAMINIDASE A)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	4 / 6	ASP A 260 GLN B1205 GLU B1206 TYR B1198	None	1.34A	2ya7C-5ip9A: undetectable	2ya7C-5ip9A: 13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZM9_A_ACAA502_1 (6-AMINOHEXANOATE-DIM ER HYDROLASE)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Saccharomyces cerevisiae)	4 / 8	ALA A1440 HIS A 851 GLY A1439 ILE A1436	None	0.71A	2zm9A-5ip9A: undetectable	2zm9A-5ip9A: 12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3A25_A_SAMA279_1 (UNCHARACTERIZED PROTEIN PH0793)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	3 / 3	MET B 662 GLU B 810 ASP B1043	None	1.10A	3a25A-5ip9B: undetectable	3a25A-5ip9B: 13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ABM_J_CHDJ60_0 (CYTOCHROME C OXIDASE POLYPEPTIDE 7A1 CYTOCHROME C OXIDASE SUBUNIT 1)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	4 / 6	LEU B1128 ARG B1108 THR A 375 LEU A 374	None	1.01A	3abmA-5ip9B: undetectable 3abmJ-5ip9B: undetectable	3abmA-5ip9B: 16.88 3abmJ-5ip9B: 4.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3AI8_A_HNQA255_1 (CATHEPSIN B)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	4 / 7	GLN A 510 HIS A 451 CYH A 520 HIS B1141	None	1.20A	3ai8A-5ip9A: undetectable	3ai8A-5ip9A: 8.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3AU7_A_AG2A7011_1 (PUTATIVE UNCHARACTERIZED PROTEIN)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	4 / 4	ASN B 538 VAL B 522 CYH B 523 ARG B 496	None	1.14A	3au7A-5ip9B: 0.0	3au7A-5ip9B: 17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3B9M_A_SALA1100_1 (SERUM ALBUMIN)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	4 / 4	LEU B1207 ARG A1399 LEU A1397 ALA A1412	None	1.13A	3b9mA-5ip9B: 2.5	3b9mA-5ip9B: 18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BOG_C_DVAC10_0 (6.5 KDA GLYCINE-RICH ANTIFREEZE PROTEIN)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	3 / 3	GLY B1142 GLY A1061 GLY A1437	None	0.40A	3bogC-5ip9B: undetectable	3bogC-5ip9B: 5.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3BOG_D_DVAD10_0 (6.5 KDA GLYCINE-RICH ANTIFREEZE PROTEIN)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	3 / 3	GLY B1142 GLY A1061 GLY A1437	None	0.36A	3bogD-5ip9B: undetectable	3bogD-5ip9B: 5.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3CYX_A_ROCA201_4 (HIV-1 PROTEASE)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	4 / 4	LEU B1030 ASP B 760 VAL B1023 THR A 669	None	0.96A	3cyxB-5ip9B: undetectable	3cyxB-5ip9B: 6.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3D91_B_REMB350_2 (RENIN)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Saccharomyces cerevisiae)	4 / 4	VAL A 946 TYR A1365 PRO A 955 PHE A 947	None	1.31A	3d91B-5ip9A: undetectable	3d91B-5ip9A: 11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EEO_A_SAMA328_1 (MODIFICATION METHYLASE HHAI)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Saccharomyces cerevisiae)	3 / 3	GLU A1139 SER A1145 VAL A1146	None	0.73A	3eeoA-5ip9A: undetectable	3eeoA-5ip9A: 11.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EEY_B_SAMB300_0 (PUTATIVE RRNA METHYLASE)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	5 / 12	ASN B 538 ILE B 545 GLN B  46 GLY B 631 ASN B 499	None	0.99A	3eeyB-5ip9B: undetectable	3eeyB-5ip9B: 10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EM0_B_CHDB152_0 (ILEAL BILE ACID-BINDING PROTEIN)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Saccharomyces cerevisiae)	4 / 8	ILE A 436 ASN A 488 VAL A 364 GLY A 365	None	0.83A	3em0B-5ip9A: undetectable	3em0B-5ip9A: 5.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3G4L_D_ROFD904_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4D)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	3 / 3	ASN B 822 MET B 778 PHE B 851	None	1.09A	3g4lD-5ip9B: undetectable	3g4lD-5ip9B: 14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3G8I_A_RO7A1_1 (PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR ALPHA)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Saccharomyces cerevisiae)	5 / 12	VAL A  17 CYH A1421 SER A 859 ILE A1429 ILE A1436	None	1.47A	3g8iA-5ip9A: undetectable	3g8iA-5ip9A: 10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3HCO_A_CHDA3_0 (FERROCHELATASE, MITOCHONDRIAL)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Saccharomyces cerevisiae)	4 / 4	LEU A 956 PRO A 957 LEU A1021 ARG A1023	None	1.45A	3hcoA-5ip9A: undetectable	3hcoA-5ip9A: 11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3HJO_A_EAAA211_1 (GLUTATHIONE S-TRANSFERASE P)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Saccharomyces cerevisiae)	4 / 8	VAL A 102 TRP A 139 ILE A 128 GLY A 223	None	0.88A	3hjoA-5ip9A: undetectable	3hjoA-5ip9A: 8.