SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '5ipf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 5ipf HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE (HGPRT)
(Schistosoma
mansoni) 		4 / 7 MET A  44
ILE A  13
ARG A 173
MET A  52
 None
 1.48A 4f4dA-5ipfA:
3.1		 4f4dA-5ipfA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_1
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 5ipf HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE (HGPRT)
(Schistosoma
mansoni) 		4 / 4 ASP A 200
GLY A  76
ASP A 141
ASP A 144
 None
None
IMP  A1300 (-2.4A)
IMP  A1300 (-4.3A)
 1.10A 5e72A-5ipfA:
undetectable		 5e72A-5ipfA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 5ipf HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE (HGPRT)
(Schistosoma
mansoni) 		4 / 7 TYR A 201
ILE A 214
GLY A 196
PHE A 205
 None
 0.79A 5nooA-5ipfA:
undetectable		 5nooA-5ipfA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_A_486A801_1
(GLUCOCORTICOID
RECEPTOR)		 5ipf HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE (HGPRT)
(Schistosoma
mansoni) 		5 / 12 LEU A  84
LEU A  81
GLY A  77
VAL A  73
LEU A 137
 None
 1.16A 5uc1A-5ipfA:
undetectable		 5uc1A-5ipfA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_2
(GLUCOCORTICOID
RECEPTOR)		 5ipf HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE (HGPRT)
(Schistosoma
mansoni) 		5 / 12 LEU A  84
LEU A  81
GLY A  77
VAL A  73
LEU A 137
 None
 1.15A 5uc1B-5ipfA:
undetectable		 5uc1B-5ipfA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_B_HISB402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 5ipf HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE (HGPRT)
(Schistosoma
mansoni) 		5 / 9 VAL A 189
VAL A 213
LEU A 170
GLY A 196
LEU A 199
 None
None
None
None
IMP  A1300 ( 4.4A)
 1.29A 6czmA-5ipfA:
undetectable
6czmB-5ipfA:
undetectable		 6czmA-5ipfA:
22.38
6czmB-5ipfA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_E_HISE402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 5ipf HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE (HGPRT)
(Schistosoma
mansoni) 		5 / 9 VAL A 189
VAL A 213
LEU A 170
GLY A 196
LEU A 199
 None
None
None
None
IMP  A1300 ( 4.4A)
 1.27A 6czmD-5ipfA:
undetectable
6czmE-5ipfA:
undetectable		 6czmD-5ipfA:
22.38
6czmE-5ipfA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_F_HISF402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 5ipf HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE (HGPRT)
(Schistosoma
mansoni) 		5 / 10 VAL A 189
VAL A 213
LEU A 170
GLY A 196
LEU A 199
 None
None
None
None
IMP  A1300 ( 4.4A)
 1.30A 6czmE-5ipfA:
undetectable
6czmF-5ipfA:
undetectable		 6czmE-5ipfA:
22.38
6czmF-5ipfA:
22.38