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3HJO_B_EAAB211_1 (GLUTATHIONE S-TRANSFERASE P)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Saccharomyces cerevisiae)	4 / 8	VAL A 102 TRP A 139 ILE A 128 GLY A 223	None	0.89A	3hjoB-5ip9A: undetectable	3hjoB-5ip9A: 8.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3JZJ_A_ACRA405_1 (ACARBOSE/MALTOSE BINDING PROTEIN GACH)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Saccharomyces cerevisiae)	5 / 12	GLY A 223 GLU A1417 ASP A 130 GLY A1395 ARG A1399	None	1.28A	3jzjA-5ip9A: undetectable	3jzjA-5ip9A: 12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3KP6_B_SALB3001_1 (TRANSCRIPTIONAL REGULATOR TCAR)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Saccharomyces cerevisiae)	4 / 8	GLU A 280 ASN A 282 HIS A 281 ILE A 274	None	1.23A	3kp6A-5ip9A: undetectable 3kp6B-5ip9A: undetectable	3kp6A-5ip9A: 6.72 3kp6B-5ip9A: 6.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LCV_B_SAMB301_1 (SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Saccharomyces cerevisiae)	3 / 3	ARG A 350 ASP A 481 GLN A1078	None MG  A1803 (-3.5A) None	0.82A	3lcvB-5ip9A: undetectable	3lcvB-5ip9A: 10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LN1_C_CELC682_2 (PROSTAGLANDIN G/H SYNTHASE 2)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	4 / 7	ARG B 635 SER B 746 LEU B 514 PHE A 813	None	0.82A	3ln1C-5ip9B: undetectable	3ln1C-5ip9B: 19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3MDR_B_GJZB506_1 (CHOLESTEROL 24-HYDROXYLASE)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	4 / 6	ILE B 827 ALA B 826 ALA B 823 THR B1090	None	1.08A	3mdrB-5ip9B: undetectable	3mdrB-5ip9B: 17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3N23_A_OBNA1_1 (SODIUM/POTASSIUM-TRA NSPORTING ATPASE SUBUNIT ALPHA-1)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	5 / 11	GLN A 650 ASP A 526 ASN A 654 PHE A 482 ILE B1011	None	1.14A	3n23A-5ip9A: undetectable	3n23A-5ip9A: 20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3N9J_A_EAAA210_1 (GLUTATHIONE S-TRANSFERASE P)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	4 / 8	TYR B 859 VAL B 968 ARG B 942 GLY B 947	None	0.90A	3n9jA-5ip9B: undetectable	3n9jA-5ip9B: 10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OCT_A_1N1A663_2 (TYROSINE-PROTEIN KINASE BTK)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Saccharomyces cerevisiae)	4 / 5	ILE A1227 MET A1267 ASN A1270 PHE A1225	None	1.37A	3octA-5ip9A: 2.3	3octA-5ip9A: 9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3OU6_C_SAMC300_1 (SAM-DEPENDENT METHYLTRANSFERASE)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	3 / 3	TYR B1217 GLY B1164 ASP B1190	None	0.66A	3ou6C-5ip9B: undetectable	3ou6C-5ip9B: 10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3P2K_A_SAMA6735_0 (16S RRNA METHYLASE)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	5 / 12	GLY B1142 ALA A 506 ALA A 457 LEU B1147 LEU A 501	None	0.95A	3p2kA-5ip9B: undetectable	3p2kA-5ip9B: 10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3P2K_C_SAMC6735_1 (16S RRNA METHYLASE)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Saccharomyces cerevisiae)	4 / 5	ASN A 953 GLU A 618 THR A 621 SER A 882	None	1.49A	3p2kC-5ip9A: undetectable	3p2kC-5ip9A: 8.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3P2K_D_SAMD6735_0 (16S RRNA METHYLASE)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	5 / 12	GLY B1142 ALA A 506 ALA A 457 LEU B1147 LEU A 501	None	1.04A	3p2kD-5ip9B: undetectable	3p2kD-5ip9B: 10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3RD0_A_EDPA175_1 (FERRITIN LIGHT CHAIN)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3 (Saccharomyces cerevisiae)	4 / 6	LEU H 122 TYR H 115 ALA H 101 LEU A 598	None	1.12A	3rd0A-5ip9H: undetectable	3rd0A-5ip9H: 22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3S3O_A_DLUA399_1 (PFV INTEGRASE)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	4 / 7	ASP A 485 TYR B 769 GLN B 776 ARG B 766	MG  A1803 (-4.1A) None None None	1.28A	3s3oA-5ip9A: undetectable	3s3oA-5ip9A: 12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3S56_A_ROCA201_2 (PROTEASE)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	5 / 9	ASP B1101 GLY B 977 ILE B 976 ILE A 370 ILE B1103	None	1.06A	3s56B-5ip9B: undetectable	3s56B-5ip9B: 6.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3SP9_A_IL2A901_1 (PEROXISOME PROLIFERATOR-ACTIVAT ED RECEPTOR DELTA)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	5 / 12	LEU B 661 HIS A 786 ILE B 703 LEU B 651 VAL B 653	None	1.29A	3sp9A-5ip9B: undetectable	3sp9A-5ip9B: 13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3TM4_A_SAMA401_1 (TRNA (GUANINE N2-)-METHYLTRANSFERA SE TRM14)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	4 / 5	HIS B 648 THR B 736 GLU B 650 ASP B  29	None	1.25A	3tm4A-5ip9B: undetectable	3tm4A-5ip9B: 16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3TM4_B_SAMB401_1 (TRNA (GUANINE N2-)-METHYLTRANSFERA SE TRM14)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	4 / 5	HIS B 648 THR B 736 GLU B 650 ASP B  29	None	1.26A	3tm4B-5ip9B: undetectable	3tm4B-5ip9B: 16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3TVX_B_PNXB902_1 (CAMP-SPECIFIC 3',5'-CYCLIC PHOSPHODIESTERASE 4A)	5ip9	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3 (Saccharomyces cerevisiae)	4 / 7	TYR H  98 ASN H 139 PHE H 118 MET H 123	None	1.21A	3tvxB-5ip9H: undetectable	3tvxB-5ip9H: 17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3UGR_A_IMNA2001_2 (ALDO-KETO REDUCTASE FAMILY 1 MEMBER C3)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	4 / 7	ASN B1211 GLU A  26 GLN A  18 PRO A 240	None	1.25A	3ugrA-5ip9B: undetectable	3ugrA-5ip9B: 13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3V4T_H_ACTH504_0 (UDP-N-ACETYLGLUCOSAM INE 1-CARBOXYVINYLTRANSF ERASE)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	3 / 3	LYS B 625 GLU B 623 TRP B 586	None	0.88A	3v4tH-5ip9B: undetectable	3v4tH-5ip9B: 17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3W9T_F_W9TF512_1 (HEMOLYTIC LECTIN CEL-III)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	4 / 6	ASN B 538 CYH B 523 GLY B 750 ILE B 756	None	1.03A	3w9tF-5ip9B: undetectable	3w9tF-5ip9B: 15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3WEM_A_ACRA1001_1 (ALPHA-GLUCOSIDASE)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	5 / 12	ALA B 793 ASN B 794 ILE B 204 ARG B 788 ASP B 790	None	1.46A	3wemA-5ip9B: undetectable	3wemA-5ip9B: 21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3WEN_A_ACRA1001_1 (ALPHA-GLUCOSIDASE)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	5 / 12	ALA B 793 ASN B 794 ILE B 204 ARG B 788 ASP B 790	None	1.44A	3wenA-5ip9B: undetectable	3wenA-5ip9B: 21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3WEO_A_ACRA1001_1 (ALPHA-GLUCOSIDASE)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	5 / 12	ALA B 793 ASN B 794 ILE B 204 ARG B 788 ASP B 790	None	1.46A	3weoA-5ip9B: undetectable	3weoA-5ip9B: 21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A9K_A_TYLA2200_1 (CREB-BINDING PROTEIN)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Saccharomyces cerevisiae)	4 / 6	VAL A 990 LEU A1046 ILE A1049 VAL A1031	None	0.84A	4a9kA-5ip9A: undetectable	4a9kA-5ip9A: 6.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4AX8_A_SAMA1474_1 (WBDD)	5ip9	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3 (Saccharomyces cerevisiae)	4 / 6	TYR H 115 ASP H  41 GLU H  14 LEU H 125	None	1.20A	4ax8A-5ip9H: 2.1	4ax8A-5ip9H: 13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4D33_A_MTLA870_0 (NITRIC OXIDE SYNTHASE, ENDOTHELIAL)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	4 / 8	SER B1019 ARG B1020 ILE B1017 ASN A 757	None	1.15A	4d33A-5ip9B: undetectable	4d33A-5ip9B: 15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4DJF_B_C2FB300_0 (5-METHYLTETRAHYDROFO LATE CORRINOID/IRON SULFUR PROTEIN METHYLTRANSFERASE)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Saccharomyces cerevisiae)	5 / 12	ASN A  54 ILE A  61 GLY A 258 GLN A 316 ARG A 320	None	1.33A	4djfB-5ip9A: undetectable	4djfB-5ip9A: 9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4EAH_F_ACTF402_0 (ACTIN, ALPHA SKELETAL MUSCLE)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	3 / 3	PHE B1047 ASP B1049 ARG B 730	None	0.86A	4eahF-5ip9B: undetectable	4eahF-5ip9B: 15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4EAH_G_ACTG401_0 (ACTIN, ALPHA SKELETAL MUSCLE)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	3 / 3	PHE B1047 ASP B1049 ARG B 730	None	0.86A	4eahG-5ip9B: undetectable	4eahG-5ip9B: 15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4EM2_A_SALA504_1 (UNCHARACTERIZED HTH-TYPE TRANSCRIPTIONAL REGULATOR SAR2349)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Saccharomyces cerevisiae)	4 / 8	GLY A1065 LEU A 845 ILE A 864 THR A 856	None	0.70A	4em2A-5ip9A: undetectable	4em2A-5ip9A: 7.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4F8Y_C_VK3C202_1 (NADPH QUINONE OXIDOREDUCTASE)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	4 / 7	TYR B 488 LEU B 817 ASN B 784 TYR B 190	None	1.08A	4f8yC-5ip9B: undetectable 4f8yD-5ip9B: undetectable	4f8yC-5ip9B: 9.63 4f8yD-5ip9B: 9.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4J7X_A_SASA806_1 (SEPIAPTERIN REDUCTASE)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	5 / 12	SER A 751 CYH A 529 PHE A 662 PRO B1018 GLY A 665	None	1.36A	4j7xA-5ip9A: undetectable	4j7xA-5ip9A: 10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4JKS_A_ADNA401_2 (PROBABLE SUGAR KINASE PROTEIN)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	4 / 4	SER B 546 LEU B 521 TYR B 634 PRO B 411	None	1.46A	4jksA-5ip9B: undetectable	4jksA-5ip9B: 15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4JKS_B_ADNB401_2 (PROBABLE SUGAR KINASE PROTEIN)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	4 / 4	SER B 546 LEU B 521 TYR B 634 PRO B 411	None	1.46A	4jksB-5ip9B: undetectable	4jksB-5ip9B: 15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4JKU_A_ADNA500_2 (PROBABLE SUGAR KINASE PROTEIN)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	4 / 4	SER B 546 LEU B 521 TYR B 634 PRO B 411	None	1.47A	4jkuA-5ip9B: undetectable	4jkuA-5ip9B: 15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K36_A_SAMA504_0 (ANAEROBIC SULFATASE-MATURATING ENZYME)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Saccharomyces cerevisiae)	5 / 12	TYR A1362 GLN A 881 ASN A 953 LEU A 956 ILE A 878	None	1.50A	4k36A-5ip9A: undetectable	4k36A-5ip9A: 11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K36_A_SAMA504_0 (ANAEROBIC SULFATASE-MATURATING ENZYME)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	5 / 12	GLN B  47 ASN B  52 SER B  50 LEU B 408 LEU B 416	None	1.28A	4k36A-5ip9B: undetectable	4k36A-5ip9B: 14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K37_B_SAMB504_0 (ANAEROBIC SULFATASE-MATURATING ENZYME)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	5 / 11	GLN B  47 ASN B  52 SER B  50 LEU B 408 LEU B 416	None	1.25A	4k37B-5ip9B: undetectable	4k37B-5ip9B: 15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K6I_A_9RAA500_1 (RETINOIC ACID RECEPTOR RXR-ALPHA)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Saccharomyces cerevisiae)	5 / 12	ILE A1072 ALA A1069 ALA A1068 LEU A1370 LEU A 841	None	0.95A	4k6iA-5ip9A: undetectable	4k6iA-5ip9A: 11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K8C_B_ADNB401_2 (SUGAR KINASE)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	4 / 4	SER B 546 LEU B 521 TYR B 634 PRO B 411	None	1.45A	4k8cB-5ip9B: undetectable	4k8cB-5ip9B: 15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K8K_A_ADNA401_2 (SUGAR KINASE)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	4 / 4	SER B 546 LEU B 521 TYR B 634 PRO B 411	None	1.46A	4k8kA-5ip9B: undetectable	4k8kA-5ip9B: 15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4K8K_B_ADNB403_2 (SUGAR KINASE)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	4 / 4	SER B 546 LEU B 521 TYR B 634 PRO B 411	None	1.45A	4k8kB-5ip9B: undetectable	4k8kB-5ip9B: 15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KAL_A_ADNA401_2 (PROBABLE SUGAR KINASE PROTEIN)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	4 / 4	SER B 546 LEU B 521 TYR B 634 PRO B 411	None	1.47A	4kalA-5ip9B: undetectable	4kalA-5ip9B: 15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KAL_B_ADNB401_2 (PROBABLE SUGAR KINASE PROTEIN)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	4 / 4	SER B 546 LEU B 521 TYR B 634 PRO B 411	None	1.47A	4kalB-5ip9B: undetectable	4kalB-5ip9B: 15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KCN_B_MTLB806_0 (NITRIC OXIDE SYNTHASE, BRAIN)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	4 / 7	SER A 663 GLN B1065 PHE B1086 ASN A 742	None	1.34A	4kcnB-5ip9A: undetectable	4kcnB-5ip9A: 13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KIC_A_SAMA401_0 (METHYLTRANSFERASE MPPJ)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Saccharomyces cerevisiae)	5 / 12	GLY A 869 GLY A 872 ALA A 875 ALA A1369 PHE A 866	None	1.15A	4kicA-5ip9A: undetectable	4kicA-5ip9A: 10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4LCA_A_ADNA401_2 (PROBABLE SUGAR KINASE PROTEIN)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	4 / 4	SER B 546 LEU B 521 TYR B 634 PRO B 411	None	1.47A	4lcaA-5ip9B: undetectable	4lcaA-5ip9B: 15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4LCA_B_ADNB401_2 (PROBABLE SUGAR KINASE PROTEIN)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	4 / 4	SER B 546 LEU B 521 TYR B 634 PRO B 411	None	1.47A	4lcaB-5ip9B: undetectable	4lcaB-5ip9B: 15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4OBW_C_SAMC601_0 (2-METHOXY-6-POLYPREN YL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Saccharomyces cerevisiae)	5 / 12	GLY A 365 ASP A 356 ILE A 436 ARG A 459 ASN A 439	None	1.27A	4obwC-5ip9A: undetectable	4obwC-5ip9A: 10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4OKT_A_198A1001_1 (ANDROGEN RECEPTOR)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	5 / 12	LEU B 412 LEU B 413 GLY B 410 VAL B 211 ILE B 545	None	1.30A	4oktA-5ip9B: undetectable	4oktA-5ip9B: 11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4P6S_A_DAHA304_1 (TYROSINASE)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Saccharomyces cerevisiae)	4 / 5	ASN A  54 LEU A  53 GLU A 259 THR A 263	None	1.29A	4p6sA-5ip9A: undetectable	4p6sA-5ip9A: 10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4PE5_B_QELB920_1 (GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1 GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	5 / 10	LEU A 740 ALA B1083 GLN B1084 ILE B1085 PHE B1086	None	1.32A	4pe5A-5ip9A: undetectable 4pe5B-5ip9A: undetectable	4pe5A-5ip9A: 18.04 4pe5B-5ip9A: 19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4PE5_C_QELC939_1 (GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1 GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	5 / 10	LEU A 740 ALA B1083 GLN B1084 ILE B1085 PHE B1086	None	1.32A	4pe5C-5ip9A: undetectable 4pe5D-5ip9A: undetectable	4pe5C-5ip9A: 18.04 4pe5D-5ip9A: 19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4PE5_C_QELC939_1 (GLUTAMATE RECEPTOR IONOTROPIC, NMDA 1 GLUTAMATE RECEPTOR IONOTROPIC, NMDA 2B)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	5 / 10	THR A 664 LEU A 740 ALA B1083 GLN B1084 ILE B1085	None	1.17A	4pe5C-5ip9A: undetectable 4pe5D-5ip9A: undetectable	4pe5C-5ip9A: 18.04 4pe5D-5ip9A: 19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4PEV_B_ADNB501_1 (MEMBRANE LIPOPROTEIN FAMILY PROTEIN)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Saccharomyces cerevisiae)	5 / 12	ASP A1419 SER A1415 GLY A1395 PHE A  19 GLY A1413	None	1.34A	4pevB-5ip9A: undetectable	4pevB-5ip9A: 14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4PEV_B_ADNB501_1 (MEMBRANE LIPOPROTEIN FAMILY PROTEIN)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Saccharomyces cerevisiae)	5 / 12	ASP A1419 VAL A  17 SER A1415 GLY A1395 GLY A1413	None	0.99A	4pevB-5ip9A: undetectable	4pevB-5ip9A: 14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QOI_A_ML1A303_1 (RIBOSYLDIHYDRONICOTI NAMIDE DEHYDROGENASE [QUINONE])	5ip9	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3 (Saccharomyces cerevisiae)	4 / 8	TYR H 116 PHE H 104 GLY H 127 ASN H 134	None	0.95A	4qoiA-5ip9H: undetectable 4qoiB-5ip9H: undetectable	4qoiA-5ip9H: 19.31 4qoiB-5ip9H: 19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4W5R_A_IPHA904_0 (PROTEIN ARGONAUTE-2)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	4 / 4	PHE A 347 VAL A 491 ALA B1154 PHE B1146	None	1.23A	4w5rA-5ip9A: 2.3	4w5rA-5ip9A: 18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4W5T_A_IPHA904_0 (PROTEIN ARGONAUTE-2)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	4 / 4	PHE A 347 VAL A 491 ALA B1154 PHE B1146	None	1.20A	4w5tA-5ip9A: undetectable	4w5tA-5ip9A: 18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4X1I_D_LOCD502_1 (TUBULIN BETA CHAIN)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	5 / 12	LEU B 356 LYS B 374 LEU B 378 ALA B 271 ILE B 282	None	1.14A	4x1iD-5ip9B: undetectable	4x1iD-5ip9B: 15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4X3U_B_SVRB102_1 (CHROMOBOX PROTEIN HOMOLOG 7)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Saccharomyces cerevisiae)	3 / 3	LYS A 687 ARG A 726 VAL A 765	None	1.07A	4x3uA-5ip9A: undetectable 4x3uB-5ip9A: undetectable	4x3uA-5ip9A: 4.64 4x3uB-5ip9A: 4.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4X3U_B_SVRB102_1 (CHROMOBOX PROTEIN HOMOLOG 7)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	3 / 3	LYS B 972 ARG B 904 VAL B 905	None	1.06A	4x3uA-5ip9B: 2.3 4x3uB-5ip9B: undetectable	4x3uA-5ip9B: 4.67 4x3uB-5ip9B: 4.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XIW_B_AZMB402_1 (CARBONIC ANHYDRASE, ALPHA TYPE)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Saccharomyces cerevisiae)	5 / 12	HIS A 399 HIS A 435 LEU A 374 VAL A 491 PRO A 492	None	1.12A	4xiwB-5ip9A: undetectable 4xiwE-5ip9A: undetectable	4xiwB-5ip9A: 8.09 4xiwE-5ip9A: 8.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4XP4_A_COCA706_1 (DOPAMINE TRANSPORTER)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3 (Saccharomyces cerevisiae)	5 / 11	ASP A 602 VAL H  23 TYR H  20 GLY A 574 PHE A 540	None	1.17A	4xp4A-5ip9A: undetectable	4xp4A-5ip9A: 14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YHA_B_MZMB303_1 (ALPHA-CARBONIC ANHYDRASE)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Saccharomyces cerevisiae)	5 / 10	ASP A 440 HIS A 458 VAL A 460 VAL A 364 LEU A 489	None	1.32A	4yhaB-5ip9A: undetectable	4yhaB-5ip9A: 8.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4YIA_B_IMNB401_2 (THYROXINE-BINDING GLOBULIN)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	3 / 3	LEU B 600 ARG B 601 ARG B 604	None	0.76A	4yiaB-5ip9B: undetectable	4yiaB-5ip9B: 2.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Z4C_A_IPHA905_0 (PROTEIN ARGONAUTE-2)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	4 / 5	PHE A 347 VAL A 491 ALA B1154 PHE B1146	None	1.25A	4z4cA-5ip9A: 2.7	4z4cA-5ip9A: 18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Z4D_A_IPHA904_0 (PROTEIN ARGONAUTE-2)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	4 / 5	PHE A 347 VAL A 491 ALA B1154 PHE B1146	None	1.26A	4z4dA-5ip9A: undetectable	4z4dA-5ip9A: 18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Z4E_A_IPHA906_0 (PROTEIN ARGONAUTE-2)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	4 / 5	PHE A 347 VAL A 491 ALA B1154 PHE B1146	None	1.26A	4z4eA-5ip9A: 2.6	4z4eA-5ip9A: 18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Z4G_A_IPHA904_0 (PROTEIN ARGONAUTE-2)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	4 / 4	PHE A 347 VAL A 491 ALA B1154 PHE B1146	None	1.24A	4z4gA-5ip9A: 2.4	4z4gA-5ip9A: 18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ZBQ_A_ACTA605_0 (SERUM ALBUMIN)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	4 / 6	HIS B 984 GLY B 985 ARG B 766 ASN B 762	None	1.14A	4zbqA-5ip9B: undetectable	4zbqA-5ip9B: 19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ZBQ_A_ACTA605_0 (SERUM ALBUMIN)	5ip9	DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3 (Saccharomyces cerevisiae)	4 / 6	TYR H 141 GLY H  99 GLU H 138 ASN H 139	None	1.22A	4zbqA-5ip9H: undetectable	4zbqA-5ip9H: 13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ZE1_A_X2NA602_1 (LANOSTEROL 14-ALPHA DEMETHYLASE)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	5 / 12	GLY B 168 GLY B 464 LEU B 416 PHE B  54 THR B 454	None	1.21A	4ze1A-5ip9B: undetectable	4ze1A-5ip9B: 18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ZJ8_A_SUVA2001_2 (HUMAN OX1R FUSION PROTEIN TO P.ABYSII GLYCOGEN SYNTHASE)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Saccharomyces cerevisiae)	4 / 6	ILE A 586 PRO A 583 ILE A 531 VAL A 617	None	1.01A	4zj8A-5ip9A: 5.8	4zj8A-5ip9A: 14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ZZB_D_ACTD403_0 (PROTON-GATED ION CHANNEL)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Saccharomyces cerevisiae)	4 / 4	ILE A 964 ARG A 896 TYR A1035 GLU A1034	None	1.46A	4zzbD-5ip9A: 2.9	4zzbD-5ip9A: 11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ZZC_A_ACTA401_0 (PROTON-GATED ION CHANNEL)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	4 / 6	ILE B 639 ARG B 601 ILE B 701 GLU B 697	None	1.39A	4zzcA-5ip9B: undetectable 4zzcB-5ip9B: undetectable	4zzcA-5ip9B: 14.13 4zzcB-5ip9B: 14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4ZZC_B_ACTB401_0 (PROTON-GATED ION CHANNEL)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	4 / 6	ILE B 639 ARG B 601 ILE B 701 GLU B 697	None	1.32A	4zzcB-5ip9B: undetectable 4zzcC-5ip9B: undetectable	4zzcB-5ip9B: 14.13 4zzcC-5ip9B: 14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5B8I_C_FK5C201_1 (SERINE/THREONINE-PRO TEIN PHOSPHATASE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	4 / 6	LEU B 850 PRO B1089 PHE B1087 GLU B1070	None	1.29A	5b8iA-5ip9B: undetectable	5b8iA-5ip9B: 14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5CP4_A_CAMA422_0 (CYTOCHROME P450CAM)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Saccharomyces cerevisiae)	5 / 9	THR A1329 VAL A1311 GLY A1310 THR A1308 VAL A1118	None	1.17A	5cp4A-5ip9A: undetectable	5cp4A-5ip9A: 13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5DZK_P_BEZP801_0 (ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 BEZ-LEU-LEU)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Saccharomyces cerevisiae)	4 / 5	SER A 762 ALA A 763 MET A 676 LEU A 737	None	1.28A	5dzkb-5ip9A: undetectable 5dzkp-5ip9A: undetectable	5dzkb-5ip9A: 9.54 5dzkp-5ip9A: 1.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5KI6_A_IPHA902_0 (PROTEIN ARGONAUTE-2)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	4 / 4	PHE A 347 VAL A 491 ALA B1154 PHE B1146	None	1.27A	5ki6A-5ip9A: 2.4	5ki6A-5ip9A: 18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NZY_A_CE3A1103_1 (DNA CROSS-LINK REPAIR 1A PROTEIN)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	4 / 8	THR B 549 PRO B 551 VAL B 585 GLY B 584	None	0.76A	5nzyA-5ip9B: undetectable	5nzyA-5ip9B: 15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5OJ0_A_9WTA801_0 (PENICILLIN-BINDING PROTEIN 2X)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Saccharomyces cerevisiae)	5 / 12	SER A 579 GLN A 650 SER A 573 GLY A 574 THR A 535	None	1.42A	5oj0A-5ip9A: undetectable	5oj0A-5ip9A: 17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5U6N_A_SALA505_1 (UDP-GLYCOSYLTRANSFER ASE 74F2)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	4 / 8	SER B 242 HIS B 363 PHE B 377 MET B 381	None	1.47A	5u6nA-5ip9B: undetectable	5u6nA-5ip9B: 16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5V1T_A_SAMA605_0 (RADICAL SAM)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	5 / 12	THR B 454 SER B 125 VAL B 102 SER B 105 THR B 956	None	1.30A	5v1tA-5ip9B: undetectable	5v1tA-5ip9B: 17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VKQ_A_PCFA1805_0 (NO MECHANORECEPTOR POTENTIAL C ISOFORM L)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	4 / 7	PHE A 814 HIS A 786 PRO A 785 ILE B 703	None	0.92A	5vkqA-5ip9A: 5.6 5vkqD-5ip9A: 5.6	5vkqA-5ip9A: 22.20 5vkqD-5ip9A: 22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VKQ_B_PCFB1802_0 (NO MECHANORECEPTOR POTENTIAL C ISOFORM L)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	4 / 7	PHE A 814 HIS A 786 PRO A 785 ILE B 703	None	0.93A	5vkqA-5ip9A: 5.6 5vkqB-5ip9A: 5.6	5vkqA-5ip9A: 22.20 5vkqB-5ip9A: 22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VKQ_C_PCFC1803_0 (NO MECHANORECEPTOR POTENTIAL C ISOFORM L)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	4 / 8	PHE A 814 HIS A 786 PRO A 785 ILE B 703	None	0.90A	5vkqB-5ip9A: 5.6 5vkqC-5ip9A: 5.6	5vkqB-5ip9A: 22.20 5vkqC-5ip9A: 22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VKQ_D_PCFD1803_0 (NO MECHANORECEPTOR POTENTIAL C ISOFORM L)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	4 / 7	PHE A 814 HIS A 786 PRO A 785 ILE B 703	None	0.90A	5vkqC-5ip9A: 5.6 5vkqD-5ip9A: 5.6	5vkqC-5ip9A: 22.20 5vkqD-5ip9A: 22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VUN_A_MTLA805_0 (NITRIC OXIDE SYNTHASE, BRAIN)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	4 / 8	SER A 663 GLN B1065 PHE B1086 ASN A 742	None	1.32A	5vunA-5ip9A: undetectable	5vunA-5ip9A: 13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VUN_B_MTLB805_0 (NITRIC OXIDE SYNTHASE, BRAIN)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	4 / 8	SER A 663 GLN B1065 PHE B1086 ASN A 742	None	1.30A	5vunB-5ip9A: undetectable	5vunB-5ip9A: 13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5VUO_B_MTLB805_0 (NITRIC OXIDE SYNTHASE, BRAIN)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	4 / 8	SER A 663 GLN B1065 PHE B1086 ASN A 742	None	1.32A	5vuoB-5ip9A: undetectable	5vuoB-5ip9A: 13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5X1F_J_CHDJ101_0 (CYTOCHROME C OXIDASE SUBUNIT 1 CYTOCHROME C OXIDASE SUBUNIT 7A1, MITOCHONDRIAL)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae; Saccharomyces cerevisiae)	4 / 6	LEU B1128 ARG B1108 THR A 375 LEU A 374	None	0.93A	5x1fA-5ip9B: undetectable 5x1fJ-5ip9B: undetectable	5x1fA-5ip9B: 16.88 5x1fJ-5ip9B: 4.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5YW0_A_ACTA412_0 (UNCHARACTERIZED PROTEIN KDOO)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Saccharomyces cerevisiae)	3 / 3	LYS A  49 ASN A  54 SER A 249	None	1.22A	5yw0A-5ip9A: undetectable	5yw0A-5ip9A: 9.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5Z12_B_9CRB501_1 (RETINOIC ACID RECEPTOR RXR-ALPHA)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Saccharomyces cerevisiae)	5 / 12	ILE A1072 ALA A1069 ALA A1068 LEU A1370 LEU A 841	None	0.94A	5z12B-5ip9A: undetectable	5z12B-5ip9A: 4.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6A4I_A_TRPA403_0 (TRYPTOPHAN 2,3-DIOXYGENASE)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	4 / 8	ARG B 405 GLU B 245 ILE B 554 PRO B 551	None	1.09A	6a4iA-5ip9B: undetectable	6a4iA-5ip9B: 14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6CDU_G_EY4G502_0 (CHIMERIC ALPHA1GABAA RECEPTOR)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1 (Saccharomyces cerevisiae)	4 / 8	VAL A1355 PRO A1075 ILE A1104 TYR A1349	None	0.97A	6cduG-5ip9A: 3.9 6cduH-5ip9A: undetectable	6cduG-5ip9A: 10.67 6cduH-5ip9A: 10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6D8P_A_ACTA816_0 (UNCHARACTERIZED PROTEIN)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	3 / 3	ARG B 969 ARG B 967 ASP B 950	None	0.77A	6d8pA-5ip9B: undetectable	6d8pA-5ip9B: 22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6E8Q_A_X2NA602_0 (LANOSTEROL 14-ALPHA DEMETHYLASE)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	5 / 12	GLY B 168 GLY B 464 LEU B 416 PHE B  54 THR B 454	None	1.18A	6e8qA-5ip9B: 0.9	6e8qA-5ip9B: 5.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6F6S_A_CXQA507_1 (ENVELOPE GLYCOPROTEIN,ENVELOP E GLYCOPROTEIN,GP1 ENVELOPE GLYCOPROTEIN)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	4 / 5	ARG B 118 ALA B 117 TYR B 124 GLN B 115	None	1.19A	6f6sA-5ip9B: undetectable 6f6sB-5ip9B: undetectable	6f6sA-5ip9B: 5.63 6f6sB-5ip9B: 5.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6FGD_A_ACTA826_0 (GEPHYRIN)	5ip9	DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2 (Saccharomyces cerevisiae)	3 / 3	HIS B 740 ARG B 605 ILE B 639	None	0.70A	6fgdA-5ip9B: undetectable	6fgdA-5ip9B: 16.26